IL81746A - Pharmaceutical compositions for inhibiting aromatose activity and estrogen biosynthesis containing alpha imidazolyl,triazolyl or pyridyl substituted tolunitriles,certain novel tolunitriles and their preparation - Google Patents

Pharmaceutical compositions for inhibiting aromatose activity and estrogen biosynthesis containing alpha imidazolyl,triazolyl or pyridyl substituted tolunitriles,certain novel tolunitriles and their preparation

Info

Publication number
IL81746A
IL81746A IL81746A IL8174687A IL81746A IL 81746 A IL81746 A IL 81746A IL 81746 A IL81746 A IL 81746A IL 8174687 A IL8174687 A IL 8174687A IL 81746 A IL81746 A IL 81746A
Authority
IL
Israel
Prior art keywords
alkyl
tolunitriles
substd
imidazolyl
aromatose
Prior art date
Application number
IL81746A
Other languages
English (en)
Other versions
IL81746A0 (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25274596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL81746(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of IL81746A0 publication Critical patent/IL81746A0/xx
Publication of IL81746A publication Critical patent/IL81746A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
IL81746A 1986-03-07 1987-03-03 Pharmaceutical compositions for inhibiting aromatose activity and estrogen biosynthesis containing alpha imidazolyl,triazolyl or pyridyl substituted tolunitriles,certain novel tolunitriles and their preparation IL81746A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/837,489 US4749713A (en) 1986-03-07 1986-03-07 Alpha-heterocycle substituted tolunitriles

Publications (2)

Publication Number Publication Date
IL81746A0 IL81746A0 (en) 1987-10-20
IL81746A true IL81746A (en) 1992-02-16

Family

ID=25274596

Family Applications (1)

Application Number Title Priority Date Filing Date
IL81746A IL81746A (en) 1986-03-07 1987-03-03 Pharmaceutical compositions for inhibiting aromatose activity and estrogen biosynthesis containing alpha imidazolyl,triazolyl or pyridyl substituted tolunitriles,certain novel tolunitriles and their preparation

Country Status (36)

Country Link
US (1) US4749713A (xx)
EP (1) EP0236940B3 (xx)
JP (1) JPH0755930B2 (xx)
KR (1) KR910000482B1 (xx)
AT (1) ATE94873T1 (xx)
BG (4) BG46598A3 (xx)
CA (1) CA1316928C (xx)
CY (1) CY1905A (xx)
CZ (3) CZ279028B6 (xx)
DD (1) DD264432A5 (xx)
DE (2) DE3787480T2 (xx)
DK (1) DK172190B1 (xx)
DZ (1) DZ1055A1 (xx)
ES (1) ES2059317T3 (xx)
FI (1) FI91857C (xx)
HK (1) HK50296A (xx)
HU (1) HU202843B (xx)
IE (1) IE61101B1 (xx)
IL (1) IL81746A (xx)
LU (1) LU90128I2 (xx)
LV (1) LV5769B4 (xx)
MA (1) MA20888A1 (xx)
MC (1) MC1805A1 (xx)
MT (1) MTP998B (xx)
MX (1) MX5496A (xx)
MY (1) MY102428A (xx)
NL (1) NL970011I2 (xx)
NO (2) NO170277C (xx)
PH (1) PH24159A (xx)
PL (2) PL152025B1 (xx)
PT (1) PT84410B (xx)
RO (2) RO101532B1 (xx)
SK (3) SK736787A3 (xx)
SU (3) SU1470184A3 (xx)
TN (1) TNSN87033A1 (xx)
ZA (1) ZA871637B (xx)

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US5112845A (en) * 1986-03-07 1992-05-12 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US5352795A (en) * 1986-03-07 1994-10-04 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
GB8714013D0 (en) * 1987-06-16 1987-07-22 Ici Plc (substituted-aralkyl)heterocyclic compounds
DE3811574A1 (de) * 1988-03-31 1989-10-19 Schering Ag N-substituierte imidazole, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE59010171D1 (de) * 1989-07-14 1996-04-11 Ciba Geigy Ag Substituierte Benzonitrile
DE3926365A1 (de) * 1989-08-04 1991-02-07 Schering Ag Cycloalkylenazole, verfahren zu deren herstellung, pharmazeutische praeparate, die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln
JP2602456B2 (ja) * 1990-04-12 1997-04-23 雪印乳業株式会社 子宮内膜症治療剤
EP0457716A1 (de) * 1990-04-20 1991-11-21 Ciba-Geigy Ag Naphthalinderivate
DE4039559A1 (de) * 1990-12-07 1992-06-11 Schering Ag Funktionalisierte vinylazole, verfahren zu deren herstellung, pharmazeutische praeparate die diese vinylazole enthalten sowie deren verwendung zur herstellung von arzneimitteln
TW210334B (xx) * 1990-12-12 1993-08-01 Ciba Geigy Ag
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
DE4120107A1 (de) * 1991-06-14 1992-12-17 Schering Ag Bicyclisch substituierte vinylimidazole, -triazole und -tetrazole
AU665569B2 (en) 1991-09-02 1996-01-11 Yamanouchi Pharmaceutical Co., Ltd. Triazolylated tertiary amine compound or salt thereof
US5223539A (en) * 1991-11-22 1993-06-29 G. D. Searle & Co. N,n-di-alkyl(phenoxy)benzamide derivatives
AU5285593A (en) * 1992-10-21 1994-05-09 Sankyo Company Limited Azole compound
GB2273704B (en) * 1992-12-16 1997-01-22 Orion Yhtymae Oy Triazolyl diaryl selective aromatase inhibiting compounds
US5426196A (en) * 1993-12-22 1995-06-20 Glaxo Inc. Synthesis of diaryl methanes
AU703203B2 (en) * 1996-01-30 1999-03-18 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JP2000505797A (ja) * 1996-01-30 2000-05-16 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質転移酵素の阻害剤
WO1997036876A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US6080870A (en) * 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
CA2250353A1 (en) * 1996-04-03 1997-10-09 Christopher J. Dinsmore Inhibitors of farnesyl-protein transferase
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
NZ529145A (en) 2001-05-16 2005-07-29 Novartis Ag Combination comprising N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)- 2pyrimidine-amine and a chemotherapeutic agent
WO2003050093A1 (en) * 2001-12-11 2003-06-19 Emory University Bis(cyanophenyl)methyl-triazole for use in prevention of breast cancer
GB0217636D0 (en) * 2002-07-30 2002-09-11 Novartis Ag Organic compounds
PT1534265E (pt) * 2002-07-30 2007-02-28 Novartis Ag Combinação de um inibidor da aromatase com um bisfosfonato
JP2004196795A (ja) * 2002-12-16 2004-07-15 Wyeth 外部寄生虫駆除剤としてのｎ−フェニル−３−シクロプロピルピラゾール−４−カルボニトリル
WO2005047269A1 (en) * 2003-11-14 2005-05-26 Natco Pharma Limited A method for the separation of the letrozole precursor 4-‘1-(1,2,4-triazolyl) methyl!benzonitrile from its 1,3,4-triazolyl isomer
JP4834557B2 (ja) * 2003-12-15 2011-12-14 ラボラトワール テラメックス １−ｎ−フェニルアミノ−１ｈ−イミダゾール誘導体及びこれを含む医薬組成物
US7705159B2 (en) * 2005-07-06 2010-04-27 Sicor, Inc. Process for the preparation of letrozole
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US20090082413A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched letrozole
WO2011128434A2 (en) 2010-04-16 2011-10-20 Novartis Ag Treatment of endocrine resistant breast cancer
CN103298795A (zh) 2010-08-27 2013-09-11 基因里克斯(英国)有限公司 用于制备来曲唑的纯中间体
RU2628808C2 (ru) 2011-09-08 2017-08-22 Новартис Аг Применение ингибитора ароматазы для лечения гипогонадизма и родственных заболеваний
CN104379163A (zh) 2012-06-08 2015-02-25 霍夫曼-拉罗奇有限公司 用于治疗癌症的磷酸肌醇3激酶抑制剂化合物和化疗剂的突变选择性及组合
EP3033086B1 (en) 2013-08-14 2021-09-22 Novartis AG Combination therapy for the treatment of cancer
AR104068A1 (es) 2015-03-26 2017-06-21 Hoffmann La Roche Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
GB201614179D0 (en) 2016-08-19 2016-10-05 Mereo Biopharma 2 Ltd Dosage regimen for the treatment of endometriosis
CN117281814A (zh) 2018-07-23 2023-12-26 豪夫迈·罗氏有限公司 用pi3k抑制剂gdc-0077治疗癌症的方法
CN112839642A (zh) 2018-10-08 2021-05-25 豪夫迈·罗氏有限公司 用PI3Kα抑制剂和二甲双胍治疗癌症的方法
CN114786666A (zh) 2019-12-03 2022-07-22 基因泰克公司 治疗乳腺癌的组合疗法
KR20230118587A (ko) 2020-12-11 2023-08-11 제넨테크, 인크. Her2 암 치료를 위한 병용 요법

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Also Published As

Publication number Publication date
NO870937D0 (no) 1987-03-06
SU1470184A3 (ru) 1989-03-30
KR910000482B1 (ko) 1991-01-25
IE61101B1 (en) 1994-10-05
NO870937L (no) 1987-09-08
ES2059317T3 (es) 1994-11-16
CZ279028B6 (en) 1994-11-16
CS8701512A2 (en) 1991-02-12
MA20888A1 (fr) 1987-10-01
ZA871637B (en) 1987-10-28
SU1577695A3 (ru) 1990-07-07
AU604011B2 (en) 1990-12-06
CS8707367A2 (en) 1991-02-12
NO170277C (no) 1992-09-30
SK736887A3 (en) 1998-06-03
NL970011I2 (nl) 1997-09-01
AU6976887A (en) 1987-09-10
PL152025B1 (en) 1990-10-31
NO170277B (no) 1992-06-22
SK151287A3 (en) 1998-06-03
FI91857C (fi) 1994-08-25
RO101532B1 (en) 1992-11-03
BG46598A3 (en) 1990-01-15
DE3787480T2 (de) 1994-02-24
LV5769A4 (lv) 1996-12-20
RO101533B1 (en) 1992-06-25
CA1316928C (en) 1993-04-27
SK279101B6 (sk) 1998-06-03
NO1998010I1 (no) 1998-03-04
HU202843B (en) 1991-04-29
HUT43822A (en) 1987-12-28
EP0236940B3 (en) 2011-03-23
MX5496A (es) 1993-12-01
DE3787480D1 (de) 1993-10-28
DZ1055A1 (fr) 2004-09-13
IL81746A0 (en) 1987-10-20
PT84410A (en) 1987-04-01
SK279102B6 (sk) 1998-06-03
DK172190B1 (da) 1997-12-22
BG61204B2 (bg) 1997-02-28
PL151490B1 (en) 1990-09-28
LV5769B4 (lv) 1997-04-20
SK736787A3 (en) 1998-06-03
MC1805A1 (fr) 1987-12-22
EP0236940B1 (en) 1993-09-22
MTP998B (en) 1987-08-21
BG45701A3 (en) 1989-07-14
PL264460A1 (en) 1988-07-21
EP0236940A2 (en) 1987-09-16
KR870008851A (ko) 1987-10-21
BG45700A3 (en) 1989-07-14
SK279103B6 (sk) 1998-06-03
FI870903A (fi) 1987-09-08
ATE94873T1 (de) 1993-10-15
US4749713A (en) 1988-06-07
DD264432A5 (de) 1989-02-01
LU90128I2 (fr) 1997-10-06
DK117687D0 (da) 1987-03-06
EP0236940A3 (en) 1989-10-18
DE19775016I2 (de) 2002-02-21
IE870575L (en) 1987-09-07
FI91857B (fi) 1994-05-13
JPH0755930B2 (ja) 1995-06-14
PT84410B (pt) 1989-10-04
CZ279027B6 (en) 1994-11-16
NL970011I1 (nl) 1997-05-01
FI870903A0 (fi) 1987-03-02
TNSN87033A1 (fr) 1990-01-01
CS8707368A2 (en) 1991-02-12
CY1905A (en) 1987-03-05
DK117687A (da) 1987-09-08
JPS62212369A (ja) 1987-09-18
SU1549478A3 (ru) 1990-03-07
PH24159A (en) 1990-03-22
HK50296A (en) 1996-03-29
CZ279026B6 (en) 1994-11-16
MY102428A (en) 1992-06-30

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