DE3787480T2 - Alpha-heterocyclisch-substituierte Tolunitrile. - Google Patents

Alpha-heterocyclisch-substituierte Tolunitrile.

Info

Publication number
DE3787480T2
DE3787480T2 DE87103099T DE3787480T DE3787480T2 DE 3787480 T2 DE3787480 T2 DE 3787480T2 DE 87103099 T DE87103099 T DE 87103099T DE 3787480 T DE3787480 T DE 3787480T DE 3787480 T2 DE3787480 T2 DE 3787480T2
Authority
DE
Germany
Prior art keywords
alkyl
substd
opt
alkylene
alkylthio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE87103099T
Other languages
English (en)
Other versions
DE3787480D1 (de
Inventor
Robert Mathews Bowman
Ronald Edward Steele
Leslie Johnston Browne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25274596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3787480(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of DE3787480D1 publication Critical patent/DE3787480D1/de
Publication of DE3787480T2 publication Critical patent/DE3787480T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
DE87103099T 1986-03-07 1987-03-05 Alpha-heterocyclisch-substituierte Tolunitrile. Expired - Lifetime DE3787480T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/837,489 US4749713A (en) 1986-03-07 1986-03-07 Alpha-heterocycle substituted tolunitriles

Publications (2)

Publication Number Publication Date
DE3787480D1 DE3787480D1 (de) 1993-10-28
DE3787480T2 true DE3787480T2 (de) 1994-02-24

Family

ID=25274596

Family Applications (2)

Application Number Title Priority Date Filing Date
DE87103099T Expired - Lifetime DE3787480T2 (de) 1986-03-07 1987-03-05 Alpha-heterocyclisch-substituierte Tolunitrile.
DE1997175016 Active DE19775016I2 (de) 1986-03-07 1987-03-05 Alpha-heterocyclisch-substituierte Tolunitrile

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1997175016 Active DE19775016I2 (de) 1986-03-07 1987-03-05 Alpha-heterocyclisch-substituierte Tolunitrile

Country Status (36)

Country Link
US (1) US4749713A (de)
EP (1) EP0236940B3 (de)
JP (1) JPH0755930B2 (de)
KR (1) KR910000482B1 (de)
AT (1) ATE94873T1 (de)
BG (4) BG46598A3 (de)
CA (1) CA1316928C (de)
CY (1) CY1905A (de)
CZ (3) CZ279027B6 (de)
DD (1) DD264432A5 (de)
DE (2) DE3787480T2 (de)
DK (1) DK172190B1 (de)
DZ (1) DZ1055A1 (de)
ES (1) ES2059317T3 (de)
FI (1) FI91857C (de)
HK (1) HK50296A (de)
HU (1) HU202843B (de)
IE (1) IE61101B1 (de)
IL (1) IL81746A (de)
LU (1) LU90128I2 (de)
LV (1) LV5769B4 (de)
MA (1) MA20888A1 (de)
MC (1) MC1805A1 (de)
MT (1) MTP998B (de)
MX (1) MX5496A (de)
MY (1) MY102428A (de)
NL (1) NL970011I2 (de)
NO (2) NO170277C (de)
PH (1) PH24159A (de)
PL (2) PL152025B1 (de)
PT (1) PT84410B (de)
RO (2) RO101533B1 (de)
SK (3) SK736787A3 (de)
SU (3) SU1470184A3 (de)
TN (1) TNSN87033A1 (de)
ZA (1) ZA871637B (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112845A (en) * 1986-03-07 1992-05-12 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US5352795A (en) * 1986-03-07 1994-10-04 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
GB8714013D0 (en) * 1987-06-16 1987-07-22 Ici Plc (substituted-aralkyl)heterocyclic compounds
DE3811574A1 (de) * 1988-03-31 1989-10-19 Schering Ag N-substituierte imidazole, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE59010171D1 (de) * 1989-07-14 1996-04-11 Ciba Geigy Ag Substituierte Benzonitrile
DE3926365A1 (de) * 1989-08-04 1991-02-07 Schering Ag Cycloalkylenazole, verfahren zu deren herstellung, pharmazeutische praeparate, die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln
JP2602456B2 (ja) * 1990-04-12 1997-04-23 雪印乳業株式会社 子宮内膜症治療剤
EP0457716A1 (de) * 1990-04-20 1991-11-21 Ciba-Geigy Ag Naphthalinderivate
DE4039559A1 (de) * 1990-12-07 1992-06-11 Schering Ag Funktionalisierte vinylazole, verfahren zu deren herstellung, pharmazeutische praeparate die diese vinylazole enthalten sowie deren verwendung zur herstellung von arzneimitteln
TW210334B (de) * 1990-12-12 1993-08-01 Ciba Geigy Ag
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
DE4120107A1 (de) * 1991-06-14 1992-12-17 Schering Ag Bicyclisch substituierte vinylimidazole, -triazole und -tetrazole
RO114129B1 (ro) 1991-09-02 1999-01-29 Yamanouchi Pharmaceutical Co., Ltd. Derivaţi aminici terţiari substituiţi cu triazolil
US5223539A (en) * 1991-11-22 1993-06-29 G. D. Searle & Co. N,n-di-alkyl(phenoxy)benzamide derivatives
WO1994008973A1 (en) * 1992-10-21 1994-04-28 Sankyo Company, Limited Azole compound
GB2273704B (en) * 1992-12-16 1997-01-22 Orion Yhtymae Oy Triazolyl diaryl selective aromatase inhibiting compounds
US5426196A (en) * 1993-12-22 1995-06-20 Glaxo Inc. Synthesis of diaryl methanes
JP2000505797A (ja) * 1996-01-30 2000-05-16 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質転移酵素の阻害剤
JP2000504014A (ja) * 1996-01-30 2000-04-04 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質転移酵素の阻害剤
US6080870A (en) * 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
AU715658B2 (en) * 1996-04-03 2000-02-10 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
WO1997036900A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
NZ529145A (en) 2001-05-16 2005-07-29 Novartis Ag Combination comprising N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)- 2pyrimidine-amine and a chemotherapeutic agent
JP2005515207A (ja) * 2001-12-11 2005-05-26 エモリー ユニバーシティ 乳癌の予防において使用するためのビス（シアノフェニル）メチル−トリアゾール
US20060069067A1 (en) * 2002-07-30 2006-03-30 Bhatnagar Ajay S Combination of an aromatase inhibitor with a bisphosphonate
GB0217636D0 (en) * 2002-07-30 2002-09-11 Novartis Ag Organic compounds
JP2004196795A (ja) * 2002-12-16 2004-07-15 Wyeth 外部寄生虫駆除剤としてのｎ−フェニル−３−シクロプロピルピラゾール−４−カルボニトリル
AU2003282380A1 (en) * 2003-11-14 2004-06-06 ADIBHATLA, KALI,SATYA, Bhujanga,rao A method for the separation of the letrozole precursor 4-1-(1,2,4-triazolyl) methyl benzonitrile from its 1,3,4-triazolyl isomer
OA13336A (en) * 2003-12-15 2006-04-13 Theramex 1-N-phenyl-amino-1H-imidazole derivatives and pharmaceutical compositions containing them.
EP1871750A1 (de) * 2005-07-06 2008-01-02 Sicor, Inc. Verbessertes verfahren zur herstellung von letrozol
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US20090082413A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched letrozole
WO2011128434A2 (en) 2010-04-16 2011-10-20 Novartis Ag Treatment of endocrine resistant breast cancer
CA2809086A1 (en) 2010-08-27 2012-03-01 Generics (Uk) Limited Pure intermediate
AU2012304694B2 (en) 2011-09-08 2016-04-07 Mereo Biopharma 2 Limited Pharmaceutical compositions comprising an aromatase inhibitor
WO2013182668A1 (en) 2012-06-08 2013-12-12 F. Hoffmann-La Roche Ag Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer
SI3033086T1 (sl) 2013-08-14 2022-01-31 Novartis Ag Kombinirana terapija za zdravljenje raka
AR104068A1 (es) 2015-03-26 2017-06-21 Hoffmann La Roche Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
GB201614179D0 (en) 2016-08-19 2016-10-05 Mereo Biopharma 2 Ltd Dosage regimen for the treatment of endometriosis
AU2019310335A1 (en) 2018-07-23 2021-02-11 F. Hoffmann-La Roche Ag Methods of treating cancer with PI3K inhibitor, GDC-0077
WO2020076432A1 (en) 2018-10-08 2020-04-16 Genentech, Inc. Methods of treating cancer with pi3k alpha inhibitors and metformin
IL293347A (en) 2019-12-03 2022-07-01 Genentech Inc Combined therapies for the treatment of breast cancer
WO2022125483A1 (en) 2020-12-11 2022-06-16 Genentech, Inc. Combination therapies for treatment of her2 cancer

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3290281A (en) * 1963-07-18 1966-12-06 Weinstein Julius Photochromic nitrobenzylpyridines
US3397273A (en) * 1966-02-18 1968-08-13 Lilly Co Eli Controlling phytopathogenic fungi on plants with 3-pyridyl methane derivatives
GB1170188A (en) * 1967-09-15 1969-11-12 Bayer Ag N-trityl-imidazoles and salts and uses thereof
DE1670976B2 (de) * 1968-01-29 1976-07-22 N-trityl-imidazole
DE1908991B2 (de) * 1969-02-22 1977-05-26 Bayer Ag, 5090 Leverkusen Alpha, alpha-disubstituierte n- benzylimidazole und deren salze
BR6915465D0 (pt) * 1969-03-07 1973-01-04 Bayer Ag Processo para preparar n-benzimidazois substituidos na posicao alfa por heterociclos penta-membrados com atividade antimicotica
DE2007794A1 (de) * 1970-02-20 1971-09-02 Farbenfabriken Bayer Aktiengesell schaft, 5090 Leverkusen Fungizide Mittel
DE2009020C3 (de) * 1970-02-26 1979-09-13 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von N-(l,l,l-trisubstituierten)-Methylazolen
US3764690A (en) * 1972-03-03 1973-10-09 Bayer Ag Substituted n-benzylimidazoles as antimycotic agents
US3927017A (en) * 1974-06-27 1975-12-16 Janssen Pharmaceutica Nv 1-({62 -Aryl-{62 -R-ethyl)imidazoles
DE2628152C2 (de) * 1976-06-23 1985-03-28 Bayer Ag, 5090 Leverkusen Fungizide und nematizide Mittel
DE2732531A1 (de) * 1977-07-19 1979-02-01 Hoechst Ag Imidazolcarbonsaeuren und deren derivate
DE2735314A1 (de) * 1977-08-05 1979-02-22 Basf Ag Alpha-azolylsulfide und deren derivate
US4431815A (en) * 1977-08-26 1984-02-14 Burroughs Wellcome Co. 1-[3-(2,4-Dichlorophenyl)propyl]imidazole and salts thereof
DE2862340D1 (en) * 1978-02-01 1983-11-24 Wellcome Found Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof
DE2808086A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Substituierte diphenyl-imidazolyl- methane, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2821829A1 (de) * 1978-05-19 1979-11-22 Basf Ag Mittel zur regulierung des pflanzenwachstums
JPS55313A (en) * 1978-06-13 1980-01-05 Kissei Pharmaceut Co Ltd Imidazole derivative
DE2847441A1 (de) * 1978-11-02 1980-05-22 Basf Ag Imidazol-kupferkomplexverbindungen
DK157860C (da) * 1979-06-07 1990-07-30 Shionogi & Co Analogifremgangsmaade til fremstilling af benzylimidazolderivater samt farmaceutisk acceptable syreadditionssalte deraf
US4281141A (en) * 1980-05-30 1981-07-28 Eli Lilly And Company 3-(Imidazol-4-yl)-2-phenylpropanenitriles
US4617307A (en) * 1984-06-20 1986-10-14 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors
US4562199A (en) * 1983-08-11 1985-12-31 Thorogood Peter B Imidazole derivatives, compositions and use
EP0149976A3 (de) * 1983-12-30 1986-12-10 Ciba-Geigy Ag Substituierte Imidazole
US4602025A (en) * 1984-06-18 1986-07-22 Eli Lilly And Company Aromatase inhibitors
US4755526A (en) * 1984-06-18 1988-07-05 Eli Lilly And Company Method of inhibiting aromatase
US4766140A (en) * 1984-06-18 1988-08-23 Eli Lilly And Company Method of inhibiting aromatase
US4801594A (en) * 1984-06-18 1989-01-31 Eli Lilly And Company Aromatase inhibitors
US4605661A (en) * 1984-06-18 1986-08-12 Eli Lilly And Company Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles

Also Published As

Publication number Publication date
CZ279027B6 (en) 1994-11-16
TNSN87033A1 (fr) 1990-01-01
BG46598A3 (en) 1990-01-15
NO170277B (no) 1992-06-22
NL970011I1 (nl) 1997-05-01
ZA871637B (en) 1987-10-28
IE870575L (en) 1987-09-07
PT84410A (en) 1987-04-01
MA20888A1 (fr) 1987-10-01
SU1549478A3 (ru) 1990-03-07
EP0236940B1 (de) 1993-09-22
DE19775016I2 (de) 2002-02-21
NO1998010I1 (no) 1998-03-04
PH24159A (en) 1990-03-22
NL970011I2 (nl) 1997-09-01
PT84410B (pt) 1989-10-04
LV5769A4 (lv) 1996-12-20
BG45700A3 (en) 1989-07-14
MY102428A (en) 1992-06-30
SK736887A3 (en) 1998-06-03
CY1905A (en) 1987-03-05
AU6976887A (en) 1987-09-10
SK279102B6 (sk) 1998-06-03
DD264432A5 (de) 1989-02-01
SK736787A3 (en) 1998-06-03
US4749713A (en) 1988-06-07
SU1577695A3 (ru) 1990-07-07
NO870937D0 (no) 1987-03-06
SU1470184A3 (ru) 1989-03-30
NO870937L (no) 1987-09-08
EP0236940A2 (de) 1987-09-16
DK117687A (da) 1987-09-08
EP0236940B3 (de) 2011-03-23
MC1805A1 (fr) 1987-12-22
JPH0755930B2 (ja) 1995-06-14
CZ279028B6 (en) 1994-11-16
HK50296A (en) 1996-03-29
LV5769B4 (lv) 1997-04-20
NO170277C (no) 1992-09-30
ATE94873T1 (de) 1993-10-15
CS8701512A2 (en) 1991-02-12
SK279103B6 (sk) 1998-06-03
ES2059317T3 (es) 1994-11-16
CA1316928C (en) 1993-04-27
SK151287A3 (en) 1998-06-03
IE61101B1 (en) 1994-10-05
DZ1055A1 (fr) 2004-09-13
DE3787480D1 (de) 1993-10-28
RO101532B1 (en) 1992-11-03
BG61204B2 (bg) 1997-02-28
IL81746A0 (en) 1987-10-20
KR870008851A (ko) 1987-10-21
CS8707368A2 (en) 1991-02-12
KR910000482B1 (ko) 1991-01-25
CS8707367A2 (en) 1991-02-12
FI91857B (fi) 1994-05-13
AU604011B2 (en) 1990-12-06
LU90128I2 (fr) 1997-10-06
CZ279026B6 (en) 1994-11-16
EP0236940A3 (en) 1989-10-18
DK172190B1 (da) 1997-12-22
PL152025B1 (en) 1990-10-31
FI870903A (fi) 1987-09-08
FI870903A0 (fi) 1987-03-02
SK279101B6 (sk) 1998-06-03
DK117687D0 (da) 1987-03-06
HU202843B (en) 1991-04-29
HUT43822A (en) 1987-12-28
RO101533B1 (en) 1992-06-25
IL81746A (en) 1992-02-16
PL151490B1 (en) 1990-09-28
JPS62212369A (ja) 1987-09-18
MTP998B (en) 1987-08-21
FI91857C (fi) 1994-08-25
MX5496A (es) 1993-12-01
PL264460A1 (en) 1988-07-21
BG45701A3 (en) 1989-07-14

Similar Documents

Publication Publication Date Title
DE3787480D1 (de) Alpha-heterocyclisch-substituierte Tolunitrile.
RO96133A (ro) Procedeu pentru prepararea unor derivati ai tolunitrililor heterociclic substituiti
DURFEE et al. Making coherent communication decisions in a distributed problem solving network
ES2004273A6 (es) Procedimiento para la sintesis de compuestos que tienen actividad terapeurica anti-ulcera
ES2112774A1 (es) Nuevos derivados azolicos con actividad antifungica.
IT1204495B (it) Procedimento di sintesi per l'ottenimento di molecole aventi attivita' farmacologica via uree mono e bisostiuite

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
V448 Application of spc

Free format text: PRODUCT NAME: LETROZOL; REGISTRATION NO/DATE: 38895.00.00, 19970109

Spc suppl protection certif: 197 75 016

Filing date: 19970429

8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS AG, BASEL, CH

V457 Spc granted

Free format text: PRODUCT NAME: LETROZOL; REGISTRATION NO/DATE: 38895.00.00, 19970109

Spc suppl protection certif: 197 75 016

Filing date: 19970429

8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

R071 Expiry of right

Free format text: PRODUCT NAME: FEMARA IN ALLEN DEM SCHUTZ DES GRUNDPATENTES UNTERLIEGENDEN FORMEN; NAT. REGISTRATION NO/DATE: 38895.00.00 19970109 FIRST REGISTRATION: FRANKREICH NO. 341474-2 NO. 341475-9 19960724

Spc suppl protection certif: 19775016

Filing date: 19970429

Expiry date: 20070306

Extension date: 20110724

Effective date: 20110725