MTP998B - Alpha-heterocycle substituted tolunitrites - Google Patents

Alpha-heterocycle substituted tolunitrites

Info

Publication number
MTP998B
MTP998B MT998A MTP998A MTP998B MT P998 B MTP998 B MT P998B MT 998 A MT998 A MT 998A MT P998 A MTP998 A MT P998A MT P998 B MTP998 B MT P998B
Authority
MT
Malta
Prior art keywords
alkyl
substd
opt
alkylene
alkylthio
Prior art date
Application number
MT998A
Inventor
Robert Mathews Bowman
Ronald Edward Steele
Leslie Johnston
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25274596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MTP998(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of MTP998B publication Critical patent/MTP998B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Heterocyclylalkylbenzonitrile derivs. of formula (I) and their salts are new (where R, R' = H or 1-7C alkyl; or R+R' when on adjacent C atoms, together with the benzene ring form a naphthalene or tetrahydronaphthalene ring system; R1 = H; R2 = H, 1-7C alkyl, 2-7C alkenyl, aryl, aryl-(1-7C)alkyl, 3-6C cycloalkyl or (3-6C)cycloalkyl-(1-7C)alkyl; or R1+R2 = 1-7C alkylidene opt. substd. by mono- or di-aryl, or 4-6C n-alkylene, n-alkylene substd. by 1-7C alkyl or 2-4C n-alkylene bridged by o-phenylene, to form with the attached C a corresp. opt. substd. or benzo-fused 5-, 6- or 7-membered ring; W = 1-imidazolyl, 1,2,4- or 1,3,4-triazol-1-yl or 3-pyridyl each opt. substd. by 1-7C alkyl). 1-Cyano-4-imidazolylnaphthalenes of formula (II) and their salts are new (where R1' = H; R2' = H, 1-7C alkyl, Ph, 1-7C alkylthio, Ph-(1-7C)alkylthio, PhS, pyridyl, thienyl or benzyl, or Ph, Ph-(1-7C)alkylthio, PhS or benzyl each ring mono-substd. by CN, 1-7C alkyl, 1-7C alkoxy, OH, 1-7C alkanoyloxy, aroyloxy, NO2, halogen, CF3, 1-7C alkanoyl, aroyl, 1-7C alkylsulphonyl, or CONH2 or SO2NH2 both opt. substd. by 1 or 2 1-7C alkyls; or R1'+R2' = 1-7C alkylidene, benzylidene, diphenylmethylidene or 4-6C n-alkylene; R3 = H or 1-7C alkyl).
MT998A 1986-03-07 1987-03-06 Alpha-heterocycle substituted tolunitrites MTP998B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/837,489 US4749713A (en) 1986-03-07 1986-03-07 Alpha-heterocycle substituted tolunitriles

Publications (1)

Publication Number Publication Date
MTP998B true MTP998B (en) 1987-08-21

Family

ID=25274596

Family Applications (1)

Application Number Title Priority Date Filing Date
MT998A MTP998B (en) 1986-03-07 1987-03-06 Alpha-heterocycle substituted tolunitrites

Country Status (36)

Country Link
US (1) US4749713A (en)
EP (1) EP0236940B3 (en)
JP (1) JPH0755930B2 (en)
KR (1) KR910000482B1 (en)
AT (1) ATE94873T1 (en)
BG (4) BG45700A3 (en)
CA (1) CA1316928C (en)
CY (1) CY1905A (en)
CZ (3) CZ279028B6 (en)
DD (1) DD264432A5 (en)
DE (2) DE3787480T2 (en)
DK (1) DK172190B1 (en)
DZ (1) DZ1055A1 (en)
ES (1) ES2059317T3 (en)
FI (1) FI91857C (en)
HK (1) HK50296A (en)
HU (1) HU202843B (en)
IE (1) IE61101B1 (en)
IL (1) IL81746A (en)
LU (1) LU90128I2 (en)
LV (1) LV5769B4 (en)
MA (1) MA20888A1 (en)
MC (1) MC1805A1 (en)
MT (1) MTP998B (en)
MX (1) MX5496A (en)
MY (1) MY102428A (en)
NL (1) NL970011I2 (en)
NO (2) NO170277C (en)
PH (1) PH24159A (en)
PL (2) PL152025B1 (en)
PT (1) PT84410B (en)
RO (2) RO101532B1 (en)
SK (3) SK279103B6 (en)
SU (3) SU1470184A3 (en)
TN (1) TNSN87033A1 (en)
ZA (1) ZA871637B (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112845A (en) * 1986-03-07 1992-05-12 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US5352795A (en) * 1986-03-07 1994-10-04 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
GB8714013D0 (en) * 1987-06-16 1987-07-22 Ici Plc (substituted-aralkyl)heterocyclic compounds
DE3811574A1 (en) * 1988-03-31 1989-10-19 Schering Ag N-SUBSTITUTED IMIDAZOLES, METHODS FOR THEIR PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS
DE59010171D1 (en) * 1989-07-14 1996-04-11 Ciba Geigy Ag Substituted benzonitriles
DE3926365A1 (en) * 1989-08-04 1991-02-07 Schering Ag CYCLOALKYLENAZOLES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS THAT CONTAIN THEY AND THEIR USE FOR THE PRODUCTION OF MEDICINAL PRODUCTS
JP2602456B2 (en) * 1990-04-12 1997-04-23 雪印乳業株式会社 Endometriosis treatment
EP0457716A1 (en) * 1990-04-20 1991-11-21 Ciba-Geigy Ag Naphthalin derivatives
DE4039559A1 (en) * 1990-12-07 1992-06-11 Schering Ag FUNCTIONALIZED VINYLAZOLES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING THIS VINYLAZOLES AND THE USE THEREOF FOR THE PRODUCTION OF MEDICINAL PRODUCTS
TW210334B (en) * 1990-12-12 1993-08-01 Ciba Geigy Ag
CH683151A5 (en) * 1991-04-24 1994-01-31 Ciba Geigy Ag Contraception in female primates without affecting the menstrual cycle.
DE4120107A1 (en) * 1991-06-14 1992-12-17 Schering Ag BICYCLICALLY SUBSTITUTED VINYLIMIDAZOLES, TRIAZOLES AND TETRAZOLES
HU220863B1 (en) 1991-09-02 2002-06-29 Yamanouchi Pharma Co Ltd Triazolylated tertiary amines, process for producing them and pharmaceutical compositions containing them
US5223539A (en) * 1991-11-22 1993-06-29 G. D. Searle & Co. N,n-di-alkyl(phenoxy)benzamide derivatives
AU5285593A (en) * 1992-10-21 1994-05-09 Sankyo Company Limited Azole compound
GB2273704B (en) * 1992-12-16 1997-01-22 Orion Yhtymae Oy Triazolyl diaryl selective aromatase inhibiting compounds
US5426196A (en) * 1993-12-22 1995-06-20 Glaxo Inc. Synthesis of diaryl methanes
JP2000505797A (en) * 1996-01-30 2000-05-16 メルク エンド カンパニー インコーポレーテッド Farnesyl-protein transferase inhibitor
AU703203B2 (en) * 1996-01-30 1999-03-18 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU715658B2 (en) * 1996-04-03 2000-02-10 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2250353A1 (en) * 1996-04-03 1997-10-09 Christopher J. Dinsmore Inhibitors of farnesyl-protein transferase
US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US6080870A (en) * 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
SK14042003A3 (en) 2001-05-16 2004-05-04 Novartis Ag Combination comprising N-{5-[4-(4-methyl-piperazino-methyl)- benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent
CN1325482C (en) * 2001-12-11 2007-07-11 埃默里大学 Biscyanophenylmethyl-triazole for use in prevention of breast cancer
ATE345790T1 (en) * 2002-07-30 2006-12-15 Novartis Pharma Gmbh COMBINATION OF AN AROMATIC INHIBITOR WITH A BISPHOSPHONATE
GB0217636D0 (en) * 2002-07-30 2002-09-11 Novartis Ag Organic compounds
JP2004196795A (en) * 2002-12-16 2004-07-15 Wyeth N-phenyl-3-cyclopropylpyrazole-4-carbonitrile as external parasiticide
AU2003282380A1 (en) * 2003-11-14 2004-06-06 ADIBHATLA, KALI,SATYA, Bhujanga,rao A method for the separation of the letrozole precursor 4-1-(1,2,4-triazolyl) methyl benzonitrile from its 1,3,4-triazolyl isomer
AR047144A1 (en) * 2003-12-15 2006-01-11 Theramex DERIVATIVES OF 1-N-PHENYLAMINE-1H-IMIDAZOL AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CA2608904A1 (en) * 2005-07-06 2007-09-07 Sicor Inc. Improved process for the preparation of letrozole
GT200600381A (en) 2005-08-25 2007-03-28 ORGANIC COMPOUNDS
US20090082413A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched letrozole
JP2013525296A (en) 2010-04-16 2013-06-20 ノバルティス アーゲー Treatment of endocrine therapy-resistant breast cancer
US9150524B2 (en) 2010-08-27 2015-10-06 Generics [Uk] Limited Pure intermediate
BR112014005434B1 (en) * 2011-09-08 2021-01-05 Novartis Ag PHARMACEUTICAL COMPOSITIONS UNDERSTANDING 4,4 'AROMATASE INHIBITOR - [FLUORO- (1H-1,2,4TRIAZOL-1-IL) METHYLEME] BISBENZONITRILLA AND ITS PREPARATION METHOD
CN104379163A (en) 2012-06-08 2015-02-25 霍夫曼-拉罗奇有限公司 Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer
WO2015022609A1 (en) 2013-08-14 2015-02-19 Novartis Ag Combination therapy for the treatment of cancer
AR104068A1 (en) 2015-03-26 2017-06-21 Hoffmann La Roche COMBINATIONS OF A 3-KINASE PHOSFOINOSYTIDE INHIBITOR COMPOSITE AND A CDK4 / 6 INHIBITOR COMPOUND FOR CANCER TREATMENT
GB201614179D0 (en) 2016-08-19 2016-10-05 Mereo Biopharma 2 Ltd Dosage regimen for the treatment of endometriosis
BR112021001233A2 (en) 2018-07-23 2021-04-20 F. Hoffmann-La Roche Ag method for treating cancer in a patient, using a therapeutically effective amount of gdc-0077 and therapeutically effective amount of gdc-0077
JP2022504388A (en) 2018-10-08 2022-01-13 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Cancer treatment method using PI3K alpha inhibitor and metformin
BR112022010806A2 (en) 2019-12-03 2022-08-23 Genentech Inc METHODS TO TREAT BREAST CANCER, TO STOP TUMOR GROWTH AND TO PREVENT OR DELAY THE DEVELOPMENT OF BREAST CANCER RESISTANCE
EP4259662A1 (en) 2020-12-11 2023-10-18 Genentech, Inc. Combination therapies for treatment of her2 cancer

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3290281A (en) * 1963-07-18 1966-12-06 Weinstein Julius Photochromic nitrobenzylpyridines
US3397273A (en) * 1966-02-18 1968-08-13 Lilly Co Eli Controlling phytopathogenic fungi on plants with 3-pyridyl methane derivatives
GB1170188A (en) * 1967-09-15 1969-11-12 Bayer Ag N-trityl-imidazoles and salts and uses thereof
DE1670976B2 (en) * 1968-01-29 1976-07-22 N-TRITYL IMIDAZOLE
DE1908991B2 (en) * 1969-02-22 1977-05-26 Bayer Ag, 5090 Leverkusen ALPHA, ALPHA-DISUBSTITUTED N-BENZYLIMIDAZOLES AND THEIR SALTS
BR6915465D0 (en) * 1969-03-07 1973-01-04 Bayer Ag PROCESS TO PREPARE SUBSTITUTED N-BENZIMIDAZOLES IN THE ALPHA POSITION BY PENTA-MEMBER HETEROCYCLES WITH ANTIMYCOTIC ACTIVITY
DE2007794A1 (en) * 1970-02-20 1971-09-02 Farbenfabriken Bayer Aktiengesell schaft, 5090 Leverkusen Fungicides
DE2009020C3 (en) * 1970-02-26 1979-09-13 Bayer Ag, 5090 Leverkusen Process for the preparation of N- (l, l, l-trisubstituted) -methylazoles
US3764690A (en) * 1972-03-03 1973-10-09 Bayer Ag Substituted n-benzylimidazoles as antimycotic agents
US3927017A (en) * 1974-06-27 1975-12-16 Janssen Pharmaceutica Nv 1-({62 -Aryl-{62 -R-ethyl)imidazoles
DE2628152C2 (en) * 1976-06-23 1985-03-28 Bayer Ag, 5090 Leverkusen Fungicidal and nematicidal agents
DE2732531A1 (en) * 1977-07-19 1979-02-01 Hoechst Ag IMIDAZOLE CARBONIC ACIDS AND THEIR DERIVATIVES
DE2735314A1 (en) * 1977-08-05 1979-02-22 Basf Ag ALPHA-AZOLYL SULPHIDES AND THEIR DERIVATIVES
US4431815A (en) * 1977-08-26 1984-02-14 Burroughs Wellcome Co. 1-[3-(2,4-Dichlorophenyl)propyl]imidazole and salts thereof
EP0003732B1 (en) * 1978-02-01 1983-10-19 The Wellcome Foundation Limited Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof
DE2808086A1 (en) * 1978-02-24 1979-08-30 Bayer Ag SUBSTITUTED DIPHENYL-IMIDAZOLYL-METHANES, THE PROCESS FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT
DE2821829A1 (en) * 1978-05-19 1979-11-22 Basf Ag MEANS OF REGULATING PLANT GROWTH
JPS55313A (en) * 1978-06-13 1980-01-05 Kissei Pharmaceut Co Ltd Imidazole derivative
DE2847441A1 (en) 1978-11-02 1980-05-22 Basf Ag IMIDAZOLE COPPER COMPLEX CONNECTIONS
DK157860C (en) * 1979-06-07 1990-07-30 Shionogi & Co METHOD OF ANALOGUE FOR THE PREPARATION OF BENZYLIMIDAZOLD DERIVATIVES AND PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF
US4281141A (en) * 1980-05-30 1981-07-28 Eli Lilly And Company 3-(Imidazol-4-yl)-2-phenylpropanenitriles
US4617307A (en) * 1984-06-20 1986-10-14 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors
US4562199A (en) * 1983-08-11 1985-12-31 Thorogood Peter B Imidazole derivatives, compositions and use
EP0149976A3 (en) * 1983-12-30 1986-12-10 Ciba-Geigy Ag Substituted imidazoles
US4602025A (en) * 1984-06-18 1986-07-22 Eli Lilly And Company Aromatase inhibitors
US4766140A (en) * 1984-06-18 1988-08-23 Eli Lilly And Company Method of inhibiting aromatase
US4755526A (en) * 1984-06-18 1988-07-05 Eli Lilly And Company Method of inhibiting aromatase
US4605661A (en) * 1984-06-18 1986-08-12 Eli Lilly And Company Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
US4801594A (en) * 1984-06-18 1989-01-31 Eli Lilly And Company Aromatase inhibitors

Also Published As

Publication number Publication date
CY1905A (en) 1987-03-05
SK279101B6 (en) 1998-06-03
EP0236940A3 (en) 1989-10-18
US4749713A (en) 1988-06-07
SU1549478A3 (en) 1990-03-07
CZ279027B6 (en) 1994-11-16
PT84410A (en) 1987-04-01
DE19775016I2 (en) 2002-02-21
DK117687D0 (en) 1987-03-06
MC1805A1 (en) 1987-12-22
DD264432A5 (en) 1989-02-01
HU202843B (en) 1991-04-29
HUT43822A (en) 1987-12-28
IE61101B1 (en) 1994-10-05
TNSN87033A1 (en) 1990-01-01
JPH0755930B2 (en) 1995-06-14
FI870903A0 (en) 1987-03-02
LU90128I2 (en) 1997-10-06
NO170277B (en) 1992-06-22
EP0236940B3 (en) 2011-03-23
PL152025B1 (en) 1990-10-31
IL81746A (en) 1992-02-16
DE3787480T2 (en) 1994-02-24
ATE94873T1 (en) 1993-10-15
MA20888A1 (en) 1987-10-01
IL81746A0 (en) 1987-10-20
BG61204B2 (en) 1997-02-28
BG45701A3 (en) 1989-07-14
RO101533B1 (en) 1992-06-25
DE3787480D1 (en) 1993-10-28
FI91857C (en) 1994-08-25
JPS62212369A (en) 1987-09-18
IE870575L (en) 1987-09-07
AU6976887A (en) 1987-09-10
CS8707368A2 (en) 1991-02-12
SK151287A3 (en) 1998-06-03
CA1316928C (en) 1993-04-27
CS8701512A2 (en) 1991-02-12
MY102428A (en) 1992-06-30
BG46598A3 (en) 1990-01-15
ZA871637B (en) 1987-10-28
SU1577695A3 (en) 1990-07-07
SK736887A3 (en) 1998-06-03
DK172190B1 (en) 1997-12-22
AU604011B2 (en) 1990-12-06
NL970011I1 (en) 1997-05-01
SK279102B6 (en) 1998-06-03
CZ279026B6 (en) 1994-11-16
NO870937D0 (en) 1987-03-06
SU1470184A3 (en) 1989-03-30
LV5769A4 (en) 1996-12-20
SK736787A3 (en) 1998-06-03
PT84410B (en) 1989-10-04
DZ1055A1 (en) 2004-09-13
FI870903A (en) 1987-09-08
DK117687A (en) 1987-09-08
HK50296A (en) 1996-03-29
PH24159A (en) 1990-03-22
NO1998010I1 (en) 1998-03-04
MX5496A (en) 1993-12-01
ES2059317T3 (en) 1994-11-16
NO170277C (en) 1992-09-30
NL970011I2 (en) 1997-09-01
PL264460A1 (en) 1988-07-21
SK279103B6 (en) 1998-06-03
PL151490B1 (en) 1990-09-28
KR870008851A (en) 1987-10-21
EP0236940A2 (en) 1987-09-16
CS8707367A2 (en) 1991-02-12
BG45700A3 (en) 1989-07-14
CZ279028B6 (en) 1994-11-16
FI91857B (en) 1994-05-13
EP0236940B1 (en) 1993-09-22
LV5769B4 (en) 1997-04-20
RO101532B1 (en) 1992-11-03
KR910000482B1 (en) 1991-01-25
NO870937L (en) 1987-09-08

Similar Documents

Publication Publication Date Title
IL81746A0 (en) Alpha-heterocycle substituted tolunitriles
RO96133A (en) PROCESS FOR THE PREPARATION OF DERIVATIVES OF SUBSTITUTED HETEROCYCLIC TOLUNITES
PH23065A (en) Tricyclic oxindole antiinflammatory agents
NZ222614A (en) Indene derivatives and their preparation
DURFEE et al. Making coherent communication decisions in a distributed problem solving network
ES2004273A6 (en) Prodn. of antiulcer agents
Shao A new form of Stimpsonia chamaedryoides Wright
GB1460680A (en) 1,4-benzodiazepines
ES8707936A1 (en) Benzo(l)-cinnolin-3-one derivs.