PH23065A - Tricyclic oxindole antiinflammatory agents - Google Patents

Tricyclic oxindole antiinflammatory agents

Info

Publication number
PH23065A
PH23065A PH32688A PH32688A PH23065A PH 23065 A PH23065 A PH 23065A PH 32688 A PH32688 A PH 32688A PH 32688 A PH32688 A PH 32688A PH 23065 A PH23065 A PH 23065A
Authority
PH
Philippines
Prior art keywords
sub
antiinflammatory agents
oxindole
tricyclic
tricyclic oxindole
Prior art date
Application number
PH32688A
Inventor
Lawrence Sherman Melvin Jr
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PH23065A publication Critical patent/PH23065A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicinal Preparation (AREA)

Abstract

Tricyclic oxindole antiinflammatory agents of the formula: HET-CONH-Ar (I) and their pharmaceutically acceptable base salts, wherein HET is:where R<sub>1</sub> is C<sub>1</sub>-C<sub>3</sub> alkyl or phenyl; R<sub>3</sub> and R<sub>4</sub> are each H or CH<sub>3</sub>; X is N, CH or C(CH<sub>3</sub>); Y is 0 or S; Z is 0 or CG<sub>2</sub>; n is 1 or 2, and Ar is a specified optionally substituted phenyl or heterocyclic group.
PH32688A 1984-08-24 1985-08-23 Tricyclic oxindole antiinflammatory agents PH23065A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1984/001371 WO1986001510A1 (en) 1984-08-24 1984-08-24 Tricyclic oxindole antiinflammatory agents

Publications (1)

Publication Number Publication Date
PH23065A true PH23065A (en) 1989-03-27

Family

ID=22182243

Family Applications (1)

Application Number Title Priority Date Filing Date
PH32688A PH23065A (en) 1984-08-24 1985-08-23 Tricyclic oxindole antiinflammatory agents

Country Status (21)

Country Link
US (1) US4695571A (en)
EP (1) EP0173520B1 (en)
JP (1) JPS6157554A (en)
KR (1) KR870001144B1 (en)
AT (1) ATE49211T1 (en)
AU (1) AU553859B2 (en)
CA (1) CA1244427A (en)
DE (1) DE3575140D1 (en)
DK (1) DK160098C (en)
EG (1) EG17287A (en)
ES (2) ES8704497A1 (en)
FI (1) FI79319C (en)
GR (1) GR852026B (en)
HU (2) HU203238B (en)
IE (1) IE58739B1 (en)
IL (1) IL76175A (en)
PH (1) PH23065A (en)
PL (2) PL147395B1 (en)
PT (1) PT81004B (en)
WO (1) WO1986001510A1 (en)
ZA (1) ZA856403B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531678A1 (en) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh NEW PYRROLO-BENZIMIDAZOLES, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
JPS63223492A (en) * 1987-03-11 1988-09-16 Okawara Mfg Co Ltd Heat exchanger
US5128352A (en) * 1989-01-10 1992-07-07 Pfizer Inc. Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides
HU215112B (en) * 1989-01-10 1998-12-28 Pfizer Inc. Process for producing antiphlogistic 1-heteroaryl-3-acyl-2-oxindole derivatives
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
US5300655A (en) * 1989-04-18 1994-04-05 Pfizer Inc. 2-carboxy-thiophene derivatives
JPH04217684A (en) * 1990-05-30 1992-08-07 Shionogi & Co Ltd Aldose reductase inhibitor
DE4027592A1 (en) * 1990-08-31 1992-03-05 Beiersdorf Ag NEW PYRROLOBENZIMIDAZOLE, IMIDAZOBENZOXAZINONE AND IMIDAZOCHINOLONE, PROCESS FOR THEIR PREPARATION AND THEIR USE AND THE COMPOUNDS CONTAINING PREPARATIONS
DE60234057D1 (en) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc COMPOSITIONS AND METHODS FOR MODULATING TRANSPORT BY THE BLOOD-BRAIN BARRIER
WO2005041957A1 (en) * 2003-10-29 2005-05-12 Pfizer Products Inc. Oxindole derivatives and their use as phosphodiesterase type 2 inhibitors
CN103259027A (en) 2005-04-28 2013-08-21 普罗透斯数字保健公司 Pharma-informatics system
KR20090071598A (en) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 Treatment of liver disorders by administration of receptor-associated protein(rap)-conjugates
PT2398500T (en) 2009-02-20 2019-06-14 2 Bbb Medicines B V Glutathione-based drug delivery system
TWI556839B (en) 2009-05-06 2016-11-11 研究室護膚股份有限公司 Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE756447A (en) * 1969-10-15 1971-03-22 Pfizer OXINDOLECARBOXAMIDES
US3749731A (en) * 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
US4644005A (en) * 1984-10-31 1987-02-17 Pfizer Inc. Oxindole antiinflammatory agents

Also Published As

Publication number Publication date
ES8706116A1 (en) 1987-06-01
FI861704A (en) 1986-04-23
DK382685A (en) 1986-02-25
AU4663785A (en) 1986-02-27
ATE49211T1 (en) 1990-01-15
JPH0450316B2 (en) 1992-08-13
DK160098B (en) 1991-01-28
ES546377A0 (en) 1987-04-01
FI79319B (en) 1989-08-31
IE852081L (en) 1986-02-24
HU203238B (en) 1991-06-28
DK160098C (en) 1991-06-24
IE58739B1 (en) 1993-11-03
AU553859B2 (en) 1986-07-31
JPS6157554A (en) 1986-03-24
US4695571A (en) 1987-09-22
FI79319C (en) 1989-12-11
PL255089A1 (en) 1986-12-30
EP0173520A3 (en) 1986-05-14
WO1986001510A1 (en) 1986-03-13
DK382685D0 (en) 1985-08-23
HUT47580A (en) 1989-03-28
EP0173520A2 (en) 1986-03-05
ZA856403B (en) 1987-04-29
EP0173520B1 (en) 1990-01-03
HU203350B (en) 1991-07-29
EG17287A (en) 1993-02-28
DE3575140D1 (en) 1990-02-08
ES8704497A1 (en) 1987-04-01
PL147393B1 (en) 1989-05-31
KR870001144B1 (en) 1987-06-11
IL76175A0 (en) 1985-12-31
PT81004B (en) 1987-12-30
HU902020D0 (en) 1990-07-28
KR870002143A (en) 1987-03-30
PT81004A (en) 1985-09-01
FI861704A0 (en) 1986-04-23
PL147395B1 (en) 1989-05-31
GR852026B (en) 1985-12-19
ES552044A0 (en) 1987-06-01
IL76175A (en) 1989-08-15
CA1244427A (en) 1988-11-08

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