GR852026B - - Google Patents

Info

Publication number
GR852026B
GR852026B GR852026A GR850102026A GR852026B GR 852026 B GR852026 B GR 852026B GR 852026 A GR852026 A GR 852026A GR 850102026 A GR850102026 A GR 850102026A GR 852026 B GR852026 B GR 852026B
Authority
GR
Greece
Prior art keywords
sub
het
phenyl
conh
alkyl
Prior art date
Application number
GR852026A
Other languages
Greek (el)
Inventor
Lawrence Sherman Melvin Jr
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of GR852026B publication Critical patent/GR852026B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicinal Preparation (AREA)

Abstract

Tricyclic oxindole antiinflammatory agents of the formula: HET-CONH-Ar (I) and their pharmaceutically acceptable base salts, wherein HET is:where R<sub>1</sub> is C<sub>1</sub>-C<sub>3</sub> alkyl or phenyl; R<sub>3</sub> and R<sub>4</sub> are each H or CH<sub>3</sub>; X is N, CH or C(CH<sub>3</sub>); Y is 0 or S; Z is 0 or CG<sub>2</sub>; n is 1 or 2, and Ar is a specified optionally substituted phenyl or heterocyclic group.
GR852026A 1984-08-24 1985-08-21 GR852026B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1984/001371 WO1986001510A1 (en) 1984-08-24 1984-08-24 Tricyclic oxindole antiinflammatory agents

Publications (1)

Publication Number Publication Date
GR852026B true GR852026B (en) 1985-12-19

Family

ID=22182243

Family Applications (1)

Application Number Title Priority Date Filing Date
GR852026A GR852026B (en) 1984-08-24 1985-08-21

Country Status (21)

Country Link
US (1) US4695571A (en)
EP (1) EP0173520B1 (en)
JP (1) JPS6157554A (en)
KR (1) KR870001144B1 (en)
AT (1) ATE49211T1 (en)
AU (1) AU553859B2 (en)
CA (1) CA1244427A (en)
DE (1) DE3575140D1 (en)
DK (1) DK160098C (en)
EG (1) EG17287A (en)
ES (2) ES8704497A1 (en)
FI (1) FI79319C (en)
GR (1) GR852026B (en)
HU (2) HU203238B (en)
IE (1) IE58739B1 (en)
IL (1) IL76175A (en)
PH (1) PH23065A (en)
PL (2) PL147395B1 (en)
PT (1) PT81004B (en)
WO (1) WO1986001510A1 (en)
ZA (1) ZA856403B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531678A1 (en) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh NEW PYRROLO-BENZIMIDAZOLES, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
JPS63223492A (en) * 1987-03-11 1988-09-16 Okawara Mfg Co Ltd Heat exchanger
HU215112B (en) * 1989-01-10 1998-12-28 Pfizer Inc. Process for producing antiphlogistic 1-heteroaryl-3-acyl-2-oxindole derivatives
US5128352A (en) * 1989-01-10 1992-07-07 Pfizer Inc. Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
US5300655A (en) * 1989-04-18 1994-04-05 Pfizer Inc. 2-carboxy-thiophene derivatives
JPH04217684A (en) * 1990-05-30 1992-08-07 Shionogi & Co Ltd Aldose reductase inhibitor
DE4027592A1 (en) * 1990-08-31 1992-03-05 Beiersdorf Ag NEW PYRROLOBENZIMIDAZOLE, IMIDAZOBENZOXAZINONE AND IMIDAZOCHINOLONE, PROCESS FOR THEIR PREPARATION AND THEIR USE AND THE COMPOUNDS CONTAINING PREPARATIONS
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2005041957A1 (en) * 2003-10-29 2005-05-12 Pfizer Products Inc. Oxindole derivatives and their use as phosphodiesterase type 2 inhibitors
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
PT3395372T (en) 2009-02-20 2022-05-05 Enhanx Biopharm Inc Glutathione-based drug delivery system
KR101741629B1 (en) 2009-05-06 2017-05-31 라보라토리 스킨 케어, 인크. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE756447A (en) * 1969-10-15 1971-03-22 Pfizer OXINDOLECARBOXAMIDES
US3749731A (en) * 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
US4644005A (en) * 1984-10-31 1987-02-17 Pfizer Inc. Oxindole antiinflammatory agents

Also Published As

Publication number Publication date
IL76175A0 (en) 1985-12-31
DK160098C (en) 1991-06-24
PH23065A (en) 1989-03-27
EG17287A (en) 1993-02-28
ES8706116A1 (en) 1987-06-01
WO1986001510A1 (en) 1986-03-13
ZA856403B (en) 1987-04-29
KR870002143A (en) 1987-03-30
FI861704A7 (en) 1986-04-23
JPH0450316B2 (en) 1992-08-13
PL147393B1 (en) 1989-05-31
AU553859B2 (en) 1986-07-31
IE852081L (en) 1986-02-24
DK382685D0 (en) 1985-08-23
DK382685A (en) 1986-02-25
PL255089A1 (en) 1986-12-30
CA1244427A (en) 1988-11-08
IE58739B1 (en) 1993-11-03
IL76175A (en) 1989-08-15
FI861704A0 (en) 1986-04-23
AU4663785A (en) 1986-02-27
US4695571A (en) 1987-09-22
DE3575140D1 (en) 1990-02-08
HUT47580A (en) 1989-03-28
ES552044A0 (en) 1987-06-01
EP0173520A2 (en) 1986-03-05
HU203350B (en) 1991-07-29
HU902020D0 (en) 1990-07-28
PL147395B1 (en) 1989-05-31
KR870001144B1 (en) 1987-06-11
HU203238B (en) 1991-06-28
EP0173520B1 (en) 1990-01-03
ATE49211T1 (en) 1990-01-15
PT81004B (en) 1987-12-30
ES546377A0 (en) 1987-04-01
JPS6157554A (en) 1986-03-24
PT81004A (en) 1985-09-01
EP0173520A3 (en) 1986-05-14
FI79319B (en) 1989-08-31
ES8704497A1 (en) 1987-04-01
DK160098B (en) 1991-01-28
FI79319C (en) 1989-12-11

Similar Documents

Publication Publication Date Title
GR852026B (en)
UA41290C2 (en) HETEROARYLAMINES, PHARMACEUTICAL COMPOSITION, METHOD OF CHOLINESTERASE INHIBITION IN MAMMALS, METHOD OF MEMORY IMPROVEMENT
GB2126226B (en) Pyridine derivatives
FI862757A0 (en) PYRIDONKARBONSYRADERIVAT OCH FOERFARANDE FOER FRAMSTAELLNING AV DESSA.
MY117092A (en) Chemotherapeutic pyrrolocarbazole derivatives
MY129935A (en) Dihydropyridine derivatives useful in antitumor therapy
ES466366A1 (en) Meta-sulfonamido-benzamides
ES8705425A1 (en) Isoindolinyl-alkyl-piperazines
NO164351C (en) ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 5-ALKYL-L-PHENYL-2-PIPERAZINOALKYLPYRAZOLINE-3-ON COMPOUNDS.
MX170732B (en) COMPOSITION OF SUCCINIMIDE DERIVATIVES AND THEIR USE
EP0335979A4 (en) Thienopyrimidine derivatives
AU2175083A (en) 2-(substituted amino)-pyrimid-4-one derivatives
TW334428B (en) Novel benzodiazepine derivatives
DE3268541D1 (en) Benzodioxane-imidazoline compounds, their preparation and use
ES471208A1 (en) Pyrimidino (1,2a)heterocyclic amide derivatives
ATE65986T1 (en) PROPANONE COMBATIVES.
AU8291287A (en) Piperidine and azepine derivatives
ES8307812A1 (en) Beta-lactam antibacterial agents, their preparation and use.
ES8506313A1 (en) Antibiotics, their preparation and use.