ES2192201T3 - Compuestos de piranona utiles para el tratamiento de infecciones retrovirales. - Google Patents
Compuestos de piranona utiles para el tratamiento de infecciones retrovirales.Info
- Publication number
- ES2192201T3 ES2192201T3 ES95918864T ES95918864T ES2192201T3 ES 2192201 T3 ES2192201 T3 ES 2192201T3 ES 95918864 T ES95918864 T ES 95918864T ES 95918864 T ES95918864 T ES 95918864T ES 2192201 T3 ES2192201 T3 ES 2192201T3
- Authority
- ES
- Spain
- Prior art keywords
- piranona
- treatment
- compounds useful
- onas
- retroviral infections
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 206010038997 Retroviral infections Diseases 0.000 title 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULAS (I) Y (II), QUE SON PIRAN-2-ONAS, 5,6-DIHIDROPIRAN-2-ONAS, 4-HIDROXIBENZOPIRAN-2-ONAS, 4-HIDROXI-CICLOALQUIL[B]PIRAN-2-ONAS, Y DERIVADOS DE LAS MISMAS, UTILES PARA INHIBIR UN RETROVIRUS EN UNA CELULA DE MAMIFERO INFECTADA POR DICHO RETROVIRUS, DONDE R{SUB,10} Y R{SUB,20} TOMADOS JUNTOS SON LAS FORMULAS (III) Y (IV).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23881794A | 1994-05-06 | 1994-05-06 | |
US34936194A | 1994-12-02 | 1994-12-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2192201T3 true ES2192201T3 (es) | 2003-10-01 |
Family
ID=26931995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95918864T Expired - Lifetime ES2192201T3 (es) | 1994-05-06 | 1995-05-04 | Compuestos de piranona utiles para el tratamiento de infecciones retrovirales. |
Country Status (33)
Country | Link |
---|---|
US (2) | US5852195A (es) |
EP (1) | EP0758327B1 (es) |
JP (1) | JP3883206B2 (es) |
KR (1) | KR100445929B1 (es) |
CN (2) | CN1329378C (es) |
AT (1) | ATE236894T1 (es) |
AU (2) | AU701965B2 (es) |
BR (1) | BR9507615A (es) |
CA (2) | CA2187523C (es) |
CO (1) | CO4810313A1 (es) |
CZ (1) | CZ296515B6 (es) |
DE (2) | DE122006000014I2 (es) |
DK (1) | DK0758327T3 (es) |
ES (1) | ES2192201T3 (es) |
FI (1) | FI117387B (es) |
FR (1) | FR05C0047I2 (es) |
HK (2) | HK1066796A1 (es) |
HU (1) | HU228057B1 (es) |
IL (3) | IL129871A (es) |
LU (1) | LU91220I2 (es) |
MX (1) | MX9605391A (es) |
MY (2) | MY149862A (es) |
NL (1) | NL300216I2 (es) |
NO (2) | NO315799B1 (es) |
NZ (1) | NZ285510A (es) |
PE (1) | PE23196A1 (es) |
PL (1) | PL190540B1 (es) |
PT (1) | PT758327E (es) |
RU (1) | RU2139284C1 (es) |
SI (1) | SI0758327T1 (es) |
SK (1) | SK284407B6 (es) |
TW (1) | TW504507B (es) |
WO (1) | WO1995030670A2 (es) |
Families Citing this family (68)
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US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
EP0909184B1 (en) * | 1996-07-03 | 2003-09-17 | PHARMACIA & UPJOHN COMPANY | Targeted drug delivery using sulfonamide derivatives |
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US6232333B1 (en) | 1996-11-21 | 2001-05-15 | Abbott Laboratories | Pharmaceutical composition |
JP5005847B2 (ja) * | 1997-07-29 | 2012-08-22 | ベーリンガー・インゲルハイム・インテルナツィオナール・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 親油性化合物用の自己乳化性処方 |
EP0989851B1 (en) | 1997-07-29 | 2002-10-02 | PHARMACIA & UPJOHN COMPANY | Self-emulsifying formulation for acidic lipophilic compounds |
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CA2300204C (en) * | 1997-09-11 | 2006-12-12 | Pharmacia & Upjohn Company | Process to produce 4-hydroxy-2-oxo-pyrane derivates useful as protease inhibitors |
DK1161427T3 (da) | 1999-03-18 | 2003-02-24 | Upjohn Co | Forbedret fremgangsmåde til asymmetrisk hydrogenering |
US6956048B2 (en) * | 1999-03-31 | 2005-10-18 | Pharmacia & Upjohn Company | Pharmaceutical emulsions for retroviral protease inhibitors |
ES2676151T3 (es) | 2000-01-19 | 2018-07-17 | Abbvie Inc. | Formulaciones farmacéuticas mejoradas |
US6500963B2 (en) | 2001-02-22 | 2002-12-31 | Boehringer Ingelheim Pharma Kg | Process for preparing optically active dihydropyrones |
DE10108470A1 (de) * | 2001-02-22 | 2002-09-05 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung optisch aktiver Dihydropyrone |
EP2174939A1 (en) * | 2002-02-25 | 2010-04-14 | Kudos Pharmaceuticals Limited | Pyranones useful as ATM inhibitors |
BR0308856A (pt) * | 2002-04-01 | 2005-02-22 | Pfizer | Piranon e pirandion inibidores do rna polimerase dependente do rna do vìrus da hepatite c |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
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CA2583187A1 (en) * | 2004-11-08 | 2006-05-18 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and etravirine |
EP1814547A1 (en) * | 2004-11-16 | 2007-08-08 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and darunavir |
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US20060160859A1 (en) * | 2004-12-01 | 2006-07-20 | Boehringer Ingelheim International Gmbh | Method for treating HIV infection through co-administration of tipranavir and GW873140 |
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WO2013103969A1 (en) | 2012-01-05 | 2013-07-11 | Rutgers, The State University Of New Jersey | Antibacterial agents: phloroglucinol derivatives |
CN104755475B (zh) * | 2012-09-11 | 2016-12-28 | 默沙东公司 | Hiv蛋白酶抑制剂 |
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WO2019173507A1 (en) | 2018-03-06 | 2019-09-12 | Rutgers, The State University Of New Jersey | Antibacterial agents : arylalkylcarboxamido phloroglucinols |
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US5484951A (en) * | 1990-10-19 | 1996-01-16 | Octamer, Incorporated | 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents |
EP0578745A1 (en) * | 1991-04-04 | 1994-01-19 | The Upjohn Company | Phosphorus containing compounds as inhibitors of retroviruses |
EP0765873B1 (en) * | 1991-10-11 | 2002-04-17 | Dupont Pharmaceuticals Company | Cyclic ureas and analogues useful as retroviral protease inhibitors |
JP3070767B2 (ja) * | 1991-10-22 | 2000-07-31 | オクタマー,インコーポレイティド | 抗腫瘍及び抗―レトロウィルス剤として有用なアデノシンジホスホリボースポリメラーゼ結合性ニトロソ芳香族化合物 |
DE4308451A1 (de) * | 1992-09-10 | 1994-04-14 | Bayer Ag | 3-Aryl-pyron-Derivate |
ZA938019B (en) * | 1992-11-13 | 1995-04-28 | Upjohn Co | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses |
IL108459A0 (en) * | 1993-02-05 | 1994-04-12 | Opjohn Company | 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses |
IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
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1995
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- 1995-05-04 CN CNB2004100346805A patent/CN1329378C/zh not_active Expired - Lifetime
- 1995-05-04 DE DE1995630294 patent/DE122006000014I2/de active Active
- 1995-05-04 DE DE69530294T patent/DE69530294T2/de not_active Expired - Lifetime
- 1995-05-04 SK SK1384-96A patent/SK284407B6/sk not_active IP Right Cessation
- 1995-05-04 US US08/809,224 patent/US5852195A/en not_active Expired - Lifetime
- 1995-05-04 AT AT95918864T patent/ATE236894T1/de active
- 1995-05-04 RU RU96123286A patent/RU2139284C1/ru active
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- 1995-05-04 CN CNB951935534A patent/CN1154642C/zh not_active Expired - Lifetime
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- 1995-05-04 BR BR9507615A patent/BR9507615A/pt active Search and Examination
- 1995-05-04 DK DK95918864T patent/DK0758327T3/da active
- 1995-05-04 PT PT95918864T patent/PT758327E/pt unknown
- 1995-05-04 WO PCT/US1995/005219 patent/WO1995030670A2/en active IP Right Grant
- 1995-05-04 HU HU9603074A patent/HU228057B1/hu active Protection Beyond IP Right Term
- 1995-05-04 AU AU24626/95A patent/AU701965B2/en not_active Expired
- 1995-05-04 CZ CZ0317296A patent/CZ296515B6/cs not_active IP Right Cessation
- 1995-05-04 SI SI9530660T patent/SI0758327T1/xx unknown
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- 1995-05-04 JP JP52901695A patent/JP3883206B2/ja not_active Expired - Lifetime
- 1995-05-04 ES ES95918864T patent/ES2192201T3/es not_active Expired - Lifetime
- 1995-05-05 CO CO95018810A patent/CO4810313A1/es unknown
- 1995-05-05 MY MYPI20051072A patent/MY149862A/en unknown
- 1995-05-05 MY MYPI95001195A patent/MY127701A/en unknown
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1996
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- 1996-11-05 NO NO19964676A patent/NO315799B1/no not_active IP Right Cessation
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1998
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2005
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2006
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