LU91220I2 - Tipranavir ou un de ses sels pharmaceutiques (aptivus) - Google Patents
Tipranavir ou un de ses sels pharmaceutiques (aptivus)Info
- Publication number
- LU91220I2 LU91220I2 LU91220C LU91220C LU91220I2 LU 91220 I2 LU91220 I2 LU 91220I2 LU 91220 C LU91220 C LU 91220C LU 91220 C LU91220 C LU 91220C LU 91220 I2 LU91220 I2 LU 91220I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- aptivus
- tipranavir
- ones
- pharmaceutical salt
- pyran
- Prior art date
Links
- SUJUHGSWHZTSEU-FYBSXPHGSA-N tipranavir Chemical compound C([C@@]1(CCC)OC(=O)C([C@H](CC)C=2C=C(NS(=O)(=O)C=3N=CC(=CC=3)C(F)(F)F)C=CC=2)=C(O)C1)CC1=CC=CC=C1 SUJUHGSWHZTSEU-FYBSXPHGSA-N 0.000 title 2
- SUJUHGSWHZTSEU-UHFFFAOYSA-N Tipranavir Natural products C1C(O)=C(C(CC)C=2C=C(NS(=O)(=O)C=3N=CC(=CC=3)C(F)(F)F)C=CC=2)C(=O)OC1(CCC)CCC1=CC=CC=C1 SUJUHGSWHZTSEU-UHFFFAOYSA-N 0.000 title 1
- 229940030139 aptivus Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 229960000838 tipranavir Drugs 0.000 title 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 2
- QBDAFARLDLCWAT-UHFFFAOYSA-N 2,3-dihydropyran-6-one Chemical class O=C1OCCC=C1 QBDAFARLDLCWAT-UHFFFAOYSA-N 0.000 abstract 1
- ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical class O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 abstract 1
- VXIXUWQIVKSKSA-UHFFFAOYSA-N 4-hydroxycoumarin Chemical class C1=CC=CC2=C1OC(=O)C=C2O VXIXUWQIVKSKSA-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23881794A | 1994-05-06 | 1994-05-06 | |
US34936194A | 1994-12-02 | 1994-12-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
LU91220I2 true LU91220I2 (fr) | 2006-04-10 |
Family
ID=26931995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU91220C LU91220I2 (fr) | 1994-05-06 | 2006-02-08 | Tipranavir ou un de ses sels pharmaceutiques (aptivus) |
Country Status (33)
Country | Link |
---|---|
US (2) | US5852195A (fr) |
EP (1) | EP0758327B1 (fr) |
JP (1) | JP3883206B2 (fr) |
KR (1) | KR100445929B1 (fr) |
CN (2) | CN1329378C (fr) |
AT (1) | ATE236894T1 (fr) |
AU (2) | AU701965B2 (fr) |
BR (1) | BR9507615A (fr) |
CA (2) | CA2560489C (fr) |
CO (1) | CO4810313A1 (fr) |
CZ (1) | CZ296515B6 (fr) |
DE (2) | DE122006000014I2 (fr) |
DK (1) | DK0758327T3 (fr) |
ES (1) | ES2192201T3 (fr) |
FI (1) | FI117387B (fr) |
FR (1) | FR05C0047I2 (fr) |
HK (2) | HK1066796A1 (fr) |
HU (1) | HU228057B1 (fr) |
IL (3) | IL129871A (fr) |
LU (1) | LU91220I2 (fr) |
MX (1) | MX9605391A (fr) |
MY (2) | MY149862A (fr) |
NL (1) | NL300216I2 (fr) |
NO (2) | NO315799B1 (fr) |
NZ (1) | NZ285510A (fr) |
PE (1) | PE23196A1 (fr) |
PL (1) | PL190540B1 (fr) |
PT (1) | PT758327E (fr) |
RU (1) | RU2139284C1 (fr) |
SI (1) | SI0758327T1 (fr) |
SK (1) | SK284407B6 (fr) |
TW (1) | TW504507B (fr) |
WO (1) | WO1995030670A2 (fr) |
Families Citing this family (69)
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IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
JP2001505533A (ja) * | 1996-07-03 | 2001-04-24 | ファルマシア・アンド・アップジョン・カンパニー | スルホンアミド誘導体を用いた標的化ドラッグデリバリー |
US5834506A (en) * | 1996-11-01 | 1998-11-10 | Warner-Lambert Company | Dihydropyrones with improved antiviral activity |
US6232333B1 (en) | 1996-11-21 | 2001-05-15 | Abbott Laboratories | Pharmaceutical composition |
CA2294032A1 (fr) * | 1997-07-29 | 1999-02-11 | Pharmacia & Upjohn Company | Formulation autoemulsifiante pour composes lipophiles |
DE69823663T2 (de) * | 1997-07-29 | 2005-05-19 | Pharmacia & Upjohn Co., Kalamazoo | Selbstemulgierbare formulierung enthaltend lipophile verbindungen |
KR100509131B1 (ko) * | 1997-07-29 | 2005-08-18 | 파마시아 앤드 업존 캄파니 엘엘씨 | 산성 친지성 화합물의, 자가유화 제제 형태의 제약 조성물 |
NZ503338A (en) * | 1997-09-11 | 2002-03-01 | Upjohn Co | Process to produce 4-hydroxy-2-oxo-pyrane derivatives |
EP1161427B1 (fr) | 1999-03-18 | 2002-10-23 | PHARMACIA & UPJOHN COMPANY | Procede perfectionne d'hydrogenation asymetrique |
US6956048B2 (en) * | 1999-03-31 | 2005-10-18 | Pharmacia & Upjohn Company | Pharmaceutical emulsions for retroviral protease inhibitors |
PT1248600E (pt) | 2000-01-19 | 2008-08-25 | Abbott Lab | Formulações farmacêuticas melhoradas de inibidores da protease do vih |
DE10108470A1 (de) * | 2001-02-22 | 2002-09-05 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung optisch aktiver Dihydropyrone |
US6500963B2 (en) | 2001-02-22 | 2002-12-31 | Boehringer Ingelheim Pharma Kg | Process for preparing optically active dihydropyrones |
PL370074A1 (en) * | 2002-02-25 | 2005-05-16 | Kudos Pharmaceuticals Ltd | Pyranones useful as atm inhibitors |
DE60307804T2 (de) * | 2002-04-01 | 2007-01-18 | Pfizer Inc. | Pyranon- und pyrandioninhibitoren der rna-abhängigen rna-polymerase des hepatitis-c-virus |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8841326B2 (en) | 2004-02-12 | 2014-09-23 | Stc.Unm | Therapeutic curcumin derivatives |
IL161586A (en) * | 2004-04-22 | 2015-02-26 | Rafael Advanced Defense Sys | Irreplaceable energetic material and reactive shielding that uses it |
JP2008519073A (ja) * | 2004-11-08 | 2008-06-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | チプラナビル及びエトラビリンの同時投与によるhiv感染症の治療法 |
US20060135562A1 (en) * | 2004-11-16 | 2006-06-22 | Boehringer Ingelheim International Gmbh | Method for treating HIV infection through co-administration of tipranavir and darunavir |
EP1814549A2 (fr) * | 2004-11-19 | 2007-08-08 | Boehringer Ingelheim International GmbH | Traitement de l'infection a vih par co-administration de tipranavir et d'uk-427, 857 |
EP1814548A1 (fr) * | 2004-11-19 | 2007-08-08 | Boehringer Ingelheim International Gmbh | Procede visant a traiter l'infection a vih par l'administration combinee du tipranavir et du reverset |
US20060142344A1 (en) * | 2004-12-01 | 2006-06-29 | Boehringer Ingelheim International Gmbh | Method for treating HIV infection through co-administration of tipranavir and GW695634 |
EP1819335A1 (fr) * | 2004-12-01 | 2007-08-22 | Boehringer Ingelheim International Gmbh | Procede de traitement d'une infection par le vih par co-administration de tipranavir et de sch-417690 |
CA2586384A1 (fr) * | 2004-12-01 | 2006-06-08 | Boehringer Ingelheim International Gmbh | Methode de traitement de l'infection a vih par co-administration de tipranavir et de gw873140 |
AU2008226823B2 (en) | 2007-03-12 | 2014-03-13 | Nektar Therapeutics | Oligomer-protease inhibitor conjugates |
US20090062346A1 (en) * | 2007-08-29 | 2009-03-05 | Protia, Llc | Deuterium-enriched tipranavir |
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JP2011513483A (ja) * | 2008-03-10 | 2011-04-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なピリミジンおよびピリジン |
EP2262538B1 (fr) | 2008-03-12 | 2014-12-10 | Nektar Therapeutics | Conjugués oligomères-acides aminés |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
AR074897A1 (es) | 2008-12-23 | 2011-02-23 | Pharmasset Inc | Fosforamidatos de nucleosidos |
EP2376515A1 (fr) | 2008-12-23 | 2011-10-19 | Pharmasset, Inc. | Synthèse de nucléosides de type purine |
SG172361A1 (en) | 2008-12-23 | 2011-07-28 | Pharmasset Inc | Nucleoside analogs |
JP2012528160A (ja) | 2009-05-27 | 2012-11-12 | メルク・シャープ・エンド・ドーム・コーポレイション | Hivプロテアーゼ阻害薬 |
WO2010144869A2 (fr) | 2009-06-12 | 2010-12-16 | Nektar Therapeutics | Inhibiteurs de protéase |
AP3631A (en) | 2009-06-17 | 2016-03-08 | Vertex Pharma | Inhibitors of influenza viruses replication |
KR101466245B1 (ko) * | 2010-01-15 | 2014-12-01 | 한미사이언스 주식회사 | 테트라졸 메탄설폰산 염의 제조방법 및 이에 사용되는 신규 화합물 |
PT3290428T (pt) | 2010-03-31 | 2021-12-27 | Gilead Pharmasset Llc | Comprimido compreendendo 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2h)-il)¿4¿fluoro¿3¿hidroxi¿4¿metiltetrahidrofuran¿2¿il)metoxi) (fenoxi)fosforil)amino)propanoato de (s)- isopropil cristalino |
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WO2012033846A1 (fr) | 2010-09-09 | 2012-03-15 | Rutgers, The State University Of New Jersey | Agents antibactériens à base d'arylpropionyl-tricétone |
WO2012037508A2 (fr) | 2010-09-17 | 2012-03-22 | Rutgers, The State University Of New Jersey | Agents antibactériens : dérivés de myxopyronine de puissance élevée |
WO2012055031A1 (fr) | 2010-10-28 | 2012-05-03 | Merck Canada Inc. | Inhibiteurs de la protéase du vih |
WO2012083117A1 (fr) | 2010-12-16 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la réplication des virus de la grippe |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
WO2013059928A1 (fr) | 2011-10-26 | 2013-05-02 | Merck Canada Inc. | Inhibiteurs de la protéase du vih |
WO2013103969A1 (fr) | 2012-01-05 | 2013-07-11 | Rutgers, The State University Of New Jersey | Agents antibactériens : dérivés du phloroglucinol |
JP2015527403A (ja) * | 2012-09-11 | 2015-09-17 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Hivプロテアーゼ阻害剤 |
AU2013340559B2 (en) | 2012-10-29 | 2018-03-15 | Cipla Limited | Antiviral phosphonate analogues and process for preparation thereof |
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WO2016069955A1 (fr) | 2014-10-29 | 2016-05-06 | Wisconsin Alumni Research Foundation | Inhibiteurs de protéase de vih à base d'acide borique |
WO2016183120A1 (fr) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la réplication des virus de la grippe |
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US10450292B2 (en) | 2015-12-10 | 2019-10-22 | Rutgers, The State University of New Jersesy | Inhibitors of bacterial RNA polymerase: arylpropanoyl, arylpropenoyl, and arylcyclopropanecarboxyl phloroglucinols |
WO2017156458A1 (fr) | 2016-03-11 | 2017-09-14 | University Of South Florida | Inhibiteurs de bêta-lactamases, formulations et utilisations correspondantes |
US11993590B2 (en) * | 2016-12-04 | 2024-05-28 | 712 North Inc. | Pyranone compounds useful to modulate OMA1 protease |
US11685723B2 (en) | 2018-02-13 | 2023-06-27 | Rutgers, The State University Of New Jersey | Antibacterial agents: O-alkyl-deuterated pyronins |
WO2019173507A1 (fr) | 2018-03-06 | 2019-09-12 | Rutgers, The State University Of New Jersey | Agents antibactériens : phloroglucinols arylalkylcarboxamido |
CN110551090B (zh) * | 2019-10-21 | 2021-06-18 | 扬州工业职业技术学院 | 一种超声波提取中药狗脊中抗肿瘤活性成分的方法 |
US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
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- 1995-05-04 CZ CZ0317296A patent/CZ296515B6/cs not_active IP Right Cessation
- 1995-05-04 CA CA002560489A patent/CA2560489C/fr not_active Expired - Lifetime
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- 1995-05-04 HU HU9603074A patent/HU228057B1/hu active Protection Beyond IP Right Term
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