FR05C0047I2 - - Google Patents
Info
- Publication number
- FR05C0047I2 FR05C0047I2 FR05C0047C FR05C0047C FR05C0047I2 FR 05C0047 I2 FR05C0047 I2 FR 05C0047I2 FR 05C0047 C FR05C0047 C FR 05C0047C FR 05C0047 C FR05C0047 C FR 05C0047C FR 05C0047 I2 FR05C0047 I2 FR 05C0047I2
- Authority
- FR
- France
- Prior art keywords
- ones
- pyran
- retrovirus
- hydroxy
- benzopyran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 241001430294 unidentified retrovirus Species 0.000 abstract 2
- QBDAFARLDLCWAT-UHFFFAOYSA-N 2,3-dihydropyran-6-one Chemical class O=C1OCCC=C1 QBDAFARLDLCWAT-UHFFFAOYSA-N 0.000 abstract 1
- ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical class O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 abstract 1
- VXIXUWQIVKSKSA-UHFFFAOYSA-N 4-hydroxycoumarin Chemical class C1=CC=CC2=C1OC(=O)C=C2O VXIXUWQIVKSKSA-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23881794A | 1994-05-06 | 1994-05-06 | |
US34936194A | 1994-12-02 | 1994-12-02 | |
PCT/US1995/005219 WO1995030670A2 (fr) | 1994-05-06 | 1995-05-04 | Composes de pyranone utiles pour traiter des infections a retrovirus |
Publications (2)
Publication Number | Publication Date |
---|---|
FR05C0047I1 FR05C0047I1 (fr) | 2006-03-10 |
FR05C0047I2 true FR05C0047I2 (fr) | 2007-10-19 |
Family
ID=26931995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR05C0047C Active FR05C0047I2 (fr) | 1994-05-06 | 2005-12-22 |
Country Status (33)
Country | Link |
---|---|
US (2) | US5852195A (fr) |
EP (1) | EP0758327B1 (fr) |
JP (1) | JP3883206B2 (fr) |
KR (1) | KR100445929B1 (fr) |
CN (2) | CN1154642C (fr) |
AT (1) | ATE236894T1 (fr) |
AU (2) | AU701965B2 (fr) |
BR (1) | BR9507615A (fr) |
CA (2) | CA2187523C (fr) |
CO (1) | CO4810313A1 (fr) |
CZ (1) | CZ296515B6 (fr) |
DE (2) | DE122006000014I2 (fr) |
DK (1) | DK0758327T3 (fr) |
ES (1) | ES2192201T3 (fr) |
FI (1) | FI117387B (fr) |
FR (1) | FR05C0047I2 (fr) |
HK (2) | HK1066796A1 (fr) |
HU (1) | HU228057B1 (fr) |
IL (3) | IL129871A (fr) |
LU (1) | LU91220I2 (fr) |
MX (1) | MX9605391A (fr) |
MY (2) | MY149862A (fr) |
NL (1) | NL300216I2 (fr) |
NO (2) | NO315799B1 (fr) |
NZ (1) | NZ285510A (fr) |
PE (1) | PE23196A1 (fr) |
PL (1) | PL190540B1 (fr) |
PT (1) | PT758327E (fr) |
RU (1) | RU2139284C1 (fr) |
SI (1) | SI0758327T1 (fr) |
SK (1) | SK284407B6 (fr) |
TW (1) | TW504507B (fr) |
WO (1) | WO1995030670A2 (fr) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
EP0909184B1 (fr) * | 1996-07-03 | 2003-09-17 | PHARMACIA & UPJOHN COMPANY | Distribution ciblee de medicaments a l'aide de derives de sulfonamides |
US5834506A (en) * | 1996-11-01 | 1998-11-10 | Warner-Lambert Company | Dihydropyrones with improved antiviral activity |
US6232333B1 (en) | 1996-11-21 | 2001-05-15 | Abbott Laboratories | Pharmaceutical composition |
KR100509130B1 (ko) * | 1997-07-29 | 2005-08-18 | 파마시아 앤드 업존 캄파니 엘엘씨 | 친지성 화합물의 자가유화 제제 |
BR9810729B1 (pt) * | 1997-07-29 | 2010-07-13 | composição farmacêutica para compostos lipofìlicos ácidos disposta como uma formulação auto-emulsificante. | |
JP2002511099A (ja) * | 1997-07-29 | 2002-04-09 | ファルマシア・アンド・アップジョン・カンパニー | 親油性化合物用の自己乳化性処方 |
PL193240B1 (pl) * | 1997-09-11 | 2007-01-31 | Upjohn Co | Sposób wytwarzania hydroksylaktonu i związki pośrednie stosowane w tym sposobie |
ES2185582T3 (es) * | 1999-03-18 | 2003-05-01 | Upjohn Co | Procedimiento mejorado de hidrogenacion asimetrica. |
US6956048B2 (en) * | 1999-03-31 | 2005-10-18 | Pharmacia & Upjohn Company | Pharmaceutical emulsions for retroviral protease inhibitors |
CA2395987C (fr) | 2000-01-19 | 2009-12-22 | Abbott Laboratories | Formulations pharmaceutiques ameliorees |
DE10108470A1 (de) * | 2001-02-22 | 2002-09-05 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung optisch aktiver Dihydropyrone |
US6500963B2 (en) | 2001-02-22 | 2002-12-31 | Boehringer Ingelheim Pharma Kg | Process for preparing optically active dihydropyrones |
BR0307944A (pt) * | 2002-02-25 | 2005-02-01 | Kudos Pharm Ltd | Piranonas úteis como inibidores de atm |
DE60307804T2 (de) * | 2002-04-01 | 2007-01-18 | Pfizer Inc. | Pyranon- und pyrandioninhibitoren der rna-abhängigen rna-polymerase des hepatitis-c-virus |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8841326B2 (en) | 2004-02-12 | 2014-09-23 | Stc.Unm | Therapeutic curcumin derivatives |
IL161586A (en) * | 2004-04-22 | 2015-02-26 | Rafael Advanced Defense Sys | Irreplaceable energetic material and reactive shielding that uses it |
CA2583187A1 (fr) * | 2004-11-08 | 2006-05-18 | Boehringer Ingelheim International Gmbh | Methode de traitement d'infection vih par coadministration de tipranavir et etravirine |
WO2006055455A1 (fr) * | 2004-11-16 | 2006-05-26 | Boehringer Ingelheim International, Gmbh | Procede pour le traitement d'une infection au vih par l'administration combinee de tipranavir et de darunavir |
EP1814548A1 (fr) * | 2004-11-19 | 2007-08-08 | Boehringer Ingelheim International Gmbh | Procede visant a traiter l'infection a vih par l'administration combinee du tipranavir et du reverset |
US20060122220A1 (en) * | 2004-11-19 | 2006-06-08 | Boehringer Ingelheim International Gmbh | Method for treating HIV infection through co-administration of tipranavir and UK-427,857 |
US20060142344A1 (en) * | 2004-12-01 | 2006-06-29 | Boehringer Ingelheim International Gmbh | Method for treating HIV infection through co-administration of tipranavir and GW695634 |
CA2585663A1 (fr) * | 2004-12-01 | 2006-06-08 | Boehringer Ingelheim International Gmbh | Procede de traitement d'une infection par le vih par co-administration de tipranavir et de sch-417690 |
EP1819333A1 (fr) * | 2004-12-01 | 2007-08-22 | Boehringer Ingelheim International Gmbh | Methode de traitement de l'infection a vih par co-administration de tipranavir et de gw873140 |
WO2008112289A2 (fr) | 2007-03-12 | 2008-09-18 | Nektar Therapeutics | Conjugués d'oligomère-inhibiteur de protéase |
US20090062346A1 (en) * | 2007-08-29 | 2009-03-05 | Protia, Llc | Deuterium-enriched tipranavir |
WO2009042093A1 (fr) * | 2007-09-25 | 2009-04-02 | Merck & Co., Inc. | Inhibiteurs de la protéase du vih |
EP2262498A2 (fr) * | 2008-03-10 | 2010-12-22 | Vertex Pharmceuticals Incorporated | Pyrimidines et pyridines utiles comme inhibiteurs des protéines kinases |
US9095620B2 (en) | 2008-03-12 | 2015-08-04 | Nektar Therapeutics | Reagents |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
EA019295B1 (ru) | 2008-12-23 | 2014-02-28 | Джилид Фармассет, Ллс. | Соединения пуриновых нуклеозидов и способ их получения |
AU2009329867B2 (en) | 2008-12-23 | 2015-01-29 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
NZ617066A (en) | 2008-12-23 | 2015-02-27 | Gilead Pharmasset Llc | Nucleoside analogs |
CA2762582A1 (fr) | 2009-05-27 | 2010-12-02 | Merck Sharp & Dohme Corp. | Inhibiteurs de la protease du vih |
WO2010144869A2 (fr) | 2009-06-12 | 2010-12-16 | Nektar Therapeutics | Inhibiteurs de protéase |
GEP20156325B (en) | 2009-06-17 | 2015-07-10 | Vertex Pharma | Inhibitors of influenza viruses replication |
KR101466245B1 (ko) * | 2010-01-15 | 2014-12-01 | 한미사이언스 주식회사 | 테트라졸 메탄설폰산 염의 제조방법 및 이에 사용되는 신규 화합물 |
AU2011235044A1 (en) | 2010-03-31 | 2012-11-22 | Gilead Pharmasset Llc | Stereoselective synthesis of phosphorus containing actives |
WO2012033815A1 (fr) * | 2010-09-09 | 2012-03-15 | Rutgers, The State University Of New Jersey | Agents anti-bactériens à base d'arylpropionyl-alpha-pyrone |
WO2012033846A1 (fr) | 2010-09-09 | 2012-03-15 | Rutgers, The State University Of New Jersey | Agents antibactériens à base d'arylpropionyl-tricétone |
WO2012037508A2 (fr) | 2010-09-17 | 2012-03-22 | Rutgers, The State University Of New Jersey | Agents antibactériens : dérivés de myxopyronine de puissance élevée |
US9079834B2 (en) | 2010-10-28 | 2015-07-14 | Merck Canada Inc. | HIV protease inhibitors |
WO2012083117A1 (fr) | 2010-12-16 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la réplication des virus de la grippe |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
EP2771332B1 (fr) | 2011-10-26 | 2016-06-29 | Merck Canada Inc. | Dérivés sulfonamides de thiophen et thiazol en tant qu'inhibiteurs de la protease du HIV pour le traitement du SIDA |
US9517994B2 (en) | 2012-01-05 | 2016-12-13 | Rutgers, The State University Of New Jersey | Antibacterial agents: phloroglucinol derivatives |
RU2015113091A (ru) * | 2012-09-11 | 2016-11-10 | Мерк Шарп И Доум Корп. | Ингибиторы протеазы вич |
US9227990B2 (en) | 2012-10-29 | 2016-01-05 | Cipla Limited | Antiviral phosphonate analogues and process for preparation thereof |
WO2015013835A1 (fr) | 2013-07-31 | 2015-02-05 | Merck Sharp & Dohme Corp. | Dérivés de pipérazine utilisés en tant qu'inhibiteurs de la protéase du vih |
JP6618901B2 (ja) | 2013-11-13 | 2019-12-11 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルスの複製の阻害剤を調製する方法 |
PL3068776T3 (pl) | 2013-11-13 | 2019-10-31 | Vertex Pharma | Inhibitory replikacji wirusów grypy |
US9737545B2 (en) | 2013-12-19 | 2017-08-22 | Merck Sharp & Dohme Corp. | HIV protease inhibitors |
WO2015095276A1 (fr) | 2013-12-19 | 2015-06-25 | Merck Sharp & Dohme Corp. | Inhibiteurs de la protéase du vih |
WO2015134366A1 (fr) | 2014-03-06 | 2015-09-11 | Merck Sharp & Dohme Corp. | Inhibiteurs de la protéase du vih |
WO2015138220A1 (fr) | 2014-03-10 | 2015-09-17 | Merck Sharp & Dohme Corp. | Dérivés de pipérazine utilisés en tant qu'inhibiteurs de la protéase du vih |
US9738664B2 (en) | 2014-10-29 | 2017-08-22 | Wisconsin Alumni Research Foundation | Boronic acid inhibitors of HIV protease |
EP3294735B8 (fr) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la réplication des virus de la grippe |
EP3294717B1 (fr) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Procédés de préparation d'inhibiteurs de réplication des virus de la grippe |
WO2017100645A2 (fr) | 2015-12-10 | 2017-06-15 | Rutgers, The State University Of New Jersey | Inhibiteurs d'arn polymérase bactérienne : aryl propanoyle, aryl propénoyle et aryl cyclopropane carboxyl phloroglucinols |
WO2017156458A1 (fr) * | 2016-03-11 | 2017-09-14 | University Of South Florida | Inhibiteurs de bêta-lactamases, formulations et utilisations correspondantes |
US20210246125A1 (en) * | 2016-12-04 | 2021-08-12 | 712 North, Inc. | Pyranone compounds useful to modulate oma1 protease |
WO2019160873A1 (fr) | 2018-02-13 | 2019-08-22 | Rutgers, The State University Of New Jersey | Agents antibactériens : pyronines o-alkyl-deutérés |
WO2019173507A1 (fr) | 2018-03-06 | 2019-09-12 | Rutgers, The State University Of New Jersey | Agents antibactériens : phloroglucinols arylalkylcarboxamido |
CN110551090B (zh) * | 2019-10-21 | 2021-06-18 | 扬州工业职业技术学院 | 一种超声波提取中药狗脊中抗肿瘤活性成分的方法 |
WO2021209563A1 (fr) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Composés destinés à être utilisés dans le traitement d'infections virales par un coronavirus associé au syndrome respiratoire |
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CA2091172C (fr) * | 1990-09-07 | 1997-05-20 | Adriano Afonso | Composes antiviraux et composes antihypertensifs |
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JPH06506463A (ja) * | 1991-04-04 | 1994-07-21 | ジ・アップジョン・カンパニー | Hivおよび他のレトロウイルスの治療に有用な化合物 |
DE69232568T2 (de) * | 1991-10-11 | 2002-12-19 | Bristol Myers Squibb Pharma Co | Cyclische Harnstoffe und Analoga verwendbar als retrovirale Proteasehemmer |
WO1993007868A1 (fr) * | 1991-10-22 | 1993-04-29 | Octamer, Inc. | Composes aromatiques nitreux liant l'adenosine-diphosphoribose polymerase efficaces en tant qu'agents antitumoraux et anti-retrovirus |
DE4308451A1 (de) * | 1992-09-10 | 1994-04-14 | Bayer Ag | 3-Aryl-pyron-Derivate |
ZA938019B (en) * | 1992-11-13 | 1995-04-28 | Upjohn Co | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses |
IL108459A0 (en) * | 1993-02-05 | 1994-04-12 | Opjohn Company | 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses |
IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
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1995
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1998
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2005
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