DE122006000014I2 - Pyranonverbindungen zur Behandlung retroviraler Infektionen - Google Patents
Pyranonverbindungen zur Behandlung retroviraler InfektionenInfo
- Publication number
- DE122006000014I2 DE122006000014I2 DE1995630294 DE69530294C DE122006000014I2 DE 122006000014 I2 DE122006000014 I2 DE 122006000014I2 DE 1995630294 DE1995630294 DE 1995630294 DE 69530294 C DE69530294 C DE 69530294C DE 122006000014 I2 DE122006000014 I2 DE 122006000014I2
- Authority
- DE
- Germany
- Prior art keywords
- treatment
- ones
- retroviral infections
- pyranone compounds
- pyran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical class O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 title abstract 2
- 206010038997 Retroviral infections Diseases 0.000 title 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 2
- QBDAFARLDLCWAT-UHFFFAOYSA-N 2,3-dihydropyran-6-one Chemical class O=C1OCCC=C1 QBDAFARLDLCWAT-UHFFFAOYSA-N 0.000 abstract 1
- VXIXUWQIVKSKSA-UHFFFAOYSA-N 4-hydroxycoumarin Chemical class C1=CC=CC2=C1OC(=O)C=C2O VXIXUWQIVKSKSA-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23881794A | 1994-05-06 | 1994-05-06 | |
US34936194A | 1994-12-02 | 1994-12-02 | |
PCT/US1995/005219 WO1995030670A2 (en) | 1994-05-06 | 1995-05-04 | Pyranone compounds useful to treat retroviral infections |
Publications (2)
Publication Number | Publication Date |
---|---|
DE122006000014I1 DE122006000014I1 (de) | 2006-11-16 |
DE122006000014I2 true DE122006000014I2 (de) | 2007-03-29 |
Family
ID=26931995
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69530294T Expired - Lifetime DE69530294T2 (de) | 1994-05-06 | 1995-05-04 | Pyranonverbindungenzur behandlung retroviraler infektionen |
DE1995630294 Active DE122006000014I2 (de) | 1994-05-06 | 1995-05-04 | Pyranonverbindungen zur Behandlung retroviraler Infektionen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69530294T Expired - Lifetime DE69530294T2 (de) | 1994-05-06 | 1995-05-04 | Pyranonverbindungenzur behandlung retroviraler infektionen |
Country Status (33)
Country | Link |
---|---|
US (2) | US5852195A (de) |
EP (1) | EP0758327B1 (de) |
JP (1) | JP3883206B2 (de) |
KR (1) | KR100445929B1 (de) |
CN (2) | CN1329378C (de) |
AT (1) | ATE236894T1 (de) |
AU (2) | AU701965B2 (de) |
BR (1) | BR9507615A (de) |
CA (2) | CA2560489C (de) |
CO (1) | CO4810313A1 (de) |
CZ (1) | CZ296515B6 (de) |
DE (2) | DE69530294T2 (de) |
DK (1) | DK0758327T3 (de) |
ES (1) | ES2192201T3 (de) |
FI (1) | FI117387B (de) |
FR (1) | FR05C0047I2 (de) |
HK (2) | HK1066796A1 (de) |
HU (1) | HU228057B1 (de) |
IL (3) | IL129871A (de) |
LU (1) | LU91220I2 (de) |
MX (1) | MX9605391A (de) |
MY (2) | MY127701A (de) |
NL (1) | NL300216I2 (de) |
NO (2) | NO315799B1 (de) |
NZ (1) | NZ285510A (de) |
PE (1) | PE23196A1 (de) |
PL (1) | PL190540B1 (de) |
PT (1) | PT758327E (de) |
RU (1) | RU2139284C1 (de) |
SI (1) | SI0758327T1 (de) |
SK (1) | SK284407B6 (de) |
TW (1) | TW504507B (de) |
WO (1) | WO1995030670A2 (de) |
Families Citing this family (69)
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IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
WO1998000173A2 (en) * | 1996-07-03 | 1998-01-08 | Pharmacia & Upjohn Company | Targeted drug delivery using sulfonamide derivatives |
US5834506A (en) * | 1996-11-01 | 1998-11-10 | Warner-Lambert Company | Dihydropyrones with improved antiviral activity |
US6232333B1 (en) | 1996-11-21 | 2001-05-15 | Abbott Laboratories | Pharmaceutical composition |
ATE225174T1 (de) | 1997-07-29 | 2002-10-15 | Upjohn Co | Selbstemulgierende formulierung enthaltend saure lipophile verbindungen |
KR100509130B1 (ko) | 1997-07-29 | 2005-08-18 | 파마시아 앤드 업존 캄파니 엘엘씨 | 친지성 화합물의 자가유화 제제 |
BR9811058A (pt) * | 1997-07-29 | 2000-09-05 | Upjohn Co | Formulação auto-emulsificante para compostos lipofìlicos |
EP1015441B1 (de) * | 1997-09-11 | 2004-05-12 | PHARMACIA & UPJOHN COMPANY | Verfahren zur herstellung von als protease inhibitoren wervollen 4-hydroxy-2-oxo-pyran-derivaten |
ATE226579T1 (de) * | 1999-03-18 | 2002-11-15 | Upjohn Co | Verbesserte verfahren fur assymmetrische hydrogenation |
US6956048B2 (en) * | 1999-03-31 | 2005-10-18 | Pharmacia & Upjohn Company | Pharmaceutical emulsions for retroviral protease inhibitors |
SI1248600T1 (sl) | 2000-01-19 | 2008-08-31 | Abbott Lab | Izboljšane farmacevtske formulacije inhibitorjev proteaze HIV |
DE10108470A1 (de) * | 2001-02-22 | 2002-09-05 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung optisch aktiver Dihydropyrone |
US6500963B2 (en) | 2001-02-22 | 2002-12-31 | Boehringer Ingelheim Pharma Kg | Process for preparing optically active dihydropyrones |
DK1485377T5 (da) * | 2002-02-25 | 2010-12-06 | Kudos Pharm Ltd | Pyranoner egnede som ATM-inhibitorer |
JP2005526102A (ja) * | 2002-04-01 | 2005-09-02 | ファイザー インコーポレイテッド | C型肝炎ウイルスrna依存性rnaポリメラーゼのピラノンおよびピランジオン阻害剤 |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8841326B2 (en) | 2004-02-12 | 2014-09-23 | Stc.Unm | Therapeutic curcumin derivatives |
IL161586A (en) * | 2004-04-22 | 2015-02-26 | Rafael Advanced Defense Sys | Irreplaceable energetic material and reactive shielding that uses it |
EP1812069A2 (de) * | 2004-11-08 | 2007-08-01 | Boehringer Ingelheim International GmbH | Verfahren zur behandlung von hiv-infektionen mittels verabreichung von tipranavir und etravirin |
US20060135562A1 (en) * | 2004-11-16 | 2006-06-22 | Boehringer Ingelheim International Gmbh | Method for treating HIV infection through co-administration of tipranavir and darunavir |
WO2006055660A2 (en) * | 2004-11-19 | 2006-05-26 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and uk-427, 857 |
CA2583195A1 (en) * | 2004-11-19 | 2006-05-26 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and reverset |
US20060160859A1 (en) * | 2004-12-01 | 2006-07-20 | Boehringer Ingelheim International Gmbh | Method for treating HIV infection through co-administration of tipranavir and GW873140 |
CA2585663A1 (en) * | 2004-12-01 | 2006-06-08 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and sch-417690 |
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EP2131865B1 (de) | 2007-03-12 | 2014-12-17 | Nektar Therapeutics | Oligomer-proteasehemmer-konjugate |
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JP2010540517A (ja) * | 2007-09-25 | 2010-12-24 | メルク・シャープ・エンド・ドーム・コーポレイション | Hivプロテアーゼ阻害剤 |
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EP2262538B1 (de) | 2008-03-12 | 2014-12-10 | Nektar Therapeutics | Oligomer-aminosäure konjugate |
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EP2435037B1 (de) | 2009-05-27 | 2014-11-12 | Merck Sharp & Dohme Corp. | Hiv-proteasehemmer |
US20120108501A1 (en) | 2009-06-12 | 2012-05-03 | Nektar Therapeutics | Protease Inhibitors |
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CN103492381A (zh) | 2010-12-16 | 2014-01-01 | 沃泰克斯药物股份有限公司 | 流感病毒复制的抑制剂 |
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EP2771332B1 (de) | 2011-10-26 | 2016-06-29 | Merck Canada Inc. | Thiophen- und Thiazol-Sulfonamid-Derivate als HIV Protease Inhibitoren zur Behandlung von AIDS |
WO2013103969A1 (en) | 2012-01-05 | 2013-07-11 | Rutgers, The State University Of New Jersey | Antibacterial agents: phloroglucinol derivatives |
AU2013315833A1 (en) | 2012-09-11 | 2015-03-05 | Merck Canada Inc. | HIV protease inhibitors |
WO2014068265A1 (en) | 2012-10-29 | 2014-05-08 | Cipla Limited | Antiviral phosphonate analogues and process for preparation thereof |
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EP3116862B1 (de) | 2014-03-10 | 2019-04-17 | Merck Sharp & Dohme Corp. | Piperazinderivate als hiv-proteasehemmer |
EP3212196A4 (de) | 2014-10-29 | 2018-07-11 | Wisconsin Alumni Research Foundation | Boronsäurehemmer der hiv-protease |
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MA42422A (fr) | 2015-05-13 | 2018-05-23 | Vertex Pharma | Inhibiteurs de la réplication des virus de la grippe |
WO2017100645A2 (en) | 2015-12-10 | 2017-06-15 | Rutgers, The State University Of New Jersey | Inhibitors of bacterial rna polymerase: arylpropanoyl, arylpropenoyl, and arylcyclopropanecarboxyl phloroglucinols |
WO2017156458A1 (en) | 2016-03-11 | 2017-09-14 | University Of South Florida | Beta-lactamase inhibitors, formulations, and uses thereof |
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CN112118837B (zh) | 2018-02-13 | 2024-07-09 | 罗格斯新泽西州立大学 | 抗菌剂:o-烷基氘化派洛宁 |
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CN110551090B (zh) * | 2019-10-21 | 2021-06-18 | 扬州工业职业技术学院 | 一种超声波提取中药狗脊中抗肿瘤活性成分的方法 |
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