DE122006000014I2 - Pyranonverbindungen zur Behandlung retroviraler Infektionen - Google Patents

Pyranonverbindungen zur Behandlung retroviraler Infektionen

Info

Publication number
DE122006000014I2
DE122006000014I2 DE1995630294 DE69530294C DE122006000014I2 DE 122006000014 I2 DE122006000014 I2 DE 122006000014I2 DE 1995630294 DE1995630294 DE 1995630294 DE 69530294 C DE69530294 C DE 69530294C DE 122006000014 I2 DE122006000014 I2 DE 122006000014I2
Authority
DE
Germany
Prior art keywords
treatment
ones
retroviral infections
pyranone compounds
pyran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE1995630294
Other languages
English (en)
Other versions
DE69530294D1 (de
DE69530294T2 (de
DE122006000014I1 (de
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Publication of DE122006000014I1 publication Critical patent/DE122006000014I1/de
Publication of DE122006000014I2 publication Critical patent/DE122006000014I2/de
Active legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE1995630294 1994-05-06 1995-05-04 Pyranonverbindungen zur Behandlung retroviraler Infektionen Active DE122006000014I2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23881794A 1994-05-06 1994-05-06
US34936194A 1994-12-02 1994-12-02
PCT/US1995/005219 WO1995030670A2 (en) 1994-05-06 1995-05-04 Pyranone compounds useful to treat retroviral infections

Publications (2)

Publication Number Publication Date
DE122006000014I1 DE122006000014I1 (de) 2006-11-16
DE122006000014I2 true DE122006000014I2 (de) 2007-03-29

Family

ID=26931995

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69530294T Expired - Lifetime DE69530294T2 (de) 1994-05-06 1995-05-04 Pyranonverbindungenzur behandlung retroviraler infektionen
DE1995630294 Active DE122006000014I2 (de) 1994-05-06 1995-05-04 Pyranonverbindungen zur Behandlung retroviraler Infektionen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69530294T Expired - Lifetime DE69530294T2 (de) 1994-05-06 1995-05-04 Pyranonverbindungenzur behandlung retroviraler infektionen

Country Status (33)

Country Link
US (2) US5852195A (de)
EP (1) EP0758327B1 (de)
JP (1) JP3883206B2 (de)
KR (1) KR100445929B1 (de)
CN (2) CN1329378C (de)
AT (1) ATE236894T1 (de)
AU (2) AU701965B2 (de)
BR (1) BR9507615A (de)
CA (2) CA2560489C (de)
CO (1) CO4810313A1 (de)
CZ (1) CZ296515B6 (de)
DE (2) DE69530294T2 (de)
DK (1) DK0758327T3 (de)
ES (1) ES2192201T3 (de)
FI (1) FI117387B (de)
FR (1) FR05C0047I2 (de)
HK (2) HK1066796A1 (de)
HU (1) HU228057B1 (de)
IL (3) IL129871A (de)
LU (1) LU91220I2 (de)
MX (1) MX9605391A (de)
MY (2) MY127701A (de)
NL (1) NL300216I2 (de)
NO (2) NO315799B1 (de)
NZ (1) NZ285510A (de)
PE (1) PE23196A1 (de)
PL (1) PL190540B1 (de)
PT (1) PT758327E (de)
RU (1) RU2139284C1 (de)
SI (1) SI0758327T1 (de)
SK (1) SK284407B6 (de)
TW (1) TW504507B (de)
WO (1) WO1995030670A2 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
US5914332A (en) 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
WO1998000173A2 (en) * 1996-07-03 1998-01-08 Pharmacia & Upjohn Company Targeted drug delivery using sulfonamide derivatives
US5834506A (en) * 1996-11-01 1998-11-10 Warner-Lambert Company Dihydropyrones with improved antiviral activity
US6232333B1 (en) 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
ATE225174T1 (de) 1997-07-29 2002-10-15 Upjohn Co Selbstemulgierende formulierung enthaltend saure lipophile verbindungen
KR100509130B1 (ko) 1997-07-29 2005-08-18 파마시아 앤드 업존 캄파니 엘엘씨 친지성 화합물의 자가유화 제제
BR9811058A (pt) * 1997-07-29 2000-09-05 Upjohn Co Formulação auto-emulsificante para compostos lipofìlicos
EP1015441B1 (de) * 1997-09-11 2004-05-12 PHARMACIA & UPJOHN COMPANY Verfahren zur herstellung von als protease inhibitoren wervollen 4-hydroxy-2-oxo-pyran-derivaten
ATE226579T1 (de) * 1999-03-18 2002-11-15 Upjohn Co Verbesserte verfahren fur assymmetrische hydrogenation
US6956048B2 (en) * 1999-03-31 2005-10-18 Pharmacia & Upjohn Company Pharmaceutical emulsions for retroviral protease inhibitors
SI1248600T1 (sl) 2000-01-19 2008-08-31 Abbott Lab Izboljšane farmacevtske formulacije inhibitorjev proteaze HIV
DE10108470A1 (de) * 2001-02-22 2002-09-05 Boehringer Ingelheim Pharma Verfahren zur Herstellung optisch aktiver Dihydropyrone
US6500963B2 (en) 2001-02-22 2002-12-31 Boehringer Ingelheim Pharma Kg Process for preparing optically active dihydropyrones
DK1485377T5 (da) * 2002-02-25 2010-12-06 Kudos Pharm Ltd Pyranoner egnede som ATM-inhibitorer
JP2005526102A (ja) * 2002-04-01 2005-09-02 ファイザー インコーポレイテッド C型肝炎ウイルスrna依存性rnaポリメラーゼのピラノンおよびピランジオン阻害剤
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8841326B2 (en) 2004-02-12 2014-09-23 Stc.Unm Therapeutic curcumin derivatives
IL161586A (en) * 2004-04-22 2015-02-26 Rafael Advanced Defense Sys Irreplaceable energetic material and reactive shielding that uses it
EP1812069A2 (de) * 2004-11-08 2007-08-01 Boehringer Ingelheim International GmbH Verfahren zur behandlung von hiv-infektionen mittels verabreichung von tipranavir und etravirin
US20060135562A1 (en) * 2004-11-16 2006-06-22 Boehringer Ingelheim International Gmbh Method for treating HIV infection through co-administration of tipranavir and darunavir
WO2006055660A2 (en) * 2004-11-19 2006-05-26 Boehringer Ingelheim International Gmbh Method for treating hiv infection through co-administration of tipranavir and uk-427, 857
CA2583195A1 (en) * 2004-11-19 2006-05-26 Boehringer Ingelheim International Gmbh Method for treating hiv infection through co-administration of tipranavir and reverset
US20060160859A1 (en) * 2004-12-01 2006-07-20 Boehringer Ingelheim International Gmbh Method for treating HIV infection through co-administration of tipranavir and GW873140
CA2585663A1 (en) * 2004-12-01 2006-06-08 Boehringer Ingelheim International Gmbh Method for treating hiv infection through co-administration of tipranavir and sch-417690
WO2006060159A1 (en) * 2004-12-01 2006-06-08 Boehringer Ingelheim International Gmbh Method for treating hiv infection through co-administration of tipranavir and gw695634
EP2131865B1 (de) 2007-03-12 2014-12-17 Nektar Therapeutics Oligomer-proteasehemmer-konjugate
US20090062346A1 (en) * 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched tipranavir
JP2010540517A (ja) * 2007-09-25 2010-12-24 メルク・シャープ・エンド・ドーム・コーポレイション Hivプロテアーゼ阻害剤
WO2009145814A2 (en) * 2008-03-10 2009-12-03 Vertex Pharmaceuticals Incorporated Pyrimidines and pyridines useful as inhibitors of protein kinases
EP2262538B1 (de) 2008-03-12 2014-12-10 Nektar Therapeutics Oligomer-aminosäure konjugate
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EP2376514A2 (de) 2008-12-23 2011-10-19 Pharmasset, Inc. Nukleosidanaloga
NZ593648A (en) 2008-12-23 2013-09-27 Gilead Pharmasset Llc Nucleoside phosphoramidates
CL2009002206A1 (es) 2008-12-23 2011-08-26 Gilead Pharmasset Llc Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
EP2435037B1 (de) 2009-05-27 2014-11-12 Merck Sharp & Dohme Corp. Hiv-proteasehemmer
US20120108501A1 (en) 2009-06-12 2012-05-03 Nektar Therapeutics Protease Inhibitors
WO2010148197A1 (en) 2009-06-17 2010-12-23 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
KR101466245B1 (ko) * 2010-01-15 2014-12-01 한미사이언스 주식회사 테트라졸 메탄설폰산 염의 제조방법 및 이에 사용되는 신규 화합물
KR101715981B1 (ko) 2010-03-31 2017-03-13 길리애드 파마셋 엘엘씨 뉴클레오사이드 포스포르아미데이트
US10800725B2 (en) 2010-09-09 2020-10-13 Richard H. Ebright Arylpropionyl-triketone antibacterial agents
US8772332B2 (en) * 2010-09-09 2014-07-08 Richard H. Ebright Arylpropionyl-alpha-pyrone antibacterial agents
US9133155B2 (en) 2010-09-17 2015-09-15 Rutgers, The State University Of New Jersey Antibacterial agents: high-potency myxopyronin derivatives
EP2632895B1 (de) 2010-10-28 2018-10-03 Merck Canada Inc. Hiv-proteasehemmer
CN103492381A (zh) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
EP2771332B1 (de) 2011-10-26 2016-06-29 Merck Canada Inc. Thiophen- und Thiazol-Sulfonamid-Derivate als HIV Protease Inhibitoren zur Behandlung von AIDS
WO2013103969A1 (en) 2012-01-05 2013-07-11 Rutgers, The State University Of New Jersey Antibacterial agents: phloroglucinol derivatives
AU2013315833A1 (en) 2012-09-11 2015-03-05 Merck Canada Inc. HIV protease inhibitors
WO2014068265A1 (en) 2012-10-29 2014-05-08 Cipla Limited Antiviral phosphonate analogues and process for preparation thereof
WO2015013835A1 (en) 2013-07-31 2015-02-05 Merck Sharp & Dohme Corp. Piperazine derivatives as hiv protease inhibitors
JP6615755B2 (ja) 2013-11-13 2019-12-04 バーテックス ファーマシューティカルズ インコーポレイテッド インフルエンザウイルスの複製の阻害剤
SG10201804021TA (en) 2013-11-13 2018-07-30 Vertex Pharma Methods of preparing inhibitors of influenza viruses replication
US9834526B2 (en) 2013-12-19 2017-12-05 Merck Sharp & Dohme Corp. HIV protease inhibitors
US9737545B2 (en) 2013-12-19 2017-08-22 Merck Sharp & Dohme Corp. HIV protease inhibitors
US9994587B2 (en) 2014-03-06 2018-06-12 Merck Sharp & Dohme Corp. HIV protease inhibitors
EP3116862B1 (de) 2014-03-10 2019-04-17 Merck Sharp & Dohme Corp. Piperazinderivate als hiv-proteasehemmer
EP3212196A4 (de) 2014-10-29 2018-07-11 Wisconsin Alumni Research Foundation Boronsäurehemmer der hiv-protease
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
MA42422A (fr) 2015-05-13 2018-05-23 Vertex Pharma Inhibiteurs de la réplication des virus de la grippe
WO2017100645A2 (en) 2015-12-10 2017-06-15 Rutgers, The State University Of New Jersey Inhibitors of bacterial rna polymerase: arylpropanoyl, arylpropenoyl, and arylcyclopropanecarboxyl phloroglucinols
WO2017156458A1 (en) 2016-03-11 2017-09-14 University Of South Florida Beta-lactamase inhibitors, formulations, and uses thereof
US11993590B2 (en) * 2016-12-04 2024-05-28 712 North Inc. Pyranone compounds useful to modulate OMA1 protease
CN112118837B (zh) 2018-02-13 2024-07-09 罗格斯新泽西州立大学 抗菌剂:o-烷基氘化派洛宁
US11572337B2 (en) 2018-03-06 2023-02-07 Rutgers, The State University Of New Jersey Antibacterial agents: arylalkylcarboxamido phloroglucinols
CN110551090B (zh) * 2019-10-21 2021-06-18 扬州工业职业技术学院 一种超声波提取中药狗脊中抗肿瘤活性成分的方法
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
WO2024130166A2 (en) * 2022-12-16 2024-06-20 Denali Therapeutics Inc. Compounds, compositions, and methods

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB193507A (en) 1921-11-25 1923-02-26 English Electric Co Ltd Improvements in and connected with hydraulic impulse turbines
NL80964C (de) * 1952-03-08
NL83407C (de) * 1952-05-16
US2723277A (en) * 1952-08-26 1955-11-08 Hoffmann La Roche Malonic acid derivatives and process for the manufacture thereof
US2872457A (en) * 1956-04-19 1959-02-03 Wisconsin Alumni Res Found Process for the preparation of 4-hydroxycoumarin derivatives
GB836740A (en) * 1956-04-25 1960-06-09 Bayer Ag Coumarin derivatives and their production
FR1276654A (fr) * 1958-10-01 1961-11-24 Nouveaux dérivés de l'hydroxy-4-alpha-2-pyrone
FR1463767A (fr) * 1963-04-03 1966-07-22 Clin Byla Ets Dérivés de la coumarine et leur préparation
BE674997A (de) * 1965-01-13 1966-07-12
FR1559595A (de) * 1966-12-13 1969-03-14
US3489774A (en) * 1967-04-24 1970-01-13 Dow Chemical Co 3-(beta-aryl-beta-(arylthio) (or arylseleno) propionyl)-coumarin products
US3493586A (en) * 1969-01-23 1970-02-03 Dow Chemical Co 3-(beta-aryl-beta-(arylthio) (or arylseleno)-propionyl)pyrone products
JPS4823942B1 (de) * 1969-02-14 1973-07-17
US3764693A (en) * 1969-11-21 1973-10-09 Lipha A rodenticidal compositions containing 4-hydroxy coumarins
US3835161A (en) * 1972-10-24 1974-09-10 Realisations Scient S E Res C 3-substituted-4-hydroxy-coumarins
JPS53147073A (en) * 1977-05-24 1978-12-21 Sankyo Co Ltd Mevalonolactone derivatives
NZ194557A (en) * 1979-08-17 1984-09-28 Merck & Co Inc Substituted pyranone derivatives;dihydroxy acids therefrom;pharmaceutical compositions
CA1171424A (en) * 1981-06-17 1984-07-24 Alvin K. Willard ( )-(4r, 6s) - (e)-6-[2-(4'fluro-3,3', 5-trimethyl- [l,l'-biphenyl]-2-yl)ethenyl]-3,4,5,6- tetrahydro-4-hydroxy-2h-pyran-2-one
JPS634652A (ja) * 1986-06-25 1988-01-09 Hitachi Ltd 半導体装置
WO1988004652A1 (en) 1986-12-17 1988-06-30 Nippon Soda Co., Ltd. Heterocyclic compounds having triketo skeleton
US4900754A (en) * 1987-12-21 1990-02-13 Rorer Pharmaceutical Corp. HMG-COA reductase inhibitors
AU4074789A (en) * 1988-03-01 1989-09-22 Upjohn Company, The Coumarins to inhibit reverse transcriptase in humans
DE3929913A1 (de) * 1989-09-08 1991-04-04 Hoechst Ag 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte
EP0494231A4 (en) * 1989-09-26 1992-09-16 The Regents Of The University Of California 6-amino-1,2-benzopyrones useful for treatment of viral diseases
CA2066644A1 (en) * 1989-10-27 1991-04-28 Robert L. Heinrikson Method for treating hiv and other retroviruses and compounds useful therefor
JPH03227923A (ja) 1990-01-30 1991-10-08 Sawai Seiyaku Kk ひと免疫不全ウイルス疾患処置剤
SE9000624D0 (sv) * 1990-02-22 1990-02-22 Pharmacia Ab New use
CA2035972C (en) * 1990-02-23 2006-07-11 Martin Karpf Process for the preparation of oxetanones
EP0549729B1 (de) * 1990-09-07 1997-12-17 Schering Corporation Antivirale und antihypertensive verbindungen
US5378694A (en) * 1990-09-07 1995-01-03 Schering Corporation Acyl and alkoxy substituted quinolines
EP0547145A1 (de) * 1990-09-07 1993-06-23 Schering Corporation Antivirale 2(1h)-quinolinon-verbindungen
US5484951A (en) * 1990-10-19 1996-01-16 Octamer, Incorporated 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents
AU1748792A (en) * 1991-04-04 1992-11-02 Upjohn Company, The Phosphorus containing compounds as inhibitors of retroviruses
BR9206623A (pt) * 1991-10-11 1995-05-02 Du Pont Merck Pharma Uréias cíclicas e análogas úteis como inibidoras da protease retroviral
CA2121900A1 (en) * 1991-10-22 1993-04-29 Ernest E. Kun Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as anti-tumor and anti-retroviral agents
DE4308451A1 (de) * 1992-09-10 1994-04-14 Bayer Ag 3-Aryl-pyron-Derivate
ZA938019B (en) * 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
IL108459A0 (en) * 1993-02-05 1994-04-12 Opjohn Company 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections

Also Published As

Publication number Publication date
KR970702858A (ko) 1997-06-10
NO315799B1 (no) 2003-10-27
DK0758327T3 (da) 2003-07-28
HUT77601A (hu) 1998-06-29
IL113567A (en) 2003-05-29
MX9605391A (es) 1997-12-31
CN1150424A (zh) 1997-05-21
JP3883206B2 (ja) 2007-02-21
DE69530294D1 (de) 2003-05-15
FR05C0047I2 (de) 2007-10-19
AU701965B2 (en) 1999-02-11
JPH09512821A (ja) 1997-12-22
HU228057B1 (en) 2012-09-28
CN1154642C (zh) 2004-06-23
WO1995030670A2 (en) 1995-11-16
US5852195A (en) 1998-12-22
HK1066796A1 (en) 2005-04-01
ES2192201T3 (es) 2003-10-01
PT758327E (pt) 2003-08-29
PE23196A1 (es) 1996-06-07
CA2560489A1 (en) 1995-11-16
NO2006003I2 (no) 2008-10-20
FR05C0047I1 (de) 2006-03-10
NZ285510A (en) 1998-03-25
TW504507B (en) 2002-10-01
EP0758327B1 (de) 2003-04-09
MY127701A (en) 2006-12-29
CA2187523A1 (en) 1995-11-16
SI0758327T1 (en) 2003-08-31
ATE236894T1 (de) 2003-04-15
AU2368699A (en) 1999-06-03
IL129871A (en) 2003-11-23
SK138496A3 (en) 1997-06-04
FI964441A0 (fi) 1996-11-05
NL300216I1 (nl) 2006-04-03
CN1539825A (zh) 2004-10-27
AU2462695A (en) 1995-11-29
CZ296515B6 (cs) 2006-04-12
KR100445929B1 (ko) 2005-09-30
CA2187523C (en) 2006-11-21
NO2006003I1 (no) 2006-03-13
CN1329378C (zh) 2007-08-01
RU2139284C1 (ru) 1999-10-10
IL129871A0 (en) 2000-02-29
DE69530294T2 (de) 2003-12-24
NO964676D0 (no) 1996-11-05
DE122006000014I1 (de) 2006-11-16
CZ317296A3 (en) 1997-04-16
PL190540B1 (pl) 2005-12-30
FI117387B (fi) 2006-09-29
LU91220I2 (fr) 2006-04-10
SK284407B6 (sk) 2005-03-04
HK1084667A1 (en) 2006-08-04
AU718117B2 (en) 2000-04-06
PL317061A1 (en) 1997-03-03
HU9603074D0 (en) 1997-01-28
EP0758327A1 (de) 1997-02-19
WO1995030670A3 (en) 1996-04-25
CA2560489C (en) 2010-01-12
BR9507615A (pt) 1997-09-09
CO4810313A1 (es) 1999-06-30
NO964676L (no) 1997-01-06
NL300216I2 (nl) 2006-06-01
MY149862A (en) 2013-10-31
US6169181B1 (en) 2001-01-02
FI964441A (fi) 1996-11-05

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