CZ284872B6 - Cyklické močoviny a jejich analogy a farmaceutické přípravky na jejich bázi - Google Patents

Cyklické močoviny a jejich analogy a farmaceutické přípravky na jejich bázi

Info

Publication number
CZ284872B6
CZ284872B6 CZ94814A CZ81494A CZ284872B6 CZ 284872 B6 CZ284872 B6 CZ 284872B6 CZ 94814 A CZ94814 A CZ 94814A CZ 81494 A CZ81494 A CZ 81494A CZ 284872 B6 CZ284872 B6 CZ 284872B6
Authority
CZ
Czechia
Prior art keywords
analogs
cyclic ureas
pharmaceutical preparations
preparations based
compounds
Prior art date
Application number
CZ94814A
Other languages
English (en)
Other versions
CZ81494A3 (en
Inventor
Patrick Yuk-Sun Lam
Charles Joseph Eyermann
Carl Nicholas Hodge
Prabhakar Kondaji Jadhav
George Vincent Delucca
Original Assignee
The Du Pont Merck Pharmaceutical Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Du Pont Merck Pharmaceutical Company filed Critical The Du Pont Merck Pharmaceutical Company
Publication of CZ81494A3 publication Critical patent/CZ81494A3/cs
Publication of CZ284872B6 publication Critical patent/CZ284872B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/06—Seven-membered rings having the hetero atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/04—Seven-membered rings not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Cyklické močoviny a jejich analogy obecného vzorce I, kde jednotlivé symboly mají specifický význam a jejich farmaceuticky vhodné soli a protiléčiva. Tyto sloučeniny jsou užitečné jako inhibitory retrovirové proteasy. Předmětem řešení jsou též farmaceutické přípravky na bázi výše uvedených sloučenin.ŕ
CZ94814A 1991-10-11 1992-10-13 Cyklické močoviny a jejich analogy a farmaceutické přípravky na jejich bázi CZ284872B6 (cs)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77649191A 1991-10-11 1991-10-11
US88394492A 1992-05-15 1992-05-15
US95327292A 1992-09-29 1992-09-29

Publications (2)

Publication Number Publication Date
CZ81494A3 CZ81494A3 (en) 1994-11-16
CZ284872B6 true CZ284872B6 (cs) 1999-03-17

Family

ID=27419722

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ94814A CZ284872B6 (cs) 1991-10-11 1992-10-13 Cyklické močoviny a jejich analogy a farmaceutické přípravky na jejich bázi

Country Status (18)

Country Link
EP (3) EP0765873B1 (cs)
JP (1) JP3208140B2 (cs)
KR (1) KR100268694B1 (cs)
AT (2) ATE156123T1 (cs)
AU (2) AU2871592A (cs)
BR (1) BR9206623A (cs)
CA (1) CA2120925A1 (cs)
CZ (1) CZ284872B6 (cs)
DE (2) DE69232568T2 (cs)
DK (1) DK0607334T3 (cs)
ES (1) ES2104946T3 (cs)
FI (1) FI941649L (cs)
GR (1) GR3025005T3 (cs)
HU (1) HU221816B1 (cs)
NO (1) NO306720B1 (cs)
RU (1) RU2131420C1 (cs)
SK (1) SK280882B6 (cs)
WO (1) WO1993007128A1 (cs)

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Also Published As

Publication number Publication date
FI941649A7 (fi) 1994-05-31
SK40794A3 (en) 1994-12-07
RU2131420C1 (ru) 1999-06-10
AU694417B2 (en) 1998-07-23
BR9206623A (pt) 1995-05-02
HU9401020D0 (en) 1994-07-28
HK1002257A1 (en) 1998-08-07
HUT67285A (en) 1995-03-28
ATE216371T1 (de) 2002-05-15
EP1153921A2 (en) 2001-11-14
JPH07500324A (ja) 1995-01-12
CA2120925A1 (en) 1993-04-15
DE69232568D1 (de) 2002-05-23
DE69221309D1 (de) 1997-09-04
WO1993007128A1 (en) 1993-04-15
DE69221309T2 (de) 1997-12-11
KR100268694B1 (ko) 2000-10-16
EP0765873B1 (en) 2002-04-17
AU6180894A (en) 1994-07-07
SK280882B6 (sk) 2000-08-14
EP0607334B1 (en) 1997-07-30
FI941649L (fi) 1994-05-31
GR3025005T3 (en) 1998-01-30
CZ81494A3 (en) 1994-11-16
EP0607334A1 (en) 1994-07-27
EP0765873A1 (en) 1997-04-02
NO941278L (no) 1994-06-10
AU2871592A (en) 1993-05-03
FI941649A0 (fi) 1994-04-08
JP3208140B2 (ja) 2001-09-10
ES2104946T3 (es) 1997-10-16
NO306720B1 (no) 1999-12-13
DK0607334T3 (da) 1998-02-16
EP1153921A3 (en) 2001-11-21
NO941278D0 (no) 1994-04-08
HU221816B1 (hu) 2003-01-28
DE69232568T2 (de) 2002-12-19
ATE156123T1 (de) 1997-08-15

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MM4A Patent lapsed due to non-payment of fee

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