CZ284872B6 - Cyklické močoviny a jejich analogy a farmaceutické přípravky na jejich bázi - Google Patents

Cyklické močoviny a jejich analogy a farmaceutické přípravky na jejich bázi

Info

Publication number
CZ284872B6
CZ284872B6 CZ94814A CZ81494A CZ284872B6 CZ 284872 B6 CZ284872 B6 CZ 284872B6 CZ 94814 A CZ94814 A CZ 94814A CZ 81494 A CZ81494 A CZ 81494A CZ 284872 B6 CZ284872 B6 CZ 284872B6
Authority
CZ
Czechia
Prior art keywords
analogs
cyclic ureas
pharmaceutical preparations
preparations based
compounds
Prior art date
Application number
CZ94814A
Other languages
English (en)
Other versions
CZ81494A3 (en
Inventor
Patrick Yuk-Sun Lam
Charles Joseph Eyermann
Carl Nicholas Hodge
Prabhakar Kondaji Jadhav
George Vincent Delucca
Original Assignee
The Du Pont Merck Pharmaceutical Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Du Pont Merck Pharmaceutical Company filed Critical The Du Pont Merck Pharmaceutical Company
Publication of CZ81494A3 publication Critical patent/CZ81494A3/cs
Publication of CZ284872B6 publication Critical patent/CZ284872B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/06—Seven-membered rings having the hetero atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/04—Seven-membered rings not condensed with other rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Cyklické močoviny a jejich analogy obecného vzorce I, kde jednotlivé symboly mají specifický význam a jejich farmaceuticky vhodné soli a protiléčiva. Tyto sloučeniny jsou užitečné jako inhibitory retrovirové proteasy. Předmětem řešení jsou též farmaceutické přípravky na bázi výše uvedených sloučenin.ŕ
CZ94814A 1991-10-11 1992-10-13 Cyklické močoviny a jejich analogy a farmaceutické přípravky na jejich bázi CZ284872B6 (cs)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77649191A 1991-10-11 1991-10-11
US88394492A 1992-05-15 1992-05-15
US95327292A 1992-09-29 1992-09-29

Publications (2)

Publication Number Publication Date
CZ81494A3 CZ81494A3 (en) 1994-11-16
CZ284872B6 true CZ284872B6 (cs) 1999-03-17

Family

ID=27419722

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ94814A CZ284872B6 (cs) 1991-10-11 1992-10-13 Cyklické močoviny a jejich analogy a farmaceutické přípravky na jejich bázi

Country Status (18)

Country Link
EP (3) EP0765873B1 (cs)
JP (1) JP3208140B2 (cs)
KR (1) KR100268694B1 (cs)
AT (2) ATE216371T1 (cs)
AU (2) AU2871592A (cs)
BR (1) BR9206623A (cs)
CA (1) CA2120925A1 (cs)
CZ (1) CZ284872B6 (cs)
DE (2) DE69221309T2 (cs)
DK (1) DK0607334T3 (cs)
ES (1) ES2104946T3 (cs)
FI (1) FI941649L (cs)
GR (1) GR3025005T3 (cs)
HU (1) HU221816B1 (cs)
NO (1) NO306720B1 (cs)
RU (1) RU2131420C1 (cs)
SK (1) SK280882B6 (cs)
WO (1) WO1993007128A1 (cs)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610294A (en) 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
USRE37781E1 (en) 1991-10-11 2002-07-02 Dupont Pharmaceuticals Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
DK0810209T3 (da) 1992-08-25 2002-08-12 Monsanto Co Alpha - and beta-aminosyre-hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser
AU703962B2 (en) * 1993-02-26 1999-04-01 Du Pont Pharmaceuticals Company Substituted cyclic carbonyls and derivatives
US5637780A (en) * 1993-03-30 1997-06-10 The Dupont Merck Pharmaceutical Company Method for preparing alkylating agents and their use for alkylating cyclic ureas
JPH09500120A (ja) * 1993-07-14 1997-01-07 チバ−ガイギー アクチェンゲゼルシャフト 環式ヒドラジン化合物
US5616578A (en) * 1993-08-26 1997-04-01 The Dupont Merck Pharmaceutical Company Method of treating human immunodeficiency virus infection using a cyclic protease inhibitor in combination with a reverse transcriptase inhibitor
IL110752A (en) * 1993-09-13 2000-07-26 Abbott Lab Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
US5559158A (en) * 1993-10-01 1996-09-24 Abbott Laboratories Pharmaceutical composition
US5559110A (en) * 1994-03-09 1996-09-24 The Dupont Merck Pharmaceutical Company Pharmaceutical formulations of cyclic urea type compounds
US5508400A (en) * 1994-04-20 1996-04-16 The Du Pont Merck Pharmaceutical Company Preparation of cyclic urea compounds
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
DE4422911A1 (de) * 1994-06-30 1996-01-04 Hoechst Ag Phosphinsäure-Derivate, deren Herstellung sowie deren Verwendung
US5530124A (en) * 1994-06-30 1996-06-25 The Dupont Merck Pharmaceutical Company Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors
US5466797A (en) * 1994-06-30 1995-11-14 The Du Pont Merck Pharmaceutical Company Intermediates for the preparation of cyclic urea
US5705524A (en) * 1994-11-04 1998-01-06 Gilead Sciences, Inc. Thiepane compounds
JP2002515849A (ja) * 1994-11-04 2002-05-28 ギリアード サイエンシーズ，インコーポレイテッド Ｈｉｖプロテアーゼを阻害および検出するチエパン化合物
US6034118A (en) * 1994-11-04 2000-03-07 Gilead Sciences, Inc. Thiepane compounds
CA2215536A1 (en) * 1995-03-17 1996-09-26 Du Pont Pharmaceuticals Company Cyclic urea hiv protease inhibitors
US5683999A (en) * 1995-03-17 1997-11-04 The Dupont Merck Pharmaceutical Company Cyclic urea HIV protease inhibitors
US5532356A (en) * 1995-06-06 1996-07-02 The Dupont Merck Pharmaceutical Company Method for preparing N,N'-disubstituted cyclic ureas
US5532357A (en) * 1995-06-07 1996-07-02 The Dupont Merck Pharmaceutical Company Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
AU1592697A (en) * 1995-08-22 1997-03-19 Du Pont Merck Pharmaceutical Company, The Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors
US5914332A (en) 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
CZ293628B6 (cs) * 1996-03-29 2004-06-16 Pfizer Inc. Benzyl(iden)laktamové deriváty a jejich použití a farmaceutické kompozice na jejich bázi
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
ZA979868B (en) 1996-11-08 1999-05-03 Du Pont Merck Pharma A 1-(3-aminondazol-5-yl)-3-buty-cyclic urea useful as a HIV protease inhibitor
EA001154B1 (ru) * 1996-11-08 2000-10-30 Дюпон Фармасьютикалз Компани (4r,5s,6s,7r)-гексагидро-1-[5-(3-аминоиндазол)метил]-3-бутил-5,6-дигидрокси-4,7-бис[фенилметил]-2н-1,3-диазепин-2-он и его применение в качестве ингибитора вич-протеазы
ZA9710071B (en) * 1996-11-21 1998-05-25 Abbott Lab Pharmaceutical composition.
US6232333B1 (en) 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
EP0975625A1 (en) 1997-04-14 2000-02-02 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
EP0977772A1 (en) 1997-04-14 2000-02-09 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
CA2285659A1 (en) 1997-04-14 1998-10-22 Cor Therapeutics, Inc. Selective factor xa inhibitors
CA2285705A1 (en) * 1997-04-14 1998-10-22 Cor Therapeutics, Inc. Selective factor xa inhibitors
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
KR19990016003A (ko) * 1997-08-12 1999-03-05 성재갑 치토크롬 저해제 조성물
KR100348561B1 (ko) * 1997-08-12 2002-09-18 주식회사 엘지씨아이 Lb71350과 dmp450을 함유하는 조성물
US6313110B1 (en) 1999-06-02 2001-11-06 Dupont Pharmaceuticals Company Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor
DE19962923A1 (de) * 1999-12-24 2001-07-05 Bayer Ag Substituierte Benzoylcyclohexandione
BR0011864A (pt) 2000-01-19 2004-07-20 Abbott Lab Formulações farmacêuticas
FR2810039B1 (fr) * 2000-06-13 2007-05-25 Centre Nat Rech Scient Composes urees cycliques et leur procede de preparation
UA76977C2 (en) 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
AU2003252259A1 (en) * 2002-07-26 2004-02-16 Nihon Nohyaku Co., Ltd. Novel haloalkylsulfonanilide derivatives, herbicides and usage thereof
JP2004107323A (ja) * 2002-07-26 2004-04-08 Nippon Nohyaku Co Ltd 新規なハロアルキルスルホンアニリド誘導体及び除草剤並びにその使用方法
US7834043B2 (en) 2003-12-11 2010-11-16 Abbott Laboratories HIV protease inhibiting compounds
US20080031951A1 (en) 2005-12-29 2008-02-07 Gilles Guichard Compositions and methods for the inhibition of phospholipase A2
CA2678577A1 (en) 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
WO2008112289A2 (en) 2007-03-12 2008-09-18 Nektar Therapeutics Oligomer-protease inhibitor conjugates
AR069207A1 (es) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
WO2009075835A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
WO2009114151A1 (en) 2008-03-12 2009-09-17 Nektar Therapeutics Oligomer-amino acid and olgomer-atazanavir conjugates
CN104327062A (zh) 2008-07-25 2015-02-04 贝林格尔·英格海姆国际有限公司 11β-羟基类固醇脱氢酶1的环状抑制剂
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2393807B1 (en) 2009-02-04 2013-08-14 Boehringer Ingelheim International GmbH Cyclic inhibitors of 11 -hydroxysteroid dehydrogenase 1
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
WO2011011123A1 (en) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
JP2012530069A (ja) 2009-06-12 2012-11-29 ネクター セラピューティックス プロテアーゼ阻害剤、水溶性非ペプチドオリゴマーおよび親油性部分を含む共有結合体
WO2010151852A2 (en) * 2009-06-26 2010-12-29 University Of Florida Research Foundation, Inc. Protease inhibitors, compositions and methods of use
EP2448928B1 (en) 2009-07-01 2014-08-13 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
EP2585444B1 (en) 2010-06-25 2014-10-22 Boehringer Ingelheim International GmbH Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
HUE026832T2 (en) * 2010-10-13 2016-07-28 Abbvie Bahamas Ltd Antiviral 1-phenyl-2,5-dibenzimidazol-5-ylpyrrolidine derivative
EA201300522A1 (ru) 2010-11-02 2013-11-29 Бёрингер Ингельхайм Интернациональ Гмбх Фармацевтические комбинации для лечения метаболических нарушений
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA735593B (en) * 1972-08-24 1974-07-31 Ciba Geigy Ag Piperidine derivatives and process for their manufacture
US5142056A (en) 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
US4652552A (en) 1984-09-10 1987-03-24 E. I. Du Pont De Nemours And Company Tetrapeptide methyl ketone inhibitors of viral proteases
US4644055A (en) 1984-12-17 1987-02-17 E. I. Du Pont De Nemours And Company Method for preparing specific inhibitors of virus-specified proteases
US4837204A (en) 1985-01-23 1989-06-06 Abbott Laboratories Functionalized peptidyl aminodiols and -triols
JPH072736B2 (ja) * 1985-08-27 1995-01-18 日本バイエルアグロケム株式会社 ニトロメチレン誘導体、その製法及び殺虫剤
EP0248220A3 (en) * 1986-05-06 1988-03-30 MITSUI TOATSU CHEMICALS, Inc. Process for producing cyclic ureas
US4900820A (en) * 1986-06-12 1990-02-13 Mitsui Toatsu Chemicals, Inc. Process for producing cyclic ureas
FR2600252A1 (fr) 1986-06-19 1987-12-24 Inst Nat Sante Rech Med Medicament et composition medicamenteuse pour le traitement de maladies infectieuses dues aux virus, ainsi que pour le traitement des tumeurs
GB8806449D0 (en) * 1988-03-18 1988-04-20 Janssen Pharmaceutica Nv Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones
IL90218A0 (en) 1988-05-13 1989-12-15 Abbott Lab Retroviral protease inhibitors
EP0374097A3 (de) 1988-12-15 1991-06-12 Ciba-Geigy Ag Verwendung von Peptidisosteren als retrovirale Proteasehemmer
IL93136A (en) * 1989-02-23 1995-01-24 Janssen Pharmaceutica Nv Tetrahydroimidazo (1,4) benzodiazepin-2-thione derivatives, their preparation and pharmaceutical compositions containing them
US5049548A (en) 1989-03-03 1991-09-17 Merck & Co., Inc. Renin-inhibitory di-, tri-, and tetrapeptides
CA2010531A1 (en) 1989-03-06 1990-09-06 Werner Neidhart Amino acid derivatives
CA2032259A1 (en) 1989-12-18 1991-06-19 Wayne J. Thompson Hiv protease inhibitors useful for the treatment of aids
CA2026832A1 (fr) 1990-10-03 1992-04-04 Nouredine Haouas Systeme demontable d'attache rapide pour objets tridimensionnels entre eux
US5206244A (en) * 1990-10-18 1993-04-27 E. R. Squibb & Sons, Inc. Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines

Also Published As

Publication number Publication date
HK1002257A1 (en) 1998-08-07
ATE156123T1 (de) 1997-08-15
ES2104946T3 (es) 1997-10-16
GR3025005T3 (en) 1998-01-30
HU221816B1 (hu) 2003-01-28
RU2131420C1 (ru) 1999-06-10
EP0607334B1 (en) 1997-07-30
HU9401020D0 (en) 1994-07-28
DE69221309T2 (de) 1997-12-11
SK280882B6 (sk) 2000-08-14
NO941278D0 (no) 1994-04-08
FI941649A7 (fi) 1994-05-31
DE69232568D1 (de) 2002-05-23
EP1153921A3 (en) 2001-11-21
DE69232568T2 (de) 2002-12-19
DE69221309D1 (de) 1997-09-04
JPH07500324A (ja) 1995-01-12
EP0765873A1 (en) 1997-04-02
NO941278L (no) 1994-06-10
FI941649L (fi) 1994-05-31
ATE216371T1 (de) 2002-05-15
CZ81494A3 (en) 1994-11-16
AU6180894A (en) 1994-07-07
EP0765873B1 (en) 2002-04-17
JP3208140B2 (ja) 2001-09-10
CA2120925A1 (en) 1993-04-15
AU694417B2 (en) 1998-07-23
EP1153921A2 (en) 2001-11-14
NO306720B1 (no) 1999-12-13
AU2871592A (en) 1993-05-03
SK40794A3 (en) 1994-12-07
BR9206623A (pt) 1995-05-02
KR100268694B1 (ko) 2000-10-16
DK0607334T3 (da) 1998-02-16
EP0607334A1 (en) 1994-07-27
FI941649A0 (fi) 1994-04-08
WO1993007128A1 (en) 1993-04-15
HUT67285A (en) 1995-03-28

Similar Documents

Publication Publication Date Title
CZ284872B6 (cs) Cyklické močoviny a jejich analogy a farmaceutické přípravky na jejich bázi
FI921030A0 (fi) Cykliska ureaderivat, dessa foereningar innehaollande laekemedel och foerfarande foer deras framstaellning.
BG100016A (bg) Нiv протеазни инхибитори във фармацевтични комбинации за лечение на спин
NL300283I1 (nl) Alfa- en bèta-aminozuur-hydroxyethylamino-sulfonamiden die toepasbaar zijn als retrovirale-prothease-remmers.
ES536499A0 (es) Un procedimiento para la preparacion de nuevas 2-amino-5-hidroxi-4-metilpirimidinas.
ATE273305T1 (de) Thrombin-inhibitoren
HUP0100348A2 (hu) Hattagú, egy vagy két nitrogénatomot tartalmazó kondenzál biciklusok, eljárás előállításukra, alkalmazásuk, a vegyületeket tartalmazó gyógyszerkészítmények, valamint intermedierek
HUP0100669A2 (hu) Szerin proteázokat gátló peptidszármazékok és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények
FI941457A0 (fi) Verihiutaleglyproteiini IIb/IIIa:n inhibiittoreina käyttökelpoisia syklisiä yhdisteitä
AP9200410A0 (en) Retroviral protease inhibitors.
DK93685A (da) Benzisoselenazolthioner, fremgangsmaade til fremstilling af disse forbindelser og farmaceutiske praeparater indeholdende disse forbindelser
DK0559079T3 (da) Substituerede aminophosphonatderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende derivaterne
BR0003848A (pt) Compostos de piridina, processo para sua preparação e composições farmacêuticas que os contêm
EA200000431A2 (ru) Новые замещенные димерные соединения, способ их получения и фармацевтические композиции, содержащие их
FI803264L (fi) 2-hydroxialkyl-3,4,5-trihydroxipiperidiner foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel
ES2046193T3 (es) Un procedimiento para la preparacion de un compuesto de imidazolidinona.
DK0656001T3 (da) Nye 2-substituerede indan-2-mercaptoacetylamid-tricycliske derivater til anvendelse som enkefalinasehæmmere
DK0553016T3 (da) Hidtil ukendte naphtalenamider og -sulfonamider, fremgangsmåder til deres fremstilling samt farmaceutiske midler indeholdende dem
ES2102870T3 (es) Benzopiranos y composiciones farmaceuticas que los contienen.
UY27399A1 (es) Proceso para la preparación de quinazolinas
PT1000067E (pt) Tiazolobenzo-heterociclos sua preparacao e medicamentos que os contem
DK630088D0 (da) Azelastinembonat, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater med indhold af denne forbindelse som aktivt middel
SE9800835D0 (sv) New Compounds
ATE28647T1 (de) Chinazolinonderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln.
EE9900188A (et) HIV proteaasi inhibiitoritena kasulikud 1-(3-aminoindasool-5-üül)-3-fenüülmetüül-tsüklilised uuread

Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20031013