EP0609211A4 - Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as anti-tumor and anti-retroviral agents. - Google Patents

Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as anti-tumor and anti-retroviral agents.

Info

Publication number
EP0609211A4
EP0609211A4 EP92904892A EP92904892A EP0609211A4 EP 0609211 A4 EP0609211 A4 EP 0609211A4 EP 92904892 A EP92904892 A EP 92904892A EP 92904892 A EP92904892 A EP 92904892A EP 0609211 A4 EP0609211 A4 EP 0609211A4
Authority
EP
European Patent Office
Prior art keywords
tumor
aromatic compounds
compounds useful
polymerase binding
retroviral agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP92904892A
Other languages
German (de)
French (fr)
Other versions
EP0609211A1 (en
Inventor
Ernest Kun
Jerome Mendeleyev
William G Rice
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Octamer Inc
Original Assignee
Octamer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Octamer Inc filed Critical Octamer Inc
Publication of EP0609211A1 publication Critical patent/EP0609211A1/en
Publication of EP0609211A4 publication Critical patent/EP0609211A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
EP92904892A 1991-10-22 1991-11-26 Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as anti-tumor and anti-retroviral agents. Ceased EP0609211A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78080991A 1991-10-22 1991-10-22
US780809 1991-10-22
PCT/US1991/008902 WO1993007868A1 (en) 1991-10-22 1991-11-26 Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as anti-tumor and anti-retroviral agents

Publications (2)

Publication Number Publication Date
EP0609211A1 EP0609211A1 (en) 1994-08-10
EP0609211A4 true EP0609211A4 (en) 1995-02-01

Family

ID=25120767

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92904892A Ceased EP0609211A4 (en) 1991-10-22 1991-11-26 Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as anti-tumor and anti-retroviral agents.

Country Status (5)

Country Link
EP (1) EP0609211A4 (en)
JP (1) JP3070767B2 (en)
AU (1) AU676992B2 (en)
CA (1) CA2121900A1 (en)
WO (1) WO1993007868A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877185A (en) * 1991-10-22 1999-03-02 Octamer, Inc. Synergistic compositions useful as anti-tumor agents
US5753674A (en) * 1991-10-22 1998-05-19 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents, anti-retroviral agents and anti-tumor agents
US5464871A (en) 1993-05-12 1995-11-07 Octamer, Inc. Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents
WO1994009776A1 (en) * 1992-11-02 1994-05-11 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as anti-retroviral agents and anti-tumor agents
GB9404485D0 (en) 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
IL129871A (en) 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
KR20080031266A (en) * 2005-06-10 2008-04-08 바이파 사이언스 인코포레이티드 Parp modulators and treatment of cancer
EP2059802A4 (en) * 2006-09-05 2010-09-08 Bipar Sciences Inc Methods for designing parp inhibitors and uses thereof
WO2018237327A1 (en) 2017-06-22 2018-12-27 Triact Therapeutics, Inc. Methods of treating glioblastoma
WO2019067991A1 (en) 2017-09-29 2019-04-04 Triact Therapeutics, Inc. Iniparib formulations and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9307868A1 *

Also Published As

Publication number Publication date
AU1260992A (en) 1993-05-21
AU676992B2 (en) 1997-04-10
JPH07502975A (en) 1995-03-30
JP3070767B2 (en) 2000-07-31
CA2121900A1 (en) 1993-04-29
EP0609211A1 (en) 1994-08-10
WO1993007868A1 (en) 1993-04-29

Similar Documents

Publication Publication Date Title
EP0553264A4 (en) Thermostable dna polymerase
EP0682519A4 (en) Adenosine kinase inhibitors.
EP0596328A3 (en) Printer for solid articles.
EP0609211A4 (en) Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as anti-tumor and anti-retroviral agents.
AU2386388A (en) Holder for tools and the like at perforated boards
GB2273010B (en) Electric-supply-switch relay-circuit
GB2258876B (en) Tools
GB9126489D0 (en) Wet-sanding tools
IL107249A0 (en) Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
AU112794S (en) Letter tray
EP0515108A3 (en) Azolo (1,3,5) triazines as adenosine antagonists
GB9119378D0 (en) Improvements in oligonucleotide primers
EP0455196A3 (en) Multiple-cutter insert fixing structure, particularly for wood-working tools and the like
EP0394346A4 (en) Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents
EP0636068A4 (en) Foam grip.
GB9115891D0 (en) Hand tools
GB9319930D0 (en) Tool tray
GB9206182D0 (en) Interlayered clay-based materials
GB9112795D0 (en) Nucleotide sequence
GB9123187D0 (en) Improvements in oligonucleotide primers
GB9306293D0 (en) Fibreboard tray
AU111592S (en) Letter tray
GB9204900D0 (en) Nucleotides
ZA93266B (en) Lockable holster.
AU117226S (en) multi purpose timber machiner

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19940520

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

A4 Supplementary search report drawn up and despatched

Effective date: 19941216

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

17Q First examination report despatched

Effective date: 19980316

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 19991217