ES2084702T3 - Imidazoles sustituidos utiles como inhibidores de la angiotensina ii. - Google Patents
Imidazoles sustituidos utiles como inhibidores de la angiotensina ii.Info
- Publication number
- ES2084702T3 ES2084702T3 ES90911154T ES90911154T ES2084702T3 ES 2084702 T3 ES2084702 T3 ES 2084702T3 ES 90911154 T ES90911154 T ES 90911154T ES 90911154 T ES90911154 T ES 90911154T ES 2084702 T3 ES2084702 T3 ES 2084702T3
- Authority
- ES
- Spain
- Prior art keywords
- angiotensin
- inhibitors
- substituted imidazoles
- useful
- imidazoles useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000002460 imidazoles Chemical class 0.000 title abstract 4
- 239000002333 angiotensin II receptor antagonist Substances 0.000 title 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 2
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 239000000584 angiotensin II type 2 receptor blocker Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 229940030606 diuretics Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- External Artificial Organs (AREA)
- Seal Device For Vehicle (AREA)
- Nonmetallic Welding Materials (AREA)
Abstract
LOS IMIDAZOLOS SUSTITUIDOS (I) SON UTILES COMO BLOQUEADORES DE LA ANGIOTENSINA II. ESTOS COMPUESTOS SON ACTIVOS A LA HORA DE TRATAR LA HIPERTENSION Y LAS FALTAS CARDIACOS CONGESTIVOS. SE DESCRIBEN TAMBIEN LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LOS NUEVOS IMIDAZOLES Y LOS METODOS FARMACEUTICOS QUE LOS UTILIZAN, POR SI SOLAS O JUNTO CON OTROS MEDICAMENTOS, ESPECIALMENTE DIURETICOS Y MEDICAMENTOS ANTIINFLAMATORIOS NO ESTEROIDALES (NSAID''S).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37375589A | 1989-06-30 | 1989-06-30 | |
US54455790A | 1990-06-27 | 1990-06-27 | |
US54524090A | 1990-06-27 | 1990-06-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2084702T3 true ES2084702T3 (es) | 1996-05-16 |
Family
ID=27409142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90911154T Expired - Lifetime ES2084702T3 (es) | 1989-06-30 | 1990-06-28 | Imidazoles sustituidos utiles como inhibidores de la angiotensina ii. |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0479903B1 (es) |
JP (1) | JP2550442B2 (es) |
KR (1) | KR0163595B1 (es) |
AT (1) | ATE134368T1 (es) |
AU (1) | AU644802B2 (es) |
CA (1) | CA2060656A1 (es) |
DE (1) | DE69025473T2 (es) |
DK (1) | DK0479903T3 (es) |
ES (1) | ES2084702T3 (es) |
FI (1) | FI916129A0 (es) |
HU (1) | HU217958B (es) |
NO (1) | NO915113L (es) |
RU (1) | RU2099330C1 (es) |
SG (1) | SG52709A1 (es) |
WO (1) | WO1991000277A1 (es) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5210079A (en) * | 1988-01-07 | 1993-05-11 | E. I. Du Pont De Nemours And Company | Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists |
EP0443983B1 (de) * | 1990-02-19 | 1996-02-28 | Ciba-Geigy Ag | Acylverbindungen |
EP0533840B1 (en) * | 1990-06-22 | 1996-12-11 | E.I. Du Pont De Nemours And Company | Treatment of chronic renal failure with imidazole angiotensin-ii receptor antagonists |
US5137902A (en) * | 1990-07-13 | 1992-08-11 | E. I. Du Pont De Nemours And Company | 4-alkylimidazole derivatives and anti-hypertensive use thereof |
CA2058198A1 (en) * | 1991-01-04 | 1992-07-05 | Adalbert Wagner | Azole derivatives, process for their preparation, and their use |
AT395853B (de) * | 1991-01-31 | 1993-03-25 | Chem Pharm Forsch Gmbh | Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung |
FR2672892B1 (fr) * | 1991-02-20 | 1994-01-14 | Synthelabo | Derives de 4-pyrimidinones, leur preparation et leur application en therapeutique. |
US5616599A (en) * | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
GB9110636D0 (en) * | 1991-05-16 | 1991-07-03 | Glaxo Group Ltd | Chemical compounds |
US5210211A (en) * | 1991-06-21 | 1993-05-11 | Warner-Lambert Company | 4-(1h-pyrrol-1-yl) imidazoles with angiotension ii antagonist activity |
DE4132633A1 (de) * | 1991-10-01 | 1993-04-08 | Bayer Ag | Cyclisch substituierte imidazolyl-propensaeurederivate |
DE4132631A1 (de) * | 1991-10-01 | 1993-04-08 | Bayer Ag | Imidazolyl-propensaeurederivate |
US5308853A (en) * | 1991-12-20 | 1994-05-03 | Warner-Lambert Company | Substituted-5-methylidene hydantoins with AT1 receptor antagonist properties |
FR2687674B1 (fr) * | 1992-02-07 | 1995-05-19 | Roussel Uclaf | Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
DE69329982T2 (de) * | 1992-06-02 | 2001-09-27 | Sankyo Co | 4-Carboxyimidazolderivate als Angiotensin-II-Antagonisten und ihre therapeutische Verwendung |
GB9213934D0 (en) * | 1992-06-30 | 1992-08-12 | Smithkline Beecham Corp | Chemical compounds |
US5310929A (en) * | 1992-08-06 | 1994-05-10 | E. I. Du Pont De Nemours And Company | Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists |
IT1255802B (it) * | 1992-08-07 | 1995-11-16 | Luso Farmaco Inst | Derivati imidazolici ad attivita' a ii antagonista |
NO304429B1 (no) * | 1992-12-17 | 1998-12-14 | Sankyo Co | Bifenylderivater, farmas°ytisk preparat og deres anvendelse for fremstilling av et medikament for behandling av hypertensjon og hjertesykdom |
US5721263A (en) * | 1993-06-07 | 1998-02-24 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition for angiotensin II-mediated diseases |
IT1273790B (it) * | 1994-02-18 | 1997-07-10 | Guidotti & C Spa Labor | Derivati eterociclici diazotati aventi attivita' aii antagonista |
KR100211446B1 (ko) * | 1994-03-16 | 1999-08-02 | 가와무라 요시부미 | 안압 저하제 |
US5616601A (en) * | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
US6613789B2 (en) | 1994-07-28 | 2003-09-02 | G. D. Searle & Co. | Heterocyclo-substituted imidazoles for the treatment of inflammation |
BR9908474A (pt) | 1998-03-04 | 2000-12-05 | Takeda Chemical Industries Ltd | Preparação de liberação prolongada, processo para a produção de uma preparação de liberação prolongada, e, composição farmacêutica |
AU782353B2 (en) | 1999-03-26 | 2005-07-21 | Euro-Celtique S.A. | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof |
US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
ES2391550T3 (es) | 1999-04-15 | 2012-11-27 | Bristol-Myers Squibb Company | Inhibidores cíclicos de la proteína tirosina quinasa |
SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
GB0011089D0 (en) * | 2000-05-08 | 2000-06-28 | Black James Foundation | Gastrin and cholecystokinin receptor ligands (11) |
BR0115871A (pt) | 2000-12-04 | 2003-10-28 | Hoffmann La Roche | Derivados de feniletenila ou feniletinila como antagonistas de receptores de glutamato |
CA2435067C (en) | 2001-01-26 | 2011-11-15 | Chugai Seiyaku Kabushiki Kaisha | Malonyl-coa decarboxylase inhibitors useful as metabolic modulators |
WO2002058690A2 (en) | 2001-01-26 | 2002-08-01 | Chugai Seiyaku Kabushiki Kaisha | Methods for the treatment of diseases using malonyl-coa decarbox ylase inhibitors |
JP4267920B2 (ja) | 2001-01-26 | 2009-05-27 | 中外製薬株式会社 | 代謝調節剤として有用なマロニル−CoA脱炭酸酵素阻害剤 |
HU229431B1 (en) | 2001-02-20 | 2013-12-30 | Chugai Pharmaceutical Co Ltd | Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators |
US7709510B2 (en) | 2001-02-20 | 2010-05-04 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
BR0215258A (pt) | 2001-12-21 | 2004-12-07 | Pharmacia Corp | Moduladores de receptor x de fìgado de tioéter aromático |
MXPA04011691A (es) | 2002-05-24 | 2005-09-12 | Pharmacia Corp | Moduladores del receptor x anilino hepaticos. |
CA2486651A1 (en) | 2002-05-24 | 2003-12-04 | Pharmacia Corporation | Sulfone liver x-receptor modulators |
TWI292318B (en) | 2003-03-10 | 2008-01-11 | Hoffmann La Roche | Imidazol-4-yl-ethynyl-pyridine derivatives |
CA2533747C (en) | 2003-08-01 | 2012-11-13 | Chugai Seiyaku Kabushiki Kaisha | Heterocyclic compounds useful as malonyl-coa decarboxylase inhibitors |
DE602004009582T2 (de) | 2003-08-01 | 2009-01-02 | Chugai Seiyaku K.K. | Cyanoamid-verbindungen als nützliche malonyl-coa decarboxylase-hemmer |
ATE407673T1 (de) | 2003-08-01 | 2008-09-15 | Chugai Pharmaceutical Co Ltd | Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer |
ES2309563T3 (es) | 2003-08-01 | 2008-12-16 | Chugai Seiyaku Kabushiki Kaisha | Compuestos de piperidina utiles como inhibidores de malonil coenzima a descarboxilasa. |
US7452909B2 (en) * | 2003-09-04 | 2008-11-18 | Hoffman-La Roche Inc. | Imidazole derivatives |
KR100907108B1 (ko) | 2004-06-01 | 2009-07-09 | 에프. 호프만-라 로슈 아게 | Mglu5 수용체 길항제로서 피리딘-4-일-에틴일-이미다졸및 피라졸 |
BRPI0514544A (pt) | 2004-08-23 | 2008-06-17 | Wyeth Corp | ácidos de oxazol-naftila como moduladores de inibidor tipo-1 de ativador de plasminogênio (pai-1) |
JP2008510816A (ja) | 2004-08-23 | 2008-04-10 | ワイス | チアゾロ−ナフチル酸 |
CA2577782A1 (en) | 2004-08-23 | 2006-03-02 | Wyeth | Pyrrolo-naphthyl acids as pai-1 inhibitors |
CN101568531B (zh) | 2006-12-21 | 2013-11-13 | 弗·哈夫曼-拉罗切有限公司 | Mglur5受体拮抗剂的多晶型物 |
WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EP2328910B1 (en) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US20120264753A1 (en) * | 2009-12-22 | 2012-10-18 | Kowa Company, Ltd. | Novel 1-(biphenyl-4-yl-methyl)-1h-imidazole derivative and pharmaceutical product containing same |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EP2968439A2 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
US10011637B2 (en) | 2013-06-05 | 2018-07-03 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
KR102319263B1 (ko) | 2017-11-30 | 2021-10-29 | 주식회사 엘지화학 | 방열 유체 조성물, 이의 제조방법, 이를 포함하는 전지 모듈 및 배터리 팩 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA875052B (en) * | 1986-07-11 | 1989-03-29 | Du Pont | Angiotensin ii receptor blocking imidazoles |
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
-
1990
- 1990-06-28 ES ES90911154T patent/ES2084702T3/es not_active Expired - Lifetime
- 1990-06-28 WO PCT/US1990/003683 patent/WO1991000277A1/en active IP Right Grant
- 1990-06-28 AT AT90911154T patent/ATE134368T1/de not_active IP Right Cessation
- 1990-06-28 EP EP90911154A patent/EP0479903B1/en not_active Expired - Lifetime
- 1990-06-28 CA CA002060656A patent/CA2060656A1/en not_active Abandoned
- 1990-06-28 DK DK90911154.4T patent/DK0479903T3/da active
- 1990-06-28 DE DE69025473T patent/DE69025473T2/de not_active Expired - Lifetime
- 1990-06-28 JP JP2510146A patent/JP2550442B2/ja not_active Expired - Lifetime
- 1990-06-28 RU SU915010942A patent/RU2099330C1/ru active
- 1990-06-28 SG SG1996008138A patent/SG52709A1/en unknown
- 1990-06-28 AU AU59579/90A patent/AU644802B2/en not_active Ceased
- 1990-06-28 HU HU605/90A patent/HU217958B/hu not_active IP Right Cessation
- 1990-06-28 KR KR1019910701995A patent/KR0163595B1/ko not_active IP Right Cessation
-
1991
- 1991-12-27 NO NO91915113A patent/NO915113L/no unknown
- 1991-12-27 FI FI916129A patent/FI916129A0/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JPH04506522A (ja) | 1992-11-12 |
RU2099330C1 (ru) | 1997-12-20 |
DE69025473D1 (de) | 1996-03-28 |
WO1991000277A1 (en) | 1991-01-10 |
KR920702681A (ko) | 1992-10-06 |
CA2060656A1 (en) | 1990-12-31 |
DK0479903T3 (da) | 1996-03-18 |
HU905605D0 (en) | 1992-06-29 |
HU217958B (hu) | 2000-05-28 |
NO915113D0 (no) | 1991-12-27 |
ATE134368T1 (de) | 1996-03-15 |
NO915113L (no) | 1992-02-28 |
DE69025473T2 (de) | 1996-10-17 |
EP0479903B1 (en) | 1996-02-21 |
EP0479903A1 (en) | 1992-04-15 |
AU5957990A (en) | 1991-01-17 |
KR0163595B1 (ko) | 1998-12-01 |
AU644802B2 (en) | 1993-12-23 |
HUT62575A (en) | 1993-05-28 |
JP2550442B2 (ja) | 1996-11-06 |
SG52709A1 (en) | 1998-09-28 |
FI916129A0 (fi) | 1991-12-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2084702T3 (es) | Imidazoles sustituidos utiles como inhibidores de la angiotensina ii. | |
IL83153A0 (en) | Substituted imidazoles,their preparation and pharmaceutical compositions containing them | |
ES2058342T3 (es) | Pirroles, pirazoles y triazoles sustituidos antagonistas de la angiotensina ii. | |
DE19875033I2 (de) | Angiotensin ii-Rezeptor blockierende imidazole undDiuretika enthaltende pharmazeutische Zusammenset zungen. | |
DK0624583T3 (da) | Substituerede pyridylmethylpyridoner som angiotensin II-antagonister | |
DE3876400D1 (de) | Aminosaeure-imid-derivate, ihre verwendung und diese enthaltende medizinische zusammensetzungen. | |
NO971341L (no) | Promoter for reseptor tyrosinkinase TIE | |
ES2158868T3 (es) | Imidazo(4,5-b)piridinas y bencimidazoles sustituidos como antagonistas de la angiotensina ii. | |
ES2140672T3 (es) | Compuestos biciclicos sustituidos, fusionados y puentes utilizados como agentes terapeuticos. | |
DE3766796D1 (de) | Di- oder polycyanatverbindungen und substituierte bicyclo(2.2.1)hept-5-en-2,3-dicarbonsaeureimide enthaltende gemische und deren verwendung. | |
DE3878988T2 (de) | 1,2-Di(4-isobutylphenyl)äthylen, dessen Herstellung und Verwendung als Zwischenprodukt. | |
SE8704272L (sv) | Pharmaceutisk komposition | |
IT1241456B (it) | Associazione medicamentosa per il trattamento dell'ipertensione e dell'insufficienza cardiaca congestiva. (caso 100-7516) | |
RU96122690A (ru) | Лекарственное средство для наружного лечения псориаза |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 479903 Country of ref document: ES |