ATE134368T1 - Substituierte imidazole und ihre verwendung als hemmmstoff fur angiotensin ii - Google Patents
Substituierte imidazole und ihre verwendung als hemmmstoff fur angiotensin iiInfo
- Publication number
- ATE134368T1 ATE134368T1 AT90911154T AT90911154T ATE134368T1 AT E134368 T1 ATE134368 T1 AT E134368T1 AT 90911154 T AT90911154 T AT 90911154T AT 90911154 T AT90911154 T AT 90911154T AT E134368 T1 ATE134368 T1 AT E134368T1
- Authority
- AT
- Austria
- Prior art keywords
- angiotensin
- inhibitor
- substituted imidazoles
- imidazoles
- drugs
- Prior art date
Links
- 150000002460 imidazoles Chemical class 0.000 title abstract 4
- 239000002333 angiotensin II receptor antagonist Substances 0.000 title 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 2
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 239000000584 angiotensin II type 2 receptor blocker Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 229940030606 diuretics Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- External Artificial Organs (AREA)
- Seal Device For Vehicle (AREA)
- Nonmetallic Welding Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37375589A | 1989-06-30 | 1989-06-30 | |
US54524090A | 1990-06-27 | 1990-06-27 | |
US54455790A | 1990-06-27 | 1990-06-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE134368T1 true ATE134368T1 (de) | 1996-03-15 |
Family
ID=27409142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90911154T ATE134368T1 (de) | 1989-06-30 | 1990-06-28 | Substituierte imidazole und ihre verwendung als hemmmstoff fur angiotensin ii |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0479903B1 (de) |
JP (1) | JP2550442B2 (de) |
KR (1) | KR0163595B1 (de) |
AT (1) | ATE134368T1 (de) |
AU (1) | AU644802B2 (de) |
CA (1) | CA2060656A1 (de) |
DE (1) | DE69025473T2 (de) |
DK (1) | DK0479903T3 (de) |
ES (1) | ES2084702T3 (de) |
FI (1) | FI916129A0 (de) |
HU (1) | HU217958B (de) |
NO (1) | NO915113L (de) |
RU (1) | RU2099330C1 (de) |
SG (1) | SG52709A1 (de) |
WO (1) | WO1991000277A1 (de) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5210079A (en) * | 1988-01-07 | 1993-05-11 | E. I. Du Pont De Nemours And Company | Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists |
DE59107440D1 (de) * | 1990-02-19 | 1996-04-04 | Ciba Geigy Ag | Acylverbindungen |
DE69123582T2 (de) * | 1990-06-22 | 1997-05-15 | E.I. Du Pont De Nemours & Co., Wilmington, Del. | Behandlung des chronischen nierenversagens mit imidazol-angiotensin-ii-rezeptorantagonisten |
US5137902A (en) * | 1990-07-13 | 1992-08-11 | E. I. Du Pont De Nemours And Company | 4-alkylimidazole derivatives and anti-hypertensive use thereof |
CA2058198A1 (en) * | 1991-01-04 | 1992-07-05 | Adalbert Wagner | Azole derivatives, process for their preparation, and their use |
AT395853B (de) * | 1991-01-31 | 1993-03-25 | Chem Pharm Forsch Gmbh | Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung |
FR2672892B1 (fr) * | 1991-02-20 | 1994-01-14 | Synthelabo | Derives de 4-pyrimidinones, leur preparation et leur application en therapeutique. |
US5616599A (en) * | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
GB9110636D0 (en) * | 1991-05-16 | 1991-07-03 | Glaxo Group Ltd | Chemical compounds |
US5210211A (en) * | 1991-06-21 | 1993-05-11 | Warner-Lambert Company | 4-(1h-pyrrol-1-yl) imidazoles with angiotension ii antagonist activity |
DE4132631A1 (de) * | 1991-10-01 | 1993-04-08 | Bayer Ag | Imidazolyl-propensaeurederivate |
DE4132633A1 (de) * | 1991-10-01 | 1993-04-08 | Bayer Ag | Cyclisch substituierte imidazolyl-propensaeurederivate |
US5308853A (en) * | 1991-12-20 | 1994-05-03 | Warner-Lambert Company | Substituted-5-methylidene hydantoins with AT1 receptor antagonist properties |
FR2687674B1 (fr) * | 1992-02-07 | 1995-05-19 | Roussel Uclaf | Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
DE69329982T2 (de) * | 1992-06-02 | 2001-09-27 | Sankyo Co., Ltd. | 4-Carboxyimidazolderivate als Angiotensin-II-Antagonisten und ihre therapeutische Verwendung |
GB9213934D0 (en) * | 1992-06-30 | 1992-08-12 | Smithkline Beecham Corp | Chemical compounds |
US5310929A (en) * | 1992-08-06 | 1994-05-10 | E. I. Du Pont De Nemours And Company | Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists |
IT1255802B (it) * | 1992-08-07 | 1995-11-16 | Luso Farmaco Inst | Derivati imidazolici ad attivita' a ii antagonista |
NO304429B1 (no) * | 1992-12-17 | 1998-12-14 | Sankyo Co | Bifenylderivater, farmas°ytisk preparat og deres anvendelse for fremstilling av et medikament for behandling av hypertensjon og hjertesykdom |
US5721263A (en) * | 1993-06-07 | 1998-02-24 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition for angiotensin II-mediated diseases |
IT1273790B (it) * | 1994-02-18 | 1997-07-10 | Guidotti & C Spa Labor | Derivati eterociclici diazotati aventi attivita' aii antagonista |
HUT74734A (en) * | 1994-03-16 | 1997-02-28 | Sankyo Co | Use of biphenyl methyl imidazole derivatives for producing pharmaceutical compositions having ocular tension derpessant activity |
US6613789B2 (en) | 1994-07-28 | 2003-09-02 | G. D. Searle & Co. | Heterocyclo-substituted imidazoles for the treatment of inflammation |
US5616601A (en) * | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
EE200000499A (et) | 1998-03-04 | 2002-02-15 | Takeda Chemical Industries, Ltd. | Angiotensiin II antagonistliku toimega toimeainetprolongeeritult vabastav preparaat, selle valmistamise meetod ja kasutamine |
HUP0201314A3 (en) | 1999-03-26 | 2003-02-28 | Euro Celtique Sa | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof and pharmaceutical compositions containing them |
US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
RU2312860C2 (ru) | 1999-04-15 | 2007-12-20 | Бристол-Маерс Сквибб Компани | Циклические ингибиторы протеинтирозинкиназ |
SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
GB0011089D0 (en) * | 2000-05-08 | 2000-06-28 | Black James Foundation | Gastrin and cholecystokinin receptor ligands (11) |
CZ20031795A3 (cs) | 2000-12-04 | 2004-01-14 | F. Hoffmann-La Roche Ag | Fenylethenylové nebo fenylethynylové deriváty jako antagonisté glutamátového receptoru |
ATE359773T1 (de) | 2001-01-26 | 2007-05-15 | Chugai Pharmaceutical Co Ltd | Verfahren zur behandlung von erkrankungen mit malonyl coa-decarboxylase-inhibitoren |
JP4267920B2 (ja) | 2001-01-26 | 2009-05-27 | 中外製薬株式会社 | 代謝調節剤として有用なマロニル−CoA脱炭酸酵素阻害剤 |
AU2002245294B2 (en) | 2001-01-26 | 2005-09-22 | Chugai Seiyaku Kabushiki Kaisha | Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
US7709510B2 (en) | 2001-02-20 | 2010-05-04 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
JP4155351B2 (ja) | 2001-02-20 | 2008-09-24 | 中外製薬株式会社 | 代謝調節剤として有用なマロニル−CoA脱炭酸酵素阻害剤としてのアゾール |
WO2003059874A2 (en) | 2001-12-21 | 2003-07-24 | Pharmacia Corporation | Aromatic thioether liver x-receptor modulators |
MXPA04011690A (es) | 2002-05-24 | 2005-03-31 | Pharmacia Corp | Moduladores de receptor x de higado de sulfona. |
BR0311263A (pt) | 2002-05-24 | 2005-04-26 | Pharmacia Corp | Moduladores anilino receptores-x do fìgado |
TWI292318B (en) | 2003-03-10 | 2008-01-11 | Hoffmann La Roche | Imidazol-4-yl-ethynyl-pyridine derivatives |
DE602004016530D1 (de) | 2003-08-01 | 2008-10-23 | Chugai Pharmaceutical Co Ltd | Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer |
ATE400272T1 (de) | 2003-08-01 | 2008-07-15 | Chugai Pharmaceutical Co Ltd | Piperidin-verbindungen als malonyl-coa decarboxylase-hemmer |
EP1648564B1 (de) | 2003-08-01 | 2007-10-17 | Chugai Seiyaku Kabushiki Kaisha | Cyanoamid-verbindungen als nützliche malonyl-coa decarboxylase-hemmer |
ATE487475T1 (de) | 2003-08-01 | 2010-11-15 | Chugai Pharmaceutical Co Ltd | Heterocyclische verbindungen als nützliche malonyl-coa decarboxylase-hemmer |
US7452909B2 (en) * | 2003-09-04 | 2008-11-18 | Hoffman-La Roche Inc. | Imidazole derivatives |
JP4690395B2 (ja) | 2004-06-01 | 2011-06-01 | エフ.ホフマン−ラ ロシュ アーゲー | mGlu5レセプターアンタゴニストとしてのピリジン−4−エチニル−イミダゾール及びピラゾール |
KR20070045353A (ko) | 2004-08-23 | 2007-05-02 | 와이어쓰 | 플라스미노겐 활성화제 억제제-1의 억제제로서티아졸로-나프틸 산 |
AU2005277138A1 (en) | 2004-08-23 | 2006-03-02 | Wyeth Holdings Corporation | Oxazolo-naphthyl acids as plaminogen activator inhibtor type-1 (PAI-1) modulators useful in the treatment of thrombosis and cardiovascular diseases |
CN101044136A (zh) | 2004-08-23 | 2007-09-26 | 惠氏公司 | 作为pai-1抑制剂的吡咯基-萘基酸 |
MX2009006694A (es) | 2006-12-21 | 2009-06-30 | Hoffmann La Roche | Polimorfos de un antagonista del receptor mglur5. |
AU2008261102B2 (en) | 2007-06-04 | 2013-11-28 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EP2328910B1 (de) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Für die behandlung von gastrointestinalen erkrankungen, entzündungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase |
EP3241839B1 (de) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Zur behandlung von erkrankungen des magen-darm-trakts, entzündlichen erkrankungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase |
JPWO2011077712A1 (ja) * | 2009-12-22 | 2013-05-02 | 興和株式会社 | 新規な1−(ビフェニル−4−イル−メチル)−1h−イミダゾール誘導体及びこれを含有する医薬 |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
KR102319263B1 (ko) | 2017-11-30 | 2021-10-29 | 주식회사 엘지화학 | 방열 유체 조성물, 이의 제조방법, 이를 포함하는 전지 모듈 및 배터리 팩 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA875052B (en) * | 1986-07-11 | 1989-03-29 | Du Pont | Angiotensin ii receptor blocking imidazoles |
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
-
1990
- 1990-06-28 AT AT90911154T patent/ATE134368T1/de not_active IP Right Cessation
- 1990-06-28 JP JP2510146A patent/JP2550442B2/ja not_active Expired - Lifetime
- 1990-06-28 RU SU915010942A patent/RU2099330C1/ru active
- 1990-06-28 KR KR1019910701995A patent/KR0163595B1/ko not_active IP Right Cessation
- 1990-06-28 CA CA002060656A patent/CA2060656A1/en not_active Abandoned
- 1990-06-28 WO PCT/US1990/003683 patent/WO1991000277A1/en active IP Right Grant
- 1990-06-28 EP EP90911154A patent/EP0479903B1/de not_active Expired - Lifetime
- 1990-06-28 SG SG1996008138A patent/SG52709A1/en unknown
- 1990-06-28 AU AU59579/90A patent/AU644802B2/en not_active Ceased
- 1990-06-28 ES ES90911154T patent/ES2084702T3/es not_active Expired - Lifetime
- 1990-06-28 DK DK90911154.4T patent/DK0479903T3/da active
- 1990-06-28 HU HU605/90A patent/HU217958B/hu not_active IP Right Cessation
- 1990-06-28 DE DE69025473T patent/DE69025473T2/de not_active Expired - Lifetime
-
1991
- 1991-12-27 FI FI916129A patent/FI916129A0/fi not_active Application Discontinuation
- 1991-12-27 NO NO91915113A patent/NO915113L/no unknown
Also Published As
Publication number | Publication date |
---|---|
HU905605D0 (en) | 1992-06-29 |
CA2060656A1 (en) | 1990-12-31 |
JPH04506522A (ja) | 1992-11-12 |
AU644802B2 (en) | 1993-12-23 |
AU5957990A (en) | 1991-01-17 |
KR920702681A (ko) | 1992-10-06 |
NO915113D0 (no) | 1991-12-27 |
DE69025473T2 (de) | 1996-10-17 |
SG52709A1 (en) | 1998-09-28 |
HUT62575A (en) | 1993-05-28 |
EP0479903B1 (de) | 1996-02-21 |
KR0163595B1 (ko) | 1998-12-01 |
DE69025473D1 (de) | 1996-03-28 |
NO915113L (no) | 1992-02-28 |
ES2084702T3 (es) | 1996-05-16 |
EP0479903A1 (de) | 1992-04-15 |
WO1991000277A1 (en) | 1991-01-10 |
HU217958B (hu) | 2000-05-28 |
JP2550442B2 (ja) | 1996-11-06 |
DK0479903T3 (da) | 1996-03-18 |
FI916129A0 (fi) | 1991-12-27 |
RU2099330C1 (ru) | 1997-12-20 |
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Legal Events
Date | Code | Title | Description |
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UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |