ES2158868T3 - Imidazo(4,5-b)piridinas y bencimidazoles sustituidos como antagonistas de la angiotensina ii. - Google Patents

Imidazo(4,5-b)piridinas y bencimidazoles sustituidos como antagonistas de la angiotensina ii.

Info

Publication number
ES2158868T3
ES2158868T3 ES94100846T ES94100846T ES2158868T3 ES 2158868 T3 ES2158868 T3 ES 2158868T3 ES 94100846 T ES94100846 T ES 94100846T ES 94100846 T ES94100846 T ES 94100846T ES 2158868 T3 ES2158868 T3 ES 2158868T3
Authority
ES
Spain
Prior art keywords
imidazo
bencimidazols
piridines
angiotensin
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94100846T
Other languages
English (en)
Inventor
Matthias Dr Muller-Gliemann
Jurgen Dr Dressel
Peter Dr Fey
Rudolf H Dr Hanko
Walter Dr Hubsch
Thomas Dr Kramer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2158868T3 publication Critical patent/ES2158868T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

IMIDAZO [4, 5-6] PIRIDINAS SUSTITUIDAS Y BENCIMIDAZOLES SE OBTIENEN, EN LOS QUE LOS IMIDAZO [4, 5-6] PURIDINAS O BENCIMIDAZOLES SE TRANSFORMAN CON HALOGENUROS DE BENCILO SUSTITUIDOS CORRESPONDIENTES LOS IMIDAZO [4, 5-6] PIRIDINAS SUSTITUIDAS O BENCIMIDAZOLES PUEDEN EMPLEARSE COMO SUSTANCIA ACTIVA EN MEDICAMENTOS PARTICULARMENTE PARA EL TRATAMIENTO DE HIPERTONIA ARTERIAL Y ATEROESCLEROSIS.
ES94100846T 1993-02-03 1994-01-21 Imidazo(4,5-b)piridinas y bencimidazoles sustituidos como antagonistas de la angiotensina ii. Expired - Lifetime ES2158868T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4302956A DE4302956A1 (de) 1993-02-03 1993-02-03 Substituierte Imidazo(4,5-b)pyridine und Benzimidazole

Publications (1)

Publication Number Publication Date
ES2158868T3 true ES2158868T3 (es) 2001-09-16

Family

ID=6479486

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94100846T Expired - Lifetime ES2158868T3 (es) 1993-02-03 1994-01-21 Imidazo(4,5-b)piridinas y bencimidazoles sustituidos como antagonistas de la angiotensina ii.

Country Status (9)

Country Link
US (1) US5527809A (es)
EP (1) EP0610698B1 (es)
JP (1) JPH06247968A (es)
AT (1) ATE201207T1 (es)
DE (2) DE4302956A1 (es)
DK (1) DK0610698T3 (es)
ES (1) ES2158868T3 (es)
GR (1) GR3036287T3 (es)
PT (1) PT610698E (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4443891A1 (de) * 1994-12-09 1996-06-13 Bayer Ag Heterocyclisch substituierte Oxy-phenyl-(phenyl)glycinolamide
DE19525028A1 (de) * 1995-07-10 1997-01-16 Bayer Ag Amide und Sulfonamide von heterocyclisch substituierten Benzylaminen
DE19535504A1 (de) * 1995-09-25 1997-03-27 Bayer Ag Substituierte Xanthine
DE19536378A1 (de) * 1995-09-29 1997-04-03 Bayer Ag Heterocyclische Aryl-, Alkyl- und Cycloalkylessigsäureamide
DE19546919A1 (de) * 1995-12-15 1997-06-19 Bayer Ag N-Heterocyclisch substituierte Phenylessigsäure-Derivate
DE19546918A1 (de) * 1995-12-15 1997-06-19 Bayer Ag Bicyclische Heterocyclen
US6774236B1 (en) 1996-04-04 2004-08-10 Bayer Aktiengesellschaft Process for the preparation of enantiomerically pure cycloalkano-indol -and azaindol -and pyrimido [1,2A]indolcarbocyclic acids and their activated derivatives
DE19613550A1 (de) * 1996-04-04 1997-10-09 Bayer Ag Neue Pyrimido[1,2-a]indole
DE19613549A1 (de) * 1996-04-04 1997-10-09 Bayer Ag Verfahren zur Herstellung von enantiomerenreinen Cycloalkano-indol- und azaindol-carbonsäuren und deren aktivierte Derivate
EP0802192A1 (de) * 1996-04-17 1997-10-22 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
DE19615119A1 (de) 1996-04-17 1997-10-23 Bayer Ag Neue Arylessigsäureamide
DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
CN104072425B (zh) * 2014-07-09 2016-12-07 大连理工大学 苯并咪唑类化合物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
EP0515548A4 (en) * 1990-02-13 1993-03-10 Merck & Co. Inc. Imidazole angiotensin ii antagonists incorporating a substituted benzyl element
US5240938A (en) * 1991-02-13 1993-08-31 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring
CA2075627A1 (en) * 1990-02-13 1991-08-14 William J. Greenlee Angiotensin ii antagonists incorporating a substituted benzyl element
DE4200954A1 (de) * 1991-04-26 1992-10-29 Bayer Ag Heterocyclisch substituierte phenylessigsaeurederivate

Also Published As

Publication number Publication date
EP0610698A3 (en) 1994-09-14
EP0610698B1 (de) 2001-05-16
ATE201207T1 (de) 2001-06-15
DE59409747D1 (de) 2001-06-21
GR3036287T3 (en) 2001-10-31
DK0610698T3 (da) 2001-06-18
US5527809A (en) 1996-06-18
PT610698E (pt) 2001-08-30
EP0610698A2 (de) 1994-08-17
JPH06247968A (ja) 1994-09-06
DE4302956A1 (de) 1994-08-04

Similar Documents

Publication Publication Date Title
ES2105408T3 (es) Piridilmetilpiridonas sustituidas como antagonistas de angiotensina ii.
ES2084702T3 (es) Imidazoles sustituidos utiles como inhibidores de la angiotensina ii.
TR199700213A2 (xx) 2-Aril s�bstit�entli piridinler.
ES2158868T3 (es) Imidazo(4,5-b)piridinas y bencimidazoles sustituidos como antagonistas de la angiotensina ii.
IL83153A (en) Substituted imidazoles,their preparation and pharmaceutical compositions containing them
DE69232323D1 (de) Verwendung von Adenosinantagonisten zur Vorbeugung und Behandlung von Pankreatitis und Ulcera
AU4243793A (en) 6-amino substituted imidazo(4,5-b)pyridines as angiotensin ii antagonists
ES2058342T3 (es) Pirroles, pirazoles y triazoles sustituidos antagonistas de la angiotensina ii.
ES2175066T3 (es) Antagonistas triciclicos de la vasopresina.
MY131595A (en) Heterocyclically substituted phenyl-cyclohexane- carboxylic acid derivatives
IT1233860B (it) Derivati del peridroazacicloalca (1,2-a) imidazolo ad attivita' nootropa
ATE298339T1 (de) ß3,7-DIAZABICYCLO(3.3.0)OCTANE UND DEREN VERWENDUNG BEI DER BEHANDLUNG VON HERZRHYTHMUSSTÖRUNGENß
TR199700261A2 (xx) Yeni Pirimido (1,2-a) indoller.
ES2124861T3 (es) Derivados de aminoacidos y su utilizacion como inhibidores de la encefalinasa.
FI945164A0 (fi) Biologisesti aktiivisesti ureidojohdannaiset, jotka ovat käyttökelpoisia antimetastaattisina aineina
IT1273790B (it) Derivati eterociclici diazotati aventi attivita' aii antagonista
DE69514315D1 (de) AZABICYCLOALKYLDERIVATE VON IMIDAZO[1,5-a]INDOL-3-ONE ALS 5HT3 ANTAGONISTEN
GR3023194T3 (en) Imidazole substituted phenylaceticacidprolinzamide derivatives.
FI941230A (fi) Heterotrisyklisesti substituoituja fenyylisykloheksaanikarboksyylihappojohdannaisia
PT896822E (pt) 4-aminopirrolo (3,2-d)pirimidinas como antagonistas do receptor de neuropeptideo y
ATE59777T1 (de) Therapeutische zusammenstellungen auf basis von 3-alkoxyflavonen und derivate von 3-alkoxyflavonen.
IT8421107A0 (it) Composizioni farmaceutiche conattivita' antielmintica, loro unita' di dosaggio e metodo per il trattamento di elmintiasi in animali.
IT8621517A0 (it) Derivati eterociclici azotati otticamente attivi e processi per la loro preparazione.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 610698

Country of ref document: ES