ES2175066T3 - Antagonistas triciclicos de la vasopresina. - Google Patents

Antagonistas triciclicos de la vasopresina.

Info

Publication number
ES2175066T3
ES2175066T3 ES96902143T ES96902143T ES2175066T3 ES 2175066 T3 ES2175066 T3 ES 2175066T3 ES 96902143 T ES96902143 T ES 96902143T ES 96902143 T ES96902143 T ES 96902143T ES 2175066 T3 ES2175066 T3 ES 2175066T3
Authority
ES
Spain
Prior art keywords
vasopresine
tricycle
antagonists
oxitocine
anastervastic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96902143T
Other languages
English (en)
Inventor
Aranapakam Mudumbai Venkatesan
Jay Donald Albright
George Theodore Grosu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ES2175066T3 publication Critical patent/ES2175066T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Abstract

DIAZEPINAS TRICICLICAS DE FORMULA (I), DONDE A, B, D, E, F, Y Y Z SE DEFINEN EN LA ESPECIFICACION Y CUYOS COMPUESTOS TIENEN ACTIVIDAD ANTAGONISTA DE VASOPRESINA Y OXITOCINA.
ES96902143T 1995-01-17 1996-01-16 Antagonistas triciclicos de la vasopresina. Expired - Lifetime ES2175066T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/373,125 US5521173A (en) 1995-01-17 1995-01-17 Tricyclic benzazepine vasopressin antagonists

Publications (1)

Publication Number Publication Date
ES2175066T3 true ES2175066T3 (es) 2002-11-16

Family

ID=23471074

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96902143T Expired - Lifetime ES2175066T3 (es) 1995-01-17 1996-01-16 Antagonistas triciclicos de la vasopresina.

Country Status (24)

Country Link
US (2) US5521173A (es)
EP (1) EP0805813B1 (es)
JP (2) JP4156664B2 (es)
CN (1) CN1052725C (es)
AR (1) AR002021A1 (es)
AT (1) ATE217625T1 (es)
AU (1) AU707881B2 (es)
BR (1) BR9607177A (es)
CA (1) CA2210708C (es)
CZ (1) CZ224797A3 (es)
DE (1) DE69621225T2 (es)
DK (1) DK0805813T3 (es)
EA (1) EA000056B1 (es)
ES (1) ES2175066T3 (es)
HK (1) HK1003891A1 (es)
HU (1) HUP9702459A3 (es)
IL (1) IL116774A (es)
MX (1) MX9705414A (es)
NZ (1) NZ301198A (es)
PT (1) PT805813E (es)
TW (1) TW472056B (es)
UA (1) UA48960C2 (es)
WO (1) WO1996022292A1 (es)
ZA (1) ZA96303B (es)

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US5736540A (en) * 1993-07-29 1998-04-07 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5753648A (en) * 1995-01-17 1998-05-19 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5700796A (en) * 1995-01-17 1997-12-23 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5880122A (en) * 1996-11-01 1999-03-09 American Home Products Corporation 3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines
EP0987266A4 (en) 1997-03-31 2000-07-26 Wakamoto Pharma Co Ltd BIPHENYL DERIVATIVES AND MEDICAL PREPARATIONS
US6194407B1 (en) 1997-07-30 2001-02-27 American Home Products Corporation Tricyclic pyrido vasopressin agonists
ATE277050T1 (de) * 1997-07-30 2004-10-15 Wyeth Corp Trizyclische vasopressin agoniste
US6511974B1 (en) 1997-07-30 2003-01-28 Wyeth Tricyclic vasopressin agonists
US7138393B2 (en) * 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
US6090803A (en) * 1998-07-24 2000-07-18 American Home Products Corporation Tricyclic vasopressin agonists
KR100771184B1 (ko) * 1999-01-19 2007-10-29 오르토-맥네일 파마슈티칼, 인코퍼레이티드 바소프레신 수용체 길항제로서의 트리사이클릭 벤조디아제핀
US6235900B1 (en) 1999-02-04 2001-05-22 American Home Products Corporation Tricyclic pyridine N-oxides vasopressin agonists
US6297234B1 (en) * 1999-02-04 2001-10-02 American Home Products Corporation Arylthiophene vasopressin agonists
US6620807B1 (en) 1999-02-04 2003-09-16 Wyeth Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists
AU2603000A (en) * 1999-02-04 2000-08-25 American Home Products Corporation Thienylbenzoylbenzazepines as vasopressin agonists
US6344451B1 (en) 1999-02-04 2002-02-05 American Home Products Pyrrolobenzodiazepine carboxyamide vasopressin agonists
MXPA02003191A (es) * 1999-09-27 2002-09-30 American Cyanamid Co Formulacion agonista de vasopresina y proceso para elaborar la misma.
US7189754B2 (en) * 2001-03-20 2007-03-13 Applied Research Systems Ars Holding Nv Pyrrolidine ester derivatives with oxytocin modulating activity
US7202239B2 (en) * 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US7326700B2 (en) * 2001-04-12 2008-02-05 Wyeth Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US6903087B2 (en) * 2001-04-12 2005-06-07 Wyeth Pyrido cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
DK1381608T3 (da) * 2001-04-12 2008-02-04 Wyeth Corp Cyclohexylphenylvasopressinagonister
US6977254B2 (en) * 2001-04-12 2005-12-20 Wyeth Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
DE60218646T2 (de) * 2001-04-12 2007-11-22 Wyeth N-biphenylcarbonyl- und n-phenylpyridylcarbonyl substituierte bi- und tricyclische azepine und diazepine als vasopressin-agonisten
US6900200B2 (en) 2001-04-12 2005-05-31 Wyeth Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7022699B2 (en) * 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
US7064120B2 (en) * 2001-04-12 2006-06-20 Wyeth Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7109193B2 (en) * 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
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TW201802091A (zh) 2009-12-01 2018-01-16 艾伯維有限公司 新穎三環化合物
PE20130005A1 (es) 2009-12-01 2013-02-16 Abbvie Inc Compuestos triciclicos novedosos
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en) 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US9199976B2 (en) 2010-06-01 2015-12-01 The University Of Queensland Haematopoietic-prostaglandin D2 synthase inhibitors
CN103288829A (zh) * 2012-02-24 2013-09-11 中国科学院大连化学物理研究所 一种合成手性二氢-5H-吡咯并[2,1-c][1,4]-苯并二氮杂卓-5-酮的方法
WO2014060381A1 (de) 2012-10-18 2014-04-24 Bayer Cropscience Ag Heterocyclische verbindungen als schädlingsbekämpfungsmittel
US20150284380A1 (en) 2012-10-31 2015-10-08 Bayer Cropscience Ag Novel heterocyclic compounds as pest control agents
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Also Published As

Publication number Publication date
AR002021A1 (es) 1998-01-07
HUP9702459A3 (en) 2000-08-28
AU707881B2 (en) 1999-07-22
WO1996022292A1 (en) 1996-07-25
TW472056B (en) 2002-01-11
MX9705414A (es) 1997-11-29
EA000056B1 (ru) 1998-04-30
HK1003891A1 (en) 1998-11-13
HUP9702459A2 (hu) 1998-05-28
AU4656696A (en) 1996-08-07
JP4156664B2 (ja) 2008-09-24
CA2210708C (en) 2005-05-24
DE69621225T2 (de) 2002-11-14
US5521173A (en) 1996-05-28
JPH11500424A (ja) 1999-01-12
ZA96303B (en) 1997-07-15
EA199700118A1 (ru) 1997-12-30
DE69621225D1 (de) 2002-06-20
PT805813E (pt) 2002-10-31
CA2210708A1 (en) 1996-07-25
EP0805813B1 (en) 2002-05-15
BR9607177A (pt) 1997-11-11
IL116774A0 (en) 1996-05-14
EP0805813A1 (en) 1997-11-12
DK0805813T3 (da) 2002-08-05
US5780471A (en) 1998-07-14
JP2008069176A (ja) 2008-03-27
CN1052725C (zh) 2000-05-24
ATE217625T1 (de) 2002-06-15
UA48960C2 (uk) 2002-09-16
CN1178532A (zh) 1998-04-08
IL116774A (en) 2000-12-06
NZ301198A (en) 1999-08-30
CZ224797A3 (cs) 1998-03-18

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