AR041955A1 - Procedimiento para la preparacion de compuestos de imidazolilo - Google Patents
Procedimiento para la preparacion de compuestos de imidazoliloInfo
- Publication number
- AR041955A1 AR041955A1 ARP030104180A ARP030104180A AR041955A1 AR 041955 A1 AR041955 A1 AR 041955A1 AR P030104180 A ARP030104180 A AR P030104180A AR P030104180 A ARP030104180 A AR P030104180A AR 041955 A1 AR041955 A1 AR 041955A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- alkyl
- preparation
- compound
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a un método para la preparación de un compuestos de imidazolilo de la fórmula general (1), en donde: Ra y Rb cada uno separadamente son alquilo (C1-6), alcoxialquilo (C1-6), arilo o heteroarilo opcionalmente sustituidos; o en donde Ra y Rb juntos forman un sistema homocíclico o heterocíclico adicional que comprende uno o más anillos; Ra' y Rb' son cada uno hidrógeno o juntos forman un doble enlace carbono-carbono, siendo dicho doble enlace carbono-carbono opcionalmente parte de un sistema aromático; Rc es hidrógeno, alquilo (C1-6), alcoxi (C-16), alcoxialquilo (C1-6) o halógeno; Rd es hidrógeno o alquilo (C1-4); Re es hidrógeno o alquilo (C1-4); m es 1 ó 2; y R1 es hidrógeno o alquilo (C1-4); así como sus sales de adición de ácido; caracterizado porque se hace reaccionar un compuesto de la fórmula general (2), con un compuesto de la fórmula (3), en donde: R es hidrógeno, un grupo alquilo (C1-4) opcionalmente sustituido con un grupo alcoxi o un grupo arilo opcionalmente sustituido, R', R'', R''', R'''' cada uno individualmente son un hidrógeno o un grupo alquilo (C1-4), seguido por la reacción con un compuesto de la fórmula (4), en donde R1, Rd y Re tienen los significados definidos precedentemente; y opcionalmente seguido por la reacción con un ácido adecuado. El método de acuerdo con la presente es especialmente útil para la preparación de ondansetrón y cilansetrón
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02079838 | 2002-11-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR041955A1 true AR041955A1 (es) | 2005-06-01 |
Family
ID=32319633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030104180A AR041955A1 (es) | 2002-11-18 | 2003-11-13 | Procedimiento para la preparacion de compuestos de imidazolilo |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1565445B1 (es) |
| JP (1) | JP4611026B2 (es) |
| KR (1) | KR20050075026A (es) |
| CN (1) | CN100349873C (es) |
| AR (1) | AR041955A1 (es) |
| AT (1) | ATE340783T1 (es) |
| AU (1) | AU2003296762B2 (es) |
| BR (1) | BR0316308A (es) |
| CA (1) | CA2504614C (es) |
| DE (1) | DE60308720T2 (es) |
| DK (1) | DK1565445T3 (es) |
| ES (1) | ES2273088T3 (es) |
| HK (1) | HK1081188A1 (es) |
| HR (1) | HRP20050376A2 (es) |
| IL (1) | IL168258A (es) |
| MX (1) | MXPA05005261A (es) |
| NO (1) | NO330342B1 (es) |
| PL (1) | PL376743A1 (es) |
| PT (1) | PT1565445E (es) |
| RU (1) | RU2314296C2 (es) |
| SA (1) | SA03240414B1 (es) |
| SI (1) | SI1565445T1 (es) |
| UA (1) | UA79655C2 (es) |
| WO (1) | WO2004046116A1 (es) |
| ZA (1) | ZA200503425B (es) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2059491T3 (es) * | 1987-06-29 | 1994-11-16 | Duphar Int Res | Derivados de indol con anillos condensados. |
-
2003
- 2003-11-13 AR ARP030104180A patent/AR041955A1/es unknown
- 2003-11-17 PT PT03811396T patent/PT1565445E/pt unknown
- 2003-11-17 PL PL376743A patent/PL376743A1/pl not_active Application Discontinuation
- 2003-11-17 CN CNB2003801035559A patent/CN100349873C/zh not_active Expired - Fee Related
- 2003-11-17 EP EP03811396A patent/EP1565445B1/en not_active Expired - Lifetime
- 2003-11-17 ES ES03811396T patent/ES2273088T3/es not_active Expired - Lifetime
- 2003-11-17 WO PCT/EP2003/050841 patent/WO2004046116A1/en active IP Right Grant
- 2003-11-17 AU AU2003296762A patent/AU2003296762B2/en not_active Ceased
- 2003-11-17 MX MXPA05005261A patent/MXPA05005261A/es active IP Right Grant
- 2003-11-17 UA UAA200505941A patent/UA79655C2/uk unknown
- 2003-11-17 JP JP2004552730A patent/JP4611026B2/ja not_active Expired - Fee Related
- 2003-11-17 SI SI200330519T patent/SI1565445T1/sl unknown
- 2003-11-17 AT AT03811396T patent/ATE340783T1/de active
- 2003-11-17 CA CA2504614A patent/CA2504614C/en not_active Expired - Fee Related
- 2003-11-17 DE DE60308720T patent/DE60308720T2/de not_active Expired - Lifetime
- 2003-11-17 BR BR0316308-3A patent/BR0316308A/pt active Pending
- 2003-11-17 DK DK03811396T patent/DK1565445T3/da active
- 2003-11-17 RU RU2005119155/04A patent/RU2314296C2/ru not_active IP Right Cessation
- 2003-11-17 KR KR1020057008864A patent/KR20050075026A/ko active IP Right Grant
- 2003-12-03 SA SA03240414A patent/SA03240414B1/ar unknown
-
2005
- 2005-04-27 IL IL168258A patent/IL168258A/en not_active IP Right Cessation
- 2005-04-28 HR HR20050376A patent/HRP20050376A2/xx not_active Application Discontinuation
- 2005-04-28 ZA ZA200503425A patent/ZA200503425B/xx unknown
- 2005-06-16 NO NO20052950A patent/NO330342B1/no not_active IP Right Cessation
-
2006
- 2006-01-26 HK HK06101176A patent/HK1081188A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2504614C (en) | 2010-09-28 |
| RU2314296C2 (ru) | 2008-01-10 |
| RU2005119155A (ru) | 2006-01-20 |
| HK1081188A1 (en) | 2006-05-12 |
| SI1565445T1 (sl) | 2007-02-28 |
| DK1565445T3 (da) | 2007-01-29 |
| AU2003296762B2 (en) | 2010-03-18 |
| HRP20050376A2 (en) | 2006-02-28 |
| DE60308720T2 (de) | 2007-01-11 |
| EP1565445A1 (en) | 2005-08-24 |
| DE60308720D1 (de) | 2006-11-09 |
| MXPA05005261A (es) | 2005-07-25 |
| KR20050075026A (ko) | 2005-07-19 |
| CA2504614A1 (en) | 2004-06-03 |
| NO330342B1 (no) | 2011-03-28 |
| EP1565445B1 (en) | 2006-09-27 |
| WO2004046116A1 (en) | 2004-06-03 |
| BR0316308A (pt) | 2005-09-27 |
| CN1714082A (zh) | 2005-12-28 |
| SA03240414B1 (ar) | 2006-12-05 |
| IL168258A (en) | 2010-05-31 |
| ES2273088T3 (es) | 2007-05-01 |
| JP4611026B2 (ja) | 2011-01-12 |
| UA79655C2 (en) | 2007-07-10 |
| JP2006512322A (ja) | 2006-04-13 |
| NO20052950L (no) | 2005-08-15 |
| PT1565445E (pt) | 2007-01-31 |
| AU2003296762A1 (en) | 2004-06-15 |
| CN100349873C (zh) | 2007-11-21 |
| NO20052950D0 (no) | 2005-06-16 |
| ATE340783T1 (de) | 2006-10-15 |
| ZA200503425B (en) | 2007-02-28 |
| PL376743A1 (pl) | 2006-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |