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Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Abstract
The invention concerns novel, pharmaceutically useful compounds of formula I in which Q is a 5- membered heteroaryl optionally bearing 1 or 2 substituents independently selected from (1-4C) alkyl and halogeno R1 is hydrogen, (1-6C) alkyl, or (1-4C) alkanoyl R2 ( when not as hereinbelow defined together with X) is hydrogen, (3-12C) cycloalkyl, (3-6C)alkenyl, phenyl(3-6C)alkenyl, Tetrafluorophenyl, pentafluorphenyl, 5 or 6-membered heteroaryl, optionally substituted(1-6C)alkyl or optionally substituted phenyl, X is oxy, thio, sulphinyl, sulphonyl or an imino group of formula NRa in which Ra is hydrogen, (1-6C)alkyl or together with R2 and the adjacent nitrogen atom forms as 4 to membered saturated 6- heterocyclic ring, and A is N or CT in which T is hydrogen or (1-4C) alkyl, or a pharmaceutically acceptable salt thereof, processes for the manufacture of the compounds and pharmaceutical compositions containing them, the compounds are useful as adenosine an agonists, the invention further provides novel intermediates useful in the manufacture of the compounds of formula