AR008327A1 - Aminoguanidinas y alcoxiguanidinas como inhibidores de proteasa, alcoxiaminas para su exclusivo uso en el procedimiento de obtencion de dichos compuestos, composicion farmaceutica, uso de dichos compuestos y composiciones para preparar medicamentos, dispositivo usado en la recolección, circulacion y almacenamiento de sangre y proceso para preparar dichos compuestos. - Google Patents

Aminoguanidinas y alcoxiguanidinas como inhibidores de proteasa, alcoxiaminas para su exclusivo uso en el procedimiento de obtencion de dichos compuestos, composicion farmaceutica, uso de dichos compuestos y composiciones para preparar medicamentos, dispositivo usado en la recolección, circulacion y almacenamiento de sangre y proceso para preparar dichos compuestos.

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Publication number
AR008327A1
AR008327A1 ARP970105565A ARP970105565A AR008327A1 AR 008327 A1 AR008327 A1 AR 008327A1 AR P970105565 A ARP970105565 A AR P970105565A AR P970105565 A ARP970105565 A AR P970105565A AR 008327 A1 AR008327 A1 AR 008327A1
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AR
Argentina
Prior art keywords
compounds
alkyl
aryl
cycloalkyl
hydrogen
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ARP970105565A
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English (en)
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Dimensional Pharm Inc
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Publication of AR008327A1 publication Critical patent/AR008327A1/es

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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Abstract

Amino guanidinas y alcoxiguanidinas tienen la fórmula I o un solvato, hidrato o su sal farmacéuticamente aceptable; donde R1 es uno de alquilo deC3-8, cicloalquilo, alquenilo, alquinilo, arilo, aralquilo o heteroarilo, cualquiera deellos puede ser opcionalmente sustituido; Z es uno de-NR10SO2-NR10-; -NR10C(RYRZ)-, -C(RYRZ)NR10-,OSO2-, -SO2O-,-OC(RYRZ)-NR10CO- o -CONR10-, RY y Rz son cada uno independientemente uno de hidrógeno, alquilo,cicloalquilo, arilo, aralquilo,hidroxialquilo , carboxialquilo, aminoalquilo, monoalquilaminoalquilo, dialquilaminoalquilo o carboxilo; R2, R3 y R4 son cadauno independientemente uno de hidrógeno, alquilo, cicloalquilo, alquenilo, alquinilo, arilo arlquilo, heteroarilo,trifluormetilo, ha lógeno,hidroxialquilo, ciano, nitro, carboxamido, -CO2RX,-CH2ORX o -ORX, o cuando están presentes sobre los átomos de carbono adyacentes, R2 y R3 también puedenser tomados juntos para formar uno de -CH= CH-CH= CH-o -(CH2)q-,donde q es entr e 2 y 6, y R4 se define como anteriormente; Rx en cada caso esindependientemente uno de hidrógeno, alquilo cicloalquilo donde dichos grupos de alquilo o cicloalquilo pueden opcionalmente tener una o más insaturaciones;Y es unode -O-,NR10-,-S-,CHR1 0-o un enlace covalente; R10, en cada caso, es independientemente uno de hidrógeno, alquilo, aralquilo, arilo, hidroxialquilo,aminoalquilo, monoalquilaminoalquilo (C2-10) dialquilaminoalquilo (C2-10) carboxialquilo; Xes oxígeno o NR9; R9 e s uno de hidrógeno, alquilo,cicloalquilo o arilo, donde dicho alquilo, cicloalquilo o arilo puede estar opcionalmente sustituidos con amino, monoalquilamino, dialquilamino, alcoxi,hidroxi, carboxi, alcoxicarbonilo,ariloxicarbonilo, aralcoxicarbo nilo, arilo, heteroarilo, acilamino, ciano o trifluorometilo; n es entre 0 y 8; m es entre
ARP970105565A 1996-11-26 1997-11-26 Aminoguanidinas y alcoxiguanidinas como inhibidores de proteasa, alcoxiaminas para su exclusivo uso en el procedimiento de obtencion de dichos compuestos, composicion farmaceutica, uso de dichos compuestos y composiciones para preparar medicamentos, dispositivo usado en la recolección, circulacion y almacenamiento de sangre y proceso para preparar dichos compuestos. AR008327A1 (es)

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US3182296P 1996-11-26 1996-11-26

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AR008327A1 true AR008327A1 (es) 1999-12-29

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ARP970105565A AR008327A1 (es) 1996-11-26 1997-11-26 Aminoguanidinas y alcoxiguanidinas como inhibidores de proteasa, alcoxiaminas para su exclusivo uso en el procedimiento de obtencion de dichos compuestos, composicion farmaceutica, uso de dichos compuestos y composiciones para preparar medicamentos, dispositivo usado en la recolección, circulacion y almacenamiento de sangre y proceso para preparar dichos compuestos.

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US (5) US6235778B1 (es)
EP (1) EP0944590B1 (es)
JP (1) JP2001506606A (es)
KR (1) KR100587546B1 (es)
CN (1) CN1237961A (es)
AR (1) AR008327A1 (es)
AT (1) ATE214693T1 (es)
AU (1) AU725058B2 (es)
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US6235778B1 (en) 2001-05-22
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WO1998023565A3 (en) 1998-07-30
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US20030158252A1 (en) 2003-08-21
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US6706765B2 (en) 2004-03-16
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