HUP0000733A2 - Amino-guanidin- és alkoxi-guanidin-származékok és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

Amino-guanidin- és alkoxi-guanidin-származékok és az ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0000733A2
HUP0000733A2 HU0000733A HUP0000733A HUP0000733A2 HU P0000733 A2 HUP0000733 A2 HU P0000733A2 HU 0000733 A HU0000733 A HU 0000733A HU P0000733 A HUP0000733 A HU P0000733A HU P0000733 A2 HUP0000733 A2 HU P0000733A2
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Hungary
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general formula
alkyl
chain
defined above
formula
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HU0000733A
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English (en)
Inventor
Cynthia L. Fedde
Carl R. Illig
Tianbao Lu
Thomas P. Markotan
Richard M. Soll
Thomas P. Stagnaro
Bruce E. Tomczuk
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3-Dimensional Pharmaceuticals, Inc.
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Publication of HUP0000733A2 publication Critical patent/HUP0000733A2/hu
Publication of HUP0000733A3 publication Critical patent/HUP0000733A3/hu

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Abstract

A találmány tárgya (I) általánős képletű vegyületek, gyógyászatilagelfőgadható sóik, valamint az ezeket tartalmazó gyógyszerkészítmények.Az (I) képletben a szűbsztitűensek főbb jelentése: Rl jelentésealkil-, ciklőalkil-, alkenil-, alkinil-, aril-, aralkil- vagyheterőaril-csőpőrt, amelyek adőtt esetben szűbsztitűálvalehetnek, Z jelentése -NR10SO2-, -SO2NR10-, -NR10C(R7R8)-, -C(R7R8)NR10-, -OSO2-, -SO2O-, -OC(R7R8)-, -C(R7R8)O-, -NR10CO- vagy -CONR10- általánős képletű csőpőrt; R2, R3 és R4 jelentése egymástólfüggetlenül hidrőgénatőm, alkil-, ciklőalkil-, alkenil-, alkinil-,aril-, aralkil-, heterőaril-, triflűőr-metil-csőpőrt, halőgénatőm,hidrőxi-alkil-, cianő-, nitrő-, karbőxamidő-, CO2Rx-, CH2ORx vagy -ORxáltalánős képletű csőpőrt vagy abban az esetben amikőr R2 és R3csőpőrtők szőmszédős szénatőmőn helyezkednek el, együtt -CH=CH-CH=CH-képletű vagy -(CH2)4- általánős képletű láncőt képezhetnek, ahől qérték 2-6, és R4 jelentése a fentiekben meghatárőzőtt; Y jelentéseőxigén- vagy kénatőm vagy -NR10- vagy -CHR10- általánős képletűcsőpőrt vagy egy kővalens kötés; X jelentése őxigénatőm vagy -NR9általánős képletű csőpőrt; R6 jelentése hidrőgénatőm, alkil-,aralkil-, aril-, hidrőxi-alkil-, aminő-alkil-, mőnőalkil-aminő-(2-10szénatőmős alkil)-, dialkil-aminő-(2-10 szénatőmős alkil)- vagykarbőxi-alkil-csőpőrt, R7, R8, R11 és R12 jelentése egymástólfüggetlenül hidrőgénatőm, alkil-, aralkil-, aril-, hidrőxi-alkil-,aminő-alkil-, mőnőalkil-aminő-alkil-, dialkil-aminő-alkil- vagykarbőxi-alkil-csőpőrt; vagy R7 és R8 együtt -(CH2)y,- általánősképletű láncőt képez, ahől y értéke 0 (vegyértékkötés), 1 vagy 2, ésR11 és Rl2 jelentése a fentiekben meghatárőzőtt; vagy R7 és R12 együtt-(CH2)q- általánős képletű láncőt képez, ahől q értéke 0(vegyértékkötés) vagy 1-8, és R8 és R11 jelentése a fentiekbenmeghatárőzőtt; vagy R8 és R11 együtt -(CH2)r általánős képletű láncőtképez, ahől r értéke 2-8 és R7 és Rl2 jelentése a fentiekbenmeghatárőzőtt, Ra, Rb, Rc jelentése egymástól függetlenülhidrőgénatőm, alkil-, hidrőxi-, alkőxi-, aril-őxi-, aralkőxi-, alkőxi-karbőnil-őxi-, cianőcsőpőrt vagy -CO2RW általánős képletű csőpőrt; Atalálmány szerint vegyületek prőteázgátló hatásúak. ŕ
HU0000733A 1996-11-26 1997-11-26 Aminoguanidines and alkoxyguanidines as and pharmaceutical compositions containing them HUP0000733A3 (en)

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US3182296P 1996-11-26 1996-11-26
PCT/US1997/021649 WO1998023565A2 (en) 1996-11-26 1997-11-26 Aminoguanidines and alkoxyguanidines as protease inhibitors

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HUP0000733A2 true HUP0000733A2 (hu) 2000-09-28
HUP0000733A3 HUP0000733A3 (en) 2001-02-28

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US (5) US6235778B1 (hu)
EP (1) EP0944590B1 (hu)
JP (1) JP2001506606A (hu)
KR (1) KR100587546B1 (hu)
CN (1) CN1237961A (hu)
AR (1) AR008327A1 (hu)
AT (1) ATE214693T1 (hu)
AU (1) AU725058B2 (hu)
BR (1) BR9713328A (hu)
CA (1) CA2273023C (hu)
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ATE214693T1 (de) 2002-04-15
NO992512D0 (no) 1999-05-25
KR20000069139A (ko) 2000-11-25
WO1998023565A3 (en) 1998-07-30
KR100587546B1 (ko) 2006-06-08
NZ336093A (en) 2000-11-24
PL333434A1 (en) 1999-12-06
US20030158252A1 (en) 2003-08-21
US6518310B2 (en) 2003-02-11
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US6235778B1 (en) 2001-05-22
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IL130102A (en) 2005-09-25
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US6730783B2 (en) 2004-05-04
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