HUP0001162A2 - Pirrolo-benzodiazepin-, -kinoxalin-, -pirazin-származékok és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

Pirrolo-benzodiazepin-, -kinoxalin-, -pirazin-származékok és az ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0001162A2
HUP0001162A2 HU0001162A HUP0001162A HUP0001162A2 HU P0001162 A2 HUP0001162 A2 HU P0001162A2 HU 0001162 A HU0001162 A HU 0001162A HU P0001162 A HUP0001162 A HU P0001162A HU P0001162 A2 HUP0001162 A2 HU P0001162A2
Authority
HU
Hungary
Prior art keywords
pipe powder
carbon atom
alkyl
general formula
atom
Prior art date
Application number
HU0001162A
Other languages
English (en)
Inventor
Jay Donald Albright
John Paul Dusza
Fuk-Wah Sum
Aranapakam Mudumbai Venkatesan
Original Assignee
American Cyanamid Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Company filed Critical American Cyanamid Company
Publication of HUP0001162A2 publication Critical patent/HUP0001162A2/hu
Publication of HUP0001162A3 publication Critical patent/HUP0001162A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány tárgyát az (I) általánős képletű triciklűsős vegyületek -a képletben Y jelentése -(CH2)-, A-B jelentése (b-1) vagy (c-1)általánős képletű csőpőrt, a (d) általánős képletű mőlekűlarészjelentése fenilcsőpőrt, vagy rövid szénláncú (1-3 szénatőmős)alkilcsőpőrt, halőgénatőm, aminőcsőpőrt, rövid szénláncú (1-3szénatőmős) alkőxicsőpőrt és rövid szénláncú (1-3 szénatőmős) alkil-aminő-csőpőrt közül választőtt egy vagy két szűbsztitűensselszűbsztitűált fenilcsőpőrt; és az (e) általánős képletű mőlekűlarészegy 5-tagú arőmás (telítetlen) nitrőgéntartalmú heterőciklűsős gyűrű,ahől D, E és F jelentése egymástól függetlenül szénatőm vagynitrőgénatőm, és a szénatőmők adőtt esetben szűbsztitűálva lehetnek -, valamint gyógyászatilag elfőgadható sóik, észtereik és prődrőgjaikés az ezeket tartalmazó gyógyszerkészítmények képezik. A vegyületek V1és vagy V2 receptőrőkőn antagőnista aktivitást műtatnak, és in vivővazőpresszin antagőnista aktivitással rendelkeznek, fenti hatásűkkövetkeztében a víz főkőzőtt renális reabszőrpciójával jellemzettbetegségek kezelésére alkalmazhatók. ŕ
HU0001162A 1996-06-27 1997-06-20 Pyrrolobenzodiazepine, -quinoxaline, -pyrazine derivatives and pharmaceutical compositions containing them HUP0001162A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/672,150 US5753648A (en) 1995-01-17 1996-06-27 Tricyclic benzazepine vasopressin antagonists
PCT/US1997/010736 WO1997049707A1 (en) 1996-06-27 1997-06-20 Tricyclic benzazepine vasopressin antagonists

Publications (2)

Publication Number Publication Date
HUP0001162A2 true HUP0001162A2 (hu) 2000-09-28
HUP0001162A3 HUP0001162A3 (en) 2001-02-28

Family

ID=24697350

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001162A HUP0001162A3 (en) 1996-06-27 1997-06-20 Pyrrolobenzodiazepine, -quinoxaline, -pyrazine derivatives and pharmaceutical compositions containing them

Country Status (13)

Country Link
US (1) US5753648A (hu)
EP (1) EP0915876A1 (hu)
JP (1) JP2000510154A (hu)
KR (1) KR20000022297A (hu)
CN (1) CN1231666A (hu)
AU (1) AU731925B2 (hu)
BR (1) BR9710087A (hu)
CA (1) CA2258885A1 (hu)
HU (1) HUP0001162A3 (hu)
IL (1) IL127470A0 (hu)
MX (1) MXPA99000214A (hu)
NZ (1) NZ332605A (hu)
WO (1) WO1997049707A1 (hu)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043976A1 (fr) * 1997-03-31 1998-10-08 Wakamoto Pharmaceutical Co., Ltd. Derives de biphenyle et compositions medicinales
US6235900B1 (en) 1999-02-04 2001-05-22 American Home Products Corporation Tricyclic pyridine N-oxides vasopressin agonists
US6297234B1 (en) 1999-02-04 2001-10-02 American Home Products Corporation Arylthiophene vasopressin agonists
ATE305454T1 (de) 2000-07-05 2005-10-15 Ortho Mcneil Pharm Inc Nichtpeptidische substituierte spirobenzoazepine als vasopressin antagonisten
US7053083B2 (en) 2001-04-12 2006-05-30 Wyeth Cyclohexylphenyl vasopressin agonists
BR0208823A (pt) 2001-04-12 2004-03-09 Wyeth Corp Composto, método de tratamento de distúrbios que são remediados ou aliviados pela atividade de agonista de vasopressina em um mamìfero necessitando do mesmo, e, composição farmacêutica
JP2004536057A (ja) 2001-05-11 2004-12-02 バーテックス　ファーマシューティカルズ　インコーポレイテッド ｐ３８インヒビターとして使用する２，５−二置換ピリジン、ピリミジン、ピリダジンおよび１，２，４−トリアジンの誘導体
SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
US7119088B2 (en) 2003-02-19 2006-10-10 Pfizer Inc. Triazole compounds useful in therapy
GB0303852D0 (en) * 2003-02-19 2003-03-26 Pfizer Ltd Triazole compounds useful in therapy
BRPI0407676A (pt) * 2003-02-19 2006-03-01 Pfizer compostos de triazol,uso e processos para fabricação do mesmo
JP2006523196A (ja) 2003-03-11 2006-10-12 ニューロサーチ、アクティーゼルスカブ 新規ｋｃｎｑチャネルを調節する化合物及びその医薬用途
BRPI0411598A (pt) 2003-06-17 2006-08-29 Janssen Pharmaceutica Nv espirobenzazepinas substituìdas
EP1632494A1 (en) * 2004-08-24 2006-03-08 Ferring B.V. Vasopressin v1a antagonists
EP2078022B1 (en) 2006-09-22 2011-11-09 Janssen Pharmaceutica N.V. Spiro benzazepines used as vasopressin antagonists
CN101541807A (zh) 2006-09-22 2009-09-23 詹森药业有限公司 用作血管升压素拮抗剂的螺环苯并氮杂
US8859538B2 (en) * 2007-06-21 2014-10-14 Cara Therapeutics, Inc. Uses of substituted imidazoheterocycles
NZ582760A (en) * 2007-06-21 2011-12-22 Cara Therapeutics Inc Substituted imidazoheterocycles
WO2009152133A1 (en) * 2008-06-10 2009-12-17 Abbott Laboratories Novel tricyclic compounds
SI2506716T1 (sl) 2009-12-01 2017-10-30 Abb Vie Inc. Nove triciklične spojine
US8785639B2 (en) 2009-12-01 2014-07-22 Abbvie Inc. Substituted dihydropyrazolo[3,4-D]pyrrolo[2,3-B]pyridines and methods of use thereof
BR112014011043A2 (pt) 2011-11-07 2017-06-13 Beckman Coulter Inc detecção de recipiente de espécime
BR122022024925B1 (pt) 2015-10-16 2023-11-28 Abbvie Inc Composição farmacêutica de liberação prolongada compreendendo (3s,4r)-3-etil-4-(3h-imidazo[1,2-a]pirrolo[2,3-e]pirazin-8-il)-n-(2,2,2-trifluoroetil) pirroli-dina-1-carboxamida
US11773106B2 (en) 2015-10-16 2023-10-03 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11512092B2 (en) 2015-10-16 2022-11-29 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11365198B2 (en) 2015-10-16 2022-06-21 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11524964B2 (en) 2015-10-16 2022-12-13 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US10550126B2 (en) 2015-10-16 2020-02-04 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
CA3069720A1 (en) 2017-07-11 2019-01-17 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766108A (en) * 1986-12-04 1988-08-23 Smith Kline Beckman Corporation Tyr-Arg-vasopressin antagonists
US5055448A (en) * 1987-06-25 1991-10-08 Medical College Of Ohio Linear derivatives of arginine vasopressin antagonists
DK0382185T3 (da) * 1989-02-10 1994-07-04 Otsuka Pharma Co Ltd Carbostyrilderivater
US5258510A (en) * 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
KR0167349B1 (ko) * 1989-10-20 1999-02-18 오스카 아끼히꼬 벤조헤테로 고리 화합물
US5070187A (en) * 1989-11-03 1991-12-03 Trustees Of Boston University Pharmacologically effective antagonists of arginine-vasopressin
TW199153B (hu) * 1990-08-07 1993-02-01 Dtsuka Seiyaku Kk
TW198715B (hu) * 1991-04-19 1993-01-21 Dtsuka Seiyaku Kk
US5204349A (en) * 1991-09-16 1993-04-20 Merck & Co., Inc. Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
EP0533242A3 (en) * 1991-09-16 1993-09-15 Merck & Co. Inc. Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
EP0533240A3 (en) * 1991-09-16 1993-09-29 Merck & Co. Inc. Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
DE69223573D1 (de) * 1991-09-16 1998-01-29 Merck & Co Inc Hydantoin und Succinimid-substituierte Spiroindanylcamphorsulfonyl als Oxytocin-Antagonisten
AU657431B2 (en) * 1992-08-20 1995-03-09 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds as oxytocin and vasopressin antagonists
WO1994012476A1 (en) * 1992-11-25 1994-06-09 Yamanouchi Pharmaceutical Co., Ltd. Benzanilide derivative
AU5692094A (en) * 1992-12-21 1994-07-19 Yamanouchi Pharmaceutical Co., Ltd. Novel n-(pyridylcarbonyl)benzazepine derivative and intermediate therefor
WO1994020473A1 (en) * 1993-03-11 1994-09-15 Yamanouchi Pharmaceutical Co., Ltd. Compound with vasopressin antagonism
GB9307527D0 (en) * 1993-04-13 1993-06-02 Fujisawa Pharmaceutical Co New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
US5516774A (en) * 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5521173A (en) * 1995-01-17 1996-05-28 American Home Products Corporation Tricyclic benzazepine vasopressin antagonists
US5536718A (en) * 1995-01-17 1996-07-16 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists

Also Published As

Publication number Publication date
NZ332605A (en) 2000-09-29
MXPA99000214A (es) 2002-07-22
CN1231666A (zh) 1999-10-13
IL127470A0 (en) 1999-10-28
JP2000510154A (ja) 2000-08-08
KR20000022297A (ko) 2000-04-25
EP0915876A1 (en) 1999-05-19
CA2258885A1 (en) 1997-12-31
AU731925B2 (en) 2001-04-05
HUP0001162A3 (en) 2001-02-28
AU3406397A (en) 1998-01-14
US5753648A (en) 1998-05-19
WO1997049707A1 (en) 1997-12-31
BR9710087A (pt) 1999-08-10

Similar Documents

Publication Publication Date Title
HUP0001162A2 (hu) Pirrolo-benzodiazepin-, -kinoxalin-, -pirazin-származékok és az ezeket tartalmazó gyógyszerkészítmények
TR199800697T2 (xx) Farmas�tik olarak aktif kinazolin bile�imleri.
HUP9902121A2 (hu) Gonadotropin-leadó hormon antagonista hatású indolszármazékok és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
TR199901006T2 (xx) Heterosiklik t�revler.
HUP0004556A2 (hu) Tetrazoltartalmú repamicin analógok és ezek alkalmazása gyógyászati készítmények előállítására
BG103417A (en) Condensed pyrimidine bicyclic derivatives
HUP9904567A2 (hu) Kondenzált heterogyűrűkkel és/vagy fenilcsoporttal helyettesített azo-, tio-alkil-, tio-karbonil-származékok alkalmazása csontállomány növekedés serkentésére szolgáló gyógyszerkészítmények előállítására
TR199900481T2 (xx) �ndazol t�revleri; fosfodiesteraz tip IV inhibit�rleri olarak kullan�mlar�.
BR9814389A (pt) Forma de dosagem farmacêutica revestida entérica, processo para a preparação da mesma, uso desta, pelota ou tablete encamado para a mesma, e, processos para melhorar a inibição da secreção de ácido gástrico, e para melhorar o efeito terapêutico no tratamento de distúrbios gastrointestinais associados com secreção de ácido em excesso
HUP9801602A2 (hu) Imidazo[1,2-a]piridin-származékok, eljárás ezek előállítására, ezeket tartalmazó gyógyászati készítmények, és alkalmazásuk
AU1729097A (en) Quinazoline derivatives as vegf inhibitors
TR199802685T2 (xx) �kameli/katk�l� indazol t�revleri
HUP9803018A2 (hu) Ciklooxigenáz-2 gátló hatású vegyületek alkalmazása tumorok, tumorral kapcsolatos rendellenességek és cachexia kezelésére alkalmas gyógyszerkészítmények előállítására
NO981436D0 (no) Farmasöytiske angiostatiske dipeptidsammensetninger og anvendelse derav
HUP9904434A2 (hu) Pirazolo[4,3-d]pirimidinon-, kinazolinon-, purinon- és pirido[3,2-d]pirimidinon-származékok alkalmazása nitrát-indukált tolerancia kezelésére szolgáló gyógyszerkészítmények előállítására
PT729460E (pt) Heterociclos pentagonais substituidos, sua preparacao e utilizacao
TR200000223T2 (tr) XA faktörünü engelleyen heterosiklik türevler
NO914960D0 (no) Medikamenter for canserterapi med antihistaminegenskaper
TR199802060T2 (xx) Aminoisokinolinler ve aminopiridin t�revlerinin iltihap �nleyiciler olarak kullan�m�.
MX9806171A (es) Derivados 2,3-benzodiazepina y sus usos como inhibidores del receptor-ampa.
HUP9901685A2 (hu) Kolchicinszármazékok és azokat tartalmazó gyógyászati készítmények
HUP9903168A2 (hu) Kondenzált piridazinszármazékokat tartalmazó, merevedési rendellenességek kezelésére alkalmas gyógyszerek
DK1109814T3 (da) 5-Heterocyclylpyrazolo[4,3-d]pyrimidin-7-oner til behandling af mandlig erektil dysfunktion
IL110831A0 (en) Quinazolinone-containing pharmaceutical compositions and methods for the use thereof
NO983177L (no) Anvendelse av 1-enantiomeren av centkroman til fremstilling av et farmasaytisk preparat for behandling eller profylakse av brystkreft