ME00320B - Supstituisani spirobenzazepini - Google Patents

Supstituisani spirobenzazepini

Info

Publication number
ME00320B
ME00320B MEP-2008-491A MEP49108A ME00320B ME 00320 B ME00320 B ME 00320B ME P49108 A MEP49108 A ME P49108A ME 00320 B ME00320 B ME 00320B
Authority
ME
Montenegro
Prior art keywords
heart failure
hyponatremia
hypertension
renal
cerebral
Prior art date
Application number
MEP-2008-491A
Other languages
English (en)
French (fr)
Inventor
Mona Patel
Philip J Rybczynski
Min Amy Xiang
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MEP49108A publication Critical patent/MEP49108A/xx
Publication of ME00320B publication Critical patent/ME00320B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Ovaj pronalazak se odnosi na nonapeptid supstituisane benzazepine formule (I), koji su korisni kao antagonisti vazopresin receptora za tretiranje stanja povezanih sa aktivnošću vazopresin receptora kao što su one koje uključuju povećani vaskularni otpor i srčanu insuficijenciju, uključujući kongestivni otkaz srca, hiponatremiju, i hipertenziju, među ostalim opisanim. Takođe su otkriveni farmaceutski preparati koji sadrže jedinjenje formule (I) i postupci za tretiranje stanja kao što su hipertenzija, kongestivni otkaz srca, srčana insuficijencija, koronarni vazospazam, srčana ishemija, ciroza jetre, hiponatremija, renalni vazospazam, renalni otkaz, dijabetska nefropatija, cerebralni edem, cerebralna ishemija, moždani udar, tromboza, ili retencija vode
MEP-2008-491A 2003-06-17 2004-06-16 Supstituisani spirobenzazepini ME00320B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47937803P 2003-06-17 2003-06-17
PCT/US2004/019460 WO2005037795A2 (en) 2003-06-17 2004-06-16 Substituted spirobenzazepines

Publications (2)

Publication Number Publication Date
MEP49108A MEP49108A (en) 2011-02-10
ME00320B true ME00320B (me) 2011-05-10

Family

ID=34465052

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-491A ME00320B (me) 2003-06-17 2004-06-16 Supstituisani spirobenzazepini

Country Status (30)

Country Link
US (2) US20040266752A1 (me)
EP (1) EP1633719B1 (me)
JP (1) JP5252614B2 (me)
KR (1) KR101086246B1 (me)
CN (1) CN100467454C (me)
AR (1) AR044782A1 (me)
AT (1) ATE444953T1 (me)
AU (1) AU2004281257C1 (me)
BR (1) BRPI0411598A (me)
CA (1) CA2529649C (me)
CL (1) CL2004001507A1 (me)
CR (1) CR8168A (me)
CY (1) CY1109585T1 (me)
DE (1) DE602004023501D1 (me)
DK (1) DK1633719T3 (me)
EA (1) EA011089B1 (me)
ES (1) ES2332724T3 (me)
HR (2) HRP20051006A2 (me)
IL (1) IL172630A (me)
ME (1) ME00320B (me)
NO (1) NO20060247L (me)
NZ (1) NZ544180A (me)
PL (1) PL1633719T3 (me)
PT (1) PT1633719E (me)
RS (1) RS20050930A (me)
SI (1) SI1633719T1 (me)
TW (1) TWI354555B (me)
UA (1) UA82236C2 (me)
WO (1) WO2005037795A2 (me)
ZA (1) ZA200600430B (me)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0411652A (pt) * 2003-06-17 2006-08-08 Janssen Pharmaceutica Nv processo para a preparação de derivados de espirobenzoazepina substituìdos não-peptìdicos
US20070173490A1 (en) * 2006-01-20 2007-07-26 Lian Huang Novel solid forms of (4R)-1-[2-chloro-5-fluorobenzoyl)amino-3-methoxybenzoyl]-1,2,3,5- tetrahydro-spiro[4h-1-benzazepine-4,1'-[2]cyclopentene]-3'-carboxylic acid
WO2008036759A1 (en) 2006-09-22 2008-03-27 Janssen Pharmaceutica N.V. Spiro benzazepines as vasopressin antagonists
US7825110B2 (en) * 2006-09-22 2010-11-02 Janssen Pharmaceutica Nv Substituted spiroheterocycles
AR066834A1 (es) * 2007-06-06 2009-09-16 Janssen Pharmaceutica Nv Espirobenzoazepanos como antagonistas de vasopresina, composiciones farmaceuticas que los contienen, proceso de preparacion y usos para el tratamiento de afecciones cardiacas, renales y del sistema nervioso central.
US20090118258A1 (en) * 2007-11-07 2009-05-07 Bruce Damiano Combination therapy comprising angiotensin converting enzyme inhibitors and vasopressin receptor antagonists
WO2014062888A1 (en) 2012-10-18 2014-04-24 University Of South Florida Compositions and methods for treating stroke
CN104884436B (zh) 2012-12-26 2017-06-13 株式会社三和化学研究所 苯并氮杂衍生物及其医药用途

Family Cites Families (19)

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Publication number Priority date Publication date Assignee Title
US4617302A (en) * 1984-10-15 1986-10-14 Eli Lilly And Company Inotropic agents
KR0167349B1 (ko) 1989-10-20 1999-02-18 오스카 아끼히꼬 벤조헤테로 고리 화합물
US5985869A (en) * 1989-10-20 1999-11-16 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US5258510A (en) * 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
US5663431A (en) * 1992-01-30 1997-09-02 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
US5686624A (en) * 1992-01-30 1997-11-11 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
US5849780A (en) * 1992-01-30 1998-12-15 Sanofi 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
FR2708605A1 (fr) * 1993-07-30 1995-02-10 Sanofi Sa Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
AU5292393A (en) * 1992-10-07 1994-04-26 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
US5512563A (en) 1993-07-29 1996-04-30 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5464788A (en) * 1994-03-24 1995-11-07 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
EP0978282B1 (en) * 1994-04-22 2005-12-14 Pentech Pharmaceuticals, Inc. Sublingual composition containing apomorphine for diagnosing functional impotence
US5753648A (en) 1995-01-17 1998-05-19 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
JP3282494B2 (ja) * 1995-05-16 2002-05-13 富士ゼロックス株式会社 画像定着装置
US5753715A (en) * 1995-06-02 1998-05-19 Ortho Pharmaceutical Corporation 2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents
US5726723A (en) * 1996-01-31 1998-03-10 Technology Research International Corporation Sub-twisted nematic liquid crystal display
AUPP150098A0 (en) 1998-01-27 1998-02-19 Fujisawa Pharmaceutical Co., Ltd. Benzamide derivatives
IL153710A0 (en) * 2000-07-05 2003-07-06 Ortho Mcneil Pharm Inc Nonpeptide substituted spirobenzoazepines as vasopressin antagonists
BRPI0411652A (pt) 2003-06-17 2006-08-08 Janssen Pharmaceutica Nv processo para a preparação de derivados de espirobenzoazepina substituìdos não-peptìdicos

Also Published As

Publication number Publication date
US7687494B2 (en) 2010-03-30
ZA200600430B (en) 2009-08-26
AU2004281257B2 (en) 2010-02-04
JP5252614B2 (ja) 2013-07-31
EP1633719A2 (en) 2006-03-15
WO2005037795A3 (en) 2005-07-28
KR20060023157A (ko) 2006-03-13
AU2004281257A1 (en) 2005-04-28
IL172630A (en) 2011-10-31
PL1633719T3 (pl) 2010-03-31
EP1633719B1 (en) 2009-10-07
CY1109585T1 (el) 2014-08-13
CA2529649A1 (en) 2005-04-28
RS20050930A (en) 2008-04-04
TW200515911A (en) 2005-05-16
NZ544180A (en) 2009-01-31
US20070179128A1 (en) 2007-08-02
SI1633719T1 (sl) 2010-01-29
AR044782A1 (es) 2005-10-05
KR101086246B1 (ko) 2011-11-23
CN100467454C (zh) 2009-03-11
MEP49108A (en) 2011-02-10
HRP20090606T1 (hr) 2010-01-31
NO20060247L (no) 2006-03-13
CR8168A (es) 2008-09-10
EA200501831A1 (ru) 2006-06-30
ES2332724T3 (es) 2010-02-11
DE602004023501D1 (de) 2009-11-19
US20040266752A1 (en) 2004-12-30
ATE444953T1 (de) 2009-10-15
UA82236C2 (en) 2008-03-25
WO2005037795A2 (en) 2005-04-28
CA2529649C (en) 2012-01-31
IL172630A0 (en) 2006-04-10
BRPI0411598A (pt) 2006-08-29
TWI354555B (en) 2011-12-21
PT1633719E (pt) 2009-11-11
CL2004001507A1 (es) 2005-05-27
DK1633719T3 (da) 2010-01-04
CN1835925A (zh) 2006-09-20
JP2007521272A (ja) 2007-08-02
HRP20051006A2 (en) 2006-05-31
AU2004281257C1 (en) 2010-07-01
EA011089B1 (ru) 2008-12-30

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