ME00320B - Supstituisani spirobenzazepini - Google Patents
Supstituisani spirobenzazepiniInfo
- Publication number
- ME00320B ME00320B MEP-2008-491A MEP49108A ME00320B ME 00320 B ME00320 B ME 00320B ME P49108 A MEP49108 A ME P49108A ME 00320 B ME00320 B ME 00320B
- Authority
- ME
- Montenegro
- Prior art keywords
- heart failure
- hyponatremia
- hypertension
- renal
- cerebral
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Ovaj pronalazak se odnosi na nonapeptid supstituisane benzazepine formule (I), koji su korisni kao antagonisti vazopresin receptora za tretiranje stanja povezanih sa aktivnošću vazopresin receptora kao što su one koje uključuju povećani vaskularni otpor i srčanu insuficijenciju, uključujući kongestivni otkaz srca, hiponatremiju, i hipertenziju, među ostalim opisanim. Takođe su otkriveni farmaceutski preparati koji sadrže jedinjenje formule (I) i postupci za tretiranje stanja kao što su hipertenzija, kongestivni otkaz srca, srčana insuficijencija, koronarni vazospazam, srčana ishemija, ciroza jetre, hiponatremija, renalni vazospazam, renalni otkaz, dijabetska nefropatija, cerebralni edem, cerebralna ishemija, moždani udar, tromboza, ili retencija vode
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47937803P | 2003-06-17 | 2003-06-17 | |
PCT/US2004/019460 WO2005037795A2 (en) | 2003-06-17 | 2004-06-16 | Substituted spirobenzazepines |
Publications (2)
Publication Number | Publication Date |
---|---|
MEP49108A MEP49108A (en) | 2011-02-10 |
ME00320B true ME00320B (me) | 2011-05-10 |
Family
ID=34465052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-2008-491A ME00320B (me) | 2003-06-17 | 2004-06-16 | Supstituisani spirobenzazepini |
Country Status (30)
Country | Link |
---|---|
US (2) | US20040266752A1 (me) |
EP (1) | EP1633719B1 (me) |
JP (1) | JP5252614B2 (me) |
KR (1) | KR101086246B1 (me) |
CN (1) | CN100467454C (me) |
AR (1) | AR044782A1 (me) |
AT (1) | ATE444953T1 (me) |
AU (1) | AU2004281257C1 (me) |
BR (1) | BRPI0411598A (me) |
CA (1) | CA2529649C (me) |
CL (1) | CL2004001507A1 (me) |
CR (1) | CR8168A (me) |
CY (1) | CY1109585T1 (me) |
DE (1) | DE602004023501D1 (me) |
DK (1) | DK1633719T3 (me) |
EA (1) | EA011089B1 (me) |
ES (1) | ES2332724T3 (me) |
HR (2) | HRP20051006A2 (me) |
IL (1) | IL172630A (me) |
ME (1) | ME00320B (me) |
NO (1) | NO20060247L (me) |
NZ (1) | NZ544180A (me) |
PL (1) | PL1633719T3 (me) |
PT (1) | PT1633719E (me) |
RS (1) | RS20050930A (me) |
SI (1) | SI1633719T1 (me) |
TW (1) | TWI354555B (me) |
UA (1) | UA82236C2 (me) |
WO (1) | WO2005037795A2 (me) |
ZA (1) | ZA200600430B (me) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0411652A (pt) * | 2003-06-17 | 2006-08-08 | Janssen Pharmaceutica Nv | processo para a preparação de derivados de espirobenzoazepina substituìdos não-peptìdicos |
US20070173490A1 (en) * | 2006-01-20 | 2007-07-26 | Lian Huang | Novel solid forms of (4R)-1-[2-chloro-5-fluorobenzoyl)amino-3-methoxybenzoyl]-1,2,3,5- tetrahydro-spiro[4h-1-benzazepine-4,1'-[2]cyclopentene]-3'-carboxylic acid |
WO2008036759A1 (en) | 2006-09-22 | 2008-03-27 | Janssen Pharmaceutica N.V. | Spiro benzazepines as vasopressin antagonists |
US7825110B2 (en) * | 2006-09-22 | 2010-11-02 | Janssen Pharmaceutica Nv | Substituted spiroheterocycles |
AR066834A1 (es) * | 2007-06-06 | 2009-09-16 | Janssen Pharmaceutica Nv | Espirobenzoazepanos como antagonistas de vasopresina, composiciones farmaceuticas que los contienen, proceso de preparacion y usos para el tratamiento de afecciones cardiacas, renales y del sistema nervioso central. |
US20090118258A1 (en) * | 2007-11-07 | 2009-05-07 | Bruce Damiano | Combination therapy comprising angiotensin converting enzyme inhibitors and vasopressin receptor antagonists |
WO2014062888A1 (en) | 2012-10-18 | 2014-04-24 | University Of South Florida | Compositions and methods for treating stroke |
CN104884436B (zh) | 2012-12-26 | 2017-06-13 | 株式会社三和化学研究所 | 苯并氮杂衍生物及其医药用途 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4617302A (en) * | 1984-10-15 | 1986-10-14 | Eli Lilly And Company | Inotropic agents |
KR0167349B1 (ko) | 1989-10-20 | 1999-02-18 | 오스카 아끼히꼬 | 벤조헤테로 고리 화합물 |
US5985869A (en) * | 1989-10-20 | 1999-11-16 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
US5258510A (en) * | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
US5663431A (en) * | 1992-01-30 | 1997-09-02 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
US5686624A (en) * | 1992-01-30 | 1997-11-11 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
US5849780A (en) * | 1992-01-30 | 1998-12-15 | Sanofi | 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
FR2708605A1 (fr) * | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
AU5292393A (en) * | 1992-10-07 | 1994-04-26 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
US5512563A (en) | 1993-07-29 | 1996-04-30 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
US5464788A (en) * | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
EP0978282B1 (en) * | 1994-04-22 | 2005-12-14 | Pentech Pharmaceuticals, Inc. | Sublingual composition containing apomorphine for diagnosing functional impotence |
US5753648A (en) | 1995-01-17 | 1998-05-19 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
JP3282494B2 (ja) * | 1995-05-16 | 2002-05-13 | 富士ゼロックス株式会社 | 画像定着装置 |
US5753715A (en) * | 1995-06-02 | 1998-05-19 | Ortho Pharmaceutical Corporation | 2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents |
US5726723A (en) * | 1996-01-31 | 1998-03-10 | Technology Research International Corporation | Sub-twisted nematic liquid crystal display |
AUPP150098A0 (en) | 1998-01-27 | 1998-02-19 | Fujisawa Pharmaceutical Co., Ltd. | Benzamide derivatives |
IL153710A0 (en) * | 2000-07-05 | 2003-07-06 | Ortho Mcneil Pharm Inc | Nonpeptide substituted spirobenzoazepines as vasopressin antagonists |
BRPI0411652A (pt) | 2003-06-17 | 2006-08-08 | Janssen Pharmaceutica Nv | processo para a preparação de derivados de espirobenzoazepina substituìdos não-peptìdicos |
-
2004
- 2004-06-16 NZ NZ544180A patent/NZ544180A/en unknown
- 2004-06-16 UA UAA200512207A patent/UA82236C2/uk unknown
- 2004-06-16 EA EA200501831A patent/EA011089B1/ru not_active IP Right Cessation
- 2004-06-16 KR KR1020057024157A patent/KR101086246B1/ko active IP Right Grant
- 2004-06-16 ME MEP-2008-491A patent/ME00320B/me unknown
- 2004-06-16 EP EP04809449A patent/EP1633719B1/en not_active Expired - Lifetime
- 2004-06-16 CN CNB2004800231176A patent/CN100467454C/zh not_active Expired - Fee Related
- 2004-06-16 SI SI200431304T patent/SI1633719T1/sl unknown
- 2004-06-16 AR ARP040102087A patent/AR044782A1/es not_active Application Discontinuation
- 2004-06-16 TW TW093117253A patent/TWI354555B/zh not_active IP Right Cessation
- 2004-06-16 US US10/869,746 patent/US20040266752A1/en not_active Abandoned
- 2004-06-16 PL PL04809449T patent/PL1633719T3/pl unknown
- 2004-06-16 BR BRPI0411598-8A patent/BRPI0411598A/pt not_active Application Discontinuation
- 2004-06-16 PT PT04809449T patent/PT1633719E/pt unknown
- 2004-06-16 WO PCT/US2004/019460 patent/WO2005037795A2/en active Application Filing
- 2004-06-16 DE DE602004023501T patent/DE602004023501D1/de not_active Expired - Lifetime
- 2004-06-16 ES ES04809449T patent/ES2332724T3/es not_active Expired - Lifetime
- 2004-06-16 CA CA2529649A patent/CA2529649C/en not_active Expired - Fee Related
- 2004-06-16 JP JP2006517373A patent/JP5252614B2/ja not_active Expired - Fee Related
- 2004-06-16 DK DK04809449T patent/DK1633719T3/da active
- 2004-06-16 AU AU2004281257A patent/AU2004281257C1/en not_active Ceased
- 2004-06-16 RS YUP-2005/0930A patent/RS20050930A/sr unknown
- 2004-06-16 AT AT04809449T patent/ATE444953T1/de active
- 2004-06-17 CL CL200401507A patent/CL2004001507A1/es unknown
-
2005
- 2005-12-15 IL IL172630A patent/IL172630A/en active IP Right Grant
- 2005-12-16 HR HR20051006A patent/HRP20051006A2/hr not_active Application Discontinuation
-
2006
- 2006-01-02 CR CR8168A patent/CR8168A/es not_active Application Discontinuation
- 2006-01-16 ZA ZA200600430A patent/ZA200600430B/xx unknown
- 2006-01-17 NO NO20060247A patent/NO20060247L/no not_active Application Discontinuation
-
2007
- 2007-04-13 US US11/735,149 patent/US7687494B2/en not_active Expired - Fee Related
-
2009
- 2009-11-11 HR HR20090606T patent/HRP20090606T1/hr unknown
- 2009-12-11 CY CY20091101295T patent/CY1109585T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ME00129B (me) | Triciklicnj benzodiazepini kao antagonisti receptora vazopresina | |
ATE384050T1 (de) | Benzazepinderivate als histamin-h3-antagonisten | |
BG66084B1 (bg) | Циклопентаноиндоли, състави,съдържащи такива съединения и използването им | |
MA27771A1 (fr) | 5,7-diaminopyrazolo[4,3-d]pyrimidines utiles dans le traitement de l'hypertension | |
TNSN05190A1 (fr) | DERIVES DE PYRAZOLO [1,5-a][1,3,5] TRIAZINE SERVANT DE LIGANDS DES RECEPTEURS DE CANNABINOIDES | |
EA200500392A1 (ru) | Производные пиримидина и их применение в качестве модуляторов св2 | |
MA28151A1 (fr) | Derives de pyrazolyle et d'imidazolyle bicycliques et leurs utilisations | |
MA30077B1 (fr) | 3-aminocyclopentanecarboxamides servant de modulateurs de recepteurs de chimiokines | |
MA32438B1 (fr) | Composés tricycliques présentant une activité antagoniste envers le facteur de libération de la corticotropine et compositions pharmaceutiques les contenant | |
CR8168A (es) | Espirobenzazepinas sustituidas | |
ATE532786T1 (de) | Spirobenzazepine als vasopressinantagonisten | |
TWI316057B (en) | Nonpeptide substituted spirobenzoazepines as vasopressin antagonists | |
TNSN05276A1 (fr) | 5,7-diaminopyrazolo[4,3-d] pyrimidines utiles dans le traitement de l'hypertension | |
PT1214323E (pt) | Indoloazepinas como antagonistas do receptor de vasopressina | |
DE60224509D1 (de) | Imidazolderivate verwendbar als histamin h3 rezeptorliganden | |
BR0015299A (pt) | Benzotiazepinas substituìdas não-peptìdicas como antagonistas de vasopressina | |
WO2006049984A3 (en) | Novel [1,4]benzodiazepines as vasopressin v2 receptor antagonists | |
TH87268A (th) | ไธอิโนไพราโซล |