BRPI0411598A - espirobenzazepinas substituìdas - Google Patents
espirobenzazepinas substituìdasInfo
- Publication number
- BRPI0411598A BRPI0411598A BRPI0411598-8A BRPI0411598A BRPI0411598A BR PI0411598 A BRPI0411598 A BR PI0411598A BR PI0411598 A BRPI0411598 A BR PI0411598A BR PI0411598 A BRPI0411598 A BR PI0411598A
- Authority
- BR
- Brazil
- Prior art keywords
- heart failure
- hypertension
- formula
- substituted
- treating conditions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
"ESPIROBENZAZEPINAS SUBSTITUìDAS". A presente invenção refere-se a benzazepinas substituídas não - peptídicas de fórmula (I), que são úteis como antagonistas do receptor de vasopressina para tratar condições associadas a atividade do receptor de vasopressina, tais como aquelas que envolvem resistência vascular aumentada e insuficiência cardíaca, incluindo insuficiência cardíaca congestiva, hiponatremia e hipertensão, entre outras descritas. Também estão descritas composições farmacêuticas compreendendo um composto de fórmula (I) e métodos para tratar condições, tais como hipertensão, insuficiência cardíaca congestiva, insuficiência cardíaca, vasoespasmo coronário, isquemia cardíaca, cirrose hepática, vasoespasmo renal, insuficiência renal, nefropatia diabética, edema cerebral, isquemia cerebral, derrame, trombose ou retenção de líquido.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47937803P | 2003-06-17 | 2003-06-17 | |
PCT/US2004/019460 WO2005037795A2 (en) | 2003-06-17 | 2004-06-16 | Substituted spirobenzazepines |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0411598A true BRPI0411598A (pt) | 2006-08-29 |
Family
ID=34465052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0411598-8A BRPI0411598A (pt) | 2003-06-17 | 2004-06-16 | espirobenzazepinas substituìdas |
Country Status (30)
Country | Link |
---|---|
US (2) | US20040266752A1 (pt) |
EP (1) | EP1633719B1 (pt) |
JP (1) | JP5252614B2 (pt) |
KR (1) | KR101086246B1 (pt) |
CN (1) | CN100467454C (pt) |
AR (1) | AR044782A1 (pt) |
AT (1) | ATE444953T1 (pt) |
AU (1) | AU2004281257C1 (pt) |
BR (1) | BRPI0411598A (pt) |
CA (1) | CA2529649C (pt) |
CL (1) | CL2004001507A1 (pt) |
CR (1) | CR8168A (pt) |
CY (1) | CY1109585T1 (pt) |
DE (1) | DE602004023501D1 (pt) |
DK (1) | DK1633719T3 (pt) |
EA (1) | EA011089B1 (pt) |
ES (1) | ES2332724T3 (pt) |
HR (2) | HRP20051006A2 (pt) |
IL (1) | IL172630A (pt) |
ME (1) | ME00320B (pt) |
NO (1) | NO20060247L (pt) |
NZ (1) | NZ544180A (pt) |
PL (1) | PL1633719T3 (pt) |
PT (1) | PT1633719E (pt) |
RS (1) | RS20050930A (pt) |
SI (1) | SI1633719T1 (pt) |
TW (1) | TWI354555B (pt) |
UA (1) | UA82236C2 (pt) |
WO (1) | WO2005037795A2 (pt) |
ZA (1) | ZA200600430B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007516177A (ja) * | 2003-06-17 | 2007-06-21 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 非ペプチド置換スピロベンゾアゼピン誘導体の製造方法 |
CA2637838A1 (en) * | 2006-01-20 | 2007-07-26 | Janssen Pharmaceutica N.V. | Novel solid forms of (4r)-1-¬4-(2-chloro-5-fluorobenzoyl)amino-3-methoxybenzoyl|-1,2,3,5-tetrahydro-spiro¬4h-1-benzazepine-4,1'-¬2|cyclopentene|-3'-carboxylic acid |
CN101541806A (zh) | 2006-09-22 | 2009-09-23 | 詹森药业有限公司 | 用作血管升压素拮抗剂的螺环苯并氮杂 |
JP2010504352A (ja) * | 2006-09-22 | 2010-02-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | バソプレッシン拮抗薬としてのスピロベンズアゼピン類 |
AR066834A1 (es) * | 2007-06-06 | 2009-09-16 | Janssen Pharmaceutica Nv | Espirobenzoazepanos como antagonistas de vasopresina, composiciones farmaceuticas que los contienen, proceso de preparacion y usos para el tratamiento de afecciones cardiacas, renales y del sistema nervioso central. |
JP2011503085A (ja) * | 2007-11-07 | 2011-01-27 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | アンギオテンシン変換酵素阻害剤及びバソプレッシン受容体拮抗薬を含む複合治療 |
US20150238502A1 (en) | 2012-10-18 | 2015-08-27 | University Of South Florida | Compositions and Methods for Treating Stroke |
RU2642783C2 (ru) | 2012-12-26 | 2018-01-26 | Санва Кагаку Кенкюсо Ко., Лтд. | Новое производное бензоазепина и его медицинское применение |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4617302A (en) | 1984-10-15 | 1986-10-14 | Eli Lilly And Company | Inotropic agents |
US5985869A (en) * | 1989-10-20 | 1999-11-16 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
ES2089033T3 (es) | 1989-10-20 | 1996-10-01 | Otsuka Pharma Co Ltd | Compuestos benzoheterociclicos. |
US5258510A (en) * | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
FR2708605A1 (fr) * | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
US5686624A (en) * | 1992-01-30 | 1997-11-11 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
US5849780A (en) | 1992-01-30 | 1998-12-15 | Sanofi | 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
US5663431A (en) * | 1992-01-30 | 1997-09-02 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
CA2143117A1 (en) * | 1992-10-07 | 1994-04-14 | Ben E. Evans | Tocolytic oxytocin receptor antagonists |
US5512563A (en) | 1993-07-29 | 1996-04-30 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
US5464788A (en) * | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
PT758895E (pt) * | 1994-04-22 | 2000-05-31 | Univ Kingston | Formas de dosagem sublingual contendo apomorfina para uso no tratamento da disfuncao erectil |
US5753648A (en) | 1995-01-17 | 1998-05-19 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
JP3282494B2 (ja) * | 1995-05-16 | 2002-05-13 | 富士ゼロックス株式会社 | 画像定着装置 |
US5753715A (en) | 1995-06-02 | 1998-05-19 | Ortho Pharmaceutical Corporation | 2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents |
US5726723A (en) * | 1996-01-31 | 1998-03-10 | Technology Research International Corporation | Sub-twisted nematic liquid crystal display |
AUPP150098A0 (en) | 1998-01-27 | 1998-02-19 | Fujisawa Pharmaceutical Co., Ltd. | Benzamide derivatives |
ATE305454T1 (de) * | 2000-07-05 | 2005-10-15 | Ortho Mcneil Pharm Inc | Nichtpeptidische substituierte spirobenzoazepine als vasopressin antagonisten |
JP2007516177A (ja) | 2003-06-17 | 2007-06-21 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 非ペプチド置換スピロベンゾアゼピン誘導体の製造方法 |
-
2004
- 2004-06-16 CA CA2529649A patent/CA2529649C/en not_active Expired - Fee Related
- 2004-06-16 BR BRPI0411598-8A patent/BRPI0411598A/pt not_active Application Discontinuation
- 2004-06-16 TW TW093117253A patent/TWI354555B/zh not_active IP Right Cessation
- 2004-06-16 SI SI200431304T patent/SI1633719T1/sl unknown
- 2004-06-16 EP EP04809449A patent/EP1633719B1/en not_active Expired - Lifetime
- 2004-06-16 WO PCT/US2004/019460 patent/WO2005037795A2/en active Application Filing
- 2004-06-16 AT AT04809449T patent/ATE444953T1/de active
- 2004-06-16 ES ES04809449T patent/ES2332724T3/es not_active Expired - Lifetime
- 2004-06-16 CN CNB2004800231176A patent/CN100467454C/zh not_active Expired - Fee Related
- 2004-06-16 ME MEP-2008-491A patent/ME00320B/me unknown
- 2004-06-16 PT PT04809449T patent/PT1633719E/pt unknown
- 2004-06-16 KR KR1020057024157A patent/KR101086246B1/ko active IP Right Grant
- 2004-06-16 UA UAA200512207A patent/UA82236C2/uk unknown
- 2004-06-16 RS YUP-2005/0930A patent/RS20050930A/sr unknown
- 2004-06-16 JP JP2006517373A patent/JP5252614B2/ja not_active Expired - Fee Related
- 2004-06-16 NZ NZ544180A patent/NZ544180A/en unknown
- 2004-06-16 EA EA200501831A patent/EA011089B1/ru not_active IP Right Cessation
- 2004-06-16 DE DE602004023501T patent/DE602004023501D1/de not_active Expired - Lifetime
- 2004-06-16 AR ARP040102087A patent/AR044782A1/es not_active Application Discontinuation
- 2004-06-16 PL PL04809449T patent/PL1633719T3/pl unknown
- 2004-06-16 AU AU2004281257A patent/AU2004281257C1/en not_active Ceased
- 2004-06-16 DK DK04809449T patent/DK1633719T3/da active
- 2004-06-16 US US10/869,746 patent/US20040266752A1/en not_active Abandoned
- 2004-06-17 CL CL200401507A patent/CL2004001507A1/es unknown
-
2005
- 2005-12-15 IL IL172630A patent/IL172630A/en active IP Right Grant
- 2005-12-16 HR HR20051006A patent/HRP20051006A2/hr not_active Application Discontinuation
-
2006
- 2006-01-02 CR CR8168A patent/CR8168A/es not_active Application Discontinuation
- 2006-01-16 ZA ZA200600430A patent/ZA200600430B/xx unknown
- 2006-01-17 NO NO20060247A patent/NO20060247L/no not_active Application Discontinuation
-
2007
- 2007-04-13 US US11/735,149 patent/US7687494B2/en not_active Expired - Fee Related
-
2009
- 2009-11-11 HR HR20090606T patent/HRP20090606T1/hr unknown
- 2009-12-11 CY CY20091101295T patent/CY1109585T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI9917086B8 (pt) | benzodiazepina tricíclica, suas composições farmacêuticas bem como compostos intermediários | |
PL2078022T3 (pl) | Spirobenzoazepiny stosowane jako antagoniści wazopresyny | |
ATE384050T1 (de) | Benzazepinderivate als histamin-h3-antagonisten | |
CR8168A (es) | Espirobenzazepinas sustituidas | |
BR0112372A (pt) | Espirobenzoazepinas substituìdas por não-peptìdeo como antagonistas de vasopressina | |
DE602004011204D1 (de) | Quinoxalin-3-on-verdindungen als orexin-rezeptor antagonisten. | |
BRPI0412843A (pt) | lactamas substituìdas e uso das mesmas como agentes anticáncer | |
MY144635A (en) | 2-oxo-1,2,4,5-tetrahydro-1,-3-benzodiazepin-3-yl-piperidines used as cgrp antagonists | |
BR0015299A (pt) | Benzotiazepinas substituìdas não-peptìdicas como antagonistas de vasopressina | |
DK1214323T3 (da) | Indoloazepiner som vasopressinreceptorantagonister | |
PE20001416A1 (es) | Uso de difenil-acetanilidas como antagonistas de neuropeptidos y | |
WO2006049984A3 (en) | Novel [1,4]benzodiazepines as vasopressin v2 receptor antagonists | |
TH87268B (th) | ไธอิโนไพราโซล | |
TH87268A (th) | ไธอิโนไพราโซล |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8, 10, 13 E 25 DA LPI |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |