CY1109585T1 - Υποκατεστημενες σπειροβενζαζεπινες - Google Patents

Υποκατεστημενες σπειροβενζαζεπινες

Info

Publication number
CY1109585T1
CY1109585T1 CY20091101295T CY091101295T CY1109585T1 CY 1109585 T1 CY1109585 T1 CY 1109585T1 CY 20091101295 T CY20091101295 T CY 20091101295T CY 091101295 T CY091101295 T CY 091101295T CY 1109585 T1 CY1109585 T1 CY 1109585T1
Authority
CY
Cyprus
Prior art keywords
cardiac
angiopressin
hypertension
formula
treatment
Prior art date
Application number
CY20091101295T
Other languages
English (en)
Inventor
Mona Patel
Philip J Rybczynski
Min Amy Xiang
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of CY1109585T1 publication Critical patent/CY1109585T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η εφεύρεση κατευθύνεται σε υποκατεστημένες βενζαζεπίνες μη-πεπτίδιο του Τύπου (I), που είναι χρήσιμες ως ανταγωνιστές υποδοχέα αγγειοπιεσίνης για θεραπεία καταστάσεων που συνδυάζονται με δραστικότητα υποδοχέα αγγειοπιεσίνης, όπως αυτές που περιλαμβάνουν αυξημένη αγγειακή αντίσταση και καρδιακή ανεπάρκεια, συμπεριλαμβανομένης συμφορητικής καρδιακής ανεπάρκειας, υπονατραιμίας και υπέρτασης, μεταξύ άλλων αποκαλυπτόμενες. Φαρμακευτικές συνθέσεις που περιλαμβάνουν μία ένωση του Τύπου (I) και μέθοδοι θεραπείας καταστάσεων, όπως υπέρτασης, συμφορητικής καρδιακής ανεπάρκειας, καρδιακής ανεπάρκειας, αγγειόσπασμο στεφανιαίας, καρδιακής ισχαιμίας, κίρρωσης του ήπατος, υπονατραιμίας, νεφρικού αγγειόσπασμου, νεφρικής ανεπάρκειας, διαβητικής νεφροπάθειας, εγκεφαλικού οιδήματος, εγκεφαλικής ισχαιμίας, συμφόρησης, θρόμβωσης ή κατακράτησης ύδατος, αποκαλύπτονται επίσης.
CY20091101295T 2003-06-17 2009-12-11 Υποκατεστημενες σπειροβενζαζεπινες CY1109585T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47937803P 2003-06-17 2003-06-17
EP04809449A EP1633719B1 (en) 2003-06-17 2004-06-16 Substituted spirobenzazepines

Publications (1)

Publication Number Publication Date
CY1109585T1 true CY1109585T1 (el) 2014-08-13

Family

ID=34465052

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091101295T CY1109585T1 (el) 2003-06-17 2009-12-11 Υποκατεστημενες σπειροβενζαζεπινες

Country Status (30)

Country Link
US (2) US20040266752A1 (el)
EP (1) EP1633719B1 (el)
JP (1) JP5252614B2 (el)
KR (1) KR101086246B1 (el)
CN (1) CN100467454C (el)
AR (1) AR044782A1 (el)
AT (1) ATE444953T1 (el)
AU (1) AU2004281257C1 (el)
BR (1) BRPI0411598A (el)
CA (1) CA2529649C (el)
CL (1) CL2004001507A1 (el)
CR (1) CR8168A (el)
CY (1) CY1109585T1 (el)
DE (1) DE602004023501D1 (el)
DK (1) DK1633719T3 (el)
EA (1) EA011089B1 (el)
ES (1) ES2332724T3 (el)
HR (2) HRP20051006A2 (el)
IL (1) IL172630A (el)
ME (1) ME00320B (el)
NO (1) NO20060247L (el)
NZ (1) NZ544180A (el)
PL (1) PL1633719T3 (el)
PT (1) PT1633719E (el)
RS (1) RS20050930A (el)
SI (1) SI1633719T1 (el)
TW (1) TWI354555B (el)
UA (1) UA82236C2 (el)
WO (1) WO2005037795A2 (el)
ZA (1) ZA200600430B (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060023164A (ko) * 2003-06-17 2006-03-13 얀센 파마슈티카 엔.브이. 비펩티드 치환 스피로벤조아제핀 유도체의 제조방법
US20070173490A1 (en) * 2006-01-20 2007-07-26 Lian Huang Novel solid forms of (4R)-1-[2-chloro-5-fluorobenzoyl)amino-3-methoxybenzoyl]-1,2,3,5- tetrahydro-spiro[4h-1-benzazepine-4,1'-[2]cyclopentene]-3'-carboxylic acid
EP2076517A1 (en) 2006-09-22 2009-07-08 Janssen Pharmaceutica N.V. Spiro benzazepines as vasopressin antagonists
SI2078022T1 (sl) 2006-09-22 2012-01-31 Janssen Pharmaceutica Nv Spiro benzazepini, uporabljeni kot antagonisti vazopresina
AR066834A1 (es) * 2007-06-06 2009-09-16 Janssen Pharmaceutica Nv Espirobenzoazepanos como antagonistas de vasopresina, composiciones farmaceuticas que los contienen, proceso de preparacion y usos para el tratamiento de afecciones cardiacas, renales y del sistema nervioso central.
WO2009061786A2 (en) * 2007-11-07 2009-05-14 Janssen Pharmaceutica N.V. Combination therapy comprising angiotensin converting enzyme inhibitors and vasopressin receptor antagonists
WO2014062888A1 (en) 2012-10-18 2014-04-24 University Of South Florida Compositions and methods for treating stroke
CN104884436B (zh) 2012-12-26 2017-06-13 株式会社三和化学研究所 苯并氮杂衍生物及其医药用途

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Also Published As

Publication number Publication date
HRP20051006A2 (en) 2006-05-31
RS20050930A (en) 2008-04-04
DE602004023501D1 (de) 2009-11-19
UA82236C2 (en) 2008-03-25
HRP20090606T1 (hr) 2010-01-31
EA200501831A1 (ru) 2006-06-30
IL172630A (en) 2011-10-31
CN100467454C (zh) 2009-03-11
CA2529649A1 (en) 2005-04-28
SI1633719T1 (sl) 2010-01-29
EP1633719B1 (en) 2009-10-07
PL1633719T3 (pl) 2010-03-31
AU2004281257A1 (en) 2005-04-28
EP1633719A2 (en) 2006-03-15
CN1835925A (zh) 2006-09-20
US7687494B2 (en) 2010-03-30
NO20060247L (no) 2006-03-13
PT1633719E (pt) 2009-11-11
KR20060023157A (ko) 2006-03-13
ATE444953T1 (de) 2009-10-15
NZ544180A (en) 2009-01-31
ZA200600430B (en) 2009-08-26
US20040266752A1 (en) 2004-12-30
DK1633719T3 (da) 2010-01-04
WO2005037795A2 (en) 2005-04-28
JP5252614B2 (ja) 2013-07-31
TWI354555B (en) 2011-12-21
CR8168A (es) 2008-09-10
BRPI0411598A (pt) 2006-08-29
CL2004001507A1 (es) 2005-05-27
KR101086246B1 (ko) 2011-11-23
EA011089B1 (ru) 2008-12-30
ME00320B (me) 2011-05-10
JP2007521272A (ja) 2007-08-02
MEP49108A (en) 2011-02-10
CA2529649C (en) 2012-01-31
TW200515911A (en) 2005-05-16
US20070179128A1 (en) 2007-08-02
AU2004281257C1 (en) 2010-07-01
ES2332724T3 (es) 2010-02-11
AU2004281257B2 (en) 2010-02-04
AR044782A1 (es) 2005-10-05
WO2005037795A3 (en) 2005-07-28
IL172630A0 (en) 2006-04-10

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