MA32438B1 - Composés tricycliques présentant une activité antagoniste envers le facteur de libération de la corticotropine et compositions pharmaceutiques les contenant - Google Patents

Composés tricycliques présentant une activité antagoniste envers le facteur de libération de la corticotropine et compositions pharmaceutiques les contenant

Info

Publication number
MA32438B1
MA32438B1 MA33084A MA33084A MA32438B1 MA 32438 B1 MA32438 B1 MA 32438B1 MA 33084 A MA33084 A MA 33084A MA 33084 A MA33084 A MA 33084A MA 32438 B1 MA32438 B1 MA 32438B1
Authority
MA
Morocco
Prior art keywords
pharmaceutical compositions
compositions containing
antagonist activity
releasing factor
corticotropin releasing
Prior art date
Application number
MA33084A
Other languages
Arabic (ar)
English (en)
Inventor
Katsumi Kobayashi
Kazuyoshi Aso
Takafumi Takai
Takuto Kojima
Kazuyuki Tokumaru
Michiyo Mochizuki
Yasutaka Hoashi
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of MA32438B1 publication Critical patent/MA32438B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne un composé représenté par la formule (i') dans laquelle x est de l'azote ou crx, rx est de l'hydrogène, etc., r1 est un groupe hydrocarbure éventuellement substitué, etc., r2 est un groupe hydrocarbure éventuellement substitué, etc., le noyau a est un noyau hétérocyclique de 5 à 8 chaînons, etc., et y1, y2 et y3 sont chacun du carbone ou de l'azote éventuellement substitués, etc.. L'invention concerne également un sel ou un promédicament dudit composé, présentant une activité antagoniste sur le récepteur crf, ainsi que leur utilisation.
MA33084A 2008-01-22 2010-08-13 Composés tricycliques présentant une activité antagoniste envers le facteur de libération de la corticotropine et compositions pharmaceutiques les contenant MA32438B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US655408P 2008-01-22 2008-01-22
PCT/JP2009/051299 WO2009093747A1 (fr) 2008-01-22 2009-01-21 Composés tricycliques présentant une activité antagoniste envers le facteur de libération de la corticotropine et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
MA32438B1 true MA32438B1 (fr) 2011-07-03

Family

ID=40637104

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33084A MA32438B1 (fr) 2008-01-22 2010-08-13 Composés tricycliques présentant une activité antagoniste envers le facteur de libération de la corticotropine et compositions pharmaceutiques les contenant

Country Status (26)

Country Link
US (2) US8901141B2 (fr)
EP (1) EP2240485B1 (fr)
JP (1) JP5431341B2 (fr)
KR (1) KR20100130596A (fr)
CN (1) CN101981031A (fr)
AR (1) AR070218A1 (fr)
AU (1) AU2009206936A1 (fr)
BR (1) BRPI0907230A2 (fr)
CA (1) CA2712347A1 (fr)
CL (1) CL2009000116A1 (fr)
CO (1) CO6230982A2 (fr)
CR (1) CR11636A (fr)
DO (1) DOP2010000226A (fr)
EA (1) EA201070876A1 (fr)
EC (1) ECSP10010414A (fr)
GE (1) GEP20125637B (fr)
IL (1) IL207074A0 (fr)
MA (1) MA32438B1 (fr)
MX (1) MX2010008039A (fr)
NZ (1) NZ587215A (fr)
PE (1) PE20091439A1 (fr)
SG (1) SG189803A1 (fr)
TW (1) TW200936591A (fr)
UY (1) UY31604A1 (fr)
WO (1) WO2009093747A1 (fr)
ZA (1) ZA201005340B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI370820B (en) * 2005-04-27 2012-08-21 Takeda Pharmaceutical Fused heterocyclic compounds
RU2011137419A (ru) * 2009-02-11 2013-03-20 Суновион Фармасьютикалз Инк. Обратные агонисты и антагонисты гистамина н3 и способы их применения
JP2013504580A (ja) * 2009-09-11 2013-02-07 スノヴィオン ファーマシューティカルズ インコーポレイテッド ヒスタミンｈ３インバースアゴニストおよびアンタゴニストとその使用方法
BR112014003496B1 (pt) 2011-08-18 2022-02-22 Nippon Shinyaku Co., Ltd Derivado heterocíclico, usos do mesmo e composição farmacêutica
CA2866218C (fr) 2012-03-16 2020-06-09 Vitae Pharmaceuticals, Inc. Modulateurs du recepteur x du foie
DK2825542T3 (en) 2012-03-16 2017-01-09 Vitae Pharmaceuticals Inc LIVER-X-receptor modulators
WO2014165816A1 (fr) 2013-04-05 2014-10-09 North Carolina Central University Composés utiles dans le traitement de troubles métaboliques et leur synthèse
CN103435618B (zh) * 2013-08-22 2016-03-23 中国药科大学 一种合成稠杂环化合物的方法
CA2948436A1 (fr) * 2014-05-23 2015-11-26 Active Biotech Ab Nouveaux composes utiles en tant qu'inhibiteurs de s100
CN105859630B (zh) * 2015-01-22 2019-01-18 北京大学 一种咪唑酮衍生物的合成方法及应用
EP3150604B1 (fr) 2015-10-01 2021-07-14 Idemitsu Kosan Co., Ltd. Groupes benzimidazolo [1,2-a] benzimidazoles portant des benzimidazolo [1,2-a] benzimidazolyles, groupes carbazolyles, groupes benzofuranes ou benzothiophènes pour diodes électroluminescentes organiques
WO2017056055A1 (fr) 2015-10-01 2017-04-06 Idemitsu Kosan Co., Ltd. Benzimidazolo[1,2-a]benzimidazole portant des groupes triazine pour diodes électroluminescentes organiques
WO2018220513A1 (fr) * 2017-05-31 2018-12-06 Alembic Pharmaceuticals Limited Procédé amélioré de préparation d'acide obéticholique

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS516993A (en) 1974-07-05 1976-01-20 Dainippon Pharmaceutical Co Adeninjudotaino seiho
CN1274690C (zh) * 2000-12-28 2006-09-13 小野药品工业株式会社 三杂环化合物和包括其作为活性组分的药物
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
WO2004113300A1 (fr) 2003-06-23 2004-12-29 Ono Pharmaceutical Co., Ltd. Nouveau compose heterocyclique tricyclique
CA2562244A1 (fr) * 2004-04-07 2005-10-27 Takeda Pharmaceutical Company Limited Composes cycliques
TWI370820B (en) 2005-04-27 2012-08-21 Takeda Pharmaceutical Fused heterocyclic compounds
EP2088861A4 (fr) 2006-10-25 2010-07-07 Takeda Pharmaceutical Composés de benzimidazole
WO2008082003A1 (fr) 2006-12-29 2008-07-10 Takeda Pharmaceutical Company Limited Composes heterocycliques lies par fusion developpant une activite antagoniste au crf
CL2009000119A1 (es) 2008-01-22 2010-03-05 Boehringer Ingelheim Int Compuestos derivados de amino-bencimidazoles sustituidos; composicion farmaceutica; y su uso en el tratamiento del alzheimer.
FR2926556B1 (fr) 2008-01-22 2010-02-19 Sanofi Aventis Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique
DK2252581T3 (da) 2008-01-22 2012-07-16 Lilly Co Eli Kappa-selektiv opioidreceptorantagonist
FR2926554B1 (fr) * 2008-01-22 2010-03-12 Sanofi Aventis Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
ECSP10010414A (es) 2010-09-30
JP2011509923A (ja) 2011-03-31
DOP2010000226A (es) 2010-10-15
US8785460B2 (en) 2014-07-22
CN101981031A (zh) 2011-02-23
US20100298287A1 (en) 2010-11-25
IL207074A0 (en) 2010-12-30
CO6230982A2 (es) 2010-12-20
TW200936591A (en) 2009-09-01
CL2009000116A1 (es) 2010-08-27
MX2010008039A (es) 2010-08-10
CR11636A (es) 2010-11-04
NZ587215A (en) 2012-08-31
CA2712347A1 (fr) 2009-07-30
SG189803A1 (en) 2013-05-31
AR070218A1 (es) 2010-03-25
WO2009093747A1 (fr) 2009-07-30
KR20100130596A (ko) 2010-12-13
EP2240485B1 (fr) 2014-10-15
UY31604A1 (es) 2009-08-31
GEP20125637B (en) 2012-09-10
ZA201005340B (en) 2011-10-26
EP2240485A1 (fr) 2010-10-20
US20090186879A1 (en) 2009-07-23
JP5431341B2 (ja) 2014-03-05
EA201070876A1 (ru) 2011-04-29
AU2009206936A1 (en) 2009-07-30
BRPI0907230A2 (pt) 2019-09-24
PE20091439A1 (es) 2009-10-19
US8901141B2 (en) 2014-12-02

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