PE20091439A1 - Compuestos triciclicos como antagonistas de crf - Google Patents
Compuestos triciclicos como antagonistas de crfInfo
- Publication number
- PE20091439A1 PE20091439A1 PE2009000069A PE2009000069A PE20091439A1 PE 20091439 A1 PE20091439 A1 PE 20091439A1 PE 2009000069 A PE2009000069 A PE 2009000069A PE 2009000069 A PE2009000069 A PE 2009000069A PE 20091439 A1 PE20091439 A1 PE 20091439A1
- Authority
- PE
- Peru
- Prior art keywords
- crf
- antagonists
- difluorometoxy
- benzymidazole
- tetrahydropyrimido
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
REFERIDA A UN COMPUESTO TRICICLICO DE FORMULA (I'), DONDE X ES N O CRx; Rx ES H O ALQUILO C1-C9; R1 ES NITRO, HALOGENO, CIANO, ENTRE OTROS; R2 ES ACILO, UN GRUPO AMINO, ENTRE OTROS; A ES UN ANILLO HETEROCICLICO DE 5 A 8 MIEMBROS OPCIONALMENTE SUSTITUIDO CON HALOGENO, CN, NITRO, H, ENTRE OTROS; Y1, Y2, E Y3 SON C, N, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 9-CLORO-6-[1-(DIFLUOROMETOXI)-2,2,2-TRIFLUOROETIL]-1-(2-METOXI-4,6-DIMETILPIRIMIDIN-5-IL)-1,2,3,4-TETRAHIDROPIRIMIDO[1,2-a]BENCIMIDAZOL, 9-CLORO-1-(2,4-DICLOROFENIL)-6-[1-(DIFLUOROMETOXI)-2,2,2-TRFLUOROETIL]-1,2,3,4-TETRAHIDROPIRIMIDO[1,2-a]BENCIMIDAZOL, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL FACTOR DE LIBERACION DE CORTICOTROPINA (CRF) Y SON UTILES EN EL TRATAMIENTO DE DEPRESION, ESQUIZOFRENIA, ENFERMEDAD DE ALZHEIMER, DEMENCIA SENIL, ESCLEROSIS MULTIPLE, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US655408P | 2008-01-22 | 2008-01-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091439A1 true PE20091439A1 (es) | 2009-10-19 |
Family
ID=40637104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009000069A PE20091439A1 (es) | 2008-01-22 | 2009-01-21 | Compuestos triciclicos como antagonistas de crf |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8785460B2 (es) |
| EP (1) | EP2240485B1 (es) |
| JP (1) | JP5431341B2 (es) |
| KR (1) | KR20100130596A (es) |
| CN (1) | CN101981031A (es) |
| AR (1) | AR070218A1 (es) |
| AU (1) | AU2009206936A1 (es) |
| BR (1) | BRPI0907230A2 (es) |
| CA (1) | CA2712347A1 (es) |
| CL (1) | CL2009000116A1 (es) |
| CO (1) | CO6230982A2 (es) |
| CR (1) | CR11636A (es) |
| DO (1) | DOP2010000226A (es) |
| EA (1) | EA201070876A1 (es) |
| EC (1) | ECSP10010414A (es) |
| GE (1) | GEP20125637B (es) |
| IL (1) | IL207074A0 (es) |
| MA (1) | MA32438B1 (es) |
| MX (1) | MX2010008039A (es) |
| NZ (1) | NZ587215A (es) |
| PE (1) | PE20091439A1 (es) |
| SG (1) | SG189803A1 (es) |
| TW (1) | TW200936591A (es) |
| UY (1) | UY31604A1 (es) |
| WO (1) | WO2009093747A1 (es) |
| ZA (1) | ZA201005340B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI370820B (en) * | 2005-04-27 | 2012-08-21 | Takeda Pharmaceutical | Fused heterocyclic compounds |
| US8063032B2 (en) | 2009-02-11 | 2011-11-22 | Sunovion Pharmaceuticals Inc. | Histamine H3 inverse agonists and antagonists and methods of use thereof |
| CN102686586A (zh) * | 2009-09-11 | 2012-09-19 | 桑诺维恩药品公司 | 组胺h3反相激动剂和拮抗剂及其使用方法 |
| AU2012295805B2 (en) | 2011-08-18 | 2017-05-04 | Nippon Shinyaku Co., Ltd. | Heterocyclic derivative and pharmaceutical drug |
| RS55166B1 (sr) | 2012-03-16 | 2017-01-31 | Vitae Pharmaceuticals Inc | Modulatori x receptora iz jetre |
| SG11201405323YA (en) | 2012-03-16 | 2014-10-30 | Vitae Pharmaceuticals Inc | Liver x receptor modulators |
| US10005720B2 (en) | 2013-04-05 | 2018-06-26 | North Carolina Central University | Compounds useful for the treatment of metabolic disorders and synthesis of the same |
| CN103435618B (zh) * | 2013-08-22 | 2016-03-23 | 中国药科大学 | 一种合成稠杂环化合物的方法 |
| JP6580074B2 (ja) * | 2014-05-23 | 2019-09-25 | アクティブ バイオテック エイビー | Ｓ１００阻害薬として有用な新規化合物 |
| CN105859630B (zh) * | 2015-01-22 | 2019-01-18 | 北京大学 | 一种咪唑酮衍生物的合成方法及应用 |
| EP3150604B1 (en) | 2015-10-01 | 2021-07-14 | Idemitsu Kosan Co., Ltd. | Benzimidazolo[1,2-a]benzimidazole carrying benzimidazolo[1,2-a]benzimidazolylyl groups, carbazolyl groups, benzofurane groups or benzothiophene groups for organic light emitting diodes |
| US20180269407A1 (en) | 2015-10-01 | 2018-09-20 | Idemitsu Kosan Co., Ltd. | Benzimidazolo[1,2-a]benzimidazole carrying triazine groups for organic light emitting diodes |
| WO2018220513A1 (en) * | 2017-05-31 | 2018-12-06 | Alembic Pharmaceuticals Limited | An improved process for preparation of obeticholic acid |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS516993A (en) | 1974-07-05 | 1976-01-20 | Dainippon Pharmaceutical Co | Adeninjudotaino seiho |
| CA2432148C (en) * | 2000-12-28 | 2011-01-18 | Ono Pharmaceutical Co., Ltd. | Tri-heterocyclic compounds and a pharmaceutical comprising them as an active ingredient |
| GB0308208D0 (en) * | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
| WO2004113300A1 (ja) * | 2003-06-23 | 2004-12-29 | Ono Pharmaceutical Co., Ltd. | 新規三環性複素環化合物 |
| EP1732541A4 (en) * | 2004-04-07 | 2008-03-05 | Takeda Pharmaceutical | CYCLIC COMPOUNDS |
| TWI370820B (en) * | 2005-04-27 | 2012-08-21 | Takeda Pharmaceutical | Fused heterocyclic compounds |
| US20100056515A1 (en) | 2006-10-25 | 2010-03-04 | Kazuyoshi Aso | Benzimidazole compounds |
| JP2010514672A (ja) | 2006-12-29 | 2010-05-06 | 武田薬品工業株式会社 | Ｃｒｆアンタゴニスト活性を有する縮合複素環化合物 |
| FR2926556B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
| ES2388708T3 (es) | 2008-01-22 | 2012-10-17 | Eli Lilly And Company | Antagonista selectivo del receptor opioide kappa |
| CA2711713A1 (en) * | 2008-01-22 | 2009-07-30 | Boehringer Ingelheim International Gmbh | Substituted amino-benzimidazoles, medicaments comprising said compound, their use and their method of manufacture |
| FR2926554B1 (fr) * | 2008-01-22 | 2010-03-12 | Sanofi Aventis | Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
-
2009
- 2009-01-21 AR ARP090100180A patent/AR070218A1/es not_active Application Discontinuation
- 2009-01-21 SG SG2013029723A patent/SG189803A1/en unknown
- 2009-01-21 KR KR1020107018307A patent/KR20100130596A/ko not_active Application Discontinuation
- 2009-01-21 CN CN2009801105455A patent/CN101981031A/zh active Pending
- 2009-01-21 TW TW098102200A patent/TW200936591A/zh unknown
- 2009-01-21 WO PCT/JP2009/051299 patent/WO2009093747A1/en active Application Filing
- 2009-01-21 PE PE2009000069A patent/PE20091439A1/es not_active Application Discontinuation
- 2009-01-21 UY UY031604A patent/UY31604A1/es not_active Application Discontinuation
- 2009-01-21 NZ NZ587215A patent/NZ587215A/xx not_active IP Right Cessation
- 2009-01-21 JP JP2010528624A patent/JP5431341B2/ja not_active Expired - Fee Related
- 2009-01-21 US US12/357,158 patent/US8785460B2/en not_active Expired - Fee Related
- 2009-01-21 CL CL2009000116A patent/CL2009000116A1/es unknown
- 2009-01-21 EP EP09704168.5A patent/EP2240485B1/en active Active
- 2009-01-21 CA CA2712347A patent/CA2712347A1/en not_active Abandoned
- 2009-01-21 GE GEAP200911925A patent/GEP20125637B/en unknown
- 2009-01-21 US US12/863,851 patent/US8901141B2/en not_active Expired - Fee Related
- 2009-01-21 AU AU2009206936A patent/AU2009206936A1/en not_active Abandoned
- 2009-01-21 MX MX2010008039A patent/MX2010008039A/es not_active Application Discontinuation
- 2009-01-21 EA EA201070876A patent/EA201070876A1/ru unknown
- 2009-01-21 BR BRPI0907230A patent/BRPI0907230A2/pt not_active IP Right Cessation
-
2010
- 2010-07-18 IL IL207074A patent/IL207074A0/en unknown
- 2010-07-21 DO DO2010000226A patent/DOP2010000226A/es unknown
- 2010-07-27 ZA ZA2010/05340A patent/ZA201005340B/en unknown
- 2010-08-13 MA MA33084A patent/MA32438B1/fr unknown
- 2010-08-18 CR CR11636A patent/CR11636A/es not_active Application Discontinuation
- 2010-08-20 EC EC2010010414A patent/ECSP10010414A/es unknown
- 2010-08-20 CO CO10102942A patent/CO6230982A2/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| US8785460B2 (en) | 2014-07-22 |
| CL2009000116A1 (es) | 2010-08-27 |
| GEP20125637B (en) | 2012-09-10 |
| ECSP10010414A (es) | 2010-09-30 |
| EP2240485A1 (en) | 2010-10-20 |
| TW200936591A (en) | 2009-09-01 |
| ZA201005340B (en) | 2011-10-26 |
| MX2010008039A (es) | 2010-08-10 |
| SG189803A1 (en) | 2013-05-31 |
| JP2011509923A (ja) | 2011-03-31 |
| CR11636A (es) | 2010-11-04 |
| KR20100130596A (ko) | 2010-12-13 |
| US8901141B2 (en) | 2014-12-02 |
| EA201070876A1 (ru) | 2011-04-29 |
| IL207074A0 (en) | 2010-12-30 |
| NZ587215A (en) | 2012-08-31 |
| WO2009093747A1 (en) | 2009-07-30 |
| BRPI0907230A2 (pt) | 2019-09-24 |
| EP2240485B1 (en) | 2014-10-15 |
| JP5431341B2 (ja) | 2014-03-05 |
| CO6230982A2 (es) | 2010-12-20 |
| AR070218A1 (es) | 2010-03-25 |
| CA2712347A1 (en) | 2009-07-30 |
| MA32438B1 (fr) | 2011-07-03 |
| UY31604A1 (es) | 2009-08-31 |
| US20100298287A1 (en) | 2010-11-25 |
| AU2009206936A1 (en) | 2009-07-30 |
| DOP2010000226A (es) | 2010-10-15 |
| CN101981031A (zh) | 2011-02-23 |
| US20090186879A1 (en) | 2009-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |