ECSP10010414A - Compuestos tricíclicos que tienen actividad antagonista de factor de liberación de corticotropina y composiciones farmacéuticas que contienen los mismos - Google Patents

Compuestos tricíclicos que tienen actividad antagonista de factor de liberación de corticotropina y composiciones farmacéuticas que contienen los mismos

Info

Publication number
ECSP10010414A
ECSP10010414A EC2010010414A ECSP10010414A ECSP10010414A EC SP10010414 A ECSP10010414 A EC SP10010414A EC 2010010414 A EC2010010414 A EC 2010010414A EC SP10010414 A ECSP10010414 A EC SP10010414A EC SP10010414 A ECSP10010414 A EC SP10010414A
Authority
EC
Ecuador
Prior art keywords
pharmaceutical compositions
same
compositions containing
antagonist activity
tricyclic compounds
Prior art date
Application number
EC2010010414A
Other languages
English (en)
Inventor
Takafumi Takai
Yasutaka Hoashi
Kazuyoshi Aso
Katsumi Kobayashi
Takuto Kojima
Kazuyuki Tokumaru
Michiyo Mochizuki
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of ECSP10010414A publication Critical patent/ECSP10010414A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

RESUMENSe proporciona un compuesto de la fórmula (I'): en donde X es un nitrógeno o CRx, Rx es un hidrógeno, etc., R1 es un grupo de hidrocarburo opcionalmente substituido etc., R2 es un grupo de hidrocarburo opcionalmente substituido, etc., el anillo A es un anillo heterocíclico de 5- a -8-miembros etc., y cada uno de Y1,. Y2 e Y3 es un carbono opcionalmente substituido o un nitrógeno, etc.; o una sal del mismo o un profármaco del mismo, que tiene actividad antagonista del receptor CRF y proporciona también el uso del mismo.
EC2010010414A 2008-01-22 2010-08-20 Compuestos tricíclicos que tienen actividad antagonista de factor de liberación de corticotropina y composiciones farmacéuticas que contienen los mismos ECSP10010414A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US655408P 2008-01-22 2008-01-22

Publications (1)

Publication Number Publication Date
ECSP10010414A true ECSP10010414A (es) 2010-09-30

Family

ID=40637104

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2010010414A ECSP10010414A (es) 2008-01-22 2010-08-20 Compuestos tricíclicos que tienen actividad antagonista de factor de liberación de corticotropina y composiciones farmacéuticas que contienen los mismos

Country Status (26)

Country Link
US (2) US8901141B2 (es)
EP (1) EP2240485B1 (es)
JP (1) JP5431341B2 (es)
KR (1) KR20100130596A (es)
CN (1) CN101981031A (es)
AR (1) AR070218A1 (es)
AU (1) AU2009206936A1 (es)
BR (1) BRPI0907230A2 (es)
CA (1) CA2712347A1 (es)
CL (1) CL2009000116A1 (es)
CO (1) CO6230982A2 (es)
CR (1) CR11636A (es)
DO (1) DOP2010000226A (es)
EA (1) EA201070876A1 (es)
EC (1) ECSP10010414A (es)
GE (1) GEP20125637B (es)
IL (1) IL207074A0 (es)
MA (1) MA32438B1 (es)
MX (1) MX2010008039A (es)
NZ (1) NZ587215A (es)
PE (1) PE20091439A1 (es)
SG (1) SG189803A1 (es)
TW (1) TW200936591A (es)
UY (1) UY31604A1 (es)
WO (1) WO2009093747A1 (es)
ZA (1) ZA201005340B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI370820B (en) * 2005-04-27 2012-08-21 Takeda Pharmaceutical Fused heterocyclic compounds
RU2011137419A (ru) * 2009-02-11 2013-03-20 Суновион Фармасьютикалз Инк. Обратные агонисты и антагонисты гистамина н3 и способы их применения
JP2013504580A (ja) * 2009-09-11 2013-02-07 スノヴィオン ファーマシューティカルズ インコーポレイテッド ヒスタミンｈ３インバースアゴニストおよびアンタゴニストとその使用方法
BR112014003496B1 (pt) 2011-08-18 2022-02-22 Nippon Shinyaku Co., Ltd Derivado heterocíclico, usos do mesmo e composição farmacêutica
CA2866218C (en) 2012-03-16 2020-06-09 Vitae Pharmaceuticals, Inc. Liver x receptor modulators
DK2825542T3 (en) 2012-03-16 2017-01-09 Vitae Pharmaceuticals Inc LIVER-X-receptor modulators
WO2014165816A1 (en) 2013-04-05 2014-10-09 North Carolina Central University Compounds useful for the treatment of metabolic disorders and synthesis of the same
CN103435618B (zh) * 2013-08-22 2016-03-23 中国药科大学 一种合成稠杂环化合物的方法
CA2948436A1 (en) * 2014-05-23 2015-11-26 Active Biotech Ab Novel compounds useful as s100-inhibitors
CN105859630B (zh) * 2015-01-22 2019-01-18 北京大学 一种咪唑酮衍生物的合成方法及应用
EP3150604B1 (en) 2015-10-01 2021-07-14 Idemitsu Kosan Co., Ltd. Benzimidazolo[1,2-a]benzimidazole carrying benzimidazolo[1,2-a]benzimidazolylyl groups, carbazolyl groups, benzofurane groups or benzothiophene groups for organic light emitting diodes
WO2017056055A1 (en) 2015-10-01 2017-04-06 Idemitsu Kosan Co., Ltd. Benzimidazolo[1,2-a]benzimidazole carrying triazine groups for organic light emitting diodes
WO2018220513A1 (en) * 2017-05-31 2018-12-06 Alembic Pharmaceuticals Limited An improved process for preparation of obeticholic acid

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS516993A (en) 1974-07-05 1976-01-20 Dainippon Pharmaceutical Co Adeninjudotaino seiho
CN1274690C (zh) * 2000-12-28 2006-09-13 小野药品工业株式会社 三杂环化合物和包括其作为活性组分的药物
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
WO2004113300A1 (ja) 2003-06-23 2004-12-29 Ono Pharmaceutical Co., Ltd. 新規三環性複素環化合物
CA2562244A1 (en) * 2004-04-07 2005-10-27 Takeda Pharmaceutical Company Limited Cyclic compounds
TWI370820B (en) 2005-04-27 2012-08-21 Takeda Pharmaceutical Fused heterocyclic compounds
EP2088861A4 (en) 2006-10-25 2010-07-07 Takeda Pharmaceutical BENZIMIDAZOLE COMPOUNDS
WO2008082003A1 (en) 2006-12-29 2008-07-10 Takeda Pharmaceutical Company Limited Fused heterocyclic compounds having crf antagonistic activity
CL2009000119A1 (es) 2008-01-22 2010-03-05 Boehringer Ingelheim Int Compuestos derivados de amino-bencimidazoles sustituidos; composicion farmaceutica; y su uso en el tratamiento del alzheimer.
FR2926556B1 (fr) 2008-01-22 2010-02-19 Sanofi Aventis Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique
DK2252581T3 (da) 2008-01-22 2012-07-16 Lilly Co Eli Kappa-selektiv opioidreceptorantagonist
FR2926554B1 (fr) * 2008-01-22 2010-03-12 Sanofi Aventis Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
JP2011509923A (ja) 2011-03-31
DOP2010000226A (es) 2010-10-15
US8785460B2 (en) 2014-07-22
CN101981031A (zh) 2011-02-23
US20100298287A1 (en) 2010-11-25
IL207074A0 (en) 2010-12-30
MA32438B1 (fr) 2011-07-03
CO6230982A2 (es) 2010-12-20
TW200936591A (en) 2009-09-01
CL2009000116A1 (es) 2010-08-27
MX2010008039A (es) 2010-08-10
CR11636A (es) 2010-11-04
NZ587215A (en) 2012-08-31
CA2712347A1 (en) 2009-07-30
SG189803A1 (en) 2013-05-31
AR070218A1 (es) 2010-03-25
WO2009093747A1 (en) 2009-07-30
KR20100130596A (ko) 2010-12-13
EP2240485B1 (en) 2014-10-15
UY31604A1 (es) 2009-08-31
GEP20125637B (en) 2012-09-10
ZA201005340B (en) 2011-10-26
EP2240485A1 (en) 2010-10-20
US20090186879A1 (en) 2009-07-23
JP5431341B2 (ja) 2014-03-05
EA201070876A1 (ru) 2011-04-29
AU2009206936A1 (en) 2009-07-30
BRPI0907230A2 (pt) 2019-09-24
PE20091439A1 (es) 2009-10-19
US8901141B2 (en) 2014-12-02

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