EA201200602A1 - Индазолы и пиразолопиридины в качестве антагонистов рецептора ccr1 - Google Patents

Индазолы и пиразолопиридины в качестве антагонистов рецептора ccr1

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Publication number
EA201200602A1
EA201200602A1 EA201200602A EA201200602A EA201200602A1 EA 201200602 A1 EA201200602 A1 EA 201200602A1 EA 201200602 A EA201200602 A EA 201200602A EA 201200602 A EA201200602 A EA 201200602A EA 201200602 A1 EA201200602 A1 EA 201200602A1
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Prior art keywords
antagonists
pyrazolopiridin
indazoles
ccr1 receptor
carbocycle
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EA201200602A
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English (en)
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EA021015B1 (ru
Inventor
Брайан Николас Кук
Даниел Кузмич
Кань Мао
Хоссейн Разави
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Бёрингер Ингельхайм Интернациональ Гмбх
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Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201200602A1 publication Critical patent/EA201200602A1/ru
Publication of EA021015B1 publication Critical patent/EA021015B1/ru

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Abstract

В заявке описаны антагонисты рецептора CCR1 формулы (I)в которой Х обозначает азот или С-R; Arобозначает карбоцикл, гетероарил или гетероциклил, каждый из которых необязательно замещен 1-3 группами R; Arобозначает карбоцикл, гетероарил или гетероциклил, каждый из которых необязательно замещен 1-3 группами R; циклический G представляет собой карбоцикл или гетероциклил, каждый из которых необязательно замещен 1-2 группами R; Rобозначает водород, C-С-алкил или С-С-алкокси-С-С-алкил. В заявке также описаны композиции, методики получения и применение соединений формулы (I).
EA201200602A 2009-10-21 2010-10-19 Индазолы и пиразолопиридины в качестве антагонистов рецептора ccr1 EA021015B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25359009P 2009-10-21 2009-10-21
PCT/US2010/053142 WO2011049917A1 (en) 2009-10-21 2010-10-19 Indazole and pyrazolopyridine compounds as ccr1 receptor antagonists

Publications (2)

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EA201200602A1 true EA201200602A1 (ru) 2012-12-28
EA021015B1 EA021015B1 (ru) 2015-03-31

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US (1) US9056858B2 (ru)
EP (1) EP2491028B1 (ru)
JP (1) JP5542946B2 (ru)
KR (1) KR20120087923A (ru)
CN (1) CN102666526A (ru)
AP (1) AP2012006204A0 (ru)
AU (1) AU2010308277A1 (ru)
BR (1) BR112012009331A2 (ru)
CA (1) CA2778060A1 (ru)
CL (1) CL2012000967A1 (ru)
CO (1) CO6531488A2 (ru)
DK (1) DK2491028T3 (ru)
EA (1) EA021015B1 (ru)
EC (1) ECSP12011904A (ru)
ES (1) ES2444780T3 (ru)
GE (1) GEP20146103B (ru)
HR (1) HRP20140213T1 (ru)
IL (1) IL218823A0 (ru)
IN (1) IN2012DN03449A (ru)
MA (1) MA33675B1 (ru)
MX (1) MX2012004644A (ru)
NZ (1) NZ599132A (ru)
PE (1) PE20121433A1 (ru)
PL (1) PL2491028T3 (ru)
PT (1) PT2491028E (ru)
RS (1) RS53130B (ru)
SI (1) SI2491028T1 (ru)
TN (1) TN2012000180A1 (ru)
WO (1) WO2011049917A1 (ru)

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JP6282759B2 (ja) 2014-04-14 2018-02-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｒｏｒガンマのモジュレーターとしての化合物
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CO6531488A2 (es) 2012-09-28
TN2012000180A1 (en) 2013-12-12
PE20121433A1 (es) 2012-11-10
CL2012000967A1 (es) 2012-09-14
US20120270870A1 (en) 2012-10-25
MX2012004644A (es) 2012-05-08
JP2013508376A (ja) 2013-03-07
EP2491028B1 (en) 2013-12-11
AP2012006204A0 (en) 2012-04-30
JP5542946B2 (ja) 2014-07-09
BR112012009331A2 (pt) 2019-09-24
NZ599132A (en) 2014-05-30
US9056858B2 (en) 2015-06-16
ES2444780T3 (es) 2014-02-26
EP2491028A1 (en) 2012-08-29
IL218823A0 (en) 2012-06-28
CN102666526A (zh) 2012-09-12
EA021015B1 (ru) 2015-03-31
PL2491028T3 (pl) 2014-05-30
PT2491028E (pt) 2014-02-04
HRP20140213T1 (hr) 2014-04-11
WO2011049917A1 (en) 2011-04-28
GEP20146103B (en) 2014-05-27
AU2010308277A1 (en) 2012-04-26
KR20120087923A (ko) 2012-08-07
CA2778060A1 (en) 2011-04-28
MA33675B1 (fr) 2012-10-01
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DK2491028T3 (da) 2014-01-13

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