ATE556998T1 - Salicylamidderivate als nikotinische alpha-7- modulatoren - Google Patents
Salicylamidderivate als nikotinische alpha-7- modulatorenInfo
- Publication number
- ATE556998T1 ATE556998T1 AT09781410T AT09781410T ATE556998T1 AT E556998 T1 ATE556998 T1 AT E556998T1 AT 09781410 T AT09781410 T AT 09781410T AT 09781410 T AT09781410 T AT 09781410T AT E556998 T1 ATE556998 T1 AT E556998T1
- Authority
- AT
- Austria
- Prior art keywords
- modulators
- nicotinic alpha
- salicylamide derivatives
- salicylamide
- derivatives
- Prior art date
Links
- SKZKKFZAGNVIMN-UHFFFAOYSA-N Salicilamide Chemical class NC(=O)C1=CC=CC=C1O SKZKKFZAGNVIMN-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/62—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8810808P | 2008-08-12 | 2008-08-12 | |
PCT/EP2009/060016 WO2010018095A1 (en) | 2008-08-12 | 2009-08-03 | Salicylamide derivatives as nicotinic alpha 7 modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE556998T1 true ATE556998T1 (de) | 2012-05-15 |
Family
ID=41055425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT09781410T ATE556998T1 (de) | 2008-08-12 | 2009-08-03 | Salicylamidderivate als nikotinische alpha-7- modulatoren |
Country Status (13)
Country | Link |
---|---|
US (1) | US8198332B2 (de) |
EP (1) | EP2323971B1 (de) |
JP (1) | JP5341190B2 (de) |
KR (1) | KR101333401B1 (de) |
CN (1) | CN102119142B (de) |
AT (1) | ATE556998T1 (de) |
AU (1) | AU2009281243A1 (de) |
BR (1) | BRPI0917803A2 (de) |
CA (1) | CA2728451C (de) |
ES (1) | ES2386760T3 (de) |
IL (1) | IL209732A0 (de) |
MX (1) | MX2011000841A (de) |
WO (1) | WO2010018095A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015191799A1 (en) * | 2014-06-13 | 2015-12-17 | Merck Sharp & Dohme Corp. | Alpha-7 nicotinic acetylcholine receptor modulators and uses thereof |
ES2901197T3 (es) | 2016-03-22 | 2022-03-21 | Merck Sharp & Dohme | Moduladores alostéricos de los receptores nicotínicos de la acetilcolina |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05239005A (ja) * | 1992-02-28 | 1993-09-17 | Kitsuen Kagaku Kenkyu Zaidan | N−(2−アミノエチル)ベンズアミド類およびその新規中間体 |
JP2008525464A (ja) * | 2004-12-22 | 2008-07-17 | メモリー・ファーマシューティカルズ・コーポレイション | α−7ニコチン性受容体リガンド並びにその製造及び使用 |
PE20080311A1 (es) * | 2006-05-30 | 2008-05-23 | Glaxo Group Ltd | Derivados de oxadiazol como agentes afines a receptores nicotinicos |
-
2009
- 2009-08-03 WO PCT/EP2009/060016 patent/WO2010018095A1/en active Application Filing
- 2009-08-03 CA CA2728451A patent/CA2728451C/en not_active Expired - Fee Related
- 2009-08-03 AU AU2009281243A patent/AU2009281243A1/en not_active Abandoned
- 2009-08-03 EP EP09781410A patent/EP2323971B1/de not_active Not-in-force
- 2009-08-03 JP JP2011522477A patent/JP5341190B2/ja not_active Expired - Fee Related
- 2009-08-03 KR KR1020117003129A patent/KR101333401B1/ko not_active IP Right Cessation
- 2009-08-03 MX MX2011000841A patent/MX2011000841A/es active IP Right Grant
- 2009-08-03 CN CN2009801310854A patent/CN102119142B/zh not_active Expired - Fee Related
- 2009-08-03 ES ES09781410T patent/ES2386760T3/es active Active
- 2009-08-03 BR BRPI0917803A patent/BRPI0917803A2/pt not_active IP Right Cessation
- 2009-08-03 AT AT09781410T patent/ATE556998T1/de active
- 2009-08-12 US US12/462,952 patent/US8198332B2/en not_active Expired - Fee Related
-
2010
- 2010-12-02 IL IL209732A patent/IL209732A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
ES2386760T3 (es) | 2012-08-29 |
MX2011000841A (es) | 2011-02-25 |
CN102119142B (zh) | 2013-12-04 |
EP2323971A1 (de) | 2011-05-25 |
AU2009281243A1 (en) | 2010-02-18 |
JP2011530560A (ja) | 2011-12-22 |
JP5341190B2 (ja) | 2013-11-13 |
KR20110028652A (ko) | 2011-03-21 |
IL209732A0 (en) | 2011-02-28 |
US20100041763A1 (en) | 2010-02-18 |
EP2323971B1 (de) | 2012-05-09 |
WO2010018095A1 (en) | 2010-02-18 |
US8198332B2 (en) | 2012-06-12 |
CA2728451C (en) | 2013-09-24 |
CA2728451A1 (en) | 2010-02-18 |
CN102119142A (zh) | 2011-07-06 |
BRPI0917803A2 (pt) | 2019-09-03 |
KR101333401B1 (ko) | 2013-11-28 |
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