PE20080311A1 - Derivados de oxadiazol como agentes afines a receptores nicotinicos - Google Patents
Derivados de oxadiazol como agentes afines a receptores nicotinicosInfo
- Publication number
- PE20080311A1 PE20080311A1 PE2007000661A PE2007000661A PE20080311A1 PE 20080311 A1 PE20080311 A1 PE 20080311A1 PE 2007000661 A PE2007000661 A PE 2007000661A PE 2007000661 A PE2007000661 A PE 2007000661A PE 20080311 A1 PE20080311 A1 PE 20080311A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- oxadiazol
- propyl
- phenyl
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
REFERIDA A UN DERIVADO DE OXADIAZOL DE FORMULA 8I), DONDE Q ES -(CH2)n-; n ES 3 O 4; Ra ES HIDROGENO O METILO; R1 ES -NR6COR7; R2 ES H, HALOGENO, ALQUILO C1-C6; R3 ES H, ALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS; R4 Y R5 SON H, ALQUILO C1-C6, CICLOALQUILO C3-C6, ENTRE OTROS; R6 ES HIDROGENO; R7 ES ALQUILO C1-C5, CICLOALQUILO C3-C8, PIRIDILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-FLUORO-N-[4-(5-{[3-(4-MORFOLINIL)PROPIL]AMINO}-1,3,4-OXADIAZOL-2-IL)FENIL]BENZAMIDA, N-[3-(METILOXI)-4-(5-{[3-(4-MORFOLINIL)PROPIL]AMINO}-1,3,4-OXADIAZOL-2-IL)FENIL]CICLOPENTANO-CARBOXAMIDA, N-[4-(5-{[3-(DIETILAMINO)PROPIL]AMINO}-1,3,4-OXADIAZOL-2-IL)-3-(METILOXI)FENIL]-2,6-DIFLUOROBENZAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN AFINIDAD POR LOS RECEPTORES NICOTINICOS, PARTICULARMENTE POR EL RECEPTOR NICOTINICO ALFA 7 Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES NEUROLOGICAS, TRASTORNOS PSIQUIATRICOS, TRASTORNOS RELACIONADOS CON EL DOLOR, ENTRE OTROS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0610657.9A GB0610657D0 (en) | 2006-05-30 | 2006-05-30 | Compounds |
GB0619710A GB0619710D0 (en) | 2006-10-05 | 2006-10-05 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080311A1 true PE20080311A1 (es) | 2008-05-23 |
Family
ID=38294122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000661A PE20080311A1 (es) | 2006-05-30 | 2007-05-28 | Derivados de oxadiazol como agentes afines a receptores nicotinicos |
Country Status (12)
Country | Link |
---|---|
US (1) | US20090105217A1 (es) |
EP (1) | EP2021331A1 (es) |
JP (1) | JP2009538865A (es) |
KR (1) | KR20090014223A (es) |
AR (1) | AR061196A1 (es) |
AU (1) | AU2007267170A1 (es) |
BR (1) | BRPI0711779A2 (es) |
CA (1) | CA2653771A1 (es) |
EA (1) | EA200870591A1 (es) |
PE (1) | PE20080311A1 (es) |
TW (1) | TW200811155A (es) |
WO (1) | WO2007138033A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0723719D0 (en) * | 2007-12-04 | 2008-01-16 | Glaxo Group Ltd | Compounds |
GB0723815D0 (en) * | 2007-12-05 | 2008-01-16 | Glaxo Group Ltd | Compounds |
TWI490214B (zh) * | 2008-05-30 | 2015-07-01 | 艾德克 上野股份有限公司 | 苯或噻吩衍生物及該等作為vap-1抑制劑之用途 |
WO2010018095A1 (en) * | 2008-08-12 | 2010-02-18 | F. Hoffmann-La Roche Ag | Salicylamide derivatives as nicotinic alpha 7 modulators |
EP2324007B1 (en) * | 2008-09-02 | 2012-08-15 | NeuroSearch A/S | Triazole derivatives and their use as nicotinic acetylcholine receptor modulators |
WO2011079439A1 (en) * | 2009-12-30 | 2011-07-07 | Zannan Scitech Co., Ltd. | Highly active metathesis catalysts selective for romp and rcm reactions |
CA3058533A1 (en) * | 2017-03-31 | 2018-10-04 | Perenna Pharmaceuticals, Inc. | Compounds useful as inhibitors of alcat 1 |
CN111960983A (zh) * | 2020-08-31 | 2020-11-20 | 南通大学 | 一种n-甲基-3-(1-甲基吡咯烷-3-基)丙-1-胺及其合成方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1551835T3 (da) * | 2002-09-30 | 2007-06-04 | Neurosearch As | Hidtil ukendte 1,4-diazabicycloalkanderivater, deres fremstilling og anvendelse |
-
2007
- 2007-05-28 PE PE2007000661A patent/PE20080311A1/es not_active Application Discontinuation
- 2007-05-28 TW TW096118892A patent/TW200811155A/zh unknown
- 2007-05-28 AR ARP070102281A patent/AR061196A1/es unknown
- 2007-05-29 JP JP2009512565A patent/JP2009538865A/ja active Pending
- 2007-05-29 EA EA200870591A patent/EA200870591A1/ru unknown
- 2007-05-29 EP EP07729582A patent/EP2021331A1/en not_active Withdrawn
- 2007-05-29 AU AU2007267170A patent/AU2007267170A1/en not_active Abandoned
- 2007-05-29 KR KR1020087031726A patent/KR20090014223A/ko not_active Application Discontinuation
- 2007-05-29 US US12/302,054 patent/US20090105217A1/en not_active Abandoned
- 2007-05-29 WO PCT/EP2007/055159 patent/WO2007138033A1/en active Application Filing
- 2007-05-29 CA CA002653771A patent/CA2653771A1/en not_active Abandoned
- 2007-05-29 BR BRPI0711779-5A patent/BRPI0711779A2/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EA200870591A1 (ru) | 2009-06-30 |
CA2653771A1 (en) | 2007-12-06 |
JP2009538865A (ja) | 2009-11-12 |
BRPI0711779A2 (pt) | 2011-11-29 |
AR061196A1 (es) | 2008-08-13 |
TW200811155A (en) | 2008-03-01 |
KR20090014223A (ko) | 2009-02-06 |
EP2021331A1 (en) | 2009-02-11 |
AU2007267170A1 (en) | 2007-12-06 |
WO2007138033A1 (en) | 2007-12-06 |
US20090105217A1 (en) | 2009-04-23 |
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