PE20040833A1 - Derivado de 1-aminociclohexano sustituidos en la posicion 4 - Google Patents

Derivado de 1-aminociclohexano sustituidos en la posicion 4

Info

Publication number
PE20040833A1
PE20040833A1 PE2003001140A PE2003001140A PE20040833A1 PE 20040833 A1 PE20040833 A1 PE 20040833A1 PE 2003001140 A PE2003001140 A PE 2003001140A PE 2003001140 A PE2003001140 A PE 2003001140A PE 20040833 A1 PE20040833 A1 PE 20040833A1
Authority
PE
Peru
Prior art keywords
ilo
alkyl
substituted
dichlorhydrate
indol
Prior art date
Application number
PE2003001140A
Other languages
English (en)
Inventor
Claudia Hinze
Hans Schick
Helmut Sonnenschein
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20040833A1 publication Critical patent/PE20040833A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

SE REFIERE A DERIVADOS DEL 1-AMINOCICLOHEXANO SUSTITUIDO EN LA POSICION 4, DE FORMULA GENERAL I, EN DONDE n ES 0, 1 o 2; X ES UN ENLACE o C(O), C(O)NH, C(O)CH2, ENTRE OTROS; R1 Y R2 SON H, ALQUILO C1-C8 O CICLOALQUILO C3-C8, CADA UNO SATURADO O NO, RAMIFICADO O NO, SUSTITUIDO UNA O MAS VECES O NO SUSTITUIDO, ENTRE OTROS; O BIEN R1 Y R2 JUNTOS FORMAN UN ANILLO Y SON CH2CH2OCH2CH2, CH2CH2NR6CH2CH2 o (CH2)3-6; R6 ES H, ALQUILO C1-C8 O CICLOALQUILO C3-C8, ENTRE OTROS; R3 ES ALQUILO C1-C8 o CICLOALQUILO C3-C8, CADA UNO SATURADO O NO; R4 Y R5 SON H, ALQUILO C1-C6, O-ALQUILO C1-C3, ENTRE OTROS. ESTOS COMPUESTOS SE PUEDEN PRESENTAR EN FORMA DE SUS RACEMATOS, ESTEREOISOMEROS PUROS, ENANTIOMEROS, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: DICLORHIDRATO DE {4-[3-(1H-INDOL-3-ILO)-PIRROLIDIN-1-ILO]-1-FENIL-CICLOHEXIL}-DIMETILAMINA (DIASTEREOMERO NO POLAR); DICLORHIDRATO DE {4-[3-(1H-INDOL-3-ILO)-PIRROLIDIN-1-ILO]-1-FENIL-CICLOHEXIL}-DIMETILAMINA (MEZCLA DE DIASTEREOISOMEROS); DICLORHIDRATO DE {4-[4-(5-CLORO-1H-INDOL-3-ILO)-PIPERIDIN-1-ILO]-1-FENIL-CICLOHEXIL}-DIMETILAMINA (DIASTEREOMERO NO POLAR); ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA SU PREPARACION. ESTOS COMPUESTOS INFLUYEN SOBRE EL RECEPTOR ORL1 DE NOCICEPTINA Y/O EL RECEPTOR OPIATO m Y SON UTILES PARA TRATAMIENTO DEL DOLOR, EN ESPECIAL DEL DOLOR AGUDO, VISCERAL, NEUROPATICO O CRONICO
PE2003001140A 2002-11-11 2003-11-11 Derivado de 1-aminociclohexano sustituidos en la posicion 4 PE20040833A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10252666A DE10252666A1 (de) 2002-11-11 2002-11-11 N-Piperidyl-cyclohexan-Derivate

Publications (1)

Publication Number Publication Date
PE20040833A1 true PE20040833A1 (es) 2004-11-17

Family

ID=32308522

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003001140A PE20040833A1 (es) 2002-11-11 2003-11-11 Derivado de 1-aminociclohexano sustituidos en la posicion 4

Country Status (13)

Country Link
US (1) US7759385B2 (es)
EP (1) EP1560823B1 (es)
AR (1) AR041941A1 (es)
AT (1) ATE400569T1 (es)
AU (1) AU2003287993A1 (es)
CY (1) CY1108378T1 (es)
DE (2) DE10252666A1 (es)
DK (1) DK1560823T3 (es)
ES (1) ES2309373T3 (es)
PE (1) PE20040833A1 (es)
PT (1) PT1560823E (es)
SI (1) SI1560823T1 (es)
WO (1) WO2004043949A1 (es)

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DE10252665A1 (de) * 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
EP2080757A1 (en) * 2003-07-24 2009-07-22 Euro-Celtique S.A. Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain
CN101914088A (zh) * 2003-07-24 2010-12-15 尤罗塞尔蒂克股份有限公司 哌啶化合物和含有它们的药物组合物
DE10337184A1 (de) * 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
DE102004023635A1 (de) * 2004-05-10 2006-04-13 Grünenthal GmbH Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023507A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexylessigsäure-Derivate
DE102004023522A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023632A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Substituierte Cyclohexylcarbonsäure-Derivate
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
EP2178534A4 (en) 2007-07-17 2011-03-30 Merck Sharp & Dohme SOLUBLE EPOXY HYDROLASE INHIBITORS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND PROCESSING METHODS
CN101848910B (zh) * 2007-11-05 2013-12-04 默克专利股份公司 作为选择性11-β-羟基类固醇脱氢酶1型抑制剂的7-氮杂吲哚衍生物
AR070398A1 (es) 2008-02-22 2010-03-31 Gruenenthal Chemie Derivados sustituidos de indol
CA2718209A1 (en) 2008-03-27 2009-10-01 Gruenenthal Gmbh (hetero)aryl cyclohexane derivatives
SI2271613T1 (sl) 2008-03-27 2014-08-29 Grunenthal Gmbh Hidroksimetilcikloheksilamini
ES2621407T3 (es) 2008-03-27 2017-07-04 Grünenthal GmbH Ciclohexildiaminas sustituidas
DK2257526T3 (da) 2008-03-27 2012-02-06 Gruenenthal Gmbh Spiro(5,5)undecan-derivater
CN102046595B (zh) 2008-03-27 2014-03-05 格吕伦塔尔有限公司 取代的4-氨基环己烷衍生物
CL2009000731A1 (es) 2008-03-27 2009-05-15 Gruenenthal Gmbh Compuestos derivados de ciclohexano espirociclicos sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, abuso de alcohol, hipertension, anorexia, obesidad y diarrea.
AU2012335980C1 (en) 2011-11-07 2017-12-14 Sunovion Pharmaceuticals Inc. Modulators of opioid receptors and methods of use thereof
EP3319444B1 (en) 2015-07-09 2022-03-09 The Regents of the University of California Mu opioid receptor modulators
WO2017023894A1 (en) * 2015-08-03 2017-02-09 Raze Therapeutics, Inc. Mthfd2 inhibitors and uses thereof
JP7402857B2 (ja) 2018-04-04 2023-12-21 エピオダイン，インク． オピオイド受容体モジュレーター、およびそれに関連する生成物ならびに方法
WO2020120606A1 (en) * 2018-12-12 2020-06-18 Esteve Pharmaceuticals, S.A. New pyrrolidine-2-carboxylic acid derivatives for treating pain and pain related conditions
TW202026281A (zh) * 2018-12-12 2020-07-16 西班牙商艾斯提夫製藥股份有限公司 用於治療疼痛和疼痛相關病症之新吡咯啶–2– 甲酸衍生物
MX2022007994A (es) 2019-12-26 2022-09-23 Gilgamesh Pharmaceuticals Inc Derivados de arilciclohexilamina y su uso en el tratamiento de trastornos psiquiátricos.
EP4084791A1 (en) 2020-02-18 2022-11-09 Gilgamesh Pharmaceuticals, Inc. Specific tryptamines for use in the treatment of mood disorders
TW202304869A (zh) 2021-04-05 2023-02-01 美商艾碧奧戴股份有限公司 類鴉片受體調節劑

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US4113866A (en) * 1977-04-01 1978-09-12 The Upjohn Company Analgetic compounds, compositions and process of treatment
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GB0012240D0 (en) * 2000-05-19 2000-07-12 Merck Sharp & Dohme Therapeutic agents
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DE10252665A1 (de) * 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate

Also Published As

Publication number Publication date
PT1560823E (pt) 2008-09-25
WO2004043949A1 (de) 2004-05-27
DE50310122D1 (de) 2008-08-21
DK1560823T3 (da) 2008-11-10
CY1108378T1 (el) 2014-02-12
EP1560823A1 (de) 2005-08-10
AU2003287993A1 (en) 2004-06-03
US7759385B2 (en) 2010-07-20
DE10252666A1 (de) 2004-08-05
ES2309373T3 (es) 2008-12-16
EP1560823B1 (de) 2008-07-09
AR041941A1 (es) 2005-06-01
US20050277674A1 (en) 2005-12-15
SI1560823T1 (sl) 2008-12-31
ATE400569T1 (de) 2008-07-15

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