MX2022007994A - Derivados de arilciclohexilamina y su uso en el tratamiento de trastornos psiquiátricos. - Google Patents
Derivados de arilciclohexilamina y su uso en el tratamiento de trastornos psiquiátricos.Info
- Publication number
- MX2022007994A MX2022007994A MX2022007994A MX2022007994A MX2022007994A MX 2022007994 A MX2022007994 A MX 2022007994A MX 2022007994 A MX2022007994 A MX 2022007994A MX 2022007994 A MX2022007994 A MX 2022007994A MX 2022007994 A MX2022007994 A MX 2022007994A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- psychiatric disorders
- arylcyclohexylamine
- derivatives
- arylcyclohexylamine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
En la presente se proporcionan derivados de arilciclohexilamina y su uso en el tratamiento de trastornos psiquiátricos.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962953611P | 2019-12-26 | 2019-12-26 | |
US202063037044P | 2020-06-10 | 2020-06-10 | |
US202063093830P | 2020-10-20 | 2020-10-20 | |
PCT/US2020/067235 WO2021134086A1 (en) | 2019-12-26 | 2020-12-28 | Arylcyclohexylamine derivatives and their use in the treatment of psychiatric disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022007994A true MX2022007994A (es) | 2022-09-23 |
Family
ID=74195194
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022007994A MX2022007994A (es) | 2019-12-26 | 2020-12-28 | Derivados de arilciclohexilamina y su uso en el tratamiento de trastornos psiquiátricos. |
Country Status (10)
Country | Link |
---|---|
US (2) | US11344510B2 (es) |
EP (1) | EP4081301A1 (es) |
JP (1) | JP2023508469A (es) |
KR (1) | KR20220131520A (es) |
CN (1) | CN115190815A (es) |
AU (1) | AU2020415511A1 (es) |
CA (1) | CA3165903A1 (es) |
IL (1) | IL294202A (es) |
MX (1) | MX2022007994A (es) |
WO (1) | WO2021134086A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11426367B2 (en) | 2018-05-04 | 2022-08-30 | Perception Neuroscience, Inc. | Methods of treating substance abuse |
MX2022007994A (es) | 2019-12-26 | 2022-09-23 | Gilgamesh Pharmaceuticals Inc | Derivados de arilciclohexilamina y su uso en el tratamiento de trastornos psiquiátricos. |
EP4084791A1 (en) | 2020-02-18 | 2022-11-09 | Gilgamesh Pharmaceuticals, Inc. | Specific tryptamines for use in the treatment of mood disorders |
WO2022248621A1 (en) | 2021-05-25 | 2022-12-01 | Awakn Ls Europe Holdings Limited | Ketamine the treatment of behavioural addictions |
EP4358946A1 (en) * | 2021-06-25 | 2024-05-01 | Gilgamesh Pharmaceuticals, Inc. | Arylcyclohexylamine derivatives and their use in the treatment of psychiatric disorders |
WO2023067505A1 (en) * | 2021-10-18 | 2023-04-27 | Clearmind Medicine Inc. | 2-fluorodeschloroketamine for treatment of depression, including treatment-resistant depression |
WO2023154450A2 (en) * | 2022-02-11 | 2023-08-17 | Gilgamesh Pharmaceuticals, Inc. | (ampa-pam)-nmda receptor antagonist combination therapy for treatment of mental conditions and disorders |
CN115677444A (zh) * | 2022-10-26 | 2023-02-03 | 公安部第三研究所 | 同位素毒品代谢物标记化合物及其制备方法、用途 |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB853775A (en) | 1957-09-19 | 1960-11-09 | Parke Davis & Co | Pharmaceutical compositions and methods for producing phenylcyclohexane compounds |
DE1668550A1 (de) * | 1967-09-19 | 1971-07-22 | Parke Davis & Co | 2-Alkoxyalkylamino-2-phenylcyclohexanonverbindungen und ihre Saeure-Additionssalze und Verfahren zu ihrer Herstellung |
CA1105938A (en) | 1976-06-03 | 1981-07-28 | Daniel Lednicer | 4-amino-4-arylcyclohexanone ketals |
CA1100516A (en) | 1976-06-03 | 1981-05-05 | Daniel Lednicer | 4-amino-4-arylcyclohexanones and their ketals |
US4065573A (en) | 1976-06-03 | 1977-12-27 | The Upjohn Company | 4-Amino-4-phenylcyclohexanone ketal compositions and process of use |
JP4455992B2 (ja) | 2002-06-21 | 2010-04-21 | スベン ライフ サイエンシズ リミティド | 治療薬剤として有用なセロトニン受容体親和性を有するアリールアルキル・インドール、その製造方法、並びにそれらを含む医薬組成物 |
DK1523486T3 (da) | 2002-06-21 | 2008-03-03 | Suven Life Sciences Ltd | Tetracykliske arylsulfonylindoler med serotoninreceptor-affinitet |
CN1665815A (zh) | 2002-06-21 | 2005-09-07 | 苏文生命科学有限公司 | 具有5-羟色胺受体亲和性、可用作治疗剂的新颖的四环芳基碳酰吲哚、制备工艺及包含它们的药物组合物 |
DE10252667A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE10252666A1 (de) | 2002-11-11 | 2004-08-05 | Grünenthal GmbH | N-Piperidyl-cyclohexan-Derivate |
DE10360793A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
CA2618888A1 (en) | 2005-08-10 | 2007-02-15 | Bayer Schering Pharma Aktiengesellschaft | Acyltryptophanols for fertility control |
EP1956016A1 (en) | 2006-12-15 | 2008-08-13 | Bayer Schering Pharma Aktiengesellschaft | Bicyclic acyltryptophanols |
WO2008071455A1 (en) | 2006-12-15 | 2008-06-19 | Bayer Schering Pharma Aktiengesellschaft | Bicyclic acyltryptophanols |
SI2271613T1 (sl) | 2008-03-27 | 2014-08-29 | Grunenthal Gmbh | Hidroksimetilcikloheksilamini |
EP2385944A4 (en) | 2009-01-09 | 2013-06-19 | Harvard College | FLUORINATED COMPOUNDS AND METHODS OF USE |
JP2012528120A (ja) | 2009-05-27 | 2012-11-12 | ユニヴェルシテ リブル ドゥ ブリュッセル | ミエロペルオキシダーゼ阻害3−アルキル−5−フルオロインドール誘導体 |
TWI582092B (zh) | 2010-07-28 | 2017-05-11 | 歌林達股份有限公司 | 順式-四氫-螺旋(環己烷-1,1’-吡啶[3,4-b]吲哚)-4-胺-衍生物 |
CN104276993B (zh) | 2013-07-12 | 2019-03-15 | 广东东阳光药业有限公司 | 吲哚衍生物及其在药物上的应用 |
US20180021326A1 (en) | 2016-07-23 | 2018-01-25 | Paul Edward Stamets | Compositions and methods for enhancing neuroregeneration and cognition by combining mushroom extracts containing active ingredients psilocin or psilocybin with erinacines or hericenones enhanced with niacin |
EP3519816A4 (en) | 2016-09-29 | 2020-05-06 | The Regents of the University of California | CONNECTIONS FOR INCREASING NEURONAL PLASTICITY |
WO2018148605A1 (en) | 2017-02-09 | 2018-08-16 | CaaMTech, LLC | Compositions and methods comprising a psilocybin derivative |
GB201808150D0 (en) | 2018-05-18 | 2018-07-11 | Small Pharma Ltd | Therapeutic compounds |
GB201716942D0 (en) | 2017-10-16 | 2017-11-29 | Small Pharma Ltd | Therapeutic compounds |
WO2019081764A1 (en) | 2017-10-26 | 2019-05-02 | Consejo Superior De Investigaciones Científicas (Csic) | ASSOCIATION PRODUCT FOR THE TREATMENT OF NEUROLOGICAL AND / OR PSYCHIATRIC DISORDERS |
EP3505509A1 (en) | 2017-12-29 | 2019-07-03 | Université de Liège | Methods for the preparation of arylcycloalkylamine derivatives |
JPWO2019160057A1 (ja) | 2018-02-15 | 2021-02-04 | 国立大学法人千葉大学 | 炎症性疾患若しくは骨疾患の予防又は治療剤及び医薬組成物 |
CN110343050B (zh) * | 2018-04-04 | 2021-09-24 | 上海键合医药科技有限公司 | 芳香类化合物及其制备方法和用途 |
KR102104953B1 (ko) * | 2018-04-17 | 2020-04-27 | 삼육대학교 산학협력단 | 신규 케타민 유도체 및 이의 우울증의 예방 또는 치료 용도 |
TW202026281A (zh) | 2018-12-12 | 2020-07-16 | 西班牙商艾斯提夫製藥股份有限公司 | 用於治療疼痛和疼痛相關病症之新吡咯啶–2– 甲酸衍生物 |
KR20210141968A (ko) | 2019-03-07 | 2021-11-23 | 아보멘티스 엘엘씨 | 비-환각/정신병유사 투여량 및 제형으로 투여되는 신경 가소성 작용을 갖는 물질을 포함하는 조성물 및 사용 방법 |
MX2022007994A (es) | 2019-12-26 | 2022-09-23 | Gilgamesh Pharmaceuticals Inc | Derivados de arilciclohexilamina y su uso en el tratamiento de trastornos psiquiátricos. |
CN112174851A (zh) | 2020-11-09 | 2021-01-05 | 广州万孚生物技术股份有限公司 | 一种氟胺酮半抗原、氟胺酮抗原及其制备方法和应用 |
CN113234036B (zh) | 2021-05-12 | 2023-07-14 | 斯莱普泰(上海)生物医药科技有限公司 | Nmda受体拮抗剂及其用途 |
-
2020
- 2020-12-28 MX MX2022007994A patent/MX2022007994A/es unknown
- 2020-12-28 CA CA3165903A patent/CA3165903A1/en active Pending
- 2020-12-28 CN CN202080097657.8A patent/CN115190815A/zh active Pending
- 2020-12-28 AU AU2020415511A patent/AU2020415511A1/en active Pending
- 2020-12-28 JP JP2022539383A patent/JP2023508469A/ja active Pending
- 2020-12-28 IL IL294202A patent/IL294202A/en unknown
- 2020-12-28 KR KR1020227025076A patent/KR20220131520A/ko unknown
- 2020-12-28 WO PCT/US2020/067235 patent/WO2021134086A1/en unknown
- 2020-12-28 EP EP20845344.9A patent/EP4081301A1/en active Pending
-
2021
- 2021-10-25 US US17/510,108 patent/US11344510B2/en active Active
-
2022
- 2022-04-06 US US17/714,879 patent/US20220409555A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
IL294202A (en) | 2022-08-01 |
JP2023508469A (ja) | 2023-03-02 |
AU2020415511A1 (en) | 2022-07-14 |
US20220041540A1 (en) | 2022-02-10 |
US11344510B2 (en) | 2022-05-31 |
US20220409555A1 (en) | 2022-12-29 |
WO2021134086A1 (en) | 2021-07-01 |
EP4081301A1 (en) | 2022-11-02 |
CA3165903A1 (en) | 2021-07-01 |
KR20220131520A (ko) | 2022-09-28 |
CN115190815A (zh) | 2022-10-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2022007994A (es) | Derivados de arilciclohexilamina y su uso en el tratamiento de trastornos psiquiátricos. | |
PH12019501575A1 (en) | ISOFORM-SPECIFIC, CONTEXT-PERMISSIVE TGFá1 INHIBITORS AND USE THEREOF | |
MX2021013661A (es) | Inhibidores de la autofagia de fenilaminopirimidina amida y metodos de uso de estos. | |
MX2021013662A (es) | Inhibidores de la autofagia de heteroarilaminopirimidina amida y metodos de uso de estos. | |
CA193736S (en) | Skin massager | |
AU2018263868A1 (en) | Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies | |
AU201715676S (en) | Massage Tool | |
AU201715675S (en) | Massage Tool Sleeve | |
PH12017501780A1 (en) | Maytansinoid derivatives, conjugates thereof, and methods of use | |
AU201715674S (en) | Massage Tool Sleeve | |
MX2020001406A (es) | Mavacamten para su uso en el tratamiento de la cardiomiopatia hipertrofica. | |
MX2018013663A (es) | Metodos para tratar trastornos de sueño de ritmo circadiano. | |
MX2021015628A (es) | Inhibidores de la autofagia de la amida aminopirimidina y sus metodos de uso. | |
MX2020004666A (es) | Compuestos de pilocarpina con ácido lipoico para el tratamiento de trastornos oculares. | |
MX2020008680A (es) | Terapia de combinacion con apilimod y agentes glutamatergicos. | |
MX2018008645A (es) | Derivados de 8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano. | |
AU201815816S (en) | Inhaler | |
EP3976182A4 (en) | MODULATION OF THE EFFECTS OF GAMMA CYTOKINE SIGNALING FOR THE TREATMENT OF ALOPECIA AND ALOPECIA-ASSOCIATED DISORDERS | |
PH12020551573A1 (en) | Pharmaceutical compositions for inhibiting inflammatory cytokines | |
MX2018008643A (es) | Derivados de 3-((hetero)aril)-8-amino-2-oxo-1,3-diaza-espiro-[4.5] -decano. | |
EP3702470A3 (en) | Reduction of er-mam-localized app-c99 and methods of treating alzheimer's disease | |
MX2021016050A (es) | Formulaciones transdermicas. | |
EA201991488A1 (ru) | Модуляторы калиевых каналов | |
MX2020012964A (es) | Metodos para el tratamiento de cancer de vejiga. | |
MX2019010060A (es) | Composiciones y metodo para tratar cancer. |