MX2018008645A - Derivados de 8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano. - Google Patents
Derivados de 8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano.Info
- Publication number
- MX2018008645A MX2018008645A MX2018008645A MX2018008645A MX2018008645A MX 2018008645 A MX2018008645 A MX 2018008645A MX 2018008645 A MX2018008645 A MX 2018008645A MX 2018008645 A MX2018008645 A MX 2018008645A MX 2018008645 A MX2018008645 A MX 2018008645A
- Authority
- MX
- Mexico
- Prior art keywords
- diaza
- spiro
- oxo
- amino
- decane derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
La invención se refiere a derivados de 8-amino-2-oxo-1,3-diaza-esp iro-[4.5]-decano, su preparación y su uso en medicamentos, en particular en el tratamiento del dolor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16151015 | 2016-01-13 | ||
PCT/EP2017/025008 WO2017121650A1 (en) | 2016-01-13 | 2017-01-13 | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018008645A true MX2018008645A (es) | 2018-11-19 |
Family
ID=55129636
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018008645A MX2018008645A (es) | 2016-01-13 | 2017-01-13 | Derivados de 8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano. |
Country Status (26)
Country | Link |
---|---|
US (7) | US20170197949A1 (es) |
EP (1) | EP3402782B1 (es) |
JP (1) | JP6917379B2 (es) |
KR (1) | KR20180097734A (es) |
CN (1) | CN108602778B (es) |
AR (1) | AR107359A1 (es) |
AU (1) | AU2017206911B2 (es) |
BR (1) | BR112018014301B1 (es) |
CA (1) | CA3011182A1 (es) |
CL (1) | CL2018001909A1 (es) |
CO (1) | CO2018008450A2 (es) |
CY (1) | CY1123366T1 (es) |
DK (1) | DK3402782T3 (es) |
EA (1) | EA034898B1 (es) |
EC (1) | ECSP18060875A (es) |
ES (1) | ES2821969T3 (es) |
HR (1) | HRP20201660T1 (es) |
HU (1) | HUE051642T2 (es) |
IL (1) | IL260488B (es) |
LT (1) | LT3402782T (es) |
MX (1) | MX2018008645A (es) |
PT (1) | PT3402782T (es) |
RS (1) | RS60855B1 (es) |
SI (1) | SI3402782T1 (es) |
TW (1) | TWI654181B (es) |
WO (1) | WO2017121650A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2018008646A (es) | 2016-01-13 | 2018-11-19 | Gruenenthal Gmbh | Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5] -decano. |
DK3402782T3 (da) | 2016-01-13 | 2020-09-28 | Gruenenthal Gmbh | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decanderivater |
AR107434A1 (es) | 2016-01-13 | 2018-05-02 | Gruenenthal Gmbh | Derivados de 3-((hetero)aril)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano |
CA3011175C (en) | 2016-01-13 | 2023-08-29 | Grunenthal Gmbh | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
JP6893517B2 (ja) | 2016-01-13 | 2021-06-23 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 3−((ヘテロ−)アリール)−アルキル−8−アミノ−2−オキソ−1,3−ジアザ−スピロ−[4.5]−デカン誘導体 |
WO2019039852A1 (ko) | 2017-08-22 | 2019-02-28 | 주식회사 엘지화학 | 방열 소재 디스펜싱 장치의 결정방법 |
CN110092790B (zh) * | 2019-06-11 | 2020-07-24 | 东北农业大学 | 一种生物碱类化合物及其制备方法和应用 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2734265B1 (fr) | 1995-05-17 | 1997-06-13 | Adir | Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant |
CN100441182C (zh) | 2001-04-18 | 2008-12-10 | 欧罗赛铁克股份有限公司 | 伤害感受肽化合物 |
DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
DE10135636A1 (de) * | 2001-07-17 | 2003-02-06 | Gruenenthal Gmbh | Substituierte 4-Aminocyclohexanole |
DE10210195B4 (de) | 2002-03-07 | 2005-12-15 | Schwarz Pharma Ag | Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz |
KR101052287B1 (ko) | 2002-07-05 | 2011-07-27 | 타가셉트 인코포레이티드 | N-아릴 디아자스피로시클릭 화합물, 그 제조방법, 및 그용도 |
DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
NZ544282A (en) | 2003-05-23 | 2009-07-31 | Zealand Pharma As | Triaza-spiro compounds as nociceptin analogues and uses thereof |
JO2676B1 (en) | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
DE102005044813A1 (de) | 2005-05-19 | 2007-10-04 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
DE102005023784A1 (de) | 2005-05-19 | 2006-11-30 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
DE102005030051A1 (de) | 2005-06-27 | 2006-12-28 | Grünenthal GmbH | Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
DE102006019597A1 (de) | 2006-04-27 | 2007-10-31 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
RU2439062C2 (ru) | 2006-10-19 | 2012-01-10 | Ф.Хоффманн-Ля Рош Аг | Производные имидазолона и имидазолидинона как 11в-hsd1 ингибиторы при диабете |
MX2009011006A (es) | 2007-04-09 | 2009-11-02 | Janssen Pharmaceutica Nv | Derivados de 1,3,8-trisustituido-1,3,8-triaza-espiro[4.5]decano-4- ona como ligandos del receptor de orl-1 para el tratamiento de ansiedad y depresion. |
EP2518052B1 (de) | 2008-03-27 | 2017-12-20 | Grünenthal GmbH | Substituierte 4-Aminocyclohexan-Derivate |
TW201038572A (en) | 2009-03-25 | 2010-11-01 | Gruenenthal Gmbh | Substituted spiro-amide compounds |
US8268853B2 (en) | 2009-06-25 | 2012-09-18 | Abbott Laboratories | 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof |
TWI582092B (zh) | 2010-07-28 | 2017-05-11 | 歌林達股份有限公司 | 順式-四氫-螺旋(環己烷-1,1’-吡啶[3,4-b]吲哚)-4-胺-衍生物 |
JP6359560B2 (ja) * | 2012-12-31 | 2018-07-18 | サノビオン ファーマシューティカルズ インクSunovion Pharmaceuticals Inc. | 複素環式化合物及びその使用方法 |
ES2850999T3 (es) * | 2014-03-14 | 2021-09-02 | Raqualia Pharma Inc | Derivados de azaespiro como antagonistas de TRPM8 |
MA40170A (fr) | 2014-06-13 | 2017-04-19 | Purdue Pharma Lp | Dérivés hétérocycliques de morphinan et leur utilisation |
CA3011175C (en) | 2016-01-13 | 2023-08-29 | Grunenthal Gmbh | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
AR107434A1 (es) | 2016-01-13 | 2018-05-02 | Gruenenthal Gmbh | Derivados de 3-((hetero)aril)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano |
DK3402782T3 (da) | 2016-01-13 | 2020-09-28 | Gruenenthal Gmbh | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decanderivater |
JP6893517B2 (ja) | 2016-01-13 | 2021-06-23 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 3−((ヘテロ−)アリール)−アルキル−8−アミノ−2−オキソ−1,3−ジアザ−スピロ−[4.5]−デカン誘導体 |
TWI730032B (zh) | 2016-01-13 | 2021-06-11 | 美商必治妥美雅史谷比公司 | 作為rock抑制劑之螺庚烷水楊酸醯胺及相關化合物 |
MX2018008646A (es) | 2016-01-13 | 2018-11-19 | Gruenenthal Gmbh | Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5] -decano. |
MY195199A (en) | 2016-01-13 | 2023-01-11 | Novo Nordisk As | EGF(A) Analogues with Fatty Acid Substituents |
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2017
- 2017-01-13 DK DK17700390.2T patent/DK3402782T3/da active
- 2017-01-13 RS RS20201155A patent/RS60855B1/sr unknown
- 2017-01-13 US US15/405,627 patent/US20170197949A1/en not_active Abandoned
- 2017-01-13 KR KR1020187021559A patent/KR20180097734A/ko not_active Application Discontinuation
- 2017-01-13 AR ARP170100094A patent/AR107359A1/es unknown
- 2017-01-13 TW TW106101127A patent/TWI654181B/zh active
- 2017-01-13 CO CONC2018/0008450A patent/CO2018008450A2/es unknown
- 2017-01-13 CN CN201780006515.4A patent/CN108602778B/zh active Active
- 2017-01-13 EP EP17700390.2A patent/EP3402782B1/en active Active
- 2017-01-13 AU AU2017206911A patent/AU2017206911B2/en active Active
- 2017-01-13 BR BR112018014301-4A patent/BR112018014301B1/pt active IP Right Grant
- 2017-01-13 EA EA201891608A patent/EA034898B1/ru not_active IP Right Cessation
- 2017-01-13 ES ES17700390T patent/ES2821969T3/es active Active
- 2017-01-13 PT PT177003902T patent/PT3402782T/pt unknown
- 2017-01-13 WO PCT/EP2017/025008 patent/WO2017121650A1/en active Application Filing
- 2017-01-13 LT LTEP17700390.2T patent/LT3402782T/lt unknown
- 2017-01-13 SI SI201730473T patent/SI3402782T1/sl unknown
- 2017-01-13 CA CA3011182A patent/CA3011182A1/en active Pending
- 2017-01-13 JP JP2018536384A patent/JP6917379B2/ja active Active
- 2017-01-13 MX MX2018008645A patent/MX2018008645A/es unknown
- 2017-01-13 HU HUE17700390A patent/HUE051642T2/hu unknown
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2018
- 2018-05-21 US US15/984,995 patent/US20180273516A1/en not_active Abandoned
- 2018-07-09 IL IL260488A patent/IL260488B/en unknown
- 2018-07-13 CL CL2018001909A patent/CL2018001909A1/es unknown
- 2018-08-13 EC ECSENADI201860875A patent/ECSP18060875A/es unknown
- 2018-12-03 US US16/207,916 patent/US20190100515A1/en not_active Abandoned
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2019
- 2019-06-24 US US16/450,259 patent/US10793556B2/en active Active
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2020
- 2020-08-31 US US17/007,150 patent/US20200399255A1/en not_active Abandoned
- 2020-09-28 CY CY20201100913T patent/CY1123366T1/el unknown
- 2020-10-14 HR HRP20201660TT patent/HRP20201660T1/hr unknown
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2021
- 2021-03-01 US US17/188,706 patent/US20210179595A1/en not_active Abandoned
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2023
- 2023-01-30 US US18/103,371 patent/US20230183222A1/en active Pending
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