MX2009011006A - Derivados de 1,3,8-trisustituido-1,3,8-triaza-espiro[4.5]decano-4- ona como ligandos del receptor de orl-1 para el tratamiento de ansiedad y depresion. - Google Patents
Derivados de 1,3,8-trisustituido-1,3,8-triaza-espiro[4.5]decano-4- ona como ligandos del receptor de orl-1 para el tratamiento de ansiedad y depresion.Info
- Publication number
- MX2009011006A MX2009011006A MX2009011006A MX2009011006A MX2009011006A MX 2009011006 A MX2009011006 A MX 2009011006A MX 2009011006 A MX2009011006 A MX 2009011006A MX 2009011006 A MX2009011006 A MX 2009011006A MX 2009011006 A MX2009011006 A MX 2009011006A
- Authority
- MX
- Mexico
- Prior art keywords
- triaza
- orl
- decan
- trisubstituted
- spiro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención está dirigida a nuevos derivados de 1,3,8-trisustituido-1,3,8-triaza-espiro[4.5]decan-4-ona, composiciones farmacéuticas que las contienen y su uso en el tratamiento de trastornos y condiciones, mediado por el receptor de ORL-1 acoplado con proteína G.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91067807P | 2007-04-09 | 2007-04-09 | |
PCT/US2008/053901 WO2008124209A1 (en) | 2007-04-09 | 2008-02-14 | 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009011006A true MX2009011006A (es) | 2009-11-02 |
Family
ID=39580070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009011006A MX2009011006A (es) | 2007-04-09 | 2008-02-14 | Derivados de 1,3,8-trisustituido-1,3,8-triaza-espiro[4.5]decano-4- ona como ligandos del receptor de orl-1 para el tratamiento de ansiedad y depresion. |
Country Status (7)
Country | Link |
---|---|
US (1) | US8741916B2 (es) |
EP (1) | EP2150552B1 (es) |
JP (1) | JP5490677B2 (es) |
CN (1) | CN101679430B (es) |
CA (1) | CA2683598C (es) |
MX (1) | MX2009011006A (es) |
WO (1) | WO2008124209A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA05002622A (es) | 2002-09-09 | 2005-09-08 | Johnson & Johnson | Derivados de 1,3,8,-triazaespiro [4.5]decan-4-ona sustituidos con hidroxialquilo utiles para el tratamiento de desordenes mediados por el receptor opioide huerfano. |
CA2670858C (en) | 2006-11-28 | 2015-01-13 | Janssen Pharmaceutica N.V. | Salts of 3-(3-amino-2-(r)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one |
US8741916B2 (en) | 2007-04-09 | 2014-06-03 | Janssen Pharmaceutica Nv | 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the ORL-1 receptor |
EP2242745A1 (de) * | 2008-02-07 | 2010-10-27 | Sanofi-Aventis | Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2010037081A1 (en) * | 2008-09-29 | 2010-04-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific spiro-piperidine compounds |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
CN108883103A (zh) * | 2015-12-02 | 2018-11-23 | 阿斯特来亚治疗有限责任公司 | 哌啶基痛敏肽受体化合物 |
US10112924B2 (en) | 2015-12-02 | 2018-10-30 | Astraea Therapeutics, Inc. | Piperdinyl nociceptin receptor compounds |
TWI635082B (zh) | 2016-01-13 | 2018-09-11 | 歌林達有限公司 | 3-((雜-)芳基)-8-胺基-2-側氧-1,3-二氮雜-螺-[4.5]-癸烷衍生物 |
AU2017207467B2 (en) | 2016-01-13 | 2020-07-16 | Grünenthal GmbH | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
AU2017206909B2 (en) | 2016-01-13 | 2020-07-09 | Grünenthal GmbH | 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
TWI654181B (zh) | 2016-01-13 | 2019-03-21 | 歌林達有限公司 | 8-胺基-2-側氧基-1,3-二氮-螺-[4.5]-癸烷衍生物 |
HUE049134T2 (hu) | 2016-01-13 | 2020-08-28 | Gruenenthal Gmbh | 3-(karboximetil)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-dekán származékok |
Family Cites Families (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3155699A (en) * | 1960-03-30 | 1964-11-03 | Mobay Chemical Corp | Purification of isocyanates by reduction of the hydrolyzable chlorine and acid content |
US3161644A (en) * | 1962-06-22 | 1964-12-15 | Res Lab Dr C Janssen N V | 1-benzyl-4-substituted piperidines |
US3155670A (en) * | 1962-06-22 | 1964-11-03 | Res Lab Dr C Janssen N V | 1-oxo-2, 4, 8, triaza-spiro (4, 5) decanes |
US3238216A (en) * | 1963-06-20 | 1966-03-01 | Res Lab Dr C Janssen N V | Substituted 1, 3, 8-triaza-spiro (4, 5) decanes |
US3839340A (en) * | 1968-09-27 | 1974-10-01 | Fmc Corp | Substituted 1,3,8-triazaspiro{8 4.5{9 decanes |
US3629267A (en) * | 1968-10-28 | 1971-12-21 | Smith Kline French Lab | Benzoheterocyclicalkyl derivatives of 4-(2-keto -1-benzimidazolinyl)-piperidine 4-(2-keto - 1 - benzimidazolinyl) -1 2 3 6 tetrahydropyridine 1 - phenyl - 1 3 8-triazaspiro(4 5)decan - 4 - one and 2 4 9-triazaspiro(5 5)undecan-1 3 5-trione |
US3859340A (en) * | 1970-09-09 | 1975-01-07 | Squibb & Sons Inc | ' -methylfluorene-2-acetic acid |
US4020072A (en) * | 1976-05-04 | 1977-04-26 | E. R. Squibb & Sons, Inc. | 5-Aminomethyl-1H-pyrazolo[3,4-b]pyridines |
JPS54109983A (en) * | 1978-02-13 | 1979-08-29 | Sumitomo Chem Co Ltd | Novel spiroamine derivative and its preparation |
US4526896A (en) * | 1978-12-26 | 1985-07-02 | Riker Laboratories, Inc. | Tetrazol-5-yl 2-nitro-3-phenylbenzofurans and antimicrobial use thereof |
US4329353A (en) * | 1980-10-22 | 1982-05-11 | Janssen Pharmaceutica, N.V. | 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof |
JPS57212180A (en) * | 1981-06-19 | 1982-12-27 | Yoshitomi Pharmaceut Ind Ltd | Tetrahydrofuran(thiophene) compound |
WO1988000190A1 (en) | 1986-06-25 | 1988-01-14 | Massachusetts Institute Of Technology | Optically active derivatives of glycidol |
IL96507A0 (en) | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
US5486362A (en) * | 1991-05-07 | 1996-01-23 | Dynagen, Inc. | Controlled, sustained release delivery system for treating drug dependency |
DE4135473A1 (de) * | 1991-10-28 | 1993-04-29 | Bayer Ag | Triazaspirodecanon-methylchromane |
WO1993012789A1 (en) | 1991-12-27 | 1993-07-08 | Beth Israel Hospital | Use of spiperone or spiperone derivatives as immunosuppressant agents |
FR2708606B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
IL106692A (en) * | 1993-08-13 | 1997-04-15 | Israel Atomic Energy Comm | AZIDOALKYL DERIVATIVES AND THEIR USE FOR THE PREPARATION OF 99mTc COMPLEXES FOR IMAGING |
JPH11500100A (ja) | 1993-09-09 | 1999-01-06 | サイオス ノバ インコーポレイテッド | 偽ペプチドおよび非ペプチドブラジキニンレセプターアンタゴニスト |
US5739336A (en) * | 1995-06-23 | 1998-04-14 | Syntex (U.S.A.) Inc. | 1,3,8-triaza- and 3,8-diaza-1-oxaspiro 4,5! decane derivatives |
US5821219A (en) | 1995-08-11 | 1998-10-13 | Oregon Health Sciences University | Opioid antagonists and methods of their use |
NZ500927A (en) | 1996-03-29 | 2004-11-26 | Pfizer | 6-Phenylpyridyl-2-amine derivatives |
CA2226058C (en) * | 1997-01-30 | 2008-01-29 | F. Hoffmann-La Roche Ag | 8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives |
US6013652A (en) * | 1997-12-04 | 2000-01-11 | Merck & Co., Inc. | Spiro-substituted azacycles as neurokinin antagonists |
ATE212635T1 (de) * | 1997-12-05 | 2002-02-15 | 1,3,8-triazaspiro(4,5)decan-4-on-derivate | |
EP0921125B1 (en) | 1997-12-05 | 2002-01-30 | F. Hoffmann-La Roche Ag | 1,3,8-Triazaspiro[4,5]decan-4-on derivatives |
US6277991B1 (en) * | 1998-05-18 | 2001-08-21 | Novo Nordisk A/S | 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes |
AU3809999A (en) | 1998-05-18 | 1999-12-06 | Novo Nordisk A/S | Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes |
DK0970957T3 (da) * | 1998-06-12 | 2001-12-03 | Hoffmann La Roche | Diaza-spiro[3.5]nonan-derivativer |
WO1999065494A1 (en) * | 1998-06-15 | 1999-12-23 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
US6262066B1 (en) | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
ID29137A (id) | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
US6326379B1 (en) | 1998-09-16 | 2001-12-04 | Bristol-Myers Squibb Co. | Fused pyridine inhibitors of cGMP phosphodiesterase |
DE69923744T2 (de) | 1998-10-23 | 2006-02-23 | Pfizer Inc. | 1,3,8-Triazaspiro[4,5] decanon Verbindungen als orl1-receptor Agonisten |
HUP0104959A3 (en) | 1998-11-20 | 2003-01-28 | Glaxosmithkline Lab | Quinoline-4-carboxamide derivatives their preparation, their use as nk-3 and nk-2 receptor antagonists and medicaments containing them |
JP2000169476A (ja) | 1998-12-09 | 2000-06-20 | Banyu Pharmaceut Co Ltd | 4−オキソイミダゾリジン−5−スピロ−含窒素複素環式化合物 |
WO2001036418A1 (en) | 1999-11-17 | 2001-05-25 | Novo Nordisk A/S | Novel triazaspirodecanones with high affinity for opioid receptor subtypes |
DE19956598A1 (de) | 1999-11-25 | 2001-06-13 | Bosch Gmbh Robert | Ventil zum Steuern von Flüssigkeiten |
EP1537110B1 (en) | 1999-12-06 | 2007-01-17 | Euro-Celtique, S.A. | Triazospiro compounds having nociceptin receptor affinity |
JP2005231995A (ja) | 1999-12-22 | 2005-09-02 | Meiji Seika Kaisha Ltd | オピオイドδ受容体アゴニスト/アンタゴニストとして有用なスピロ化合物 |
GB0003224D0 (en) * | 2000-02-11 | 2000-04-05 | Glaxo Group Ltd | Chemical compounds |
US6482829B2 (en) * | 2000-06-08 | 2002-11-19 | Hoffmann-La Roche Inc. | Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor |
AU2001262729A1 (en) | 2000-06-14 | 2001-12-24 | Banyu Pharmaceutical Co., Ltd | 4-oxoimidazolidine-2-spiro-nitrogenous heterocycle compounds |
EP1392687B1 (en) | 2001-04-10 | 2017-02-01 | Janssen Pharmaceuticals, Inc. | 1,3,8-triazaspiro[4,5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders |
EP1385515B1 (en) | 2001-04-18 | 2008-08-06 | Euro-Celtique S.A. | Spiropyrazole compounds |
US20030078278A1 (en) * | 2001-06-26 | 2003-04-24 | Pfizer Inc. | Spiropiperidine compounds as ligands for ORL-1 receptor |
DE60226874D1 (de) | 2001-07-23 | 2008-07-10 | Banyu Pharma Co Ltd | 4-oxoimidazolidin-2-spiro piperidin derivat |
US20040014955A1 (en) * | 2001-12-17 | 2004-01-22 | Carlos Zamudio | Identification of essential genes of cryptococcus neoformans and methods of use |
JP2005519921A (ja) * | 2002-01-28 | 2005-07-07 | ファイザー株式会社 | Orl−1受容体リガンドとしてのn置換スピロピペリジン化合物 |
WO2003066889A2 (en) | 2002-02-07 | 2003-08-14 | Axys Pharmaceuticals, Inc. | Assay for acytyltransferase or deacetylase activity |
MXPA05002622A (es) * | 2002-09-09 | 2005-09-08 | Johnson & Johnson | Derivados de 1,3,8,-triazaespiro [4.5]decan-4-ona sustituidos con hidroxialquilo utiles para el tratamiento de desordenes mediados por el receptor opioide huerfano. |
WO2005016913A1 (en) | 2003-08-19 | 2005-02-24 | Pfizer Japan, Inc. | Tetrahydroisoquinoline or isochroman compounds as orl-1 receptor ligands for the treatment of pain and cns disorders |
AU2004309419A1 (en) | 2003-12-23 | 2005-07-14 | Arena Pharmaceuticals, Inc. | Novel spiroindoline or spiroisoquinoline compounds, methods of use and compositions thereof |
EP2364705A3 (en) * | 2004-08-19 | 2012-04-04 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
CA2581150A1 (en) | 2004-09-17 | 2006-03-30 | Osi Pharmaceuticals, Inc. | (spirocyclylamido) aminothiophene compounds as c-kit proto- oncogene inhibitors |
EP1890696A4 (en) * | 2005-06-02 | 2010-05-05 | Janssen Pharmaceutica Nv | Suitable as new ORL-1 receptor modulators are 3-pyrolytic indolyl derivatives |
US20080200492A1 (en) | 2006-11-28 | 2008-08-21 | Vaidya Anil H | Methods for the treatment of alcohol abuse, addiction and dependency |
US8741916B2 (en) | 2007-04-09 | 2014-06-03 | Janssen Pharmaceutica Nv | 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the ORL-1 receptor |
US20100076003A1 (en) | 2008-09-19 | 2010-03-25 | Kathleen Battista | 5-oxazolidin-2-one substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful as orl-1 receptor modulators |
-
2008
- 2008-02-14 US US12/030,911 patent/US8741916B2/en active Active
- 2008-02-14 EP EP08729809A patent/EP2150552B1/en not_active Not-in-force
- 2008-02-14 JP JP2010503099A patent/JP5490677B2/ja not_active Expired - Fee Related
- 2008-02-14 WO PCT/US2008/053901 patent/WO2008124209A1/en active Application Filing
- 2008-02-14 CN CN2008800194372A patent/CN101679430B/zh not_active Expired - Fee Related
- 2008-02-14 MX MX2009011006A patent/MX2009011006A/es active IP Right Grant
- 2008-02-14 CA CA2683598A patent/CA2683598C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2010523687A (ja) | 2010-07-15 |
CN101679430A (zh) | 2010-03-24 |
CA2683598C (en) | 2015-11-17 |
US20080249122A1 (en) | 2008-10-09 |
CN101679430B (zh) | 2013-12-25 |
WO2008124209A1 (en) | 2008-10-16 |
JP5490677B2 (ja) | 2014-05-14 |
EP2150552B1 (en) | 2013-01-02 |
CA2683598A1 (en) | 2008-10-16 |
US8741916B2 (en) | 2014-06-03 |
EP2150552A1 (en) | 2010-02-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2009011006A (es) | Derivados de 1,3,8-trisustituido-1,3,8-triaza-espiro[4.5]decano-4- ona como ligandos del receptor de orl-1 para el tratamiento de ansiedad y depresion. | |
HK1136828A1 (en) | Spirocyclic cyclohexane derivatives | |
MX2010008638A (es) | Furo-[3,2-c]piridinas y tieno[3,2-c]piridinas. | |
TW200800981A (en) | 8-azabicyclo[3.2.1]octane compounds as MU opioid receptor antagonists | |
GEP20135744B (en) | Quinuclidine carbonate derivatives and medicinal compositions containing the same | |
UA100227C2 (uk) | Заміщені n-фенілметил-5-оксопролін-2-аміди як антагоністи p2x7-рецептора та їх застосування | |
NO20064309L (no) | Azabicyklo(3.1.0)heksanderivater anvendelige som modulatorer for dopamin D3 receptorer | |
MX2009013321A (es) | Derivados de espiro[piperidin-4,4'-tieno[3,2-c]pirano] y compuestos relacionados como inhibidores del receptor sigma para el tratamiento de psicosis. | |
ATE502939T1 (de) | Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten | |
AU2010326429B2 (en) | Diphenyl-pyrazolopyridine derivatives, preparation thereof, and use thereof as nuclear receptor NOT modulators | |
IL174678A0 (en) | Arylindenophyridines and arylindenophyrimidines and their use as adenosine a2a receptor antagonist | |
SG171681A1 (en) | Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-ht2a serotonin receptor | |
WO2007091948A3 (en) | Novel spiro [imidazolidine-4, 3´-indole] 2, 2´,5´(1h) triones for treatment of conditions associated with vanilloid receptor 1 | |
IL195891A0 (en) | Derivatives of imidazo[1,2-a]pyridine-2-carboxamides, preparation method thereof and use od same in therapeutics | |
TW200624432A (en) | Imidazo [1,2-a] pyridine compounds, compositions, uses and methods related thereto | |
MX2009006018A (es) | Derivados de quinuclidinol como antagonistas de receptores muscarinicos. | |
UA99459C2 (en) | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer | |
ATE446089T1 (de) | 2-benzoyl-imidazopyridin-derivate, herstellungsverfahren und ihre verwendung für therapeutika | |
PT1730144E (pt) | Compostos de 1,4,8-triaza-espiro[4.5]decan-2-ona substituídos | |
WO2021188948A1 (en) | Mdm2 degraders and uses thereof | |
MX2009008323A (es) | Derivados heterociclicos como receptores muscarinicos m3. | |
MXPA05011018A (es) | Compuestos de 4-fenil piperidna y sus usos como moduladores de receptores opioides. | |
JP2023552827A (ja) | Irak分解剤およびそれらの使用 | |
WO2010033451A3 (en) | 5-oxazolidin-2-one substituted 1,3,8-triazaspiro [4.5] decan-4-one derivatives useful as orl-1 receptor modulators | |
ZA200905205B (en) | 2-piperazin-1-yl-3H-imidazo[4,5-B]pyridine derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |