IL106692A - AZIDOALKYL DERIVATIVES AND THEIR USE FOR THE PREPARATION OF 99mTc COMPLEXES FOR IMAGING - Google Patents

AZIDOALKYL DERIVATIVES AND THEIR USE FOR THE PREPARATION OF 99mTc COMPLEXES FOR IMAGING

Info

Publication number
IL106692A
IL106692A IL106692A IL10669293A IL106692A IL 106692 A IL106692 A IL 106692A IL 106692 A IL106692 A IL 106692A IL 10669293 A IL10669293 A IL 10669293A IL 106692 A IL106692 A IL 106692A
Authority
IL
Israel
Prior art keywords
99mtc
preparation
compound
imaging
azidoalkyl
Prior art date
Application number
IL106692A
Other versions
IL106692A0 (en
Inventor
Jaffe Irene
Boazi Miriam
Original Assignee
Israel Atomic Energy Comm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Israel Atomic Energy Comm filed Critical Israel Atomic Energy Comm
Priority to IL106692A priority Critical patent/IL106692A/en
Publication of IL106692A0 publication Critical patent/IL106692A0/en
Priority to AU75252/94A priority patent/AU7525294A/en
Priority to PCT/US1994/009107 priority patent/WO1995005388A1/en
Publication of IL106692A publication Critical patent/IL106692A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Compounds of the formula T-R-Y wherein T is a targeting group derived from a molecule T( which has an affinity to a specific body tissue said targeting group essentially retaining the specific affinity of said molecule; R is a branched or straight alkylene chain having 1 to 6 carbon atoms; and Y is axido -N3. They are used in a method for the preparation a 99mTc complex of a compound of the above formula useful for in vivo imaging, comprising: (a) preparing an aqueous solution of the above compound; (b) preparing a reaction mixture by adding an acid and a solution of pertechnetate of 99mTc (a salt solution of 99mTcO4s); (c) providing appropriate reaction conditions whereby said complex of 99mTc with the said compound is formed.
IL106692A 1993-08-13 1993-08-13 AZIDOALKYL DERIVATIVES AND THEIR USE FOR THE PREPARATION OF 99mTc COMPLEXES FOR IMAGING IL106692A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IL106692A IL106692A (en) 1993-08-13 1993-08-13 AZIDOALKYL DERIVATIVES AND THEIR USE FOR THE PREPARATION OF 99mTc COMPLEXES FOR IMAGING
AU75252/94A AU7525294A (en) 1993-08-13 1994-08-12 Azide derivatives suitable for preparation of 99mtc complexes for imaging and their use
PCT/US1994/009107 WO1995005388A1 (en) 1993-08-13 1994-08-12 AZIDE DERIVATIVES SUITABLE FOR PREPARATION OF 99mTc COMPLEXES FOR IMAGING AND THEIR USE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL106692A IL106692A (en) 1993-08-13 1993-08-13 AZIDOALKYL DERIVATIVES AND THEIR USE FOR THE PREPARATION OF 99mTc COMPLEXES FOR IMAGING

Publications (2)

Publication Number Publication Date
IL106692A0 IL106692A0 (en) 1993-12-08
IL106692A true IL106692A (en) 1997-04-15

Family

ID=11065160

Family Applications (1)

Application Number Title Priority Date Filing Date
IL106692A IL106692A (en) 1993-08-13 1993-08-13 AZIDOALKYL DERIVATIVES AND THEIR USE FOR THE PREPARATION OF 99mTc COMPLEXES FOR IMAGING

Country Status (3)

Country Link
AU (1) AU7525294A (en)
IL (1) IL106692A (en)
WO (1) WO1995005388A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080075661A1 (en) * 2004-10-07 2008-03-27 Koninklijke Philips Electronics, N.V. Compounds, Kits and Methods for Use in Medical Imaging
EP2026840A2 (en) * 2005-10-04 2009-02-25 Koninklijke Philips Electronics N.V. Targeted imaging and/or therapy using the [3+2]-azide-alkyne cycloaddition
CA2683598C (en) * 2007-04-09 2015-11-17 Janssen Pharmaceutica Nv 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB940488A (en) * 1961-07-21 1963-10-30 Beecham Res Lab Penicillins
US4943523A (en) * 1984-01-30 1990-07-24 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
JPS6248684A (en) * 1985-08-26 1987-03-03 Sumitomo Chem Co Ltd Novel iodobutyrophenone derivative and production thereof
JPH085882B2 (en) * 1986-12-26 1996-01-24 住友化学工業株式会社 Novel iodospiroperidol derivative and process for producing the same
US4971959A (en) * 1987-04-14 1990-11-20 Warner-Lambert Company Trisubstituted phenyl analogs having activity for congestive heart failure
US4871527A (en) * 1987-04-29 1989-10-03 The United States Of America As Represented By The United States Department Of Energy No-carrier-added [18 F]-N-fluoroalkylspiroperidols
US5008391A (en) * 1989-07-07 1991-04-16 Eli Lilly And Company Enantioselective synthesis of antifolates
US5124471A (en) * 1990-03-26 1992-06-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Bifunctional dtpa-type ligand

Also Published As

Publication number Publication date
AU7525294A (en) 1995-03-14
IL106692A0 (en) 1993-12-08
WO1995005388A1 (en) 1995-02-23

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
RH1 Patent not in force