PE20060367A1 - Compuestos 8-azoniabiciclo[3.2.1]octanos como antagonistas del receptor de acetilcolina muscarinico - Google Patents

Compuestos 8-azoniabiciclo[3.2.1]octanos como antagonistas del receptor de acetilcolina muscarinico

Info

Publication number
PE20060367A1
PE20060367A1 PE2005000591A PE2005000591A PE20060367A1 PE 20060367 A1 PE20060367 A1 PE 20060367A1 PE 2005000591 A PE2005000591 A PE 2005000591A PE 2005000591 A PE2005000591 A PE 2005000591A PE 20060367 A1 PE20060367 A1 PE 20060367A1
Authority
PE
Peru
Prior art keywords
alkyl
cyane
compounds
bromide
azoniabicycle
Prior art date
Application number
PE2005000591A
Other languages
English (en)
Inventor
Jakob Busch-Petersen
Christopher E Neipp
Michael R Palovich
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20060367A1 publication Critical patent/PE20060367A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE ALCOHOL TERCIARIO DE 8-AZONIABICICLO[3.2.1]OCTANOS, DE FORMULA (I), EN DONDE R1 Y R2 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C12), ALQUENILO(C2-C10), ALQUIL(C1-C6)CICLOALQUILO(C3-C6), ALQUIL(C1-C10)-ARILO, ALQUIL(C1-C10)-CN, ENTRE OTROS; R3 Y R4 SON INDEPENDIENTEMENTE ALQUILO(C1-C6) LINEAL O RAMIFICADO, CICLOALQUILO((C5-C6), CICLOALQUILALQUILO(C6-C10), 2-TIENILO, ARILO, HETEROERILO (C5-C6), CON HETEROETOMOS DE N U O; ENTRE OTROS; Y ES HIDROXI O CIANO; X- ES ANION ASOCIADO A UN N CON CARGA POSITIVA, TALES COMO CLORURO, BROMURO, YODURO, HIDROXI, SULFATO, ENTRE OTROS; LA CADENA LATERAL INDICADA PUEDE TENER ORIENTACION ENDO O EXO, PREFERENTEMENTE ENDO. SON PREFERIDOS: BROMURO DE 4-[CIANO(DI-2-TIENIL)METIL]-1-[3-(FENILOXI)PROPIL]-1-AZONIABICICLO[2.2.2]-OCTANO, BROMURO DE 4-[CIANO(DIFENIL)METIL]-1-[3-(FENILOXI)PROPIL]-1-AZONIABICICLO[2.2.2]-OCTANO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE LOS RECEPTORES DE ACETILCOLINA MUSCARINICO (mAChR), POR LO QUE SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES DEL TRACTO RESPIRATORIO COMO ENFERMEDAD OBSTRUCTIVA PULMONAR OBSTRUCTIVA CRONICA, FIBROSIS O EFISEMA PULMONAR Y RINITIS ALERGICA
PE2005000591A 2004-05-28 2005-05-26 Compuestos 8-azoniabiciclo[3.2.1]octanos como antagonistas del receptor de acetilcolina muscarinico PE20060367A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57532904P 2004-05-28 2004-05-28

Publications (1)

Publication Number Publication Date
PE20060367A1 true PE20060367A1 (es) 2006-04-28

Family

ID=35462875

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000591A PE20060367A1 (es) 2004-05-28 2005-05-26 Compuestos 8-azoniabiciclo[3.2.1]octanos como antagonistas del receptor de acetilcolina muscarinico

Country Status (7)

Country Link
US (1) US7579345B2 (es)
EP (1) EP1749012A4 (es)
JP (1) JP2008501020A (es)
AR (1) AR048976A1 (es)
PE (1) PE20060367A1 (es)
TW (1) TW200606161A (es)
WO (1) WO2005118594A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20050250A1 (es) * 2003-07-17 2005-04-08 Glaxo Group Ltd Antagonistas de los receptores muscarinicos de la acetilcolina
EP1677796A4 (en) * 2003-10-17 2006-12-27 Glaxo Group Ltd MUSCARIN ACETYLCHOLIN RECEPTOR ANTAGONISTS
PE20050489A1 (es) * 2003-11-04 2005-09-02 Glaxo Group Ltd Antagonistas de receptores de acetilcolina muscarinicos
WO2005087236A1 (en) * 2004-03-11 2005-09-22 Glaxo Group Limited Novel m3 muscarinic acetylcholine receptor antagonists
JP2007529513A (ja) * 2004-03-17 2007-10-25 グラクソ　グループ　リミテッド Ｍ３ムスカリン性アセチルコリン受容体アンタゴニスト
PE20060259A1 (es) 2004-04-27 2006-03-25 Glaxo Group Ltd Compuestos de quinuclidina como antagonistas del receptor de acetilcolina muscarinico
JP2007537261A (ja) * 2004-05-13 2007-12-20 グラクソ　グループ　リミテッド ムスカリン性アセチルコリン受容体アンタゴニスト
WO2006055553A2 (en) * 2004-11-15 2006-05-26 Glaxo Group Limited Novel m3 muscarinic acetylcholine receptor antagonists
US20080275079A1 (en) * 2005-08-02 2008-11-06 Glaxo Group Limited M3 Muscarinic Acetylcholine Receptor Antagonists
WO2007022351A2 (en) * 2005-08-18 2007-02-22 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists
BRPI0807615A8 (pt) 2007-02-23 2017-12-05 Theravance Inc Compostos de difenilmetil amônico quaternário úteis como antagonistas de receptor muscarínico
PE20091553A1 (es) 2008-02-06 2009-10-30 Glaxo Group Ltd Farmacoforos duales - antagonistas muscarinicos de pde4
TW201000476A (en) 2008-02-06 2010-01-01 Glaxo Group Ltd Dual pharmacophores-PDE4-muscarinic antagonistics
TW200946525A (en) 2008-02-06 2009-11-16 Glaxo Group Ltd Dual pharmacophores-PDE4-muscarinic antagonistics
WO2010094643A1 (en) 2009-02-17 2010-08-26 Glaxo Group Limited Quinoline derivatives and their uses for rhinitis and urticaria

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6476046B1 (en) 2000-12-04 2002-11-05 Sepracor, Inc. Diazabicyclo[4.3.0]nonanes, and methods of use thereof
US6696462B2 (en) * 2002-01-31 2004-02-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics, processes for the preparation thereof, and pharmaceutical compositions

Also Published As

Publication number Publication date
JP2008501020A (ja) 2008-01-17
EP1749012A1 (en) 2007-02-07
AR048976A1 (es) 2006-06-14
WO2005118594A1 (en) 2005-12-15
US7579345B2 (en) 2009-08-25
US20070232599A1 (en) 2007-10-04
EP1749012A4 (en) 2009-07-29
TW200606161A (en) 2006-02-16

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