PE20080858A1 - Compuestos de n-aril pirazol y composiciones que los contienen - Google Patents
Compuestos de n-aril pirazol y composiciones que los contienenInfo
- Publication number
- PE20080858A1 PE20080858A1 PE2007001365A PE2007001365A PE20080858A1 PE 20080858 A1 PE20080858 A1 PE 20080858A1 PE 2007001365 A PE2007001365 A PE 2007001365A PE 2007001365 A PE2007001365 A PE 2007001365A PE 20080858 A1 PE20080858 A1 PE 20080858A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cycloalkyl
- compounds
- thiofen
- pyrimidin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE N-ARIL PIRAZOL DE FORMULA (II) DONDE L ES UN ENLACE SIMPLE, ALQUENILENO(C2-C5), -(CH2)n-O-(CH2)p-, -(CH2)n-N(R6)-(CH2)p, ENTRE OTROS, DONDE n Y p SON CADA UNO DE 0 A 3; R6 ES H, ALQUILO(C1-C8), FLUOROALQUILO(C1-C4), ARILALQUILO(C1-C4), ENTRE OTROS; V ES CICLOALQUILO(C3-C7), HETEROCICLOALQUILO(C3-C7), ARILO, ENTRE OTROS; W ES UN ENLACE SIMPLE, ALQUILENO(C1-C5), ALQUENILENO(C2-C5), -O-, ENTRE OTROS; R1 ES ALQUILO(C1-C6), HETEROALQUILO(C2-C6), CICLOALQUILO(C3-C7), ENTRE OTROS; R2 ES H, HALOGENO, ALQUILO(C1-C6), CN, HALOALCOXI(C1-C6), ENTRE OTROS; R3 Y R5 SON CADA UNO H, HIDROXI, HALOGENO, CN, ALQUILO(C1-C6), ENTRE OTROS; R4 ES ALQUILO(C1-C8), CICLOALQUILO(C3-C7), ARILALQUILO(C1-C4), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 5-(METOXIMETIL)-1-(5-METIL-4-(TIOFEN-2-IL)PIRIMIDIN-2-IL)-N-(PIRIDIN-4-ILMETIL)-1H-PIRAZOL-4-CARBOXAMIDA, 5-BUTIL-N-(3-METOXIPROPIL)-1-(5-METIL-4-(TIOFEN-2-IL)PIRIMIDIN-2-IL)-1H-PIRAZOL-4-CARBOXAMIDA, 5-BUTIL-1-(5-METIL-4-(TIOFEN-2-IL)PIRIMIDIN-2-IL)-N-(3-(METILSULFONIL)PROPIL)-1H-PIRAZOL-4-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LA SECRECION DE INSULINA DE LAS CELULAS B PANCREATICAS SIENDO UTILES EN EL TRATAMIENTO DE DIABETES TIPO 2, HIPERGLUCEMIA, OBESIDAD, ASMA, PSORIASIS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85108306P | 2006-10-10 | 2006-10-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080858A1 true PE20080858A1 (es) | 2008-08-06 |
Family
ID=39047570
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007001365A PE20080858A1 (es) | 2006-10-10 | 2007-10-10 | Compuestos de n-aril pirazol y composiciones que los contienen |
Country Status (12)
Country | Link |
---|---|
US (1) | US8022061B2 (es) |
EP (1) | EP2079728B1 (es) |
JP (1) | JP2010505957A (es) |
AR (1) | AR063240A1 (es) |
AU (1) | AU2007308154A1 (es) |
CA (1) | CA2675511A1 (es) |
CL (1) | CL2007002904A1 (es) |
ES (1) | ES2430821T3 (es) |
MX (1) | MX2009003821A (es) |
PE (1) | PE20080858A1 (es) |
TW (1) | TW200831491A (es) |
WO (1) | WO2008045484A1 (es) |
Families Citing this family (27)
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KR101152162B1 (ko) | 2006-12-08 | 2012-07-10 | 에프. 호프만-라 로슈 아게 | 치환된 피리미딘 및 jnk 조절제로서 그의 용도 |
MY154668A (en) * | 2007-07-19 | 2015-07-15 | Lundbeck & Co As H | 5-membered heterocyclic amides and related compounds |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
JP5298129B2 (ja) | 2007-09-06 | 2013-09-25 | メルク・シャープ・アンド・ドーム・コーポレーション | 可溶性グアニレートシクラーゼ活性化因子 |
CA2753434C (en) | 2009-02-26 | 2014-07-15 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2011146354A1 (en) * | 2010-05-20 | 2011-11-24 | Merck Sharp & Dohme Corp. | Novel prolylcarboxypeptidase inhibitors |
EA023254B1 (ru) | 2010-05-27 | 2016-05-31 | Мерк Шарп Энд Домэ Корп. | Активаторы растворимой гуанилатциклазы |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
JP5605104B2 (ja) * | 2010-09-10 | 2014-10-15 | セントラル硝子株式会社 | ピラゾール化合物の製造方法 |
AR087701A1 (es) * | 2011-08-31 | 2014-04-09 | Japan Tobacco Inc | Derivados de pirazol con actividad inhibidora de sglt1 |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
US9328116B2 (en) | 2012-12-07 | 2016-05-03 | Chemocentryx, Inc. | Diazole lactams |
CA2894715C (en) * | 2012-12-21 | 2021-06-15 | Chemocentryx, Inc. | Diazole amides |
CN103772282B (zh) * | 2014-02-26 | 2015-09-23 | 上海毕得医药科技有限公司 | 一种3-叔丁基-1h-吡唑-4-甲醛的制备方法 |
WO2016138631A1 (en) | 2015-03-03 | 2016-09-09 | Eli Lilly And Company | Imidazo benzamide compounds |
KR20180114910A (ko) | 2016-02-05 | 2018-10-19 | 데날리 테라퓨틱스 인크. | 수용체-상호작용 단백질 키나제 1의 억제제 |
ES2864148T3 (es) | 2016-04-07 | 2021-10-13 | Chemocentryx Inc | Reducción de la carga tumoral mediante la administración de los antagonistas de CCR1 en combinación con inhibidores de PD-1 o inhibidores de PD-L1 |
LT3552017T (lt) | 2016-12-09 | 2022-05-10 | Denali Therapeutics Inc. | Junginiai, naudotini kaip ripk1 inhibitoriai |
AU2019249560B2 (en) * | 2018-04-04 | 2023-10-05 | Japan Tobacco Inc. | Heteroaryl-substituted pyrazole compound and medicinal use thereof |
WO2020007729A1 (en) | 2018-07-04 | 2020-01-09 | Boehringer Ingelheim International Gmbh | Triazole benzamide derivatives as gpr142 agonists |
CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
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JP3774184B2 (ja) | 2002-10-25 | 2006-05-10 | 株式会社フジクラ | 光ファイバ心線テープ被覆除去具及び光ファイバ心線テープ被覆除去方法 |
DE602004029242D1 (en) | 2003-05-01 | 2010-11-04 | Bristol Myers Squibb Co | Pyrazolamidverbindungen |
JP2004339080A (ja) | 2003-05-13 | 2004-12-02 | Tokyo Institute Of Technology | ピラゾ−ル誘導体を含有する高血圧治療剤 |
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JP2007514003A (ja) | 2003-12-15 | 2007-05-31 | アルミラル プロデスファルマ アーゲー | アデノシン受容体アンタゴニストとしての2,6−ビスヘテロアリール−4−アミノピリミジン |
JP2007535565A (ja) | 2004-04-30 | 2007-12-06 | バイエル ファーマシューティカルス コーポレーション | 癌の治療に有用な置換ピラゾリル尿素誘導体 |
WO2007008541A2 (en) * | 2005-07-08 | 2007-01-18 | Kalypsys, Inc. | Cellular cholesterol absorption modifiers |
US20090275586A1 (en) * | 2006-10-06 | 2009-11-05 | Kalypsys, Inc. | Heterocyclic inhibitors of pde4 |
-
2007
- 2007-10-09 US US11/973,900 patent/US8022061B2/en not_active Expired - Fee Related
- 2007-10-09 WO PCT/US2007/021678 patent/WO2008045484A1/en active Application Filing
- 2007-10-09 JP JP2009532398A patent/JP2010505957A/ja not_active Withdrawn
- 2007-10-09 TW TW096137866A patent/TW200831491A/zh unknown
- 2007-10-09 EP EP07839443.4A patent/EP2079728B1/en active Active
- 2007-10-09 ES ES07839443T patent/ES2430821T3/es active Active
- 2007-10-09 AU AU2007308154A patent/AU2007308154A1/en not_active Abandoned
- 2007-10-09 MX MX2009003821A patent/MX2009003821A/es unknown
- 2007-10-09 CA CA002675511A patent/CA2675511A1/en not_active Abandoned
- 2007-10-09 CL CL200702904A patent/CL2007002904A1/es unknown
- 2007-10-10 AR ARP070104489A patent/AR063240A1/es unknown
- 2007-10-10 PE PE2007001365A patent/PE20080858A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AR063240A1 (es) | 2009-01-14 |
US8022061B2 (en) | 2011-09-20 |
EP2079728B1 (en) | 2013-09-25 |
CA2675511A1 (en) | 2008-04-17 |
ES2430821T3 (es) | 2013-11-21 |
US20080153778A1 (en) | 2008-06-26 |
EP2079728A1 (en) | 2009-07-22 |
TW200831491A (en) | 2008-08-01 |
AU2007308154A1 (en) | 2008-04-17 |
WO2008045484A1 (en) | 2008-04-17 |
JP2010505957A (ja) | 2010-02-25 |
CL2007002904A1 (es) | 2008-06-06 |
MX2009003821A (es) | 2009-05-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |