SI1560823T1 - 4-substituirani 1-aminocikloheksanski derivati zauporabo kot ligandi ORL1-receptorja in opioidnegami-receptorja - Google Patents

4-substituirani 1-aminocikloheksanski derivati zauporabo kot ligandi ORL1-receptorja in opioidnegami-receptorja

Info

Publication number
SI1560823T1
SI1560823T1 SI200331366T SI200331366T SI1560823T1 SI 1560823 T1 SI1560823 T1 SI 1560823T1 SI 200331366 T SI200331366 T SI 200331366T SI 200331366 T SI200331366 T SI 200331366T SI 1560823 T1 SI1560823 T1 SI 1560823T1
Authority
SI
Slovenia
Prior art keywords
receptor
orl1
utilization
substituted
aminocyclohexane derivatives
Prior art date
Application number
SI200331366T
Other languages
English (en)
Inventor
Claudia Hinze
Hans Schick
Helmut Sonnenschein
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of SI1560823T1 publication Critical patent/SI1560823T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
SI200331366T 2002-11-11 2003-11-05 4-substituirani 1-aminocikloheksanski derivati zauporabo kot ligandi ORL1-receptorja in opioidnegami-receptorja SI1560823T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10252666A DE10252666A1 (de) 2002-11-11 2002-11-11 N-Piperidyl-cyclohexan-Derivate
PCT/EP2003/012306 WO2004043949A1 (de) 2002-11-11 2003-11-05 4-substituierte 1-aminocyclohexan-derivate zur verwendung als orl1-rezeptor- und mu-opiat-rezeptor-liganden
EP03779845A EP1560823B1 (de) 2002-11-11 2003-11-05 4-substituierte 1-aminocyclohexan-derivate zur verwendung als orl1-rezeptor- und mu-opiat-rezeptor-liganden

Publications (1)

Publication Number Publication Date
SI1560823T1 true SI1560823T1 (sl) 2008-12-31

Family

ID=32308522

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200331366T SI1560823T1 (sl) 2002-11-11 2003-11-05 4-substituirani 1-aminocikloheksanski derivati zauporabo kot ligandi ORL1-receptorja in opioidnegami-receptorja

Country Status (13)

Country Link
US (1) US7759385B2 (sl)
EP (1) EP1560823B1 (sl)
AR (1) AR041941A1 (sl)
AT (1) ATE400569T1 (sl)
AU (1) AU2003287993A1 (sl)
CY (1) CY1108378T1 (sl)
DE (2) DE10252666A1 (sl)
DK (1) DK1560823T3 (sl)
ES (1) ES2309373T3 (sl)
PE (1) PE20040833A1 (sl)
PT (1) PT1560823E (sl)
SI (1) SI1560823T1 (sl)
WO (1) WO2004043949A1 (sl)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252665A1 (de) * 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
EP2080757A1 (en) * 2003-07-24 2009-07-22 Euro-Celtique S.A. Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain
CN101914088A (zh) * 2003-07-24 2010-12-15 尤罗塞尔蒂克股份有限公司 哌啶化合物和含有它们的药物组合物
DE10337184A1 (de) * 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
DE102004023635A1 (de) * 2004-05-10 2006-04-13 Grünenthal GmbH Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023507A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexylessigsäure-Derivate
DE102004023522A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023632A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Substituierte Cyclohexylcarbonsäure-Derivate
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
EP2178534A4 (en) 2007-07-17 2011-03-30 Merck Sharp & Dohme SOLUBLE EPOXY HYDROLASE INHIBITORS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND PROCESSING METHODS
CN101848910B (zh) * 2007-11-05 2013-12-04 默克专利股份公司 作为选择性11-β-羟基类固醇脱氢酶1型抑制剂的7-氮杂吲哚衍生物
AR070398A1 (es) 2008-02-22 2010-03-31 Gruenenthal Chemie Derivados sustituidos de indol
CA2718209A1 (en) 2008-03-27 2009-10-01 Gruenenthal Gmbh (hetero)aryl cyclohexane derivatives
SI2271613T1 (sl) 2008-03-27 2014-08-29 Grunenthal Gmbh Hidroksimetilcikloheksilamini
ES2621407T3 (es) 2008-03-27 2017-07-04 Grünenthal GmbH Ciclohexildiaminas sustituidas
DK2257526T3 (da) 2008-03-27 2012-02-06 Gruenenthal Gmbh Spiro(5,5)undecan-derivater
CN102046595B (zh) 2008-03-27 2014-03-05 格吕伦塔尔有限公司 取代的4-氨基环己烷衍生物
CL2009000731A1 (es) 2008-03-27 2009-05-15 Gruenenthal Gmbh Compuestos derivados de ciclohexano espirociclicos sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, abuso de alcohol, hipertension, anorexia, obesidad y diarrea.
AU2012335980C1 (en) 2011-11-07 2017-12-14 Sunovion Pharmaceuticals Inc. Modulators of opioid receptors and methods of use thereof
EP3319444B1 (en) 2015-07-09 2022-03-09 The Regents of the University of California Mu opioid receptor modulators
WO2017023894A1 (en) * 2015-08-03 2017-02-09 Raze Therapeutics, Inc. Mthfd2 inhibitors and uses thereof
JP7402857B2 (ja) 2018-04-04 2023-12-21 エピオダイン，インク． オピオイド受容体モジュレーター、およびそれに関連する生成物ならびに方法
WO2020120606A1 (en) * 2018-12-12 2020-06-18 Esteve Pharmaceuticals, S.A. New pyrrolidine-2-carboxylic acid derivatives for treating pain and pain related conditions
TW202026281A (zh) * 2018-12-12 2020-07-16 西班牙商艾斯提夫製藥股份有限公司 用於治療疼痛和疼痛相關病症之新吡咯啶–2– 甲酸衍生物
MX2022007994A (es) 2019-12-26 2022-09-23 Gilgamesh Pharmaceuticals Inc Derivados de arilciclohexilamina y su uso en el tratamiento de trastornos psiquiátricos.
EP4084791A1 (en) 2020-02-18 2022-11-09 Gilgamesh Pharmaceuticals, Inc. Specific tryptamines for use in the treatment of mood disorders
TW202304869A (zh) 2021-04-05 2023-02-01 美商艾碧奧戴股份有限公司 類鴉片受體調節劑

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US4113555A (en) * 1973-11-08 1978-09-12 Svenska Traforskningsinstitutet Hard board or medium density board, process for production thereof and means for practicizing the process
US4113866A (en) * 1977-04-01 1978-09-12 The Upjohn Company Analgetic compounds, compositions and process of treatment
TW438587B (en) * 1995-06-20 2001-06-07 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
US5763445A (en) * 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
US6172087B1 (en) * 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
MA26659A1 (fr) * 1998-08-06 2004-12-20 Pfizer Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
AU1816901A (en) * 1999-12-06 2001-06-12 Euro-Celtique S.A. Benzimidazole compounds having nociceptin receptor affinity
GB0012240D0 (en) * 2000-05-19 2000-07-12 Merck Sharp & Dohme Therapeutic agents
KR100526091B1 (ko) 2000-10-06 2005-11-08 다나베 세이야꾸 가부시키가이샤 지방족 질소 함유 오원환 화합물
DE10252665A1 (de) * 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate

Also Published As

Publication number Publication date
PT1560823E (pt) 2008-09-25
WO2004043949A1 (de) 2004-05-27
DE50310122D1 (de) 2008-08-21
DK1560823T3 (da) 2008-11-10
CY1108378T1 (el) 2014-02-12
EP1560823A1 (de) 2005-08-10
AU2003287993A1 (en) 2004-06-03
US7759385B2 (en) 2010-07-20
DE10252666A1 (de) 2004-08-05
PE20040833A1 (es) 2004-11-17
ES2309373T3 (es) 2008-12-16
EP1560823B1 (de) 2008-07-09
AR041941A1 (es) 2005-06-01
US20050277674A1 (en) 2005-12-15
ATE400569T1 (de) 2008-07-15

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