DK1560823T3 - 4-Substituerede 1-aminocyclohexanderivater til anvendelse som ORL-1-receptor- og Á-opiat-receptor-ligander - Google Patents
4-Substituerede 1-aminocyclohexanderivater til anvendelse som ORL-1-receptor- og Á-opiat-receptor-liganderInfo
- Publication number
- DK1560823T3 DK1560823T3 DK03779845T DK03779845T DK1560823T3 DK 1560823 T3 DK1560823 T3 DK 1560823T3 DK 03779845 T DK03779845 T DK 03779845T DK 03779845 T DK03779845 T DK 03779845T DK 1560823 T3 DK1560823 T3 DK 1560823T3
- Authority
- DK
- Denmark
- Prior art keywords
- receptor
- orl
- substituted
- aminocyclohexane derivatives
- opiate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10252666A DE10252666A1 (de) | 2002-11-11 | 2002-11-11 | N-Piperidyl-cyclohexan-Derivate |
PCT/EP2003/012306 WO2004043949A1 (de) | 2002-11-11 | 2003-11-05 | 4-substituierte 1-aminocyclohexan-derivate zur verwendung als orl1-rezeptor- und mu-opiat-rezeptor-liganden |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1560823T3 true DK1560823T3 (da) | 2008-11-10 |
Family
ID=32308522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03779845T DK1560823T3 (da) | 2002-11-11 | 2003-11-05 | 4-Substituerede 1-aminocyclohexanderivater til anvendelse som ORL-1-receptor- og Á-opiat-receptor-ligander |
Country Status (13)
Country | Link |
---|---|
US (1) | US7759385B2 (da) |
EP (1) | EP1560823B1 (da) |
AR (1) | AR041941A1 (da) |
AT (1) | ATE400569T1 (da) |
AU (1) | AU2003287993A1 (da) |
CY (1) | CY1108378T1 (da) |
DE (2) | DE10252666A1 (da) |
DK (1) | DK1560823T3 (da) |
ES (1) | ES2309373T3 (da) |
PE (1) | PE20040833A1 (da) |
PT (1) | PT1560823E (da) |
SI (1) | SI1560823T1 (da) |
WO (1) | WO2004043949A1 (da) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10252665A1 (de) * | 2002-11-11 | 2004-06-03 | Grünenthal GmbH | 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate |
ES2326979T3 (es) * | 2003-07-24 | 2009-10-22 | Euro-Celtique S.A. | Compuestos de piperidina y composiciones farmaceuticas que contienen a los mismos. |
DK1648879T3 (da) * | 2003-07-24 | 2009-02-23 | Euro Celtique Sa | Heteroaryl-tetrahydropyridyl-forbindelser, der er anvendelige til behandling eller forebyggelse af smerte |
DE10337184A1 (de) * | 2003-08-13 | 2005-03-10 | Gruenenthal Gmbh | Substituierte 3-Pyrrolidin-Indol-Derivate |
DE102004023635A1 (de) * | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
DE102004023522A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexyl-1,4-diamin-Derivate |
DE102004023507A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexylessigsäure-Derivate |
DE102004023632A1 (de) * | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Substituierte Cyclohexylcarbonsäure-Derivate |
DE102006033109A1 (de) * | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
US8455520B2 (en) | 2007-07-17 | 2013-06-04 | Merck Sharp & Dohme Corp. | Soluble epoxide hydrolase inhibitors, compositions containing such compounds and methods of treatment |
KR101624596B1 (ko) * | 2007-11-05 | 2016-05-26 | 메르크 파텐트 게엠베하 | 선택적 11-베타-하이드록시스테로이드 디하이드로게나제 타입 1 억제제로서 7-아자인돌 유도체 |
AR070398A1 (es) | 2008-02-22 | 2010-03-31 | Gruenenthal Chemie | Derivados sustituidos de indol |
TWI466866B (zh) | 2008-03-27 | 2015-01-01 | 被取代之環己基二胺 | |
RU2503660C2 (ru) * | 2008-03-27 | 2014-01-10 | Грюненталь Гмбх | Замещенные производные 4-аминоциклогексана |
PT2260042E (pt) | 2008-03-27 | 2011-12-06 | Gruenenthal Gmbh | Derivados de ciclo-hexano espirocíclicos substituídos |
CA2719739A1 (en) | 2008-03-27 | 2009-10-01 | Sven Frormann | Hydroxymethylcyclohexylamines |
AU2009228637B2 (en) | 2008-03-27 | 2013-12-19 | Grunenthal Gmbh | (Hetero-)aryl cyclohexane derivatives |
ES2375543T3 (es) | 2008-03-27 | 2012-03-01 | Grünenthal GmbH | Derivados de espiro(5.5)undecano. |
US9580409B2 (en) | 2011-11-07 | 2017-02-28 | Sunovion Pharmaceuticals, Inc. | Modulators of opioid receptors and methods of use thereof |
WO2017007695A1 (en) * | 2015-07-09 | 2017-01-12 | The Regents Of The University Of California | Mu opioid receptor modulators |
EP3331530A4 (en) * | 2015-08-03 | 2018-12-19 | Raze Therapeutics Inc. | Mthfd2 inhibitors and uses thereof |
CA3096059A1 (en) | 2018-04-04 | 2019-10-10 | Epiodyne, Inc. | Opioid receptor modulators and products and methods related thereto |
WO2020120606A1 (en) * | 2018-12-12 | 2020-06-18 | Esteve Pharmaceuticals, S.A. | New pyrrolidine-2-carboxylic acid derivatives for treating pain and pain related conditions |
TW202026281A (zh) * | 2018-12-12 | 2020-07-16 | 西班牙商艾斯提夫製藥股份有限公司 | 用於治療疼痛和疼痛相關病症之新吡咯啶–2– 甲酸衍生物 |
JP2023508469A (ja) | 2019-12-26 | 2023-03-02 | ギルガメッシュ・ファーマシューティカルズ・インコーポレイテッド | アリールシクロヘキシルアミン誘導体及び精神障害の処置におけるそれらの使用 |
KR102567903B1 (ko) | 2020-02-18 | 2023-08-18 | 길가메쉬 파마슈티컬스, 인코포레이티드 | 기분 장애 치료에 사용되기 위한 특이적 트립타민 |
TW202304869A (zh) | 2021-04-05 | 2023-02-01 | 美商艾碧奧戴股份有限公司 | 類鴉片受體調節劑 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4113555A (en) * | 1973-11-08 | 1978-09-12 | Svenska Traforskningsinstitutet | Hard board or medium density board, process for production thereof and means for practicizing the process |
US4113866A (en) * | 1977-04-01 | 1978-09-12 | The Upjohn Company | Analgetic compounds, compositions and process of treatment |
TWI238064B (en) * | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
US5763445A (en) * | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
US6172087B1 (en) * | 1998-06-03 | 2001-01-09 | Gpi Nil Holding, Inc. | N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
MA26659A1 (fr) * | 1998-08-06 | 2004-12-20 | Pfizer | Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation. |
JP2003524634A (ja) * | 1999-12-06 | 2003-08-19 | ユーロ−セルティーク,エス.エイ. | ノシセプチン受容体親和性を有するベンズイミダゾール化合物 |
GB0012240D0 (en) * | 2000-05-19 | 2000-07-12 | Merck Sharp & Dohme | Therapeutic agents |
NZ524974A (en) * | 2000-10-06 | 2005-10-28 | Tanabe Seiyaku Co | Aliphatic nitrogen-containing 5-membered ring compound |
DE10252665A1 (de) * | 2002-11-11 | 2004-06-03 | Grünenthal GmbH | 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate |
-
2002
- 2002-11-11 DE DE10252666A patent/DE10252666A1/de not_active Withdrawn
-
2003
- 2003-11-05 SI SI200331366T patent/SI1560823T1/sl unknown
- 2003-11-05 DK DK03779845T patent/DK1560823T3/da active
- 2003-11-05 PT PT03779845T patent/PT1560823E/pt unknown
- 2003-11-05 DE DE50310122T patent/DE50310122D1/de not_active Expired - Lifetime
- 2003-11-05 WO PCT/EP2003/012306 patent/WO2004043949A1/de active IP Right Grant
- 2003-11-05 ES ES03779845T patent/ES2309373T3/es not_active Expired - Lifetime
- 2003-11-05 AU AU2003287993A patent/AU2003287993A1/en not_active Abandoned
- 2003-11-05 EP EP03779845A patent/EP1560823B1/de not_active Expired - Lifetime
- 2003-11-05 AT AT03779845T patent/ATE400569T1/de active
- 2003-11-11 PE PE2003001140A patent/PE20040833A1/es not_active Application Discontinuation
- 2003-11-12 AR ARP030104144A patent/AR041941A1/es unknown
-
2005
- 2005-05-10 US US11/125,151 patent/US7759385B2/en not_active Expired - Fee Related
-
2008
- 2008-09-25 CY CY20081101060T patent/CY1108378T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US7759385B2 (en) | 2010-07-20 |
ATE400569T1 (de) | 2008-07-15 |
US20050277674A1 (en) | 2005-12-15 |
AU2003287993A1 (en) | 2004-06-03 |
AR041941A1 (es) | 2005-06-01 |
CY1108378T1 (el) | 2014-02-12 |
EP1560823B1 (de) | 2008-07-09 |
SI1560823T1 (sl) | 2008-12-31 |
PE20040833A1 (es) | 2004-11-17 |
DE10252666A1 (de) | 2004-08-05 |
WO2004043949A1 (de) | 2004-05-27 |
PT1560823E (pt) | 2008-09-25 |
ES2309373T3 (es) | 2008-12-16 |
EP1560823A1 (de) | 2005-08-10 |
DE50310122D1 (de) | 2008-08-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1560823T3 (da) | 4-Substituerede 1-aminocyclohexanderivater til anvendelse som ORL-1-receptor- og Á-opiat-receptor-ligander | |
HK1247610A1 (zh) | 作為nk1拮抗劑的哌啶衍生物 | |
NO20052739D0 (no) | CCR5-antagonister som medikamenter | |
DK1501809T3 (da) | Trizolderivater som tachykininreceptorantagonister | |
NO20040465L (no) | N-fenylpyrrolguanidin-derivater som melanokortin-mottagerligander | |
ATE481402T1 (de) | Pyrazolopyridin-derivate | |
NO20052512D0 (no) | Purinforbindelser og anvendelse deav som kannabinoiode reseptorligander | |
DK2208727T3 (da) | Diarylethere som opioidreceptorantagonister | |
DK1802307T3 (da) | Pyrrolidinderivater som histamin-receptor-ligander | |
DK1833791T3 (da) | 2,3,4,9-tetrahydor-1H-carbazolderivater som CRTH2 receptorantagonister | |
NO20020314D0 (no) | 2-arylimino-2,3-dihydrotiazoler og deres anvendelse som ligander for somatostatin-reseptorer | |
DK1773810T3 (da) | Hidtil ukendte 4-benzylidenpiperidinderivater | |
EP1743763A4 (en) | BASIC PROTECTION METHOD | |
PT1626964E (pt) | Novos derivados de benzimidazole | |
NO20044373L (no) | Azetidinderivater som CCR-3-reseptorantagonister | |
NO20042294L (no) | Heteroarylderivater som overlegne ligander for nociceptinreseptor ORL-1 | |
DE602004031538D1 (de) | Gaszufuhrvorrichtung | |
NO20043799L (no) | 2-oksasolaminer og deres anvendelse som 5-HT2B reseptor antagonister | |
ATE325092T1 (de) | Azetidinyldiamine als nociceptin-rezeptor orl-1 liganden | |
NO20022504D0 (no) | Sikringsanordning for stige | |
TW562059U (en) | Adjustable base structure for building forms | |
GB0305736D0 (en) | Rafter support device | |
FIU20030173U0 (fi) | Laatoituksen aloitustuki | |
AU2002329501A1 (en) | 4-(1-piperidiny)-butylcarboxamide as d3 dopamine receptor subtype selective ligands | |
TH105710B (th) | โอพิออยด์รีเซปเตอร์แอนตะกอนิสต์ |