MX2012004644A - Compuestos de indazol y pirazolopiridina como antagonistas del receptor de ccr1. - Google Patents

Compuestos de indazol y pirazolopiridina como antagonistas del receptor de ccr1.

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Publication number
MX2012004644A
MX2012004644A MX2012004644A MX2012004644A MX2012004644A MX 2012004644 A MX2012004644 A MX 2012004644A MX 2012004644 A MX2012004644 A MX 2012004644A MX 2012004644 A MX2012004644 A MX 2012004644A MX 2012004644 A MX2012004644 A MX 2012004644A
Authority
MX
Mexico
Prior art keywords
sub
receptor antagonists
indazole
ccr1 receptor
pyrazolopyridine compounds
Prior art date
Application number
MX2012004644A
Other languages
English (en)
Inventor
Daniel Kuzmich
Hossein Razavi
Brian Nicholas Cook
Can Mao
Original Assignee
Boehringer Ingelheim Int
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Publication date
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Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2012004644A publication Critical patent/MX2012004644A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Diabetes (AREA)
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  • Pulmonology (AREA)
  • Dermatology (AREA)
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  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
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  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Communicable Diseases (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describen antagonistas del receptor CCR1 de la fórmula (I), (ver fórmula (I)) donde X es nitrógeno o C-R2 Ar1 es carbociclo, heteroarilo o heterociclilo, cada uno opcionalmente sustituido por uno a tres Ra; Ar2 es carbociclo, heteroarilo o heterocíclico, cada uno opcionalmente sustituido por uno a tres Rb; el ciclico G es carbociclo, o heterociclilo cada uno opcionalmente sustituido por uno a dos R8; R1 es hidrógeno, C1-6 alquilo o C1-6 alcoxi-C1-6 alquilo. También se describen composiciones, métodos para elaborar y usar los compuestos de la fórmula (I).
MX2012004644A 2009-10-21 2010-10-19 Compuestos de indazol y pirazolopiridina como antagonistas del receptor de ccr1. MX2012004644A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25359009P 2009-10-21 2009-10-21
PCT/US2010/053142 WO2011049917A1 (en) 2009-10-21 2010-10-19 Indazole and pyrazolopyridine compounds as ccr1 receptor antagonists

Publications (1)

Publication Number Publication Date
MX2012004644A true MX2012004644A (es) 2012-05-08

Family

ID=43126891

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MX2012004644A MX2012004644A (es) 2009-10-21 2010-10-19 Compuestos de indazol y pirazolopiridina como antagonistas del receptor de ccr1.

Country Status (29)

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US (1) US9056858B2 (es)
EP (1) EP2491028B1 (es)
JP (1) JP5542946B2 (es)
KR (1) KR20120087923A (es)
CN (1) CN102666526A (es)
AP (1) AP2012006204A0 (es)
AU (1) AU2010308277A1 (es)
BR (1) BR112012009331A2 (es)
CA (1) CA2778060A1 (es)
CL (1) CL2012000967A1 (es)
CO (1) CO6531488A2 (es)
DK (1) DK2491028T3 (es)
EA (1) EA021015B1 (es)
EC (1) ECSP12011904A (es)
ES (1) ES2444780T3 (es)
GE (1) GEP20146103B (es)
HR (1) HRP20140213T1 (es)
IL (1) IL218823A0 (es)
IN (1) IN2012DN03449A (es)
MA (1) MA33675B1 (es)
MX (1) MX2012004644A (es)
NZ (1) NZ599132A (es)
PE (1) PE20121433A1 (es)
PL (1) PL2491028T3 (es)
PT (1) PT2491028E (es)
RS (1) RS53130B (es)
SI (1) SI2491028T1 (es)
TN (1) TN2012000180A1 (es)
WO (1) WO2011049917A1 (es)

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BR112012009331A2 (pt) 2019-09-24
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US9056858B2 (en) 2015-06-16
WO2011049917A1 (en) 2011-04-28
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RS53130B (en) 2014-06-30
EP2491028A1 (en) 2012-08-29
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US20120270870A1 (en) 2012-10-25
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EP2491028B1 (en) 2013-12-11

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