PL2225238T3 - Pochodne amidów kwasu 6,7-dihydro-5H-imidazo[1,2-a]imidazolo-3-karboksylowego - Google Patents

Pochodne amidów kwasu 6,7-dihydro-5H-imidazo[1,2-a]imidazolo-3-karboksylowego

Info

Publication number
PL2225238T3
PL2225238T3 PL08853791T PL08853791T PL2225238T3 PL 2225238 T3 PL2225238 T3 PL 2225238T3 PL 08853791 T PL08853791 T PL 08853791T PL 08853791 T PL08853791 T PL 08853791T PL 2225238 T3 PL2225238 T3 PL 2225238T3
Authority
PL
Poland
Prior art keywords
imidazoý1
dihydro
imidazole
derivatives
carboxylic acid
Prior art date
Application number
PL08853791T
Other languages
English (en)
Inventor
Rene M Lemieux
Antonio Jose Del Moral Barbosa
Joerg Martin Bentzien
Steven Richard Brunette
Zhidong Chen
Derek Cogan
Donghong A Gao
Alexander Heim-Riether
Joshua Courtney Horan
Jennifer A Kowalski
Michael David Lawlor
Weimin Liu
Bryan Mckibben
Craig Andrew Miller
Neil Moss
Matt Aaron Tschantz
Zhaoming Xiong
Hui Yu
Yang Yu
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PL2225238T3 publication Critical patent/PL2225238T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL08853791T 2007-11-29 2008-11-20 Pochodne amidów kwasu 6,7-dihydro-5H-imidazo[1,2-a]imidazolo-3-karboksylowego PL2225238T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US99096007P 2007-11-29 2007-11-29
US4795708P 2008-04-25 2008-04-25
PCT/US2008/084149 WO2009070485A1 (en) 2007-11-29 2008-11-20 DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-α]IMIDAZOLE-3- CARBOXYLIC ACID AMIDES
EP08853791.5A EP2225238B1 (en) 2007-11-29 2008-11-20 Derivatives of 6,7-dihydro-5h-imidazoý1,2- ¨imidazole-3- carboxylic acid amides

Publications (1)

Publication Number Publication Date
PL2225238T3 true PL2225238T3 (pl) 2015-03-31

Family

ID=40193954

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08853791T PL2225238T3 (pl) 2007-11-29 2008-11-20 Pochodne amidów kwasu 6,7-dihydro-5H-imidazo[1,2-a]imidazolo-3-karboksylowego

Country Status (31)

Country Link
US (1) US8552205B2 (pl)
EP (1) EP2225238B1 (pl)
JP (1) JP5485164B2 (pl)
KR (1) KR20100101095A (pl)
CN (1) CN101889011B (pl)
AR (1) AR069513A1 (pl)
AU (1) AU2008329909B2 (pl)
BR (1) BRPI0819831A2 (pl)
CA (1) CA2705583A1 (pl)
CL (1) CL2008003576A1 (pl)
CO (1) CO6210701A2 (pl)
CY (1) CY1115857T1 (pl)
DK (1) DK2225238T3 (pl)
EA (1) EA017688B1 (pl)
EC (1) ECSP10010196A (pl)
ES (1) ES2525237T3 (pl)
HR (1) HRP20141171T1 (pl)
IL (1) IL205189A (pl)
MA (1) MA31905B1 (pl)
MX (1) MX2010004995A (pl)
MY (1) MY151004A (pl)
NZ (1) NZ585640A (pl)
PE (1) PE20091427A1 (pl)
PL (1) PL2225238T3 (pl)
PT (1) PT2225238E (pl)
RS (1) RS53602B1 (pl)
SI (1) SI2225238T1 (pl)
TN (1) TN2010000240A1 (pl)
TW (2) TWI475990B (pl)
UY (1) UY31493A1 (pl)
WO (1) WO2009070485A1 (pl)

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CN103906750B9 (zh) 2011-10-03 2016-10-12 欧洲筛选有限公司 作为选择性NK-3受体拮抗剂的新型手性N-酰基-5,6,7,(8-取代的)-四氢-[1，2,4]三唑并[4，3-a]吡嗪、药物组合物、用于NK-3受体介导的疾病中的方法及其手性合成
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CN106631827B (zh) * 2016-12-30 2018-10-23 上海毕得医药科技有限公司 一种(1-环丙基-1-甲基)乙基胺及其盐酸盐的合成方法
CN109369432B (zh) * 2018-11-02 2021-06-25 永农生物科学有限公司 (s)-4-氯-2-氨基丁酸酯的制备方法
CN118496197A (zh) 2019-12-20 2024-08-16 拜耳公司 取代的噻吩甲酰胺、噻吩甲酸及其衍生物
CN111848521A (zh) * 2020-08-26 2020-10-30 韶远科技（上海)有限公司 一种2-取代-4-烷氧基咪唑化合物的制备方法
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JP2011505359A (ja) 2011-02-24
CN101889011B (zh) 2014-05-28
EA017688B1 (ru) 2013-02-28
WO2009070485A8 (en) 2014-08-14
US8552205B2 (en) 2013-10-08
EP2225238B1 (en) 2014-09-03
TWI475990B (zh) 2015-03-11
DK2225238T3 (en) 2014-11-24
US20110224188A1 (en) 2011-09-15
AU2008329909A8 (en) 2010-06-03
BRPI0819831A2 (pt) 2019-09-24
MX2010004995A (es) 2010-05-20
SI2225238T1 (sl) 2014-12-31
WO2009070485A1 (en) 2009-06-04
CN101889011A (zh) 2010-11-17
HRP20141171T1 (hr) 2015-01-30
MA31905B1 (fr) 2010-12-01
AR069513A1 (es) 2010-01-27
ECSP10010196A (es) 2010-07-30
TW200922562A (en) 2009-06-01
IL205189A (en) 2014-09-30
TW201417810A (zh) 2014-05-16
CO6210701A2 (es) 2010-10-20
CA2705583A1 (en) 2009-06-04
EP2225238A1 (en) 2010-09-08
UY31493A1 (es) 2009-07-17
AU2008329909A1 (en) 2009-06-04
CL2008003576A1 (es) 2010-02-12
MY151004A (en) 2014-03-31
EA201000866A1 (ru) 2010-12-30
CY1115857T1 (el) 2017-01-25
TWI475991B (zh) 2015-03-11
HK1145683A1 (en) 2011-04-29
PT2225238E (pt) 2014-12-18
TN2010000240A1 (en) 2011-11-11
ES2525237T3 (es) 2014-12-19
JP5485164B2 (ja) 2014-05-07
PE20091427A1 (es) 2009-10-19
NZ585640A (en) 2011-03-31
AU2008329909B2 (en) 2013-10-03
RS53602B1 (sr) 2015-02-27
IL205189A0 (en) 2010-12-30
KR20100101095A (ko) 2010-09-16

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