CO6210701A2 - Derivados de amidas del acido 6,7-dihidro-5h-imidazo[1,2-a]imidazol-3-carboxilico - Google Patents
Derivados de amidas del acido 6,7-dihidro-5h-imidazo[1,2-a]imidazol-3-carboxilicoInfo
- Publication number
- CO6210701A2 CO6210701A2 CO10060410A CO10060410A CO6210701A2 CO 6210701 A2 CO6210701 A2 CO 6210701A2 CO 10060410 A CO10060410 A CO 10060410A CO 10060410 A CO10060410 A CO 10060410A CO 6210701 A2 CO6210701 A2 CO 6210701A2
- Authority
- CO
- Colombia
- Prior art keywords
- optionally substituted
- halogen
- alkyl
- phenyl
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Derivados de amida del ácido 6,7-dihidro-5H-imidazo[1,2-a]imidazol-3-carboxílico exhiben buen efecto inhibidor tras la interacción entre CAM y Leucointegrinas y, por consiguiente, son útiles en el tratamiento de enfermedades inflamatorias.1.- Un compuesto de fórmula I:en donde:R1 se selecciona de -CN, -OCF3, halógeno, heteroarilo, opcionalmente sustituido con halógeno o alquilo C1-3 opcionalmente sustituido con halógeno y fenilo, opcionalmente sustituido con halógeno;R2 se selecciona de:(A) H;(B) alquilo C1-3 opcionalmente sustituido con uno o dos grupos seleccionados de:a) cicloalquilo C3-6,b) -OR9,c) -NR9R10,d) -SOR9,e) -SO2R9,f) -C(O)NH2,g) heteroarilo opcionalmente sustituido con alquilo C1-2,h) heterociclilo,i) fenilo,f) -CO2R9,k) -OPO(OH)2, yl) -OSO2(OH);(C) cicloalquilo C3-6,(D) heteroarilo, y(E) fenilo, opcionalmente sustituido con halógeno, -OR9, -CN o-CF3; R3 es H o alquilo C1-3; o R2 y R3, junto con el carbono al que están unidos, forman un anillo hidrocarbonado saturado de 3 a 7 átomos de carbono y en donde un átomo de carbono en dicho anillo hidrocarbonado puede estar opcionalmente reemplazado por -O-, -S-, -S(O)-, -SO2-, -NC(O)R9- o-NR9-; ...
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99096007P | 2007-11-29 | 2007-11-29 | |
| US4795708P | 2008-04-25 | 2008-04-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6210701A2 true CO6210701A2 (es) | 2010-10-20 |
Family
ID=40193954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10060410A CO6210701A2 (es) | 2007-11-29 | 2010-05-20 | Derivados de amidas del acido 6,7-dihidro-5h-imidazo[1,2-a]imidazol-3-carboxilico |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US8552205B2 (es) |
| EP (1) | EP2225238B1 (es) |
| JP (1) | JP5485164B2 (es) |
| KR (1) | KR20100101095A (es) |
| CN (1) | CN101889011B (es) |
| AR (1) | AR069513A1 (es) |
| AU (1) | AU2008329909B2 (es) |
| BR (1) | BRPI0819831A2 (es) |
| CA (1) | CA2705583A1 (es) |
| CL (1) | CL2008003576A1 (es) |
| CO (1) | CO6210701A2 (es) |
| CY (1) | CY1115857T1 (es) |
| DK (1) | DK2225238T3 (es) |
| EA (1) | EA017688B1 (es) |
| EC (1) | ECSP10010196A (es) |
| ES (1) | ES2525237T3 (es) |
| HK (1) | HK1145683A1 (es) |
| HR (1) | HRP20141171T1 (es) |
| IL (1) | IL205189A (es) |
| MA (1) | MA31905B1 (es) |
| MX (1) | MX2010004995A (es) |
| MY (1) | MY151004A (es) |
| NZ (1) | NZ585640A (es) |
| PE (1) | PE20091427A1 (es) |
| PL (1) | PL2225238T3 (es) |
| PT (1) | PT2225238E (es) |
| RS (1) | RS53602B1 (es) |
| SI (1) | SI2225238T1 (es) |
| TN (1) | TN2010000240A1 (es) |
| TW (2) | TWI475990B (es) |
| UY (1) | UY31493A1 (es) |
| WO (1) | WO2009070485A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8481750B2 (en) | 2009-06-02 | 2013-07-09 | Boehringer Ingelheim International Gmbh | Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amides |
| MX2011012717A (es) * | 2009-06-02 | 2011-12-14 | Boehringer Ingelheim Int | Derivados de amidas del acido 6,7-dihidro-5h-imidazo[1,2-a]imidazo l-3-carboxilico. |
| IN2012DN03449A (es) | 2009-10-21 | 2015-10-23 | Boehringer Ingelheim Int | |
| US8912221B2 (en) * | 2010-12-27 | 2014-12-16 | Hoffmann-La Roche Inc. | Biaryl amide derivatives |
| CN103649059B (zh) * | 2011-04-27 | 2016-10-26 | 盐野义制药株式会社 | 具有npy y5受体拮抗作用的五元环芳香族杂环衍生物 |
| CN103874697A (zh) | 2011-08-03 | 2014-06-18 | 协和发酵麒麟株式会社 | 二苯并氧杂*衍生物 |
| RS54833B1 (sr) | 2011-10-03 | 2016-10-31 | Euroscreen Sa | Novi hiralni n-acil-5,6,7, (8-supstituisan)-tetrahidro-[1,2,4]triazolo [4,3-a]pirazini kao selektivni antagonisti nk-3 receptora, farmaceutsko jedinjenje, i postupci za upotrebu u nk-3 receptorom posredovanim poremećajima |
| WO2016058896A1 (en) | 2014-10-14 | 2016-04-21 | Syngenta Participations Ag | Process for the preparation of 1-(3,5-dichloro-4-fluoro-phenyl)-2,2,2-trifluoro-ethanone |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| CN106631827B (zh) * | 2016-12-30 | 2018-10-23 | 上海毕得医药科技有限公司 | 一种(1-环丙基-1-甲基)乙基胺及其盐酸盐的合成方法 |
| CN109369432B (zh) * | 2018-11-02 | 2021-06-25 | 永农生物科学有限公司 | (s)-4-氯-2-氨基丁酸酯的制备方法 |
| CR20220294A (es) | 2019-12-20 | 2022-08-03 | Bayer Ag | Tiofenocarboxamidas sustituidas y sus derivados |
| CN111848521A (zh) * | 2020-08-26 | 2020-10-30 | 韶远科技（上海)有限公司 | 一种2-取代-4-烷氧基咪唑化合物的制备方法 |
| WO2024013736A1 (en) * | 2022-07-12 | 2024-01-18 | Adama Makhteshim Ltd. | Process for preparing substituted benzamides |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2015493A1 (es) | 1968-08-12 | 1970-04-30 | Sumitomo Chemical Co | |
| DK123717B (da) | 1968-11-25 | 1972-07-24 | Sumitomo Chemical Co | 3-(3',5'-Dihalogenphenyl)-imidazolidin-2,4-dionderivater med mirobicid virkning. |
| JPS5136332B1 (es) | 1970-12-09 | 1976-10-07 | ||
| EP0091596B1 (de) | 1982-04-08 | 1991-09-11 | Shell Internationale Researchmaatschappij B.V. | Neue Hydantoine, ihre Herstellung und Verwendung |
| JPS63270665A (ja) | 1987-04-30 | 1988-11-08 | Wakamoto Pharmaceut Co Ltd | イミダゾ−ル誘導体 |
| JPS63270667A (ja) | 1987-04-30 | 1988-11-08 | Wakamoto Pharmaceut Co Ltd | １−ベンジルイミダゾ−ル誘導体 |
| IE940525L (en) | 1988-05-25 | 1989-11-25 | Warner Lambert Co | Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents |
| US5208250A (en) | 1988-05-25 | 1993-05-04 | Warner-Lambert Company | Known and selected novel arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and anti-inflammatory agents |
| US5306822A (en) | 1988-05-25 | 1994-04-26 | Warner-Lambert Company | Arylmethylenyl derivatives of oxazolidinone |
| US4977270A (en) | 1988-12-01 | 1990-12-11 | Ici Americas Inc. | Substituted 2,4-dioxodiazolidines and -thiadiazolidines and their use as herbicides |
| US4911748A (en) | 1988-12-22 | 1990-03-27 | Ici Americas Inc. | Herbicidal 5-substituted-3-phenyl-imidazolidine-2,4-diones |
| JPH04273877A (ja) | 1991-02-28 | 1992-09-30 | Sumitomo Pharmaceut Co Ltd | 新規なイミダゾール誘導体 |
| EP0545478A1 (en) | 1991-12-03 | 1993-06-09 | MERCK SHARP & DOHME LTD. | Heterocyclic compounds as tachykinin antagonists |
| JPH05188631A (ja) | 1992-01-10 | 1993-07-30 | Mita Ind Co Ltd | 電子写真感光体 |
| TW521073B (en) | 1994-01-05 | 2003-02-21 | Hoechst Marion Roussel Inc | New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them |
| US20040006011A1 (en) | 1996-07-12 | 2004-01-08 | Gour Barbara J. | Peptidomimetic modulators of cell adhesion |
| US6063628A (en) | 1996-10-28 | 2000-05-16 | University Of Washington | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA |
| DE69811867T2 (de) | 1997-03-03 | 2003-11-20 | Boehringer Ingelheim Pharma | Kleine moleküle anwendbar in der behandlung von entzündgskrankheiten |
| US6355664B1 (en) | 1997-03-03 | 2002-03-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Phenylpyrrolidines, phenylimidazolidines, 3-phenyl-1,3-oxizolidines and 3-phenyl-1,3-thiazolidines and their use in the treatment of inflammatory disease |
| DE69839399T2 (de) | 1997-08-28 | 2009-05-20 | Novartis Ag | Lymphozyten funktion antigen-1 antagonisten |
| IL138297A0 (en) | 1998-03-27 | 2001-10-31 | Genentech Inc | Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders |
| US6492408B1 (en) * | 1999-07-21 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Small molecules useful in the treatment of inflammatory disease |
| WO2001007052A1 (en) | 1999-07-21 | 2001-02-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | Small molecules useful in the treatment of inflammatory disease |
| WO2001007044A1 (en) | 1999-07-21 | 2001-02-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | Small molecules useful in the treatment of inflammatory disease |
| US6414153B1 (en) | 1999-07-21 | 2002-07-02 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1-phenylpydrrolidin-2-ones and -thiones and 1-(4-pyridyl)pydrrolidin-2-ones and -thiones which are useful in the treatment of inflammatory disease |
| WO2001007048A1 (en) | 1999-07-21 | 2001-02-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | Small molecules useful in the treatment of inflammatory disease |
| WO2001030781A2 (en) | 1999-10-20 | 2001-05-03 | Tanabe Seiyaku Co., Ltd. | INHIBITORS OF αLβ2 MEDIATED CELL ADHESION |
| WO2002050080A1 (en) | 2000-12-19 | 2002-06-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Small molecules useful in the treatment of inflammatory disease |
| EP1359916A4 (en) * | 2001-01-26 | 2004-04-07 | Bristol Myers Squibb Co | IMIDAZOLYLATED DERIVATIVES AS INHIBITORS OF CORTICOTROPIN RELEASE FACTOR |
| US20030232817A1 (en) | 2002-05-29 | 2003-12-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Small molecules useful for the treatment of inflammatory disease |
| US6844360B2 (en) * | 2002-10-30 | 2005-01-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide |
| US6852748B1 (en) | 2002-10-30 | 2005-02-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide |
| WO2006014828A1 (en) | 2004-07-27 | 2006-02-09 | Boehringer Ingelheim International, Gmbh | Synthesis of 6,7-dihydro-5h-imidazo[1,2-a]imidazole-3-sulfonic acid amides |
| JP2008534685A (ja) | 2005-04-05 | 2008-08-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 炎症性疾患の治療に有用な置換ベンジルイミダゾール |
| US7589114B2 (en) | 2005-04-06 | 2009-09-15 | Boehringer Ingelheim International Gmbh | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-azetidine-carboxylic acids, esters and amides |
| CN101166743A (zh) * | 2005-05-19 | 2008-04-23 | 贝林格尔·英格海姆国际有限公司 | 6,7-二氢-5H-咪唑并[1,2-α]咪唑-3-磺酸的衍生物 |
| TW200831488A (en) | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
| EP2080758A3 (de) | 2007-11-29 | 2009-08-26 | Bayer CropScience AG | Halogen substituierte delta-1-Pyrroline |
| JP2009149609A (ja) | 2007-11-29 | 2009-07-09 | Sumitomo Chemical Co Ltd | アミド化合物及びその用途 |
| TW200936146A (en) | 2007-11-29 | 2009-09-01 | Metabasis Therapeutics Inc | Antiviral nucleoside compounds |
| RU2483072C2 (ru) | 2007-11-29 | 2013-05-27 | Актелион Фармасьютиклз Лтд | Производные фосфоновой кислоты и их применение в качестве антагонистов рецептора p2y12 |
| MX2011012717A (es) | 2009-06-02 | 2011-12-14 | Boehringer Ingelheim Int | Derivados de amidas del acido 6,7-dihidro-5h-imidazo[1,2-a]imidazo l-3-carboxilico. |
| US8481750B2 (en) | 2009-06-02 | 2013-07-09 | Boehringer Ingelheim International Gmbh | Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amides |
-
2008
- 2008-11-20 DK DK08853791.5T patent/DK2225238T3/en active
- 2008-11-20 PL PL08853791T patent/PL2225238T3/pl unknown
- 2008-11-20 MY MYPI20102238 patent/MY151004A/en unknown
- 2008-11-20 ES ES08853791.5T patent/ES2525237T3/es active Active
- 2008-11-20 RS RSP20140622 patent/RS53602B1/en unknown
- 2008-11-20 KR KR1020107011875A patent/KR20100101095A/ko not_active Application Discontinuation
- 2008-11-20 WO PCT/US2008/084149 patent/WO2009070485A1/en active Application Filing
- 2008-11-20 PT PT88537915T patent/PT2225238E/pt unknown
- 2008-11-20 JP JP2010536067A patent/JP5485164B2/ja not_active Expired - Fee Related
- 2008-11-20 US US12/745,439 patent/US8552205B2/en active Active
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