AR071925A1 - Malonamidas como antagonistas de orexina - Google Patents

Malonamidas como antagonistas de orexina

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Publication number
AR071925A1
AR071925A1 ARP080101021A ARP080101021A AR071925A1 AR 071925 A1 AR071925 A1 AR 071925A1 AR P080101021 A ARP080101021 A AR P080101021A AR P080101021 A ARP080101021 A AR P080101021A AR 071925 A1 AR071925 A1 AR 071925A1
Authority
AR
Argentina
Prior art keywords
lower alkyl
substituted
halogen
compounds
antagonists
Prior art date
Application number
ARP080101021A
Other languages
English (en)
Inventor
Luca Gobbi
Mark Rogers-Evans
Emmanuel Pinard
Matthias Nettekoven
Henner Knust
Parichehr Malherbe
Olivier Roche
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR071925A1 publication Critical patent/AR071925A1/es

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Abstract

La presente se refiere a compuestos de la formula (1) en la que Ar1 y Ar2 con independencia entre s¡ son arilo o heteroarilo sustituidos o sin sustituir; R1/R2 con independencia entre s¡ son hidrogeno, alquilo inferior, alquilo inferior sustituido por halogeno, -(CH2)o-O-alquilo inferior, - (CH2)o-N-(alquilo inferior)2, (CH2)p-cicloalquilo, (CH2)p-heterocicloalquilo, (CH2)p-arilo, (CH2)-heteroarilo, dichos anillos pueden estar sustituidos por R, o R1 y R2 junto con el  tomo de N al que est n unidos pueden formar un anillo heteroc¡clico, opcionalmente con otros hetero tomos en el anillo elegidos entre N, O y S, dicho anillo puede estar sustituido por R; R es halogeno, alquilo inferior, alquilo inferior sustituido por halogeno, alcoxi inferior o alcoxi inferior sustituido por halogeno; R3 es H o alquilo inferior; n es el numero 0, 1, 2, 3 o 4; o es el numero 1, 2 o 3; p es el numero 0, 1 o 2; o las sales de adicion de  cido farmaceuticamente idoneas, enantiomeros opticamente puros, racematos o mezclas diastereomericas de los mismos. Se ha encontrado que los compuestos de la formula (1) son antagonistas de receptores de orexina y los compuestos afines son utiles para el tratamiento de trastornos, en los que intervienen los mecanismos de la orexina, por ejemplo los trastornos del sueno.
ARP080101021A 2007-03-15 2008-03-13 Malonamidas como antagonistas de orexina AR071925A1 (es)

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EP07104232 2007-03-15

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AR071925A1 true AR071925A1 (es) 2010-07-28

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US (1) US7501541B2 (es)
EP (1) EP2121579B1 (es)
JP (1) JP5148636B2 (es)
KR (1) KR101132475B1 (es)
CN (1) CN101636378A (es)
AR (1) AR071925A1 (es)
AT (1) ATE506343T1 (es)
AU (1) AU2008225922B2 (es)
BR (1) BRPI0808737A2 (es)
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CL (1) CL2008000738A1 (es)
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PE (1) PE20090521A1 (es)
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WO (1) WO2008110488A1 (es)

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