PE20070022A1 - Compuestos derivados de pirrolopiridina como inhibidores de dipeptidil peptidasa iv - Google Patents

Compuestos derivados de pirrolopiridina como inhibidores de dipeptidil peptidasa iv

Info

Publication number
PE20070022A1
PE20070022A1 PE2006000540A PE2006000540A PE20070022A1 PE 20070022 A1 PE20070022 A1 PE 20070022A1 PE 2006000540 A PE2006000540 A PE 2006000540A PE 2006000540 A PE2006000540 A PE 2006000540A PE 20070022 A1 PE20070022 A1 PE 20070022A1
Authority
PE
Peru
Prior art keywords
ona
dichlorophenyl
pyridin
methyl
inhibitors
Prior art date
Application number
PE2006000540A
Other languages
English (en)
Inventor
Pratik Devasthale
Wei Wang
Lawrence G Hamann
John M Fevig
Stephen P O'connor
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20070022A1 publication Critical patent/PE20070022A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE --- ES UNO O DOS ENLACES DOBLES EN EL ANILLO CON LA CONDICION DE QUE EL ANILLO DE SEIS MIEMBROS ES UN ANILLO AROMATICO; n ES 1 O 2; R ES H, HALOGENO, CF3, CN, AMINO, ENTRE OTROS; X Y Z SON CH2, CH, C=O, C=S, ENTRE OTROS; A ES H, ALQUILO(C1-C10), CICLOALQUILO(C3-C10), ALQUENILO(C2-C12), ENTRE OTROS; Y ES ARILO(C5-C20) O HETEROARILO OPCIONALMENTE SUSTITUIDOS CON H, HALO, ALQUILO(C1-C10), ALCOXI(C1-C10), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-(AMINOMETIL)-4-(2,4-DICLOROFENIL)-2-METIL-6-FENIL-6,7-DIHIDROPIRROL[3,4-b]PIRIDIN-5-ONA, 3-(AMINOMETIL)-4-(2,4-DICLOROFENIL)-6-(4-METOXIFENIL)-2-METIL-6,7-DIHIDROPIRROLO[3,4-b]PIRIDIN-5-ONA, 3-(AMINOMETIL)-6-BENCIL-4-(2,4-DICLOROFENIL)-2-METIL-5,6-DIHIDROPIRROLO[3,4-b]PIRIDIN-5-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA DIPEPTIDIL PEPTIDASA IV (DPP-4) SIENDO UTILES EN EL TRATAMIENTO DE DIABETES DE TIPO II, TOLERANCIA DE GLUCOSA DISMINUIDA, RESISTENCIA A LA INSULINA
PE2006000540A 2005-05-20 2006-05-22 Compuestos derivados de pirrolopiridina como inhibidores de dipeptidil peptidasa iv PE20070022A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68296805P 2005-05-20 2005-05-20
US11/430,657 US7521557B2 (en) 2005-05-20 2006-05-09 Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods

Publications (1)

Publication Number Publication Date
PE20070022A1 true PE20070022A1 (es) 2007-01-18

Family

ID=37074817

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000540A PE20070022A1 (es) 2005-05-20 2006-05-22 Compuestos derivados de pirrolopiridina como inhibidores de dipeptidil peptidasa iv

Country Status (20)

Country Link
US (1) US7521557B2 (es)
EP (1) EP1888589B1 (es)
JP (1) JP2008540651A (es)
KR (1) KR20080026544A (es)
AR (1) AR054193A1 (es)
AT (1) ATE557025T1 (es)
AU (1) AU2006249497A1 (es)
BR (1) BRPI0610138A2 (es)
CA (1) CA2609508A1 (es)
EA (1) EA200702567A1 (es)
ES (1) ES2385497T3 (es)
GE (1) GEP20104941B (es)
IL (1) IL187304A0 (es)
MX (1) MX2007014503A (es)
MY (1) MY142252A (es)
NO (1) NO20075706L (es)
NZ (1) NZ562914A (es)
PE (1) PE20070022A1 (es)
TW (1) TW200722427A (es)
WO (1) WO2006127287A2 (es)

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Also Published As

Publication number Publication date
MX2007014503A (es) 2008-02-07
KR20080026544A (ko) 2008-03-25
US20060264457A1 (en) 2006-11-23
US7521557B2 (en) 2009-04-21
TW200722427A (en) 2007-06-16
AR054193A1 (es) 2007-06-06
JP2008540651A (ja) 2008-11-20
EP1888589A2 (en) 2008-02-20
MY142252A (en) 2010-11-15
EP1888589B1 (en) 2012-05-09
IL187304A0 (en) 2008-04-13
ATE557025T1 (de) 2012-05-15
AU2006249497A1 (en) 2006-11-30
NZ562914A (en) 2010-11-26
WO2006127287A2 (en) 2006-11-30
WO2006127287A3 (en) 2007-06-07
BRPI0610138A2 (pt) 2010-06-01
EA200702567A1 (ru) 2008-06-30
GEP20104941B (en) 2010-04-12
CA2609508A1 (en) 2006-11-30
ES2385497T3 (es) 2012-07-25
NO20075706L (no) 2007-12-18

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