PE20090229A1 - DIFENIL-DIHIDRO-IMIDAZOPIRIDINONAS COMO INHIBIDORES DE LA INTERACCION DE MDM2 CON EL PEPTIDO p-53 - Google Patents

DIFENIL-DIHIDRO-IMIDAZOPIRIDINONAS COMO INHIBIDORES DE LA INTERACCION DE MDM2 CON EL PEPTIDO p-53

Info

Publication number
PE20090229A1
PE20090229A1 PE2008000636A PE2008000636A PE20090229A1 PE 20090229 A1 PE20090229 A1 PE 20090229A1 PE 2008000636 A PE2008000636 A PE 2008000636A PE 2008000636 A PE2008000636 A PE 2008000636A PE 20090229 A1 PE20090229 A1 PE 20090229A1
Authority
PE
Peru
Prior art keywords
dihydro
imidazo
chloro
bis
phenyl
Prior art date
Application number
PE2008000636A
Other languages
English (en)
Inventor
Romyr Dominique
Robert Alan Goodnow Jr
Qi Qiao
Binh Thanh Vu
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20090229A1 publication Critical patent/PE20090229A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A UN DERIVADO DE IMIDAZOPIRIDINONA DE FORMULA (1), DONDE Y1 E Y2 SON HALOGENO, TRIFLUOROMETILO, NO2, CIANO, ENTRE OTROS; X ES SO2, CO O C=OCH2; R1 ES H, ALQUILO SUSTITUIDO POR HETEROCICLO, ENTRE OTROS; R2 ES ALQUILO, ARILO, HETEROARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 5-[RAC-CIS-2,3-BIS-(4-CLORO-FENIL)-5-OXO-2,3-DIHIDRO-5H-IMIDAZO[1,2-a]PIRIDINA-1-SULFONIL]-2-FLUOR-BENZONITRILO, 5-[2R*,3S*-BIS-(4-CLORO-FENIL)-5-OXO-2,3-DIHIDRO-5H-IMIDAZO[1,2-a]PIRIDINA-1-SULFONIL]-2-FLUOR-BENZONITRILO, RAC-CIS-2,3-BIS-(4-CLORO-FENIL)-1-(2,4-DIFLUOR-BENCENOSULFONIL)-2,3-DIHIDRO-1H-IMIDAZO[1,2-a]PIRIDIN-5-ONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA INTERACCION DE LA PROTEINA MDM2 CON UN PEPTIDO DE TIPO p-53 Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS
PE2008000636A 2007-04-12 2008-04-10 DIFENIL-DIHIDRO-IMIDAZOPIRIDINONAS COMO INHIBIDORES DE LA INTERACCION DE MDM2 CON EL PEPTIDO p-53 PE20090229A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92311007P 2007-04-12 2007-04-12

Publications (1)

Publication Number Publication Date
PE20090229A1 true PE20090229A1 (es) 2009-03-27

Family

ID=39478351

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000636A PE20090229A1 (es) 2007-04-12 2008-04-10 DIFENIL-DIHIDRO-IMIDAZOPIRIDINONAS COMO INHIBIDORES DE LA INTERACCION DE MDM2 CON EL PEPTIDO p-53

Country Status (18)

Country Link
US (1) US7625895B2 (es)
EP (1) EP2146986B1 (es)
JP (1) JP2010523616A (es)
KR (1) KR20090118116A (es)
CN (1) CN101657449B (es)
AR (1) AR066014A1 (es)
AT (1) ATE514696T1 (es)
AU (1) AU2008238062A1 (es)
BR (1) BRPI0810495A2 (es)
CA (1) CA2684008A1 (es)
CL (1) CL2008001047A1 (es)
ES (1) ES2367228T3 (es)
IL (1) IL201021A0 (es)
MX (1) MX2009011019A (es)
PE (1) PE20090229A1 (es)
RU (1) RU2009141522A (es)
TW (1) TW200848033A (es)
WO (1) WO2008125487A1 (es)

Families Citing this family (23)

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BRPI1007334A2 (pt) 2009-01-16 2016-02-10 Daiichi Sankyo Co Ltd composto, inibidor, medicamento, composição farmacêutica, uso de um composto, agente anticâncer,e , método para tratar câncer.
WO2011060049A2 (en) 2009-11-12 2011-05-19 The Regents Of The University Of Michigan Spiro-oxindole mdm2 antagonists
US10159669B2 (en) * 2010-03-02 2018-12-25 Ian H. Chan Individual and combination of mdivi-1 and nutlin-3 for topical or intravitreal ophthalmic use
JO2998B1 (ar) 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
FR2967072B1 (fr) 2010-11-05 2013-03-29 Univ Dundee Procede pour ameliorer la production de virus et semences vaccinales influenza
UA109464C2 (uk) 2010-11-12 2015-08-25 Дзе Ріджентс Оф Дзе Юніверсіті Оф Мічіган Спірооксіндольні антагоністи mdm2
CA2835422C (en) 2011-05-11 2016-10-11 The Regents Of The University Of Michigan Spiro-oxindole mdm2 antagonists
JP6093770B2 (ja) 2011-09-27 2017-03-08 アムジエン・インコーポレーテツド 癌の治療のためのｍｄｍ２阻害剤としての複素環化合物
CA2895504A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
EP2961735B1 (en) 2013-02-28 2017-09-27 Amgen Inc. A benzoic acid derivative mdm2 inhibitor for the treatment of cancer
AU2014236812B2 (en) 2013-03-14 2018-03-01 Amgen Inc. Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer
JOP20200296A1 (ar) 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
EA036942B1 (ru) 2013-11-11 2021-01-18 Эмджен Инк. Применение amg232 в комбинации с цитарабином или децитабином для лечения острого миелогенного лейкоза
WO2015116735A1 (en) 2014-01-28 2015-08-06 Mayo Foundation For Medical Education And Research Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders
US10328058B2 (en) 2014-01-28 2019-06-25 Mayo Foundation For Medical Education And Research Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques
SG10201805670QA (en) 2014-01-28 2018-08-30 Buck Inst Res Aging Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
CN113788818A (zh) 2016-04-06 2021-12-14 密执安大学评议会 Mdm2蛋白质降解剂
EP3440082A1 (en) 2016-04-06 2019-02-13 The Regents of The University of Michigan Monofunctional intermediates for ligand-dependent target protein degradation
JP2019522633A (ja) 2016-05-20 2019-08-15 ジェネンテック， インコーポレイテッド Ｐｒｏｔａｃ抗体コンジュゲート及び使用方法
CN112912143A (zh) 2018-10-08 2021-06-04 美国密歇根州立大学试剂中心 小分子mdm2蛋白降解剂
TW202200543A (zh) 2020-03-19 2022-01-01 美商凱麥拉醫療公司 Mdm2降解劑及其用途
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1067079A (en) * 1976-07-22 1979-11-27 Yamanouchi Pharmaceutical Co. Nitrogen-containing heterobicyclic compounds
JPH02101065A (ja) 1988-10-06 1990-04-12 Tanabe Seiyaku Co Ltd イミダゾリン誘導体及びその製法
GB9704762D0 (en) * 1997-03-07 1997-04-23 Zeneca Ltd Chemical process
GB2351082A (en) 1999-06-18 2000-12-20 Lilly Forschung Gmbh Synthesis of Cyclic Substituted Amidines
DE60227108D1 (de) * 2001-12-18 2008-07-24 Hoffmann La Roche Cis-imidazoline als mdm2-hemmer
ES2301717T3 (es) * 2001-12-18 2008-07-01 F. Hoffmann-La Roche Ag Cis-2,4,5-trifenil-imidazolinas y su utilizacion para el tratamiento de tumores.
CN100465163C (zh) * 2003-06-17 2009-03-04 霍夫曼-拉罗奇有限公司 顺式-2,4,5-三芳基-咪唑啉类化合物
JP4814228B2 (ja) 2004-05-18 2011-11-16 エフ．ホフマン−ラ ロシュ アーゲー 新規ｃｉｓ−イミダゾリン
US7893278B2 (en) 2004-06-17 2011-02-22 Hoffman-La Roche Inc. CIS-imidazolines
BRPI0710477A2 (pt) 2006-01-18 2011-08-16 Hoffmann La Roche cis-4, 5- biarila - 2- imidazolinas heterocìclicas como inibidores da mdm2
US8232298B2 (en) 2006-03-22 2012-07-31 Janssen Pharmaceutica N.V. Inhibitors of the interaction between MDM2 and P53

Also Published As

Publication number Publication date
WO2008125487A1 (en) 2008-10-23
JP2010523616A (ja) 2010-07-15
CA2684008A1 (en) 2008-10-23
BRPI0810495A2 (pt) 2018-10-30
CL2008001047A1 (es) 2009-01-16
EP2146986B1 (en) 2011-06-29
AU2008238062A1 (en) 2008-10-23
AR066014A1 (es) 2009-07-15
EP2146986A1 (en) 2010-01-27
MX2009011019A (es) 2009-10-29
ES2367228T3 (es) 2011-10-31
US20080255119A1 (en) 2008-10-16
US7625895B2 (en) 2009-12-01
IL201021A0 (en) 2010-05-17
CN101657449A (zh) 2010-02-24
CN101657449B (zh) 2012-06-06
TW200848033A (en) 2008-12-16
KR20090118116A (ko) 2009-11-17
RU2009141522A (ru) 2011-05-20
ATE514696T1 (de) 2011-07-15

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