SG10201805670QA - Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders - Google Patents

Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders

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Publication number
SG10201805670QA
SG10201805670QA SG10201805670QA SG10201805670QA SG10201805670QA SG 10201805670Q A SG10201805670Q A SG 10201805670QA SG 10201805670Q A SG10201805670Q A SG 10201805670QA SG 10201805670Q A SG10201805670Q A SG 10201805670QA SG 10201805670Q A SG10201805670Q A SG 10201805670QA
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SG
Singapore
Prior art keywords
disorders
senescence
methods
diseases
senescent cells
Prior art date
Application number
SG10201805670QA
Inventor
Remi-Martin Laberge
Judith Campisi
Albert Davalos
Marco Demaria
Nathaniel David
Alain Vasserot
Darren Baker
Bennett Childs
James Kirkland
Tamar Tchkonia
Deursen Jan Van
Yi Zhu
Jennifer Elisseeff
Chaekyu Kim
Okhee Jeon
Original Assignee
Buck Inst Res Aging
Unity Biotechnology Inc
Mayo Found Medical Education & Res
Univ Johns Hopkins
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Publication date
Application filed by Buck Inst Res Aging, Unity Biotechnology Inc, Mayo Found Medical Education & Res, Univ Johns Hopkins filed Critical Buck Inst Res Aging
Publication of SG10201805670QA publication Critical patent/SG10201805670QA/en

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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Abstract

METHODS AND COMPOSITIONS FOR KILLING SENESCENT CELLS AND FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence- associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders. Fig. 8
SG10201805670QA 2014-01-28 2015-01-28 Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders SG10201805670QA (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201461932704P 2014-01-28 2014-01-28
US201461932711P 2014-01-28 2014-01-28
US201461979911P 2014-04-15 2014-04-15
US201462002709P 2014-05-23 2014-05-23
US201462042708P 2014-08-27 2014-08-27
US201462044664P 2014-09-02 2014-09-02
US201462057820P 2014-09-30 2014-09-30
US201462057828P 2014-09-30 2014-09-30
US201462057825P 2014-09-30 2014-09-30
US201462061629P 2014-10-08 2014-10-08
US201462061627P 2014-10-08 2014-10-08

Publications (1)

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SG10201805670QA true SG10201805670QA (en) 2018-08-30

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US (19) US9993472B2 (en)
EP (2) EP3099380B1 (en)
JP (5) JP6688224B2 (en)
KR (1) KR102496146B1 (en)
CN (3) CN110623956A (en)
AU (3) AU2015211021B2 (en)
BR (1) BR112016017564A8 (en)
CA (2) CA2939121C (en)
HK (1) HK1231392A1 (en)
IL (2) IL286427B1 (en)
MX (2) MX2016009753A (en)
NZ (1) NZ723035A (en)
RU (1) RU2716256C2 (en)
SG (2) SG11201606239UA (en)
WO (1) WO2015116740A1 (en)

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