ATE514696T1 - Diphenyl-dihydro-imidazopyridinone - Google Patents

Diphenyl-dihydro-imidazopyridinone

Info

Publication number
ATE514696T1
ATE514696T1 AT08735669T AT08735669T ATE514696T1 AT E514696 T1 ATE514696 T1 AT E514696T1 AT 08735669 T AT08735669 T AT 08735669T AT 08735669 T AT08735669 T AT 08735669T AT E514696 T1 ATE514696 T1 AT E514696T1
Authority
AT
Austria
Prior art keywords
imidazopyridinone
dihydro
diphenyl
Prior art date
Application number
AT08735669T
Other languages
English (en)
Inventor
Romyr Dominique
Robert Alan Goodnow
Qi Qiao
Binh Thanh Vu
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE514696T1 publication Critical patent/ATE514696T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT08735669T 2007-04-12 2008-04-02 Diphenyl-dihydro-imidazopyridinone ATE514696T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92311007P 2007-04-12 2007-04-12
PCT/EP2008/053903 WO2008125487A1 (en) 2007-04-12 2008-04-02 Diphenyl-dihydro-imidazopyridinones

Publications (1)

Publication Number Publication Date
ATE514696T1 true ATE514696T1 (de) 2011-07-15

Family

ID=39478351

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08735669T ATE514696T1 (de) 2007-04-12 2008-04-02 Diphenyl-dihydro-imidazopyridinone

Country Status (18)

Country Link
US (1) US7625895B2 (de)
EP (1) EP2146986B1 (de)
JP (1) JP2010523616A (de)
KR (1) KR20090118116A (de)
CN (1) CN101657449B (de)
AR (1) AR066014A1 (de)
AT (1) ATE514696T1 (de)
AU (1) AU2008238062A1 (de)
BR (1) BRPI0810495A2 (de)
CA (1) CA2684008A1 (de)
CL (1) CL2008001047A1 (de)
ES (1) ES2367228T3 (de)
IL (1) IL201021A0 (de)
MX (1) MX2009011019A (de)
PE (1) PE20090229A1 (de)
RU (1) RU2009141522A (de)
TW (1) TW200848033A (de)
WO (1) WO2008125487A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG173028A1 (en) 2009-01-16 2011-08-29 Daiichi Sankyo Co Ltd Imidazothiazole derivative having proline ring structure
KR20120099462A (ko) 2009-11-12 2012-09-10 더 리젠츠 오브 더 유니버시티 오브 미시건 스피로-옥신돌 ｍｄｍ2 길항제
US10159669B2 (en) * 2010-03-02 2018-12-25 Ian H. Chan Individual and combination of mdivi-1 and nutlin-3 for topical or intravitreal ophthalmic use
JO2998B1 (ar) 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
FR2967072B1 (fr) 2010-11-05 2013-03-29 Univ Dundee Procede pour ameliorer la production de virus et semences vaccinales influenza
MX2013005238A (es) 2010-11-12 2013-09-02 Univ Michigan Antagonistas de mdm2 de espiro-oxindol.
BR112013028983A2 (pt) 2011-05-11 2017-02-07 Sanofi Sa antagonistas mdm2 espiro-oxindol
CA2850166C (en) 2011-09-27 2019-12-03 Amgen Inc. Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer
US8846657B2 (en) 2012-12-20 2014-09-30 Merck Sharp & Dohme Corp. Substituted imidazopyridines as HDM2 inhibitors
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
WO2014134201A1 (en) 2013-02-28 2014-09-04 Amgen Inc. A benzoic acid derivative mdm2 inhibitor for the treatment of cancer
EP2970237B1 (de) 2013-03-14 2017-09-27 Amgen Inc. Cis-morpholinon und andere verbindungen als mdm2-inhibitoren zur behandlung von krebs
CN105358530A (zh) 2013-06-10 2016-02-24 美国安进公司 制备mdm2抑制剂的方法及其结晶形式
MX391859B (es) 2013-11-11 2025-03-12 Amgen Inc Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres
US20190269675A1 (en) 2014-01-28 2019-09-05 Buck Institute for Research and Aging Treatment of parkinson's disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents
US10328058B2 (en) 2014-01-28 2019-06-25 Mayo Foundation For Medical Education And Research Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques
US20170216286A1 (en) 2014-01-28 2017-08-03 Mayo Foundation For Medical Education And Research Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid
EP3099380B1 (de) 2014-01-28 2021-08-11 Buck Institute for Research on Aging Verfahren und zusammensetzungen zum töten von seneszenten zellen und zur behandlung von erkrankungen und störungen im zusammenhang mit seneszenz
CN113788818A (zh) 2016-04-06 2021-12-14 密执安大学评议会 Mdm2蛋白质降解剂
AU2017246453A1 (en) 2016-04-06 2018-11-08 The Regents Of The University Of Michigan Monofunctional intermediates for ligand-dependent target protein degradation
CN118436801A (zh) 2016-05-20 2024-08-06 豪夫迈·罗氏有限公司 Protac抗体缀合物及其使用方法
EP3863720A1 (de) 2018-10-08 2021-08-18 The Regents Of The University Of Michigan Kleinmolekülige mdm2-proteindegrader
MX2022011602A (es) 2020-03-19 2023-01-04 Kymera Therapeutics Inc Degradadores de la proteína de homólogo de ratón de minuto 2 (mdm2) y usos de los mismos.
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
WO2024240858A1 (en) 2023-05-23 2024-11-28 Valerio Therapeutics Protac molecules directed against dna damage repair system and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2358891A1 (fr) * 1976-07-22 1978-02-17 Yamanouchi Pharma Co Ltd Composes heterocycliques contenant un azote, utilise comme agents analgesiques et anti-inflammatoires
JPH02101065A (ja) 1988-10-06 1990-04-12 Tanabe Seiyaku Co Ltd イミダゾリン誘導体及びその製法
GB9704762D0 (en) * 1997-03-07 1997-04-23 Zeneca Ltd Chemical process
GB2351082A (en) 1999-06-18 2000-12-20 Lilly Forschung Gmbh Synthesis of Cyclic Substituted Amidines
DE60225719T2 (de) * 2001-12-18 2009-04-23 F. Hoffmann-La Roche Ag Cis-2,4,5- triphenyl-imidazoline und ihre verwendung bei der behandlung von tumoren
WO2003051360A1 (en) * 2001-12-18 2003-06-26 F. Hoffmann-La Roche Ag Cis-imidazolines as mdm2 inhibitors
BRPI0411841A (pt) * 2003-06-17 2006-08-08 Hoffmann La Roche cis-2,4,5-triaril-imidazolinas
MXPA06013246A (es) 2004-05-18 2007-02-08 Hoffmann La Roche Nuevas imidazolinas cis.
US7893278B2 (en) 2004-06-17 2011-02-22 Hoffman-La Roche Inc. CIS-imidazolines
WO2007082805A1 (en) 2006-01-18 2007-07-26 F. Hoffmann-La Roche Ag Cis-4, 5-biaryl-2-heterocyclic-imidazolines as mdm2 inhibitors
JP5385125B2 (ja) 2006-03-22 2014-01-08 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ＭＤＭ２とｐ５３の間の相互作用の阻害剤

Also Published As

Publication number Publication date
BRPI0810495A2 (pt) 2018-10-30
RU2009141522A (ru) 2011-05-20
ES2367228T3 (es) 2011-10-31
PE20090229A1 (es) 2009-03-27
KR20090118116A (ko) 2009-11-17
US7625895B2 (en) 2009-12-01
AR066014A1 (es) 2009-07-15
CL2008001047A1 (es) 2009-01-16
CA2684008A1 (en) 2008-10-23
AU2008238062A1 (en) 2008-10-23
CN101657449B (zh) 2012-06-06
JP2010523616A (ja) 2010-07-15
IL201021A0 (en) 2010-05-17
TW200848033A (en) 2008-12-16
CN101657449A (zh) 2010-02-24
MX2009011019A (es) 2009-10-29
US20080255119A1 (en) 2008-10-16
EP2146986A1 (de) 2010-01-27
EP2146986B1 (de) 2011-06-29
WO2008125487A1 (en) 2008-10-23

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