ATE501136T1 - Imidazopyridinone - Google Patents
ImidazopyridinoneInfo
- Publication number
- ATE501136T1 ATE501136T1 AT08788941T AT08788941T ATE501136T1 AT E501136 T1 ATE501136 T1 AT E501136T1 AT 08788941 T AT08788941 T AT 08788941T AT 08788941 T AT08788941 T AT 08788941T AT E501136 T1 ATE501136 T1 AT E501136T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazopyridinone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95370707P | 2007-08-03 | 2007-08-03 | |
| PCT/IB2008/001962 WO2009019553A2 (en) | 2007-08-03 | 2008-07-22 | Imidazopyridinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE501136T1 true ATE501136T1 (de) | 2011-03-15 |
Family
ID=40193849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08788941T ATE501136T1 (de) | 2007-08-03 | 2008-07-22 | Imidazopyridinone |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20090221631A1 (de) |
| EP (1) | EP2188280B1 (de) |
| JP (1) | JP2010535755A (de) |
| AR (1) | AR067757A1 (de) |
| AT (1) | ATE501136T1 (de) |
| CA (1) | CA2707030A1 (de) |
| CL (1) | CL2008002228A1 (de) |
| DE (1) | DE602008005470D1 (de) |
| ES (1) | ES2359123T3 (de) |
| PA (1) | PA8791701A1 (de) |
| PE (1) | PE20090511A1 (de) |
| TW (1) | TW200914003A (de) |
| UY (1) | UY31261A1 (de) |
| WO (1) | WO2009019553A2 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY32306A (es) | 2008-12-09 | 2010-07-30 | Gilead Sciences Inc | Derivados de pteridinona y pirimidinodiazepinona y composiciones farmacéuticas que modulan en forma selectiva los receptores tipo toll, métodos y usos |
| US9950062B2 (en) | 2009-09-02 | 2018-04-24 | Glaxosmithkline Biologicals Sa | Compounds and compositions as TLR activity modulators |
| WO2011031965A1 (en) * | 2009-09-14 | 2011-03-17 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
| BR112012009329A2 (pt) | 2009-10-22 | 2016-06-07 | Gilead Sciences Inc | derivados de purina ou deazapurina úteis para o tratamento de infecções virais (inter alia) |
| JP5689321B2 (ja) * | 2010-01-21 | 2015-03-25 | 石原産業株式会社 | ２−アミノ−４−トリフルオロメチルピリジン類の製造方法 |
| JP2013538217A (ja) | 2010-09-01 | 2013-10-10 | ノバルティス アーゲー | 不溶性金属塩への免疫増強物質の吸着 |
| EP2471776A1 (de) | 2010-12-28 | 2012-07-04 | Bayer CropScience AG | Pyridin-2-ylpropandinitrile und deren Verwendung als Herbizide |
| CN103533954B (zh) * | 2011-03-02 | 2015-09-09 | 诺华股份有限公司 | 含较低剂量的抗原和/或佐剂的联合疫苗 |
| SG11201400210RA (en) | 2011-09-01 | 2014-03-28 | Novartis Ag | Adjuvanted formulations of staphylococcus aureus antigens |
| WO2013131983A1 (en) | 2012-03-07 | 2013-09-12 | Novartis Ag | Adjuvanted formulations of streptococcus pneumoniae antigens |
| AU2013229465A1 (en) | 2012-03-07 | 2014-09-04 | Novartis Ag | Adjuvanted formulations of rabies virus immunogens |
| CA2866406A1 (en) | 2012-03-08 | 2013-09-12 | Novartis Ag | Adjuvanted formulations of booster vaccines |
| BR112015005056A2 (pt) | 2012-09-06 | 2017-11-21 | Novartis Ag | vacinas de combinação com sorogrupo b meningococcus e d/t/p |
| US10471139B2 (en) * | 2013-08-15 | 2019-11-12 | The University Of Kansas | Toll-like receptor agonists |
| SI3166607T1 (sl) | 2014-07-11 | 2023-01-31 | Gilead Sciences, Inc. | Modulatorji toličnih receptorjev za zdravljenje HIV-a |
| CN112898308B (zh) | 2014-08-15 | 2026-08-07 | 正大天晴药业集团股份有限公司 | 作为tlr7激动剂的吡咯并嘧啶化合物 |
| CN110305133A (zh) | 2014-09-16 | 2019-10-08 | 吉利德科学公司 | Toll样受体调节剂的固体形式 |
| CN107043380A (zh) | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途 |
| WO2019209811A1 (en) | 2018-04-24 | 2019-10-31 | Bristol-Myers Squibb Company | Macrocyclic toll-like receptor 7 (tlr7) agonists |
| US11554120B2 (en) | 2018-08-03 | 2023-01-17 | Bristol-Myers Squibb Company | 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor |
| US11072610B2 (en) | 2018-09-12 | 2021-07-27 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
| CN113924114A (zh) | 2019-05-22 | 2022-01-11 | 吉利德科学公司 | Tlr7调节化合物和hiv疫苗的组合 |
| CN114667285B (zh) | 2019-09-26 | 2025-08-08 | 诺华股份有限公司 | 抗病毒吡唑并吡啶酮化合物 |
| JP2023512206A (ja) | 2020-01-27 | 2023-03-24 | ブリストル－マイヤーズ スクイブ カンパニー | トール様受容体７（ＴＬＲ７）アゴニストとしての１Ｈ－ピラゾロ［４，３－ｄ］ピリミジン化合物 |
| JP7684316B2 (ja) | 2020-01-27 | 2025-05-27 | ブリストル－マイヤーズ スクイブ カンパニー | トール様受容体７（ＴＬＲ７）アゴニストとしての１Ｈ－ピラゾロ［４，３－ｄ］ピリミジン化合物 |
| US20230127326A1 (en) | 2020-01-27 | 2023-04-27 | Bristol-Myers Squibb Company | C3-SUBSTITUTED 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS |
| CN115210235A (zh) | 2020-01-27 | 2022-10-18 | 百时美施贵宝公司 | 作为Toll样受体7(TLR7)激动剂的1H-吡唑并[4,3-d]嘧啶化合物 |
| KR20220132594A (ko) | 2020-01-27 | 2022-09-30 | 브리스톨-마이어스 스큅 컴퍼니 | 톨-유사 수용체 7 (TLR7) 효능제로서의 1H-피라졸로[4,3-d]피리미딘 화합물 |
| CN115279765B (zh) | 2020-01-27 | 2024-11-12 | 百时美施贵宝公司 | 作为Toll样受体7(TLR7)激动剂的1H-吡唑并[4,3-d]嘧啶化合物 |
| CN115151547A (zh) | 2020-01-27 | 2022-10-04 | 百时美施贵宝公司 | 作为Toll样受体7(TLR7)激动剂的1H-吡唑并[4,3-d]嘧啶化合物 |
| WO2021154662A1 (en) | 2020-01-27 | 2021-08-05 | Bristol-Myers Squibb Company | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS |
| JP7712941B2 (ja) | 2020-01-27 | 2025-07-24 | ブリストル－マイヤーズ スクイブ カンパニー | トール様受容体７（ＴＬＲ７）アゴニストとしての１Ｈ－ピラゾロ［４，３－ｄ］ピリミジン化合物 |
| CN117736210A (zh) * | 2021-01-28 | 2024-03-22 | 上海翊石医药科技有限公司 | 一类芳杂环类化合物及其制备方法和用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101253173A (zh) * | 2005-09-02 | 2008-08-27 | 辉瑞有限公司 | 羟基取代的1h-咪唑并吡啶和方法 |
| AU2007216247A1 (en) * | 2006-02-17 | 2007-08-23 | Pfizer Limited | 3 -deazapurine derivatives as TLR7 modulators |
-
2008
- 2008-07-22 AT AT08788941T patent/ATE501136T1/de not_active IP Right Cessation
- 2008-07-22 JP JP2010519534A patent/JP2010535755A/ja not_active Withdrawn
- 2008-07-22 ES ES08788941T patent/ES2359123T3/es active Active
- 2008-07-22 CA CA2707030A patent/CA2707030A1/en not_active Abandoned
- 2008-07-22 EP EP08788941A patent/EP2188280B1/de not_active Not-in-force
- 2008-07-22 DE DE602008005470T patent/DE602008005470D1/de active Active
- 2008-07-22 WO PCT/IB2008/001962 patent/WO2009019553A2/en not_active Ceased
- 2008-07-29 CL CL2008002228A patent/CL2008002228A1/es unknown
- 2008-07-30 PA PA20088791701A patent/PA8791701A1/es unknown
- 2008-07-31 AR ARP080103322A patent/AR067757A1/es not_active Application Discontinuation
- 2008-07-31 UY UY31261A patent/UY31261A1/es not_active Application Discontinuation
- 2008-08-01 TW TW097129257A patent/TW200914003A/zh unknown
- 2008-08-01 PE PE2008001300A patent/PE20090511A1/es not_active Application Discontinuation
-
2009
- 2009-05-15 US US12/184,494 patent/US20090221631A1/en not_active Abandoned
-
2010
- 2010-10-28 US US12/914,530 patent/US20110039884A1/en not_active Abandoned
-
2011
- 2011-11-22 US US13/302,085 patent/US20120302598A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110039884A1 (en) | 2011-02-17 |
| US20090221631A1 (en) | 2009-09-03 |
| AR067757A1 (es) | 2009-10-21 |
| DE602008005470D1 (en) | 2011-04-21 |
| US20120302598A1 (en) | 2012-11-29 |
| PE20090511A1 (es) | 2009-05-07 |
| UY31261A1 (es) | 2009-03-31 |
| CL2008002228A1 (es) | 2009-04-17 |
| CA2707030A1 (en) | 2009-02-12 |
| TW200914003A (en) | 2009-04-01 |
| WO2009019553A3 (en) | 2009-04-02 |
| PA8791701A1 (es) | 2009-04-23 |
| WO2009019553A2 (en) | 2009-02-12 |
| EP2188280A2 (de) | 2010-05-26 |
| ES2359123T3 (es) | 2011-05-18 |
| JP2010535755A (ja) | 2010-11-25 |
| EP2188280B1 (de) | 2011-03-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |