PA8791701A1 - Imidazopiridinonas - Google Patents

Imidazopiridinonas

Info

Publication number
PA8791701A1
PA8791701A1 PA20088791701A PA8791701A PA8791701A1 PA 8791701 A1 PA8791701 A1 PA 8791701A1 PA 20088791701 A PA20088791701 A PA 20088791701A PA 8791701 A PA8791701 A PA 8791701A PA 8791701 A1 PA8791701 A1 PA 8791701A1
Authority
PA
Panama
Prior art keywords
tlr7
imidazopiridinones
entirely
procedures
talcom
Prior art date
Application number
PA20088791701A
Other languages
English (en)
Inventor
Cameron Pryde David
Jones Peter
Duc Tran Thien
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of PA8791701A1 publication Critical patent/PA8791701A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

LA INVENCIÓN SE REFIERE A IMIDAZOPIRIDINONAS,A SU USO EN MEDICINA,A COMPOSICIONES QUE LAS CONTIENEN,A PROCEDIMIENTOS PARA SU PREPARACIÓN Y A INTERMEDIOS USADOS EN TALES PROCEDIMIENTOS.MEDIANTE LA ACTIVACIÓN DE TLR,DEBE SER POSIBLE INDUCIR O ESTIMULAR CÉLULAS INMUNES PARA DESENCADENAR UNA RESPUESTA INMUNE.EN PARTICULAR,TLR7 HA ESTADO IMPLICADO EN INFECCIONES VIRALES(TALCOMO VHC O VHB),CÁNCERES Y TUMORES,Y ENFERMEDADES MEDIADAS POR CÉLULAS COOPERADORAS T2(TH2),Y POR LO TANTO LOS AGONISTAS DE TLR7 SON POTENCIALMENTE ÚTILES EN EL TRATAMIENTO DE TALES ENFERMEDADES. LOS INVENTORES HAN ENCONTRADO AHORA UNA SERIE DE IMIDAZOPIRIDINONAS QUE SON AGONISTAS DE TLR7.DE ACUERDO CON LO ANTERIOR,SE PROPORCIONA UN COMPUESTO DE FÓRMULA (1)O UNA SAL O SOLVATO FARMACÉUTICAMENTE ACEPTABLE DEL MISMO,EN EL QUE R1 ES UN GRUPO HETEROCÍCLICO SATURADO DE 3 A 8 MIEMBROS EN EL QUE UN MIEMBRO DEL ANILLO ES -O-;Y R2 ES FENILO O PIRIDINILO,CADA UNO OPCIONALMENTE SUSTITUIDO POR -ALQUILO C1-C6.
PA20088791701A 2007-08-03 2008-07-30 Imidazopiridinonas PA8791701A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95370707P 2007-08-03 2007-08-03

Publications (1)

Publication Number Publication Date
PA8791701A1 true PA8791701A1 (es) 2009-04-23

Family

ID=40193849

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20088791701A PA8791701A1 (es) 2007-08-03 2008-07-30 Imidazopiridinonas

Country Status (14)

Country Link
US (3) US20090221631A1 (es)
EP (1) EP2188280B1 (es)
JP (1) JP2010535755A (es)
AR (1) AR067757A1 (es)
AT (1) ATE501136T1 (es)
CA (1) CA2707030A1 (es)
CL (1) CL2008002228A1 (es)
DE (1) DE602008005470D1 (es)
ES (1) ES2359123T3 (es)
PA (1) PA8791701A1 (es)
PE (1) PE20090511A1 (es)
TW (1) TW200914003A (es)
UY (1) UY31261A1 (es)
WO (1) WO2009019553A2 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101787309B1 (ko) * 2008-12-09 2017-10-18 길리애드 사이언시즈, 인코포레이티드 톨-유사 수용체의 조절제
MX2012002723A (es) 2009-09-02 2012-04-11 Novartis Ag Composiciones inmunogenicas que incluyen moduladores de la actividad de receptores tipo toll.
ES2661850T3 (es) * 2009-09-14 2018-04-04 Gilead Sciences, Inc. Moduladores de receptores del tipo toll
NZ598933A (en) 2009-10-22 2013-04-26 Gilead Sciences Inc Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections
JP5689321B2 (ja) * 2010-01-21 2015-03-25 石原産業株式会社 ２−アミノ−４−トリフルオロメチルピリジン類の製造方法
ES2458355T3 (es) 2010-09-01 2014-05-05 Novartis Ag Adsorción de inmunopotenciadores sobre sales metálicas insolubles
EP2471776A1 (de) 2010-12-28 2012-07-04 Bayer CropScience AG Pyridin-2-ylpropandinitrile und deren Verwendung als Herbizide
RU2013144207A (ru) * 2011-03-02 2015-04-10 Новартис Аг Комбинированные вакцины с пониженными дозами антигена и/или адъюванта
EP2763695A1 (en) 2011-09-01 2014-08-13 Novartis AG Adjuvanted formulations of staphylococcus aureus antigens
WO2013131984A1 (en) 2012-03-07 2013-09-12 Novartis Ag Adjuvanted formulations of rabies virus immunogens
WO2013131983A1 (en) 2012-03-07 2013-09-12 Novartis Ag Adjuvanted formulations of streptococcus pneumoniae antigens
RU2014140521A (ru) 2012-03-08 2016-04-27 Новартис Аг Адъювантные составы бустерных вакцин
CA2882619A1 (en) 2012-09-06 2014-03-13 Novartis Ag Combination vaccines with serogroup b meningococcus and d/t/p
US10471139B2 (en) * 2013-08-15 2019-11-12 The University Of Kansas Toll-like receptor agonists
US11116774B2 (en) 2014-07-11 2021-09-14 Gilead Sciences, Inc. Modulators of toll-like receptors for the treatment of HIV
UA117634C2 (uk) 2014-08-15 2018-08-27 Чиа Тай Тяньцін Фармасьютикал Ґруп Ко., Лтд. Піролопіримідинові сполуки, що використовуються як агоніст tlr7
EA201790369A1 (ru) 2014-09-16 2017-10-31 Джилид Сайэнс, Инк. Твердые формы модулятора толл-подобного рецептора
CN107043380A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
US11485741B2 (en) 2018-04-24 2022-11-01 Bristol-Myers Squibb Company Macrocyclic toll-like receptor 7 (TLR7) agonists
US11554120B2 (en) 2018-08-03 2023-01-17 Bristol-Myers Squibb Company 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor
AU2019339777B2 (en) 2018-09-12 2022-09-01 Novartis Ag Antiviral pyridopyrazinedione compounds
TW202126649A (zh) 2019-09-26 2021-07-16 瑞士商諾華公司 抗病毒吡唑并吡啶酮化合物
WO2021154668A1 (en) 2020-01-27 2021-08-05 Bristol-Myers Squibb Company 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS
EP4097104A1 (en) 2020-01-27 2022-12-07 Bristol-Myers Squibb Company 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists
US20230127326A1 (en) 2020-01-27 2023-04-27 Bristol-Myers Squibb Company C3-SUBSTITUTED 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS
CN115210236A (zh) 2020-01-27 2022-10-18 百时美施贵宝公司 作为Toll样受体7(TLR7)激动剂的1H-吡唑并[4,3-d]嘧啶化合物
CN115135655A (zh) 2020-01-27 2022-09-30 百时美施贵宝公司 作为Toll样受体7(TLR7)激动剂的1H-吡唑并[4,3-d]嘧啶化合物
EP4097100A1 (en) 2020-01-27 2022-12-07 Bristol-Myers Squibb Company 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists
WO2021154669A1 (en) 2020-01-27 2021-08-05 Bristol-Myers Squibb Company 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS
WO2021154662A1 (en) 2020-01-27 2021-08-05 Bristol-Myers Squibb Company 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS
CN115135654A (zh) 2020-01-27 2022-09-30 百时美施贵宝公司 作为Toll样受体7(TLR7)激动剂的1H-吡唑并[4,3-d]嘧啶化合物
CN114805341B (zh) * 2021-01-28 2023-12-08 上海翊石医药科技有限公司 一类芳杂环类化合物及其制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS20080128A (en) * 2005-09-02 2009-05-06 Pfizer Inc., Hydroxy substituted 1h-imidazopyridines and methods
CA2640672A1 (en) * 2006-02-17 2007-08-23 Pfizer Limited 3 -deazapurine derivatives as tlr7 modulators

Also Published As

Publication number Publication date
DE602008005470D1 (en) 2011-04-21
US20120302598A1 (en) 2012-11-29
AR067757A1 (es) 2009-10-21
ATE501136T1 (de) 2011-03-15
PE20090511A1 (es) 2009-05-07
UY31261A1 (es) 2009-03-31
EP2188280B1 (en) 2011-03-09
JP2010535755A (ja) 2010-11-25
TW200914003A (en) 2009-04-01
US20110039884A1 (en) 2011-02-17
EP2188280A2 (en) 2010-05-26
WO2009019553A3 (en) 2009-04-02
US20090221631A1 (en) 2009-09-03
CL2008002228A1 (es) 2009-04-17
ES2359123T3 (es) 2011-05-18
WO2009019553A2 (en) 2009-02-12
CA2707030A1 (en) 2009-02-12

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