UA117634C2 - Піролопіримідинові сполуки, що використовуються як агоніст tlr7 - Google Patents
Піролопіримідинові сполуки, що використовуються як агоніст tlr7Info
- Publication number
- UA117634C2 UA117634C2 UAA201702350A UAA201702350A UA117634C2 UA 117634 C2 UA117634 C2 UA 117634C2 UA A201702350 A UAA201702350 A UA A201702350A UA A201702350 A UAA201702350 A UA A201702350A UA 117634 C2 UA117634 C2 UA 117634C2
- Authority
- UA
- Ukraine
- Prior art keywords
- compounds used
- tlr7 agonist
- pyrrolopyrimidine compounds
- compounds
- pyrrolopyrimidine
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Abstract
Цей винахід стосується піролопіримідинової сполуки як агоніста TLR7 і, зокрема, стосується сполуки формули (І) або її фармацевтично прийнятної солі, способу отримання таких з'єднань, фармацевтичної композиції, що містить такі сполуки, і їх застосування для отримання лікарського засобу проти вірусної інфекції. , (I)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410405136.0A CN105367576A (zh) | 2014-08-15 | 2014-08-15 | 作为tlr7激动剂的吡咯并嘧啶化合物 |
CN201510392499 | 2015-07-06 | ||
PCT/CN2015/086909 WO2016023511A1 (zh) | 2014-08-15 | 2015-08-14 | 作为tlr7激动剂的吡咯并嘧啶化合物 |
Publications (1)
Publication Number | Publication Date |
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UA117634C2 true UA117634C2 (uk) | 2018-08-27 |
Family
ID=55303885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201702350A UA117634C2 (uk) | 2014-08-15 | 2015-08-14 | Піролопіримідинові сполуки, що використовуються як агоніст tlr7 |
Country Status (26)
Country | Link |
---|---|
US (2) | US9962388B2 (uk) |
EP (1) | EP3190113B1 (uk) |
JP (2) | JP6328341B2 (uk) |
KR (2) | KR102215609B1 (uk) |
CN (4) | CN106661034B (uk) |
AU (3) | AU2015303558B2 (uk) |
BR (1) | BR112017002811B1 (uk) |
CA (1) | CA2958097C (uk) |
CL (1) | CL2017000379A1 (uk) |
DK (1) | DK3190113T3 (uk) |
EA (1) | EA032824B1 (uk) |
ES (1) | ES2875313T3 (uk) |
HR (1) | HRP20210927T1 (uk) |
HU (1) | HUE054672T2 (uk) |
IL (2) | IL250586B (uk) |
LT (1) | LT3190113T (uk) |
MX (1) | MX2017002028A (uk) |
MY (1) | MY190026A (uk) |
PH (2) | PH12017500281B1 (uk) |
PL (1) | PL3190113T3 (uk) |
PT (1) | PT3190113T (uk) |
SG (2) | SG10201809918RA (uk) |
SI (1) | SI3190113T1 (uk) |
UA (1) | UA117634C2 (uk) |
WO (1) | WO2016023511A1 (uk) |
ZA (1) | ZA201803736B (uk) |
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