CN112105620A - 用于治疗肺癌的tlr7激动剂及其药物组合 - Google Patents

用于治疗肺癌的tlr7激动剂及其药物组合 Download PDF

Info

Publication number
CN112105620A
CN112105620A CN201980033499.7A CN201980033499A CN112105620A CN 112105620 A CN112105620 A CN 112105620A CN 201980033499 A CN201980033499 A CN 201980033499A CN 112105620 A CN112105620 A CN 112105620A
Authority
CN
China
Prior art keywords
pyrrolo
pyrimidin
butoxy
amine
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980033499.7A
Other languages
English (en)
Inventor
张喜全
杨玲
张颖
张旻澄
宋伟
徐宏江
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Original Assignee
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chia Tai Tianqing Pharmaceutical Group Co Ltd filed Critical Chia Tai Tianqing Pharmaceutical Group Co Ltd
Publication of CN112105620A publication Critical patent/CN112105620A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

本申请涉及用于治疗肺癌的作为Toll样受体7(TLR7)激动剂的式I化合物或其药学上可接受的盐，用于治疗肺癌的TLR7激动剂和酪氨酸激酶抑制剂的药物组合，以及式I化合物或其药学上可接受的盐所述药物组合在治疗肺癌中的用途。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201980033499.7A 2018-05-25 2019-05-24 用于治疗肺癌的tlr7激动剂及其药物组合 Pending CN112105620A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201810560770 2018-05-25
CN201810560770X 2018-05-25
PCT/CN2019/088360 WO2019223788A1 (zh) 2018-05-25 2019-05-24 用于治疗肺癌的tlr7激动剂及其药物组合

Publications (1)

Publication Number Publication Date
CN112105620A true CN112105620A (zh) 2020-12-18

Family

ID=68616579

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980033499.7A Pending CN112105620A (zh) 2018-05-25 2019-05-24 用于治疗肺癌的tlr7激动剂及其药物组合

Country Status (7)

Country Link
US (1) US20210220362A1 (zh)
EP (1) EP3816166A4 (zh)
JP (1) JP7385602B2 (zh)
KR (1) KR20210013183A (zh)
CN (1) CN112105620A (zh)
CA (1) CA3101370A1 (zh)
WO (1) WO2019223788A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022156678A1 (zh) * 2021-01-20 2022-07-28 上海维申医药有限公司 大环tlr7激动剂、其制备方法、药物组合物及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2477987T3 (pl) * 2009-09-14 2018-06-29 Gilead Sciences, Inc. Modulatory receptorów toll-podobnych
CN105311029A (zh) * 2014-06-06 2016-02-10 正大天晴药业集团股份有限公司 抗肿瘤活性的喹啉衍生物
CN105367576A (zh) * 2014-08-15 2016-03-02 正大天晴药业集团股份有限公司 作为tlr7激动剂的吡咯并嘧啶化合物
US9962388B2 (en) * 2014-08-15 2018-05-08 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Pyrrolopyrimidine compounds used as TLR7 agonist
CN105732635A (zh) * 2014-12-29 2016-07-06 南京明德新药研发股份有限公司 一类Toll样受体7激动剂
MY189991A (en) 2015-11-05 2022-03-22 Chia Tai Tianqing Pharmaceutical Group Co Ltd 7-(thiazol-5-yl)pyrrolopyrimidine compound as tlr7 agonist
CN107043380A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
CN107043377A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途
CN107043379A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的晶型a、其制备方法和医药用途

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022156678A1 (zh) * 2021-01-20 2022-07-28 上海维申医药有限公司 大环tlr7激动剂、其制备方法、药物组合物及其用途
CN115119508A (zh) * 2021-01-20 2022-09-27 上海维申医药有限公司 大环tlr7激动剂、其制备方法、药物组合物及其用途
CN115119508B (zh) * 2021-01-20 2024-05-24 上海维申医药有限公司 大环tlr7激动剂、其制备方法、药物组合物及其用途

Also Published As

Publication number Publication date
AU2019272478A1 (en) 2020-12-17
JP7385602B2 (ja) 2023-11-22
CA3101370A1 (en) 2019-11-28
EP3816166A4 (en) 2022-04-06
US20210220362A1 (en) 2021-07-22
JP2021525260A (ja) 2021-09-24
WO2019223788A1 (zh) 2019-11-28
KR20210013183A (ko) 2021-02-03
EP3816166A1 (en) 2021-05-05

Similar Documents

Publication Publication Date Title
CN110382499B (zh) Fgfr抑制剂及其应用
TWI726363B (zh) Fak/alk/ros1抑制劑與egfr抑制劑的組合治療癌症的方法
US20220363648A1 (en) Glucose Uptake Inhibitors
TW201915004A (zh) 噻吩並嘧啶類化合物、其製備方法、藥用組合物及其應用
TW202304914A (zh) 經取代之四環羧酸、其類似物及使用其之方法
CN112839947B (zh) 用于治疗结直肠癌的tlr7激动剂及其药物组合
US20210251991A1 (en) Substituted 2,2'-bipyrimidinyl compounds, analogues thereof, and methods using same
CN112105620A (zh) 用于治疗肺癌的tlr7激动剂及其药物组合
KR20210063332A (ko) 퀴놀린카르복사미드 유도체를 사용하는 암 병용 요법
AU2019272478B2 (en) TLR7 agonist and pharmaceutical combination thereof for treating lung cancer
TW202132285A (zh) 經取代異吲哚啉基2,2’-聯嘧啶基化合物、其類似物及使用其之方法
JP2023507028A (ja) 複素環式化合物とその医薬組成物、調製方法、中間体及び使用
EP4029503A1 (en) Drug combination containing tlr7 agonist
CN112759583B (zh) 包含呋喃基的喹啉类衍生物及其制备方法和用途
CN112625025B (zh) 吡啶基取代的喹啉类衍生物及其制备方法和用途
CN114105977B (zh) 雌激素受体调节剂化合物及其用途
US11795179B2 (en) Discovery of imidazothiazole- and imidazooxazole-based selective HER4 kinase inhibitors as potential anticancer agents
CN113164487A (zh) 磷酸二酯酶抑制剂
US20240051940A1 (en) Sulfonamides with egfr inhibition activities and their use thereof
TW202400578A (zh) 新穎的化合物及其用於抑制檢查點激酶２的用途
CN116261455A (zh) 一种药物组合物及其在治疗癌症中的用途

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40039547

Country of ref document: HK